TCM Prescription: Bu Shen Yi Jing Pills



Prescription Description
Prescription IDTCMF3006
Pinyin NameBu Shen Yi Jing Wan
Chinese Name补肾益精丸
English NameBu Shen Yi Jing Pills
Function Description眩晕, 遗精, 遗精
IndicationsInvoluntary ejaculation disorder, Vertigo disorder, Dizziness
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationLung, Uterus, Heart, Stomach, Uterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 10.5601
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 8.56931
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MCL1, MET, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 7.86275
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH 7.66176
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 7.31901
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 7.31901
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.96128
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 6.79957
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.57291
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH 6.57291
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.4985
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.40905
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, PTPN1, SRC, TEK, XDH 6.40905
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PTPN1, SMAD3, SRC, TEK 6.28382
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, NR3C1, PPARA, RORC, SRC, TEK, TRPV1, TYR 6.27346
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.05992
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.05264
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.04842
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.04842
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, NUAK1, PTPN1, SRC, TEK, XDH 6.04842
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 5.94382
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MCL1, MET, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.92711
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA 5.75877
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.75877
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TEK, TRPV1, TYR 5.71503
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 5.69282
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, PIM1, PTPN1, SMAD3, SRC, TEK 5.68723
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.59737
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.58757
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.57479
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MCL1, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.55738
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.55738
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.4814
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.4814
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 5.42572
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MCL1, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.39024
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.3556
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MCL1, MET, SMAD3, SRC, TRPV1 5.33279
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.30352
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 5.29678
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 5.24349
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 5.15927
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MCL1, MET, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TYR 5.15759
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.0755
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 5.0244
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, XDH 4.99614
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.98514
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.97026
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.88968
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MCL1, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TYR 4.88968
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MCL1, MET, MMP12, PIM1, PPARA, RORC, SLC5A1, SMAD3, SRC, TEK, TRPV1, TYR 4.85079
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NR3C1, RORC, SMAD3, SRC, TRPV1 4.83059
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TYR, XDH 4.82877
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 4.73194
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.71641
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, XDH 4.70398
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, NR3C1, RORC, SMAD3, SRC, TRPV1 4.61711
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.54425
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.53502
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH 4.42353
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.41691
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, PTPN1, SMAD3, SRC, TEK, XDH 4.29577
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 4.26557
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.1654
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 4.15787
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.09658
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.09658
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.08815
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HSD11B1, HSD17B1, HSD17B2 4.06912
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.06209
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 4.06209
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.0539
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.01992
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.98027
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.98027
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP12, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR 3.97603
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.95125
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.93955
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.9365
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.93138
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.90039
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.89878
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.83379
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 3.83179
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.80742
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.80342
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79409
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.78572
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.75377
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.68623
[BP] GO:0071407 cellular response to organic cyclic compound APP, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 3.66957
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.66434
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.64869
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.59556
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.57771
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 3.57771
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.55537
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.51471
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.46309
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.46309
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 3.43194
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.42823
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.41698
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 3.39812
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1, TYR 3.36939
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2921
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.25279
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, EGFR, FABP4, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.24902
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTPN1, PTPRS, XDH 3.23975
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 3.23563
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 3.21459
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.18899
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.18899
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 3.12335
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 3.11657
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 3.11657
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.11657
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1, TYR 3.08075
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 3.05518
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, PPARA, PTPN1, SMAD3, SRC, TRPV1 3.04382
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.01818
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.99703
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.99703
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.98678
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.98678
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PTPN1, SRC, TEK, XDH 2.98586
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.97063
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.96713
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PTPN1, SRC 2.95899
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.95221
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.94236
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.94012
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.94012
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.94012
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.93029
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.91205
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 2.82759
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.82759
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, TEK 2.82759
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.82421
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.79834
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, PTPN1, SMAD3, SRC, TEK, TRPV1 2.79834
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.79337
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC, TEK 2.79304
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.79304
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.79304
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.79304
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.79304
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.79304
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SRC, TEK, XDH 2.79304
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.78147
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.7803
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, NR3C1, RORC, SRC, TRPV1 2.7719
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.7719
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.74918
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.73261
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.68539
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.67513
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, PPARA, PTPRS, SMAD3, TEK 2.63445
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.63264
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.63264
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP12, SRC, XDH 2.62746
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.61161
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.59789
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.58259
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 2.57061
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.56909
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56909
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.56909
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.56909
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.56909
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.56238
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC, TRPV1 2.54998
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, SRC, TEK 2.5382
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.5382
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MCL1, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.52465
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.51645
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.51498
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.49339
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.48821
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.46856
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.45966
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, FLT3, IGF1R, INSR, NR3C1, SMAD3, SRC, TRPV1 2.45896
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.4456
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.4456
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.4456
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.44056
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP12, PIM1, SMAD3, SRC, TEK, TRPV1 2.42064
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39118
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.36923
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.35976
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.3546
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4 2.35368
[BP] GO:0051894 None KDR, SMAD3, TEK 2.35233
[BP] GO:0061900 None APP, EGFR, TRPV1 2.35233
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35233
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34143
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34143
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.2893
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PIM1, PTPRS, SMAD3, SRC, TEK, TRPV1, XDH 2.28284
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.26283
[BP] GO:1903393 None KDR, SMAD3, TEK 2.26283
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.25028
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.23156
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.21168
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR 2.20889
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.20274
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.19527
[BP] GO:0034219 None SLC5A1, SLC5A2, SLC5A4 2.18031
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.17425
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.16046
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MCL1, MET, PPARA, PTPN1, SMAD3 2.15851
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.15851
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.15851
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.15851
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.15851
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, KDR, SRC, TRPV1 2.15225
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.15131
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.13757
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.11341
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.11341
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TYR, XDH 2.09356
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.09356
[BP] GO:1901890 None KDR, SMAD3, TEK 2.0801
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.0801
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.0801
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.0801
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.05002
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, SMAD3, TRPV1 2.05002
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC5A1, SLC5A2, SLC5A4, TRPV1 2.05002
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.05002
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, PPARA, SMAD3, SRC, TEK 2.02752
[BP] GO:1990535 None APP, INSR 2.02752
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.02752
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.02752
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, RORC, SMAD3, SRC, TRPV1 2.02752
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.02752
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.02752
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.02752
[BP] GO:0010907 None INSR, PPARA, SRC 2.02752
[BP] GO:0106027 None APP, IGF1R, INSR 2.02752
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.01027
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.00325
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, MCL1, MET, PPARA, SMAD3 2.00321
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 3.66434
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 3.57337
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 3.2921
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PIM1, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 2.82759
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MCL1, MET, PTPN1, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1, TYR 2.82759
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.6354
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MCL1, MET, PIM1, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR 2.59671
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02752
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 10.5601
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1044
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TYR, XDH 8.52422
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.42656
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH 7.36872
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.79957
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.42474
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.40905
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.0134
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 5.75877
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.74365
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.66967
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.47606
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.24827
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.69484
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.28776
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NR3C1 4.20916
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.17471
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.98184
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.93138
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.93137
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 3.6454
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.57983
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.57701
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.53475
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.42823
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42823
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.38368
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH 3.23975
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.22233
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.21097
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3 3.12335
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.98586
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH 2.97871
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TRPV1, XDH 2.96713
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.94012
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.94012
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 2.84502
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.73013
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.67493
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.56909
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.56909
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.56909
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.56909
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.48821
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 2.48757
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.48665
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.45896
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 2.45858
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.4456
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.37512
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 2.37075
[MF] GO:0015145 None SLC5A1, SLC5A2, SLC5A4 2.35233
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TRPV1 2.35233
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.34143
[MF] GO:0051425 None APP, INSR 2.34143
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.34143
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.26283
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 2.24833
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.22068
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.22068
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15851
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15851
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.15225
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.15225
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.11158
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0801
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.05002
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.05002
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.05002
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02752
[MF] GO:0005496 steroid binding CYP3A4, HSD17B1, NR3C1, RORC 2.02752
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PTPN1, SMAD3 2.01303


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.9416
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4653
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.573
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.8182
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.7018
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 5.1481
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4766
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3255
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7929
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, MCL1, IGF1R 3.1543
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1773
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.3475
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET, EGFR, CDC25B, MCL1 2.7178
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.6494
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.6494
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.7178
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12 2.6494
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7178
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4085
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0893
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4134
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2832
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, TRPV1, NR3C1 2.224
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2615
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.26
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2822
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.253
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8962
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, EGFR, HSPA1A 1.8962
Bile secretion_Homo sapiens_hsa04976 CA2, SLC5A1, CYP3A4 2.253
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2579
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MET, EGFR, IGF1R 1.6566
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8162
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6434
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5964
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4053
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3607
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3607
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4162
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1 1.0892
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1615
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3894
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1594
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1056
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1494
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1312
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9743
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3607
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4053
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1605
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2414
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9686
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.957
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9101
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3607
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.957
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8965
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8931
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8931
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC 0.8844
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8887
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8965
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8671
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3328
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.8604
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8604
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6499
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7192
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6906
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7247
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2711
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5852
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3378
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3774
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3707
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3643
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.37
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3707
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3703
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3774
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4043
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3641
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4317
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4437
Platelet activation_Homo sapiens_hsa04611 SRC 0.4671
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4671
Axon guidance_Homo sapiens_hsa04360 MET 0.4592
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4748
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4935
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8567
Melanogenesis_Homo sapiens_hsa04916 TYR 0.521
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.521
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5139
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.521
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5287
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.537
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5286
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5372
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5471
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5376
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5376
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5328
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5375
Peroxisome_Homo sapiens_hsa04146 XDH 0.5476
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5844
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5854
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5834
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5722
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5921
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7375
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6107
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8162
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6137
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.63
Shigellosis_Homo sapiens_hsa05131 SRC 0.6123
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6218
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6529
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6731
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6554
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0462
Malaria_Homo sapiens_hsa05144 MET 0.6872
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.6761
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6906
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 SLC5A1 0.7066
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7496
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7889
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.863
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7889
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.828
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8671
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8362
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.863
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0893


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)