TCM Prescription: Dan Xiang Qing Zhi Granules



Prescription Description
Prescription IDTCMF3
Pinyin NameDan Xiang Qing Zhi Ke Li
Chinese Name丹香清脂颗粒
English NameDan Xiang Qing Zhi Granules
Function Description活血化瘀, 行气通络之功效。用于高脂血症属气滞血瘀证者
IndicationsBlood stasis pattern, Qi stagnation pattern, Hyperlipidemia
Disease ICD-11 Category SF01 [Blood stasis pattern (TM1), 血瘀证 (TM1) ];
SE91 [Qi stagnation pattern (TM1), 气滞证 (TM1) ];
5C80.Z [Hyperlipoproteinaemia, unspecified, 高脂蛋白血症，未特指的 ];
Human Tissues Associated with IndicationBlood, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2209
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2209
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CES1, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 13.4484
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KCNH2, KDR, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, XDH 11.8454
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 11.8454
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGS1, PTGS2, TBXAS1 10.8439
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGS1, PTGS2, TBXAS1 10.5539
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, RORC, SLC6A4, SRC, TYR 10.5521
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FUT7, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 10.4838
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 10.4716
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 9.53105
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CES1, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.96398
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TBXAS1 8.9469
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 8.8187
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGS1, PTGS2, TBXAS1 8.69989
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, POLB, PTGS2, SLC6A2, SLC6A4, SRC 8.64128
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 8.50993
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 8.20003
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.96648
[BP] GO:0007187 None ADRA2A, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.92552
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SLC6A4, SRC, TYR 7.88603
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, SLC6A4 7.77299
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, SLC6A4, SRC 7.71751
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.64504
[BP] GO:0032501 multicellular organismal process ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TYR 7.53433
[BP] GO:0042127 regulation of cell proliferation ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 7.39773
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, SLC6A4, SRC 7.12778
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.84235
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TBXAS1 6.7055
[BP] GO:0010647 positive regulation of cell communication ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.63988
[BP] GO:0023056 positive regulation of signaling ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.60764
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.53224
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC 6.53224
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.5253
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 6.50375
[BP] GO:0003018 None ADRA2A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 6.33739
[BP] GO:0007193 None ADRA2A, CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.33739
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NQO2, PTGS1, RORC 6.281
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 6.281
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 6.21895
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.14395
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 6.02317
[BP] GO:0097746 None ADRA2A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 5.99821
[BP] GO:0035296 None ADRA2A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 5.99821
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.99355
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CES1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TYR 5.9191
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 5.91402
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.91346
[BP] GO:0050880 None ADRA2A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 5.80164
[BP] GO:0035150 None ADRA2A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 5.77862
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.71049
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC, TERT 5.64911
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TERT 5.63592
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.62235
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.62235
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.60628
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.49624
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.49624
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PTGS2, SRC 5.46938
[BP] GO:0003013 None ADRA2A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 5.35983
[BP] GO:0007188 None ADRA2A, CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.26624
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.18141
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.04098
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 4.96495
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 4.95517
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KCNH2, KDR, MIF, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT 4.92484
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 4.92148
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 4.91584
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.91236
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 4.89732
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 4.89732
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.88252
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 4.88252
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.86458
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, ADRA2A, CA2, CHRM2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 4.79424
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 4.74653
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.73933
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.71325
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 4.70851
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.6614
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.59351
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 4.58345
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SLC6A4, SRC 4.55392
[BP] GO:0007165 signal transduction ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTPN1, RORC, SRC 4.55392
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.54356
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.54356
[BP] GO:0043271 negative regulation of ion transport ADRA2A, BCL2, CNR1, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 4.54356
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.54054
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.53366
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.47569
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.4744
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.40538
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.4041
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 4.39089
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31118
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2, SLC6A4 4.29416
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.29416
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.19434
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, KCNH2, MET, PIK3CA, PIK3CB 4.15445
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.14472
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SLC6A4, SRC, TERT 4.13971
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.13803
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 4.1351
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 4.1351
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 4.12406
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.08837
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.04568
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.04383
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.03195
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, POLB, PTGS2, TERT 4.03195
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIK3CB, PIM1, POLA1, SRC, TYR 4.00136
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.97307
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.93126
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 3.91144
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, POLB, PPARA, PTGS2, SLC6A4, SRC, TERT, TYR 3.84806
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.84388
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.80618
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.72797
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.71854
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 3.70161
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.67538
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.67021
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.66042
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.64878
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 3.64576
[BP] GO:0043269 regulation of ion transport ADRA2A, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, KCNH2, MIF, MMP9, PTGS2, SLC6A4 3.63602
[BP] GO:0007200 None ADRA2A, CHRM2, ESR1, HTR2A, HTR2B, HTR2C 3.60802
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.57777
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.57777
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 3.56594
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TYR, XDH 3.50686
[BP] GO:0014062 None HTR1A, HTR1B, SLC6A4 3.50686
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.50686
[BP] GO:0032845 None ADRA2A, BCL2, HTR2A, HTR2B, HTR2C, MIF, SRC 3.47514
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.43975
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.43734
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.41258
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MIF, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT 3.39081
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, PPARA, RORC, SLC6A4, SRC 3.38773
[BP] GO:0007154 None AXL, BCL2, CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, SLC6A2 3.34706
[BP] GO:0090066 None ADRA2A, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 3.34135
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TYR, XDH 3.3406
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 3.33399
[BP] GO:0006693 None CES2, MIF, PTGS1, PTGS2 3.31442
[BP] GO:0006692 None CES2, MIF, PTGS1, PTGS2 3.31442
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.30123
[BP] GO:0048583 regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.29969
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.29686
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.28875
[BP] GO:0003008 None ADRA2A, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, PTGS2, SLC6A4, SRC, TYR 3.25917
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, XDH 3.22255
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2, SLC6A4 3.21783
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2, SLC6A4 3.21783
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.21654
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.18738
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.17895
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SLC6A4, SRC 3.17159
[BP] GO:0009056 catabolic process ACHE, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.16239
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.15543
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 3.15543
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.11703
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 3.10071
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.09812
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.09775
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.09775
[BP] GO:0023052 None CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNH2, SLC6A2 3.08566
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 3.04725
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.04691
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 3.0147
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.97845
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 2.96456
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, XDH 2.93981
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.93981
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.92075
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX15, BCL2, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.8871
[BP] GO:0051046 None ACHE, ADRA2A, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SLC6A4, SRC 2.87636
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.87264
[BP] GO:0007267 None CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 2.87264
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.86211
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, FLT3, HTR2A, HTR2B, IGF1R, MIF, PIK3CB, PTPN1, SRC 2.85484
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 2.84671
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.83835
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, MIF, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 2.8143
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, FLT3, HTR2A, HTR2B, MIF, PIK3CB, PTPN1, SRC 2.79556
[BP] GO:0007208 None HTR2A, HTR2C 2.79556
[BP] GO:0009115 None AOX1, XDH 2.79556
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 2.78776
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 2.78427
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 2.7703
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74203
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.74203
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.74203
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.73711
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC 2.72459
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.71013
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, MIF, PTPN1, SRC 2.71013
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 2.69614
[BP] GO:0030334 regulation of cell migration ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 2.69116
[BP] GO:0040012 regulation of locomotion ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, HTR1D, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 2.68823
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.68458
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65698
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.64009
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KCNH2, KDR, PTGS2, SRC 2.63403
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.6335
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.55989
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 2.55989
[BP] GO:0050999 None CNR1, CNR2, HTR2B, TERT 2.52295
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.49583
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.49176
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49176
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.49176
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.47967
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.4748
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.45254
[BP] GO:2000145 regulation of cell motility ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 2.43478
[BP] GO:0050433 None ADRA2A, CNR1, HTR1B, HTR2A 2.42268
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.38895
[BP] GO:0046110 None AOX1, XDH 2.38895
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38895
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.38895
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTGS2, SLC6A4, SRC 2.38436
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, AXL, BCL2, CA2, CYP19A1, HTR2B, KCNH2, MIF, MMP12, PTGS2, SLC6A4, SRC, TERT 2.36127
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.35314
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.34546
[BP] GO:0009966 regulation of signal transduction ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 2.34114
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRA2A, AXL, BCL2, CA2, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, HTR2A, HTR2B, HTR2C, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SRC, TERT, XDH 2.3333
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.31951
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, CDC25B, FLT3, HTR2A, HTR2B, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.29513
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.29074
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, MIF, PIK3CA, PIK3CB, POLB, PTPN1, SRC 2.28738
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.27993
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.27993
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.27705
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 2.26866
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.26866
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.26679
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, SLC6A2 2.22205
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.21418
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC 2.20861
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.19626
[BP] GO:0032768 None CNR1, CNR2, HTR2B, TERT 2.19626
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.1771
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.17274
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.17274
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 2.16758
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADRA2A, FLT3, HTR2A, MIF, PTPN1, SRC 2.16163
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.15906
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.15906
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.15194
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SLC6A4 2.15166
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.14507
[BP] GO:0006145 None AOX1, XDH 2.14507
[BP] GO:0038171 None CNR1, CNR2 2.14507
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14507
[BP] GO:0014827 None HTR1D, HTR2B 2.14507
[BP] GO:0051270 regulation of cellular component movement ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 2.14267
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, MIF, PTGS1, PTGS2 2.14029
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.14021
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.13991
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.13566
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.12313
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, CDC25B, FLT3, HTR2A, HTR2B, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.11902
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.11127
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.10807
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.0917
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0917
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, BCL2, CNR1, ESRRB, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.0917
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.08198
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRA2A, FLT3, HTR2A, HTR2B, MIF, PIK3CB, PTPN1, SRC 2.08198
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.08198
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB 2.07657
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.06953
[BP] GO:0009895 negative regulation of catabolic process ADRA2A, BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA 2.06827
[BP] GO:0009894 regulation of catabolic process ADRA2A, BCL2, CNR1, CSNK2A1, ESRRB, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.06791
[BP] GO:0080134 regulation of response to stress ADRA2A, CNR1, CNR2, CYP19A1, ESR1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.06611
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.05524
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.05314
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05314
[BP] GO:0031399 regulation of protein modification process ADRA2A, ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.04188
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, XDH 2.04188
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.04188
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.03684
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.00646
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, AURKB, CDC25B, FLT3, HTR2A, HTR2B, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.00416
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRA2A, AXL, CA4, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SLC6A2, SLC6A4 5.71049
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SLC6A2, SLC6A4 5.42518
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRA2A, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 4.69046
[CC] GO:0044459 plasma membrane part ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTGS2, SLC6A2, SLC6A4, SRC 4.33822
[CC] GO:0044425 membrane part ACHE, ADORA3, ADRA2A, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TBXAS1, TYR 4.03749
[CC] GO:0016020 membrane ACHE, ADORA3, ADRA2A, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TYR 3.97307
[CC] GO:0044464 cell part ACHE, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 2.19414
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.14507
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2209
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2209
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.1987
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.1987
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.8761
[MF] GO:0008227 None ADRA2A, CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.4382
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TYR, XDH 13.2071
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 11.7281
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC6A4 10.7139
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.6422
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.3991
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TBXAS1, TERT, TYR, XDH 10.3991
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.90748
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.57899
[MF] GO:0038023 signaling receptor activity ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC 8.96398
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TYR, XDH 8.30133
[MF] GO:0004872 receptor activity ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC 7.8647
[MF] GO:0060089 molecular transducer activity ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC 7.58446
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 7.01866
[MF] GO:0004871 signal transducer activity ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC 6.96297
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.36895
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TBXAS1, XDH 6.22756
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.93938
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, SRC, TBXAS1 5.91346
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.71049
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC 5.69058
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, SRC, TBXAS1 5.66583
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 5.65655
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TBXAS1, TYR 5.28579
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.95517
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.95517
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TBXAS1, TERT, TYR, XDH 4.94441
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.89068
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.89068
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.77961
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TBXAS1, TYR 4.53454
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.47859
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 4.19434
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.96018
[MF] GO:0004930 None ADORA3, ADRA2A, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.96018
[MF] GO:0097159 organic cyclic compound binding ADRA2A, ALDH2, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, XDH 3.79268
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.78801
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.78576
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.74355
[MF] GO:1901363 heterocyclic compound binding ALDH2, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, XDH 3.57777
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50686
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.31442
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25917
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.15543
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.15543
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.9334
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.88809
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.79556
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79556
[MF] GO:0003845 None HSD11B1, HSD11B2 2.79556
[MF] GO:0071886 None HTR2A, HTR2C 2.79556
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.79556
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.71616
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TERT 2.69614
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 2.60281
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.58328
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.38895
[MF] GO:0004949 None CNR1, CNR2 2.38895
[MF] GO:0005330 None SLC6A2, SLC6A4 2.38895
[MF] GO:0047374 None CES1, CES2 2.38895
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.23294
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.14507
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.14507
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.088
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.088
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.05524


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, CYP2C19, PTGS1, SLC6A4, HTR6, HTR7, ALOX5 19.449
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, ADRA2A, HTR6, HTR7, CNR2, CNR1, ADORA3 11.6692
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9352
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 7.7402
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7846
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.4909
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGS2, CYP2C19, PTGS1 6.8147
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 6.7069
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.5835
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.5835
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 6.0647
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.9974
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.4248
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.272
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0691
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.4248
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.272
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9626
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.7967
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 3.7147
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.6661
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9566
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.95
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.3933
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.2318
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.0542
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2465
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.743
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.7902
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 2.7902
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.0344
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 2.965
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.7077
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.7176
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.7675
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8342
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9991
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.7176
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7428
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5891
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.7176
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.5174
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4379
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4439
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3506
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3506
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3506
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.3318
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1188
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.9739
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB, ADRA2A 1.8959
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7981
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.654
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.6383
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.5812
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8608
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5354
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7932
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.1686
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.506
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1728
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3831
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7981
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.3831
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.4503
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.4302
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4129
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4503
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1831
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2046
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4158
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.157
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2662
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3701
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2901
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3572
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2586
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3413
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1686
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.1163
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8542
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1591
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.38
Axon guidance_Homo sapiens_hsa04360 MET 0.3749
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.38
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6834
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.684
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8156
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6826
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8348
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4309
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8297
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.803
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4417
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4423
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4546
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4537
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0015
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9813
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0015
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4708
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0559
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9914
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0477
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.012
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.473
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.473
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9914
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0015
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.472
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.9473
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.6966
Peroxisome_Homo sapiens_hsa04146 XDH 0.4883
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.763
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.5134
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5294
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5275
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.539
Bile secretion_Homo sapiens_hsa04976 CA2 0.5367
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2191
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2191
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2619
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2322
Shigellosis_Homo sapiens_hsa05131 SRC 0.5607
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7428
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5524
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5607
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.2765
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5849
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2619
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3483
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4199
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.3831
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.637
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6413
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6457
Malaria_Homo sapiens_hsa05144 MET 0.6503
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4639
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6633
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4639
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.506
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6828
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7104
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7981
DNA replication_Homo sapiens_hsa03030 POLA1 0.7493
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.803
Base excision repair_Homo sapiens_hsa03410 POLB 0.7809
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.756
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.803
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8156
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.838
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8055
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8339
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8339
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9859
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8633
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9914
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0477
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0344
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3583


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)