Prescription Description
| Prescription ID | TCMF3068 |
| Pinyin Name | Bu Xue Tiao Jing Pian |
| Chinese Name | 补血调经片 |
| English Name | Bu Xue Tiao Jing Tablets |
| Function Description | 血劳, 带下病, 痛经, 崩漏, 闭经 |
| Indications | Metrorrhagia disorder, Amenorrhea disorder, Dysmenorrhea disorder, Leukorrhea disorder, Irregular menstruation |
| Disease ICD-11 Category |
SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1)
]; SB94 [Amenorrhea disorder (TM1), 闭经 (TM1) ]; SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ]; SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ]; GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ]; |
| Human Tissues Associated with Indication | Uterus |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1036 | Spatholobus suberectus | 鸡血藤 | TCMH1036 | ITSAK2607-14 |
| TCMH541 | Colla corii asini | 阿胶 | TCMH541 | |
| TCMH668 | Rhodomyrtus tomentosa | 岗稔子 | TCMH668 | TCHDC002-16 |
| TCMH1742 | Cinnamomum cassia | 肉桂 | TCMH1742 | GQ255631 |
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH12 | Artemisia argyi | 艾叶 | TCMH12 | ITSAE2504-14 |
| TCMH2473 | Leonurus japonicus | 益母草 | TCMH2473 | ITSAN1807-14 |
| TCMH1133 | Rosa laevigata | 金樱子 | TCMH1133 | ITSAJ4477-14 |
| TCMH2215 | Ficus simplicissima | 五指毛桃 | TCMH2215 | |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH511 | Litsea cubeba | 豆豉姜 | TCMH511 | GBVG4364-11, GBVG4358-11 |
| TCMH672 | Alpinia officinarum | 高良姜 | TCMH672 | ITSAK2176-14 |
| TCMH211 | Atractylodes lancea | 苍术 | TCMH211 | ITSAN4439-14 |
| TCMH1657 | Radix moghaniae philippinensis | 千斤拔 | TCMH1657 | |
| TCMH1791 | Loranthus parasiticus | 桑寄生 | TCMH1791 | |
| TCMH43 | Mallotus apelta | 白背叶 | TCMH43 | ITSAO3511-14 |
| TCMH317 | Capsella bursa-pastoris | 荠菜 | TCMH317 | WAT267-12, FOND036-12 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 135 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1207 | Legionella pneumophila |
Showing 1 to 10 of 81 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, SRC | 3.15392 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGES, PTGS2, SRC | 2.41838 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD3, EGFR, HTR1A, INSR, PTGS2, SMAD3 | 3.84265 |
| [BP] GO:0001516 | None | MIF, PTGES, PTGS1, PTGS2 | 4.52644 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, PPARA, PTGS2, SMAD3, SRC, TEK | 3.7983 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGES, PTGS1, PTGS2 | 4.49641 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, CXCL8, EGFR, FLT3, FUT7, HSPA1A, MIF, RORC, SMAD3, SRC | 2.01988 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALK, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, HTR2B, IGF1R, INSR, KDR, MIF, PTGS2, PTK2, PTPN1, SRC, TEK, XDH | 4.47719 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALK, APP, BCL2, CDC25B, EGFR, FLT3, HTR2B, INSR, KDR, MIF, PTGS2, PTK2, PTPN1, SRC, TEK, XDH | 4.26889 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PTK2, SMAD3, SRC, TEK | 4.42716 |
Showing 1 to 10 of 508 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2605 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.5074 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5039 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3209 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, CXCL8, BCL2, PIM1, F3 | 3.3282 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1 | 0.2734 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.473 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.2871 |
| Amoebiasis_Homo sapiens_hsa05146 | CXCL8, PTK2 | 0.9234 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5107 |
Showing 1 to 10 of 171 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples