TCM Prescription: Shen Lu Bu Tablets



Prescription Description
Prescription IDTCMF3301
Pinyin NameShen Lu Bu Pian
Chinese Name参鹿补片
English NameShen Lu Bu Tablets
Function Description眩晕, 耳鸣
IndicationsTinnitus disorder, Vertigo disorder, Tinnitus, Dizziness
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
MC41 [Tinnitus, 耳鸣 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH1354 NA 鹿肉 TCMH1354
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH693 Cudrania cochinchinensis 狗脊 TCMH693
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH2551 Polygonatum odoratum 玉竹 TCMH2551 ITSAM921-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2056 Cynomorium songaricum 锁阳 TCMH2056 ITSAO3649-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2252 Agrimonia pilosa var. japonica 仙鹤草 TCMH2252
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.99324
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, PPARA, RORC, SMAD3, SRC, TEK, TYR 8.96235
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.96235
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MCL1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.17783
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 7.50913
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 7.50913
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 7.45718
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.22644
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.22644
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PTPN1, SMAD3, SRC, TEK 7.22644
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, PPARA, RORC, SRC, TEK, TYR 7.18025
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.18025
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, PPARA, RORC, SMAD3, SRC, TEK, TYR 7.18025
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, SRC, TEK 7.18025
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MCL1, MET, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR 7.1475
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MCL1, MET, PPARA, SMAD3, SRC, TEK, XDH 7.1102
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 7.04608
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 7.04608
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 6.95079
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 6.95079
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.91023
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 6.76762
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 6.76086
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC, TEK, TYR 6.76086
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.76086
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MCL1, PIM1, PTPN1, SMAD3, SRC, TEK 6.72107
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 6.72107
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.72107
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.41448
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, NUAK1, PTPN1, SRC, TEK, XDH 6.35515
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.24431
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.93304
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, PTPN1, SRC, TEK, XDH 5.91069
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.86752
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, XDH 5.78219
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.70584
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.65425
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 5.48401
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 5.4768
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MCL1, MET, SMAD3, SRC 5.46342
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, XDH 5.46301
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.42243
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 5.38613
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 5.08573
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 5.07274
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, MCL1, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TYR 5.05136
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MCL1, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.02704
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, RORC, SMAD3, SRC 4.93105
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MCL1, MET, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.93105
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.93105
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 4.87141
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.8114
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.79351
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 4.79351
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP12, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 4.77067
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, RORC, SMAD3, SRC 4.72007
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.63362
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.6321
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.63018
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.52034
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.51154
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 4.34339
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.16393
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.11558
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 4.11558
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.11558
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.11233
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.10585
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, PPARA, PTPN1, SMAD3 4.00101
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.96341
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 3.95165
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.94944
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 3.94944
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.93129
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, HSD17B2, IGF1R, INSR, MCL1, MET, MMP12, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.92655
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 3.85078
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA 3.77732
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.77307
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.72442
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, SRC 3.72442
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, SRC 3.71769
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC 3.6853
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.64806
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.64308
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.63087
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MCL1, MET, PPARA, SMAD3 3.63015
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 3.5938
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 3.51514
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.50493
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, TEK 3.47065
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, SRC 3.4512
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.43944
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.43944
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.41706
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 3.40934
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.40541
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.3201
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MCL1, MET, PTPN1, SRC, XDH 3.29032
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 3.28671
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.27847
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27297
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.26066
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 3.23006
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MCL1, MET, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A 3.22948
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.22619
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.17959
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 3.13328
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 3.0693
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.05726
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.00758
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.00758
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.00758
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, PPARA, SMAD3, SRC, TEK, TYR 2.98151
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.98151
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PTPN1, SRC 2.98151
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96351
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.9479
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.93989
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, SRC 2.92598
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.92561
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.92283
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.92283
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89679
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.89679
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, PTPN1, SRC 2.8817
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.86351
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, SRC 2.86351
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.86207
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.86207
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, SRC 2.85866
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.85866
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.85866
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.85598
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, SRC 2.84714
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.84714
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.84072
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.81882
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.81663
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.79817
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.79817
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.79817
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.79817
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.79379
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.78952
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.78952
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.78952
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.78952
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.78952
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.78952
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.78504
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.78504
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.78083
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.78083
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.78083
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.77369
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.76276
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.7584
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.7584
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.72257
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP12, SRC, XDH 2.71589
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.69878
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.69878
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.67816
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.67524
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.66458
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.66458
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.66458
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, PPARA, PTPN1, SMAD3, SRC 2.66458
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.66458
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTPN1, PTPRS, XDH 2.66245
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, PTPN1, PTPRS 2.65104
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MCL1, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.63425
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.6132
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC 2.61293
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.61083
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.59335
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.59304
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58266
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PTPN1, SRC, TEK, XDH 2.57431
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.56014
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.56014
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.54513
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.53098
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.52509
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.51313
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.51313
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.50849
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.50849
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.50849
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.4767
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.47426
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.46255
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, PTPN1, SMAD3, SRC, TEK, XDH 2.46108
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.4569
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, PTPN1, SMAD3, SRC, TEK 2.44906
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.44244
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.41527
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41527
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.41475
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.41353
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.41332
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SRC, TEK, XDH 2.40228
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, PIM1, PTPRS, SMAD3, SRC, TEK, XDH 2.39058
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.37584
[BP] GO:0051894 None KDR, SMAD3, TEK 2.37374
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37374
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.35138
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35138
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.34237
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.34237
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.29506
[BP] GO:1903393 None KDR, SMAD3, TEK 2.28348
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.28257
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.27955
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR 2.23837
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, RORC, SRC 2.22321
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.19715
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.1726
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.16838
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.16832
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 2.16616
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.1652
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.12663
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.12663
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.12663
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.11828
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.11828
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.11095
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.11038
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.10045
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.10045
[BP] GO:1901890 None KDR, SMAD3, TEK 2.09969
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.0969
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, PTPN1, SRC 2.0938
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MMP12, SRC 2.08625
[BP] GO:0030308 None BCL2, ESR2, HSPA1A, PTPRS, SMAD3 2.08524
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.06652
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.05952
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.0528
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 2.04469
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, RORC 2.0416
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.04013
[BP] GO:0010907 None INSR, PPARA, SRC 2.04013
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.04013
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MCL1, NUAK1, PTPN1, SRC, TOP2A 2.03986
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MCL1, MET, NUAK1, PTPN1, SRC, TEK 2.03846
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIM1, PTPRS, SMAD3 2.03846
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, MMP12, PTPN1, PTPRS, SMAD3, SRC 2.03794
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.0305
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PTPN1, SRC 2.0305
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP12, PIM1, SMAD3, SRC, TEK 2.02425
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1 2.02425
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MMP12, SRC 2.02342
[BP] GO:2001240 None BCL2, HSPA1A, MCL1 2.0223
[BP] GO:1901099 None BCL2, HSPA1A, MCL1 2.0223
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, TEK, TYR 2.0223
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.0223
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.67816
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TOP2A, TYR, XDH 2.34237
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK 2.29506
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MCL1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TOP2A, TYR, XDH 2.10633
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04013
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.68195
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TOP2A, TYR, XDH 9.50856
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 8.99324
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.75217
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.53991
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.18025
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.07703
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.74188
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.78219
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.7375
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 5.34345
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 5.05202
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.77067
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, GLO1, MMP12, PPARA, PTPN1, RORC, SMAD3 4.57816
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 4.37036
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.95332
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.92655
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.84213
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.64879
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.60974
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 3.44211
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.40541
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 3.30976
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.24815
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 3.20257
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.04691
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 3.04691
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 2.96739
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.95391
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.92283
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89953
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.89953
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.89679
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.8817
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.8817
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.87121
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.79379
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.78952
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.78952
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.70734
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.65846
[MF] GO:0000166 nucleotide binding ALDH2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.58266
[MF] GO:1901265 nucleoside phosphate binding ALDH2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.58249
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.56277
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.55881
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.55094
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.54074
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.43993
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.41475
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.35138
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.31477
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MCL1, MET, SMAD3, TOP2A, TYR, XDH 2.26442
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, DUSP3, PTPN1, PTPRS 2.22321
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP2A, XDH 2.21204
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.16578
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16578
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.16578
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.1652
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH 2.15036
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.11828
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, DUSP3, PTPN1, PTPRS 2.09969
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.09969
[MF] GO:0046982 protein heterodimerization activity ADORA1, AXL, BCL2, EGFR, MCL1, SMAD3, TOP2A, TYR 2.08973
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK 2.0528
[MF] GO:0005496 steroid binding ESR1, ESR2, HSD17B1, RORC 2.0416
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04013
[MF] GO:0035258 None ESR1, FLT3, SMAD3, SRC 2.02342
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, PTPN1, SMAD3, SRC, TOP2A 2.0223
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP2A 2.01783


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.9642
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4798
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.7151
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2193
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1321
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, TEK, MET, EGFR, MCL1, IGF1R 3.8993
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.833
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, CYP1B1 3.8993
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.833
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.833
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.7905
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.5558
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MET, EGFR, CDC25B, MCL1 3.5558
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5558
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.3143
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2608
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1144
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, BCL2, MET, EGFR, IGF1R 2.2413
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3763
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3763
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2647
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.3487
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2413
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2413
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2191
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2167
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1 1.8389
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.923
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9813
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2393
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7846
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7007
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6293
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5822
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6923
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.5129
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, MCL1 1.43
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3851
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2538
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3611
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.2628
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3684
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4002
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3611
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 0.9855
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1667
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1456
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0234
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.108
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3684
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1341
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9855
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1651
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3599
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9048
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1355
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9634
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.902
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3611
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9158
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3684
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2473
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.902
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9634
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3611
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.902
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.902
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.902
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8972
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8726
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6293
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8655
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.841
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8125
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7135
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2761
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8182
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3435
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.6338
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3812
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3708
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3769
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3812
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3703
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4227
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4311
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4631
Platelet activation_Homo sapiens_hsa04611 SRC 0.4874
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.49
Axon guidance_Homo sapiens_hsa04360 MET 0.4791
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4874
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.512
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5438
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5361
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5438
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5438
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.545
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5499
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7846
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5494
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5627
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5635
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.572
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.565
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.565
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5666
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5643
Peroxisome_Homo sapiens_hsa04146 XDH 0.573
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6115
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6099
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5983
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6203
Bile secretion_Homo sapiens_hsa04976 CA2 0.6187
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6319
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6221
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.636
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0064
Shigellosis_Homo sapiens_hsa05131 SRC 0.634
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6576
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.6299
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6811
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.7025
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6842
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.7025
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7025
Malaria_Homo sapiens_hsa05144 MET 0.7095
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.7058
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7135
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7135
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.7135
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7135
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.7263
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7711
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8108
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8687
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.841
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8108
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8207
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8496
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.841
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8687
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.841
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8687
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8687
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8908
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0315
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1483


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)