TCM Prescription: Shen Ling Jian Er Ointment



Prescription Description
Prescription IDTCMF3269
Pinyin NameShen Ling Jian Er Gao
Chinese Name参苓健儿膏
English NameShen Ling Jian Er Ointment
Function Description疳病
IndicationsInfantile malnutrition disorder
Disease ICD-11 Category SE37 [Infantile malnutrition disorder (TM1), 疳病 (TM1) ];
Human Tissues Associated with IndicationSpleen, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH910 Tadehagi triquetrum 葫芦茶 TCMH910 ITSAJ4186-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT49 SCN9A Sodium channel protein type IX alpha subunit Ion channel Q15858
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT51 SCN11A Sodium channel protein type XI alpha subunit Ion channel Q9UI33
TCMT52 SCN8A Sodium channel protein type VIII alpha subunit Ion channel Q9UQD0
TCMT53 SCN4A Sodium channel protein type IV alpha subunit Ion channel P35499
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT54 SCN3A Sodium channel protein type III alpha subunit Ion channel Q9NY46
TCMT55 SCN2A Sodium channel protein type II alpha subunit Ion channel Q99250
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT56 SCN1A Sodium channel protein type I alpha subunit Ion channel P35498
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SMAD3, SRC, TEK, XDH 10.0214
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.27376
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SMAD3, SRC, TEK 8.42325
[BP] GO:0019228 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 7.86633
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 6.85491
[BP] GO:0086010 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 6.85491
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.73285
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 6.52354
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.47127
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 6.45372
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 6.43546
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, RORC, SCN11A, SCN9A, SMAD3, SRC, TEK, TYR 6.39568
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.39568
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, POLB, PPARA, RORC, SRC, TEK, TYR 6.21158
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 6.21158
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.09369
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, POLA1, POLB, PPARA, PTPN1, RORC, SCN11A, SCN1A, SCN2A, SCN9A, SMAD3, SRC, TEK, TOP2A, TYR 5.9638
[BP] GO:0051899 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 5.93011
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.93011
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86301
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 5.8499
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK 5.69433
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, PPARA, PTPN1, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SMAD3, SRC 5.65891
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 5.61241
[BP] GO:0001508 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 5.43293
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.40427
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.33857
[BP] GO:0042391 None ADORA1, BCL2, GPR35, KDR, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SRC 5.33857
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.22094
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.17787
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.17787
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 5.15338
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 5.09188
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, PIM1, PTPN1, SMAD3, SRC, TEK 5.0825
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 5.06724
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.96844
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.84834
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.84317
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PTPN1, RORC, SCN2A, SMAD3, SRC, TOP2A 4.82139
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 4.78752
[BP] GO:0035725 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 4.74227
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 4.71033
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 4.71033
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.68611
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, PIM1, POLB, PPARA, RORC, SCN8A, SMAD3, SRC, TEK, TOP2A, TYR 4.68611
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, XDH 4.62895
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.62895
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 4.59049
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 4.58247
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.57803
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SCN9A, SRC 4.50407
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 4.49767
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 4.41127
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37219
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 4.36914
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.29595
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, POLB, PPARA, SCN1A, SCN2A, SMAD3, SRC, TEK, TYR 4.29145
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.18393
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.17052
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.1641
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.93613
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.89358
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.87751
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 3.84868
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.79956
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, RORC, SCN8A, SMAD3, SRC, TEK, TYR 3.791
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 3.78807
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.78394
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.71918
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, HSD17B2, IGF1R, INSR, MET, MMP12, PIM1, PPARA, RORC, SCN1A, SCN4A, SCN9A, SMAD3, SRC, TEK, TYR 3.71918
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, GPR35, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.70362
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 3.67536
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, SCN11A, SRC 3.6612
[BP] GO:0006814 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.6548
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.6404
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 3.62341
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60098
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.5997
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.59049
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.59049
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, RORC, SMAD3, SRC 3.51419
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.46592
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.46592
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, SRC 3.46592
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 3.44968
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.41911
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, SRC 3.41779
[BP] GO:0034762 None BCL2, CA2, GPR35, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.39699
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.37664
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, RORC, SMAD3, SRC 3.36742
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.35357
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.26546
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.25735
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 3.19469
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.15634
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, SRC 3.14254
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1332
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, TBXAS1 3.1016
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC, TOP2A 3.06709
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.04945
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.03931
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.02335
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, POLB, PPARA, SMAD3, SRC, TEK 3.00505
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 3.00299
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, NUAK1, POLA1, POLB, PPARA, PTPN1, SCN2A, SCN9A, SMAD3, SRC, TEK, TOP2A 3.00134
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 2.98273
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.95074
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 2.9162
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8172
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.79525
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.79173
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.78067
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.71565
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.70325
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.6585
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.65326
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.64666
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.61101
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.57747
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, SRC 2.55795
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.53616
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.51502
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.51502
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.51502
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.51502
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.51502
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.51502
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.50901
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 2.50901
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.50314
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.50314
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.4885
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.46948
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.46098
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.44583
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.43405
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.42385
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, SRC 2.42385
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.42031
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.41919
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.41281
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41281
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.41281
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.41281
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.41281
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40403
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.38876
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.38876
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, TEK 2.35578
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, NUAK1, POLA1, POLB, PTPN1, SCN2A, SRC, TOP2A 2.34254
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.33971
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.3306
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.31455
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.29235
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.29235
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.28878
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, POLB, PTPN1 2.27728
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.25081
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.25081
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.25081
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.25081
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.25081
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.24418
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.23492
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.2076
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20243
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 2.18066
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.18011
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17927
[BP] GO:0051894 None KDR, SMAD3, TEK 2.15703
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15703
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 2.15635
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.14221
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.1412
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.13585
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.13585
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.13247
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.13247
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.07985
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC 2.07492
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 2.07492
[BP] GO:1903393 None KDR, SMAD3, TEK 2.07348
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.07348
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.07348
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 2.0677
[BP] GO:0034765 None GPR35, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 2.06037
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.05972
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SMAD3, SRC, TEK, TOP2A, XDH 2.05952
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.05585
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.05565
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP12, SRC, XDH 2.03868
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.03868
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.03868
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.01632
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.00133
[CC] GO:0001518 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 9.84276
[CC] GO:0034706 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 8.86501
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM2, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SRC, TEK 3.67083
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SRC, TBXAS1, TEK, TYR 3.51419
[CC] GO:0034703 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 2.93934
[CC] GO:0033268 None SCN1A, SCN2A, SCN8A 2.64535
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, EGFR, F10, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PIM1, PTPN1, SCN11A, SCN1A, SCN3A, SCN8A, SMAD3, SRC, TEK 2.56699
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SCN2A, SCN4A, SCN9A, TEK 2.49869
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.35073
[CC] GO:0034702 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 2.23054
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, PIM1, PTPN1, SCN11A, SCN1A, SCN3A, SCN8A, SMAD3, SRC, TBXAS1, TEK, TYR 2.17336
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.05952
[CC] GO:1902495 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 2.05952
[CC] GO:1990351 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 2.01632
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.74701
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 8.86501
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 8.86501
[MF] GO:0005248 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 8.60139
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SCN8A, SCN9A, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 8.42325
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 8.12509
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.23166
[MF] GO:0005272 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 6.68691
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.52354
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.52354
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.27081
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.24898
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SCN8A, SRC, TEK, TOP2A 6.17529
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.09369
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 5.69433
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.29661
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.24035
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.2359
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.13789
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.06724
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.72369
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, GLO1, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SCN9A, SMAD3, TBXAS1, TOP2A, TYR, XDH 4.49767
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.1641
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, GLO1, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SCN9A, SMAD3, TBXAS1, TOP2A, TYR, XDH 4.02685
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.95933
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.80467
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 3.70152
[MF] GO:0015081 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.6548
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.60463
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.41779
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.37664
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.26699
[MF] GO:0005244 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.08275
[MF] GO:0022832 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 3.08275
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.0715
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.05879
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SCN8A, SRC, TEK, TOP2A, XDH 2.81865
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.8172
[MF] GO:0008389 None CYP2A13, CYP2A6 2.79173
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP12, PPARA, PTPN1, RORC, SMAD3 2.63654
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.57288
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SCN8A, SRC, TEK, TOP2A 2.48179
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SCN8A, SRC, TEK, TOP2A 2.39192
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SCN8A, SRC, TEK, TOP2A 2.36369
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.29235
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SCN8A, SRC, TEK, TOP2A, XDH 2.27728
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SCN8A, SRC, TEK, TOP2A, XDH 2.27648
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.12184
[MF] GO:0005261 None SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A 2.06037
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.05585
[MF] GO:0043559 insulin binding IGF1R, INSR 2.01632


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.5058
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0799
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2606
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.8877
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.908
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.8265
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 3.9957
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.6411
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5643
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 3.8713
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.5643
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.2255
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.978
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.3311
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MET, EGFR, CDC25B 2.4067
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.5283
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1325
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1758
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, BCL2, MET, EGFR, IGF1R 1.967
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0544
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0375
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0375
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.0544
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0101
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0195
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA1, PPARA 1.7069
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8041
Taste transduction_Homo sapiens_hsa04742 SCN9A, SCN2A, SCN3A 1.8748
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1 1.7058
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0375
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, EGFR, HSPA1A 1.7069
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6415
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6515
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4734
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.5911
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.582
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4303
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.402
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GPR35, ADORA3, ADORA1 1.3849
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3088
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1504
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.2615
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.1026
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3088
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.334
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1026
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2866
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8887
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.083
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0449
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.071
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8312
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8887
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8416
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3148
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2821
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.17
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8265
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3088
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8887
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1026
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8222
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8222
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0727
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8207
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8265
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8044
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2866
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7921
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.3088
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2615
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7921
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7552
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.5493
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7438
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.7373
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6643
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7404
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7069
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5608
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4734
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3352
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3348
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3498
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3908
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3988
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4147
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4265
Axon guidance_Homo sapiens_hsa04360 MET 0.4388
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4468
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4523
Dopaminergic synapse_Homo sapiens_hsa04728 SCN1A 0.4365
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4551
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4704
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4978
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4905
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4978
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4978
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4987
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4904
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5032
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5028
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8748
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5156
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5161
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5237
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5173
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5173
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.678
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5186
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5167
Peroxisome_Homo sapiens_hsa04146 XDH 0.5245
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.6643
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5581
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5594
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6262
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5394
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5567
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5608
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5455
Bile secretion_Homo sapiens_hsa04976 CA2 0.5608
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5771
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5809
Shigellosis_Homo sapiens_hsa05131 SRC 0.5789
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6019
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6249
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6278
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6457
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6492
Malaria_Homo sapiens_hsa05144 MET 0.6607
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6643
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7347
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7552
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7291
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8162
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7552
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7902
DNA replication_Homo sapiens_hsa03030 POLA1 0.7486
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7972
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8207
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7921
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8162
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0152


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)