TCM Prescription: Bai Kou Tiao Zhong Pills



Prescription Description
Prescription IDTCMF3028
Pinyin NameBai Kou Tiao Zhong Wan
Chinese Name白蔻调中丸
English NameBai Kou Tiao Zhong Pills
Function Description胃胀, 呕吐
IndicationsEpigastric distension disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA52 [Epigastric distension disorder (TM1), 胃胀 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationStomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH214 Alpinia katsumadai 草豆蔻 TCMH214 KY454001
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH45 Lablab purpureus 白扁豆 TCMH45 ITSAM881-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2721 Perilla frutescens var. arguta 紫苏梗 TCMH2721 ITSAF2620-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 14.5411
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MPO, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TYR 13.4309
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.879
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PRKCE, PTGS2, RORC, SRC, TYR 12.1435
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1079
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 11.6379
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.8447
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 10.7994
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 10.7651
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.7401
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.7136
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 10.2158
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 10.211
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, GLO1, HSPA1A, IDO1, MPO, PIM1, PPARA, PTGS2, TYR, XDH 9.52576
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TYR 9.46059
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 9.316
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 9.1809
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.97628
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.90721
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 8.78561
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.66157
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.39971
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.26849
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.23626
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.23272
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.20296
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.1006
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MPO, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 8.1006
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.04434
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK 7.99585
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK, XDH 7.99585
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGS2 7.84531
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 7.77889
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SRC 7.7718
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F2, F3, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.67112
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.65434
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MMP12, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 7.65115
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 7.64281
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE 7.63974
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.62759
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MPO, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 7.39737
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, F3, FABP4, IDO1, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 7.36243
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 7.3474
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.15562
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, EGFR, F2, HCAR2, KDR, PRKCE, PTGS2, SRC, TNKS, TNKS2 7.14371
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.05138
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.77796
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, F2, FABP3, FLT3, HCAR2, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 6.74205
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F2, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A 6.55265
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 6.53875
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, IDO1, MMP12, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 6.53047
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 6.42725
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, IDO1, PPARA, PRKCD, PTGS2, SMAD3, TEK 6.40727
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.23543
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, KDR, PRKCD, PRKCE, SRC 6.22773
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.16502
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 6.1011
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 6.03804
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 5.98986
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.90658
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.90658
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, PRKCE 5.90658
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MET, MMP12, MPO, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 5.76251
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.76225
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.74693
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC 5.74693
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.71237
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.71051
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.6646
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 5.65228
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.62811
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC 5.60298
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, PRKCD, PTGS2, SRC 5.60298
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.60298
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 5.58822
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.4678
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.43541
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.43541
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.42613
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 5.4152
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.35255
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.34287
[BP] GO:0030168 platelet activation AXL, F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.28623
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MPO, PRKCD, PTGS2, SRC 5.24276
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.24195
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F2, F3, FABP4, IDO1, KDR, MET, PRKCA, PTGS2, SMAD3 5.18047
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA, PRKCD, SMAD3, TEK 5.15164
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PRKCA, PTGS2, TEK 5.14646
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PRKCD, PRKCE, PTGS2, SRC 5.14437
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.13859
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.1169
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.10268
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, EGFR, F2, GPR35, HCAR2, HSPA1A, INSR, KCNA3, MMP12, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC 5.10268
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.0781
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, PRKCD, PTGS2, SMAD3, XDH 5.04723
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, F2, HCAR2, PTGS2, TNKS, TNKS2 5.04723
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.04117
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.0402
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, MET, PRKCB, PRKCE, SMAD3, SRC 5.0402
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.0402
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, F2, MMP12, PPARA, PRKCD, SMAD3, TEK 5.02641
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.02641
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, IDO1, MMP12, MPO, PRKCD, PTGS2, SMAD3, SRC 5.01025
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.9865
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 4.97253
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 4.8696
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.84427
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, F2, HCAR2, HSPA1A, IDO1, MMP12, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 4.84427
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.82055
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, F2, F3, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 4.81956
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.79318
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, IDO1, MMP12, MPO, PRKCD, PTGS2, SMAD3, SRC 4.78412
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 4.75056
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PRKCD, PTGS2, SMAD3, XDH 4.72142
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS, TOP2A 4.67253
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 4.58524
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.57371
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.54273
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.54273
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.50631
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, MPO, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TYR 4.45688
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.44753
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 4.40973
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSD11B2, HSPA1A, IDO1, MPO, NUAK1, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 4.37321
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36598
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 4.35346
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 4.34356
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.34356
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.31291
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, F2, HSD11B2, IDO1, MMP12, MPO, PRKCD, PTGS2, SMAD3, SRC, TYR 4.26619
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, PRKCG, RORC, SRC, TOP2A 4.25197
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A, IDO1, MPO 4.24492
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.2403
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, PRKCD, SRC 4.2403
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.23629
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.22001
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TNKS, TOP2A 4.21814
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, MET, PRKCB, PRKCE, SMAD3 4.16763
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.1124
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.1124
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, MPO, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC 4.0802
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGS2 4.05387
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.03707
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC 4.0198
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, PRKCD, SRC 3.97098
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.96634
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.95779
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, ESRRB, F2, FLT3, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 3.91981
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.90818
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, F2, PPARA, SMAD3 3.89446
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.89053
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.87881
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PRKCA, PRKCE, PTGS2, SRC, TEK 3.86741
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.84858
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 3.83454
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNA3, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 3.78655
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.77049
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.70656
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.70062
[BP] GO:0090087 None ACHE, ADORA1, CA2, CNR1, EGFR, F2, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.67175
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, PRKCD, SRC 3.67161
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, MET, PPARA, PRKCG, SMAD3 3.65593
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 3.59439
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.57056
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, F3, IDO1, INSR, KDR, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, XDH 3.57056
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, MPO, PTGS2, SRC, TYR 3.57056
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 3.54884
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 3.53507
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.53278
[BP] GO:0010676 None ESRRB, INSR, PPARA, PRKCE, SRC 3.51593
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.5022
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48675
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.48675
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 3.48492
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, F2, KDR, PRKCE, SRC 3.47674
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.47151
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.47151
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, F2, HCAR2, INSR, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.47151
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.45331
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F2, F3, FLT3, HSPA1A, INSR, MET, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.45331
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK, XDH 3.44413
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 3.42896
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.41838
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.40516
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.38776
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 3.36577
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 3.36577
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, PRKCD, SRC, TEK, TYR 3.36469
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.36116
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.34873
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.34795
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.31871
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.29939
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 3.29939
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.29939
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.27682
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.26466
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR, PRKCE, PTGS2 3.26339
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR, PRKCE, PTGS2 3.26339
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.2501
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.24275
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.23889
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, PPARA, PTGS2 3.22775
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.22237
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, MPO, PRKCD, PTGS2 3.21305
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.17081
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.16766
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.16766
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.14493
[BP] GO:0050866 negative regulation of cell activation AXL, CNR1, CNR2, DUSP3, F2, IDO1, PRKCD 3.12672
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12592
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.10043
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.09788
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, MPO, PTGS2, SRC, TYR 3.09323
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK 3.08669
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 3.07853
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 3.07363
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.07128
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.07025
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.06348
[BP] GO:0045913 None ESRRB, INSR, PPARA, PRKCE, SRC 3.04968
[BP] GO:0070201 None ACHE, BCL2, CNR1, EGFR, F2, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.03601
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, IDO1, PRKCD, PTGS2, SMAD3, SRC, TOP2A, XDH 3.03413
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.02913
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.02913
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.0276
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 3.01478
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 3.00546
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, IDO1, PRKCD, PTGS2, SMAD3, SRC, TOP2A, XDH 3.0048
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, IDO1, MMP12, PRKCD, PRKCE, PTGS2, SRC 3.0048
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 2.99324
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, F2, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.99062
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, PRKCD, PTGS2, PTPN1, SRC, XDH 2.97643
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PRKCE, PTGS2 2.97618
[BP] GO:0010675 None ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.97618
[BP] GO:2000026 regulation of multicellular organismal development AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, XDH 2.97236
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 2.95742
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC 2.91861
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.91816
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.90568
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, PTGS2, SRC, TOP2A 2.90258
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PRKCE, SMAD3, SRC, TEK 2.90135
[BP] GO:0035408 None PRKCA, PRKCB 2.88743
[BP] GO:0009115 None AOX1, XDH 2.88743
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, MMP12, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.83414
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, F2, PRKCD, PTGS2, SMAD3, SRC 2.82229
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82229
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.82229
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 2.799
[BP] GO:0051704 multi-organism process AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, F2, HSD11B2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MPO, PRKCD, SMAD3, SRC 2.799
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK 2.75325
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.7483
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 2.7483
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73369
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, IDO1, PRKCD, PTGS2, SMAD3, SRC, TOP2A, XDH 2.73179
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, MMP12, MPO, SRC, XDH 2.7294
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, F2, PPARA, PRKCD, SMAD3, TEK 2.72313
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.72313
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC, TEK, TNKS 2.71766
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.71403
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.71403
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.69552
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, GPR35, PRKCB, PRKCE, SMAD3 2.69124
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.68778
[BP] GO:0051223 None ACHE, CNR1, EGFR, F2, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.68778
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.68332
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK 2.66808
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CNR1, CSNK2A1, EGFR, F2, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.66808
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.66548
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, PRKCE, PTGS2 2.66419
[BP] GO:0061041 regulation of wound healing F2, F3, PRKCA, PRKCD, PRKCE, SMAD3 2.63355
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNA3, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.63341
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.62817
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.62396
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 2.62271
[BP] GO:0032845 None ADORA1, BCL2, PRKCE, SRC, TNKS, TNKS2 2.62271
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, F2, FLT3, INSR, PRKCD, PTPN1, SRC, TEK, TNKS 2.61654
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, PRKCA, PRKCE, PTGS2, SRC, TEK 2.59558
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.59204
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59204
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.58803
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 2.58225
[BP] GO:0051222 positive regulation of protein transport ACHE, EGFR, F2, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.57984
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 2.56789
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.55764
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS2, SMAD3 2.55646
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.55635
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, KDR, MMP12, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.54226
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.5311
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.52552
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.52552
[BP] GO:0046110 None AOX1, XDH 2.49667
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49667
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MET, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.49451
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 2.4928
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 2.4837
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.48036
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.48036
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F2, F3, MET, PRKCA, PRKCD, PRKCE, XDH 2.47382
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.47141
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.46964
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.46435
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.46435
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, PRKCE, TNKS 2.4547
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, F2, GPR35, KCNA3, PRKCD, PRKCE, PTGS2 2.44846
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.44615
[BP] GO:0050730 None ADORA1, EGFR, FLT3, PRKCD, PRKCE, PTPN1, SRC 2.43877
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CDK6, CNR1, CNR2, CYP19A1, DUSP3, IDO1, MMP12 2.43415
[BP] GO:0042307 positive regulation of protein import into nucleus EGFR, F2, PRKCD, PTGS2, SMAD3 2.42926
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.42926
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 2.4278
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.41921
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40232
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC, TEK 2.3969
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.3947
[BP] GO:1904591 positive regulation of protein import EGFR, F2, PRKCD, PTGS2, SMAD3 2.3947
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.3947
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.39087
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.38922
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.38922
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.38922
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, TYR 2.38438
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.38393
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.38393
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.38393
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.38393
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PRKCE, PTGS2, SRC 2.38153
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.36496
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS2, TYR 2.36258
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.3603
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.33875
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.33814
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.33814
[BP] GO:1903034 regulation of response to wounding F2, F3, PRKCA, PRKCD, PRKCE, SMAD3 2.3263
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, XDH 2.30871
[BP] GO:0010811 positive regulation of cell-substrate adhesion CDK6, KDR, PRKCE, SMAD3, TEK 2.29676
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.29676
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.29676
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.29676
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, GPR35, PRKCB, PRKCE, SMAD3 2.27767
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.25925
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.25925
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.25925
[BP] GO:0070213 None TNKS, TNKS2 2.25925
[BP] GO:0006145 None AOX1, XDH 2.25925
[BP] GO:0038171 None CNR1, CNR2 2.25925
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25925
[BP] GO:0050679 None EGFR, F3, KDR, MMP12, PRKCA, TEK 2.24935
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24935
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.24935
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.24935
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, EGFR, ESR2, F2, HSPA1A, INSR, MPO, PIM1, SMAD3, TNKS2 2.22764
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MMP12, PRKCE, SRC 2.22476
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, PPARA, PRKCD, SMAD3, SRC, TNKS 2.22476
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC 2.22476
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.21697
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.21697
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, PTGS2 2.21697
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.21697
[BP] GO:0050776 regulation of immune response BCL2, CNR1, DUSP3, ESR1, F2, HSPA1A, IDO1, MMP12, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.21012
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, F2, FLT3, INSR, PRKCD, PTPN1, SRC, TEK 2.20405
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20157
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PPARA, PRKCD, PRKCE, PTPN1 2.19415
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.19415
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNA3, PPARA, PRKCB, PRKCE 2.18173
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.18173
[BP] GO:0050729 positive regulation of inflammatory response CNR1, EGFR, FABP4, IDO1, PTGS2 2.18173
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.17398
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, EGFR, HCAR2, PRKCA, PRKCE 2.1567
[BP] GO:0050865 regulation of cell activation AXL, BCL2, CNR1, CNR2, DUSP3, F2, IDO1, PRKCA, PRKCD, SRC 2.1559
[BP] GO:0051894 None KDR, SMAD3, TEK 2.15341
[BP] GO:0002791 None ACHE, ADORA1, CNR1, EGFR, HCAR2, MMP12, PRKCA, PRKCE, SRC 2.15134
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.14125
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 2.13787
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, PRKCE, RORC, SRC 2.13474
[BP] GO:0050927 None F3, KDR, SMAD3 2.10585
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.10074
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.10074
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.09851
[BP] GO:0043696 None CDK6, ESRRB 2.07814
[BP] GO:0043697 None CDK6, ESRRB 2.07814
[BP] GO:0010641 None F3, SRC 2.07814
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 2.0683
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.0683
[BP] GO:0050926 None F3, KDR, SMAD3 2.0683
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.0683
[BP] GO:1903393 None KDR, SMAD3, TEK 2.0683
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.06146
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TYR 2.06084
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.03981
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.02556
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.02556
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, HTR6, IGF1R, INSR, KCNA3, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK 3.59162
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 3.41162
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MPO, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.36577
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, F2, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, INSR, KCNA3, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 3.10043
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, GBA2, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.03413
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.76442
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.67108
[CC] GO:0045121 membrane raft CNR1, EGFR, INSR, KCNA3, KDR, PTGS2, SRC, TEK 2.60633
[CC] GO:0098857 membrane microdomain CNR1, EGFR, INSR, KCNA3, KDR, PTGS2, SRC, TEK 2.59025
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNA3, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.31436
[CC] GO:0098589 membrane region CNR1, EGFR, INSR, KCNA3, KDR, PTGS2, SRC, TEK 2.1487
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.13079
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DUSP3, EGFR, F2, F3, FLT3, GPR35, HTR6, IGF1R, INSR, KCNA3, KDR, MET, PRKCG, PTGS2, SRC, TEK 2.10585
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, BCL2, CA4, CA5A, CA5B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, KDR, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.05133
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.8067
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 16.4868
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F2, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 14.9112
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 12.6599
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0356
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9657
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 10.3154
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.97924
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, IDO1, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 8.79873
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, IDO1, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 8.52886
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 8.12702
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 7.82657
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.75791
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.03509
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.54459
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.23543
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 6.13864
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.98986
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.98986
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO, PTGS2, SRC 5.90727
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.81776
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.79615
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.72675
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK 5.71051
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO, PTGS2, SRC 5.69009
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.63838
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.28623
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.10268
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.04117
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.96348
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.96348
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.87241
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, IDO1, MPO, PTGS2, SRC, XDH 4.63366
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.52153
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.36598
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.22001
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 4.07665
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.98618
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.95779
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 3.91053
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.86623
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.8182
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.7916
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.77869
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 3.70656
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 3.70493
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 3.67241
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.46167
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, EGFR, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.41162
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 3.36337
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2, TYR 3.34795
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.3197
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.25472
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.25472
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21854
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.20401
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.19364
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.06559
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 3.0199
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.0199
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F2, F3, FLT3, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.97072
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.91816
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88743
[MF] GO:0003845 None HSD11B1, HSD11B2 2.88743
[MF] GO:0035403 None PRKCA, PRKCB 2.88743
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.799
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 2.799
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 2.799
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.7483
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.67705
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.66548
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.64432
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.63524
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.6174
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.60755
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.5553
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.52552
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.49667
[MF] GO:0004949 None CNR1, CNR2 2.49667
[MF] GO:0004699 None PRKCD, PRKCE 2.49667
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.37684
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25925
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.25925
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.25925
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.20247
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.07814
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07814
[MF] GO:0043559 insulin binding IGF1R, INSR 2.07814
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.0683
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.05133
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.02556


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.1207
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.3095
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.869
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, CNR1, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 7.3446
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4481
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PRKCB, PRKCE, PRKCD, BCL2, PIM1, PRKCA, F3 6.6035
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, CDK6, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MET, EGFR, CDC25B 6.9389
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, INSR, BCL2, PRKCA, TEK, EGFR, IGF1R 6.5938
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, KDR, PRKCA, MET, ESR1, EGFR, IGF1R 5.5442
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 5.5442
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PRKCB, PRKCA, EGFR, IGF1R 5.3867
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, SRC, KDR, PRKCA, PTGS2 5.5186
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.2391
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.997
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 5.1878
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, CDK6, SMAD3, PRKCB, FLT3, BCL2, PRKCA, PTGS2, MET, EGFR, IGF1R 5.1451
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, INSR, KDR, BCL2, PRKCA, TEK, MET, EGFR, IGF1R 4.871
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.1878
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA 5.1826
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, SMAD3, PRKCB, SRC, BCL2, PRKCA 4.6936
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.6047
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PRKCB, INSR, PRKCA 5.1878
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.8164
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, PRKCB, BCL2, PRKCA 4.3487
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, PRKCD, ESR1, EGFR, ESR2, HSPA1A 4.6047
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.1878
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, INSR, PRKCE, PRKCD, PPARA 4.3785
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PRKCB, PRKCA, EGFR 4.6047
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, HTR6, PRKCB, ALOX5, PRKCA, PTGS2 4.3415
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CNR2, GPR35, CNR1, ADORA3, ADORA1, F2 3.9241
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, SRC, PRKCA, PTGS2, EGFR 3.5998
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, SRC, PRKCA, EGFR 3.7555
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, PRKCD, PRKCA, EGFR 3.6876
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.3706
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3419
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA, EGFR 3.7447
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.667
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, HTR6, PRKCB, PRKCA, EGFR 3.3419
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, PTGS2 3.5188
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, SRC, PRKCA, ESR1 3.2625
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.238
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.9439
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.4011
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.667
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.326
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.8962
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.0292
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.0895
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, ADORA1, PPARA 2.3548
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.5906
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.7208
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA, EGFR 2.5822
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.7675
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 4.104
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.6931
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.6494
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2196
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1782
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, PRKCE, ADORA1 1.902
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 1.8262
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1773
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2, EGFR 1.6123
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.263
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2749
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.2291
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8601
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3126
Phagosome_Homo sapiens_hsa04145 MPO 0.3126
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3374
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3489
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.6191
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1701
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.1456
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3699
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.8983
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.1456
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.8035
Axon guidance_Homo sapiens_hsa04360 MET 0.3638
Platelet activation_Homo sapiens_hsa04611 SRC 0.3719
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3718
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.458
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.8601
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.4619
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4135
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.1401
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1401
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.4022
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 1.7582
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.8901
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.4042
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.777
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0828
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.0942
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.5455
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, PRKCA 1.5983
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.5093
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6914
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.324
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6607
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.5983
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5977
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4208
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA, HSPA1A 1.2284
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4283
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.7667
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8011
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7595
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4471
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8256
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8623
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.8827
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, SRC, PRKCD 1.1723
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1283
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.4636
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4661
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.1955
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.0939
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.1229
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4802
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4648
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0268
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1229
Peroxisome_Homo sapiens_hsa04146 XDH 0.4816
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0548
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5063
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.5232
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.536
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5411
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5385
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5493
Shigellosis_Homo sapiens_hsa05131 SRC 0.5522
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.555
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1802
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.2284
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCE, PRKCD 2.495
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1741
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.2284
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2384
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6071
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6071
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6227
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6273
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6273
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3341
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3046
Malaria_Homo sapiens_hsa05144 MET 0.6368
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.385
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6417
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3699
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.6607
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6467
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6977
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7481
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6096
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5333
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8256
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7838
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7652
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8262
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8011
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8315
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7222
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7937
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8444
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7823
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7036
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8256
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0082
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9731
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0675
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3719
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1988


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)