TCM Prescription: An Sou Hua Tan Pills



Prescription Description
Prescription IDTCMF2959
Pinyin NameAn Sou Hua Tan Wan
Chinese Name安嗽化痰丸
English NameAn Sou Hua Tan Pills
Function Description咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2596 Fritillaria verticillata 浙贝母 TCMH2596
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH2728 Aster tataricus 紫菀 TCMH2728 ITSAI2445-14
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 10.4131
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, SLC1A1, SRC, XDH 9.1658
[BP] GO:0007188 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.9517
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MAOB, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 8.8473
[BP] GO:0007187 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.39154
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.32281
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MAOB, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 8.17562
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.55315
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.55315
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, IGF1R, KDR, MAOB, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 7.55315
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A 7.55315
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.55315
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.55315
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 7.55315
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 7.55315
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GLO1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, TYR, XDH 7.55315
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 6.8634
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 6.52387
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 6.52051
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.51478
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MAOB, MMP9, SRC 6.48298
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CYP1A2, DRD1, FABP3, FLT3, GRM5, IGF1R, MAOB, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC 6.45858
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, GRM5, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 6.43787
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PIM1, PPARA, SRC, TYR 6.24453
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, MAOB, OPRD1, OPRK1, SRC 6.23651
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 6.21634
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, XDH 6.10664
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, XDH 6.04696
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, GRM5, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 6.01763
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, HSD17B2, MET, PDE3A, PPARA 5.93214
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PTPN1, SRC, XDH 5.93214
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, MAOB, OPRK1, OPRM1, PDE3A, SRC, TYR 5.93214
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, SRC, TOP2A, XDH 5.87734
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRM1, HCAR2, HTR2A, KDR, MET, MMP9, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.87734
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRM1, HCAR2, HTR2A, KDR, MET, MMP9, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.85055
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PTPN1, SRC, XDH 5.83506
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.82631
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.82631
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.47263
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.47116
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CYP1B1, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SIGMAR1, SRC 5.3747
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SRC, TOP2A 5.32066
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC 5.32066
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TOP2A, XDH 5.26935
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.26571
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.26571
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, GRM5, HTR1A, HTR2A, MAOB, MMP9, OPRD1, OPRK1, OPRM1 5.24935
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, GRM1, HTR2A, KDR, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.23011
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, XDH 5.22972
[BP] GO:0007200 None DRD1, DRD2, GRM5, HTR2A, OPRD1, OPRK1, OPRM1 5.20041
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, TOP2A, XDH 5.162
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.139
[BP] GO:0007267 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 5.139
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HTR2A, KDR, MAOB, OPRK1, OPRM1, PDE3A, SRC 5.139
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, FLT3, GRM1, HTR2A, KDR, MET, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.13401
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 5.10191
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 5.06702
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, GRIK5, GRM5, IGF1R, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 5.03406
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, GRM1, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, PPARA, SRC, TYR 5.00487
[BP] GO:0023052 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 4.62388
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CYP1B1, DRD2, FLT3, GRM1, HTR2A, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PTPN1, SRC, XDH 4.60632
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, TOP2A, XDH 4.6009
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 4.6009
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, MET, SRC 4.58976
[BP] GO:0051930 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 4.58976
[BP] GO:0051931 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 4.58976
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MAOB, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, SRC, XDH 4.57361
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, GLO1, GRM3, GRM8, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 4.57361
[BP] GO:0042391 None ADORA1, APP, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, OPRD1, OPRM1, SRC 4.57361
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.54741
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, GRM1, HTR2A, IGF1R, KDR, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 4.52913
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, SRC, TYR 4.50314
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HTR1A, HTR2A, MAOB, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC 4.50314
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.49991
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HCAR2, HSD17B2, HTR1A, HTR2A, OPRK1 4.47966
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, IGF1R, KDR, MAOB, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PTPN1, SRC, TOP2A, TYR 4.47385
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A, MAOB, TYR 4.46619
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2 4.44711
[BP] GO:0007626 None APP, DRD1, DRD2, GRM1, GRM5, OPRD1, OPRK1, OPRM1 4.42004
[BP] GO:0007154 None ADORA1, AXL, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 4.36688
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 4.34782
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, OPRM1 4.29011
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, MAOB, TYR 4.26028
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B, PDE5A 4.24722
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, OPRK1, PDE3B, PPARA, SRC 4.22319
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, FLT3, OPRM1, PDE3A, SRC 4.20407
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 4.16727
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CYP1B1, DRD2, FABP3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MMP2, MMP9, OPRM1, PDE5A, PIM1, SRC, XDH 4.15185
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 4.10752
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CBR1, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2A, KDR, MAOB, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, PPARA, SIGMAR1, SRC, TOP2A, TYR 4.09041
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 4.03488
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC 3.99947
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.99099
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, HCAR2, HTR2A, KDR, OPRK1, SRC 3.96788
[BP] GO:0072523 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.88392
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, PDE3A, PPARA 3.87391
[BP] GO:0007631 None APP, DRD1, DRD2, OPRD1, OPRK1, OPRM1 3.82945
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, MAOB, OPRK1, OPRM1, SRC, TYR 3.81887
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.78531
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.78136
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SIGMAR1, SLC1A1, SRC, TOP2A, TYR, XDH 3.76775
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.74565
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.70449
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 3.69334
[BP] GO:1900542 None DRD1, DRD2, GRM3, GRM8, HTR2A, OPRM1, PDE5A, PPARA 3.67653
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, GRM1, HCAR2, HTR2A, OPRD1, OPRK1, OPRM1, PDE5A, SLC1A1 3.64703
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.63969
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CDC25B, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PTPN1, SRC, XDH 3.63746
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, FABP3, PPARA, SLC1A1 3.63276
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CYP1B1, CYP2D6, DRD2, FABP4, GRM3, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTPN1, SRC 3.60991
[BP] GO:0006140 None DRD1, DRD2, GRM3, GRM8, HTR2A, OPRM1, PDE5A, PPARA 3.60344
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, OPRK1, SRC 3.60143
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, MAOB 3.59979
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.598
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 3.59212
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2, MAOB, TYR, XDH 3.58377
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.5738
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.55149
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.53852
[BP] GO:0007610 None APP, DRD1, DRD2, GRM1, GRM5, HTR1A, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 3.52409
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CYP1A2, FABP3, FLT3, MAOB, OPRK1, PDE3B, PPARA, SRC 3.50184
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.48088
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, FLT3, GRM1, HTR2A, KDR, MET, MMP9, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 3.46978
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, PDE5A, PTPN1, SRC 3.46814
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GRIK5, HTR1A, MAOB, SLC1A1 3.46289
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.45676
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD1, DRD2, HTR1A, MAOB 3.40632
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.38537
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B, PDE5A 3.38537
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CDC25B, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PTPN1, SRC, XDH 3.38368
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HTR1A, HTR2A, MAOB, OPRK1, OPRM1, SRC 3.3783
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, FLT3, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 3.37652
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, MET 3.36981
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, OPRD1 3.36413
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.35241
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B, PDE5A 3.35241
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.35241
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 3.35241
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, GLO1, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SRC 3.34892
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, OPRM1 3.33883
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.33883
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.32016
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, PDE3B, PPARA, SRC 3.31753
[BP] GO:0031644 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 3.31447
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.31346
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.29695
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29695
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 3.29695
[BP] GO:1900543 None DRD2, GRM3, GRM8, OPRM1, PPARA 3.29695
[BP] GO:0045980 None DRD2, GRM3, GRM8, OPRM1, PPARA 3.26898
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, MAOB, OPRK1, OPRM1, SRC 3.26877
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SIGMAR1, SLC1A1, SRC, TOP2A, XDH 3.23624
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, OPRM1, SRC 3.21806
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, PDE5A, PTPN1, SRC 3.204
[BP] GO:0048511 rhythmic process AXL, DRD2, HTR7, OPRK1, OPRM1, PPARA, SRC, TOP2A 3.19972
[BP] GO:0051952 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 3.1737
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.15292
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, OPRM1, PPARA, SLC1A1 3.13392
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HTR1A, HTR2A, MAOB, OPRK1, OPRM1, SRC 3.13001
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, PDE3B, SRC 3.11766
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, GLO1, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PTPN1, SRC 3.11545
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.11281
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SIGMAR1, SLC1A1, SRC, TOP2A, XDH 3.10925
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 3.09641
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, MAOB, OPRK1, OPRM1, SRC 3.09641
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, PDE5A, PTPN1, SRC 3.09608
[BP] GO:0030799 None DRD1, DRD2, GRM3, GRM8, OPRM1, PDE5A 3.03069
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 3.02715
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SIGMAR1, SRC, TOP2A, XDH 3.02715
[BP] GO:0050877 None ADORA1, APP, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HTR2A, OPRD1, OPRK1, OPRM1, TYR 3.01387
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, PDE5A, PTPN1, SRC 3.01347
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.01241
[BP] GO:0031635 None OPRK1, OPRM1 2.96298
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, HSD17B2, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC, TOP2A 2.95438
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 2.91111
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, FLT3, FUT7, GLO1, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SRC, TOP2A, TYR, XDH 2.90849
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.89601
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.89601
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 2.89601
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.89421
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.88641
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.88641
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC 2.88641
[BP] GO:0051588 None DRD1, DRD2, GRIK5, HTR1A, MAOB 2.8793
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, HTR2A, PTPN1, SRC 2.8793
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.85486
[BP] GO:0030818 None DRD2, GRM3, GRM8, OPRM1 2.85486
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, FABP3, PPARA, SLC1A1 2.82931
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, PDE5A, PTPN1, SRC 2.81223
[BP] GO:0030803 None DRD2, GRM3, GRM8, OPRM1 2.78402
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, PDE5A, PTPN1, SRC 2.73008
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, IGF1R, PDE5A, PTPN1, SRC 2.72301
[BP] GO:0030817 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.71993
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.71993
[BP] GO:0030815 None DRD2, GRM3, GRM8, OPRM1 2.71993
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.71993
[BP] GO:1900372 None DRD2, GRM3, GRM8, OPRM1 2.69004
[BP] GO:0030809 None DRD2, GRM3, GRM8, OPRM1 2.69004
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, TOP2A, XDH 2.69004
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.6875
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, XDH 2.67802
[BP] GO:0030800 None DRD2, GRM3, GRM8, OPRM1 2.66045
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 2.6501
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, IGF1R, MET, MMP9, OPRD1, OPRM1, PDE5A, PIM1, PPARA, PTPN1, SRC, XDH 2.62284
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, PTPN1, SRC 2.61888
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, FABP4, FLT3, GRM1, HTR2A, KDR, MET, MMP2, MMP9, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH 2.60799
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.60799
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC 2.6052
[BP] GO:0050994 None ADORA1, HCAR2, PDE3B, PPARA 2.6052
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, GLO1, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SRC 2.57538
[BP] GO:0019233 None GRM1, OPRD1, OPRK1, OPRM1 2.57538
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, OPRK1 2.5688
[BP] GO:0099566 None GRM1, GRM5 2.56589
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56589
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, PDE5A, PTPN1, SRC 2.56589
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP2, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SRC, TOP2A, TYR, XDH 2.56589
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, OPRM1, PPARA 2.56073
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.56073
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2 2.56073
[BP] GO:0042053 None DRD1, HTR1A, MAOB 2.55901
[BP] GO:0042069 None DRD1, HTR1A, MAOB 2.55901
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC 2.5483
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PPARA 2.53945
[BP] GO:0009187 None PDE10A, PDE3A, PDE3B, PDE5A 2.53858
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.52336
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DRD2, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, TOP2A, XDH 2.51999
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, GRM5, HTR2A, OPRK1 2.50594
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2 2.49972
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, HTR2A, KDR, OPRM1, PTPN1, SRC 2.48953
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.48953
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 2.46451
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.45761
[BP] GO:0046434 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 2.45761
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.44673
[BP] GO:0030814 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.44244
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.4378
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.4248
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD2, HCAR2, HTR2A, KDR, MET, MMP9, OPRM1, PDE3A, PDE5A, PIM1, SLC1A1, SRC 2.41764
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, SRC, XDH 2.41225
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.40459
[BP] GO:0030802 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.39797
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.39797
[BP] GO:0050995 None ADORA1, HCAR2, PDE3B 2.39797
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.39303
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.38806
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, TOP2A, XDH 2.38053
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, HTR2A, KDR, OPRM1, SRC 2.3785
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC 2.35567
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34778
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, PPARA, SRC 2.34432
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, IGF1R, MMP9, OPRM1, PDE5A, PTPN1, SRC, XDH 2.34427
[BP] GO:0097746 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.33837
[BP] GO:0035296 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.33837
[BP] GO:0007198 None HTR1A, HTR7 2.33837
[BP] GO:0060282 None PDE3A, PDE5A 2.33837
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33837
[BP] GO:1905881 None PDE3A, PDE5A 2.33837
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33837
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SENP6, SRC, TOP2A, TYR, XDH 2.33553
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2A 2.33471
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, DRD2, GRM1, HCAR2, HTR2A, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, SLC1A1, SRC, XDH 2.31421
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.31421
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.31421
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.31421
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.31147
[BP] GO:1900371 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.27195
[BP] GO:0048169 None APP, DRD2, GRM5 2.26479
[BP] GO:0030808 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.25857
[BP] GO:0050880 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.22969
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.22425
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, FABP3, GRM1, GRM5, HTR2A 2.2182
[BP] GO:0035150 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.21791
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.20435
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TOP2A 2.1839
[BP] GO:0008306 None APP, DRD1, DRD2, OPRK1 2.1839
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CDC25B, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MAOB, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 2.18191
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, OPRK1 2.18191
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.18114
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, HTR2A, IGF1R, MET, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 2.18114
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, HTR2A, IGF1R, MET, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 2.16902
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC 2.16902
[BP] GO:0021853 None DRD1, DRD2 2.15819
[BP] GO:1904936 None DRD1, DRD2 2.15819
[BP] GO:0042321 None ADORA1, DRD2 2.15819
[BP] GO:0032868 None FABP3, OPRK1, PDE3B, PPARA, SRC 2.1468
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.14454
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.14454
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.14454
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.13206
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, HTR2A, MAOB, MMP9 2.12347
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2 2.11635
[BP] GO:0034762 None APP, CA2, DRD1, DRD2, GRM5, MMP9, OPRK1, OPRM1 2.10899
[BP] GO:0019098 None APP, DRD1, OPRK1 2.10626
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.10626
[BP] GO:0050808 None ACHE, APP, DRD1, DRD2, GRM5 2.10165
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.065
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.065
[BP] GO:0008344 None APP, DRD1, DRD2, OPRD1 2.05472
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, GRM5, KDR, OPRM1, PDE3A 2.03543
[BP] GO:0007611 None APP, DRD1, DRD2, GRM5, HTR2A, OPRK1 2.03543
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DRD2, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, TOP2A, XDH 2.0275
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.02383
[BP] GO:0021843 None DRD1, DRD2 2.01374
[BP] GO:0021830 None DRD1, DRD2 2.01374
[BP] GO:0046069 None PDE10A, PDE5A 2.01374
[BP] GO:0021826 None DRD1, DRD2 2.01374
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.01374
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, SRC 2.0005
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC 2.0005
[BP] GO:0007194 None DRD2, GRM3, OPRM1 2.00014
[BP] GO:0043278 None DRD2, OPRK1, OPRM1 2.00014
[BP] GO:0014072 None DRD2, OPRK1, OPRM1 2.00014
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1 7.39689
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1 6.95272
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SLC1A1, SRC 6.48298
[CC] GO:0044456 None ACHE, ADORA1, APP, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 6.13526
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, SRC 5.22981
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, DRD1, DRD2, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SLC1A1, SRC 5.01448
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTPN1, SIGMAR1, SLC1A1, SRC, TYR 4.82683
[CC] GO:0043005 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 4.76591
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SIGMAR1, SLC1A1, SRC, TYR 4.6932
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.13781
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.13781
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 4.09041
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 4.09041
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, OPRD1, SIGMAR1 3.98583
[CC] GO:0097458 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, OPRD1, OPRK1, OPRM1, PDE10A, SIGMAR1, SRC 3.86266
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3, OPRM1 3.82921
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 3.63746
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.51052
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.38537
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 3.3783
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 3.3767
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.36413
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, DRD1, DRD2, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SLC1A1, TYR 2.97338
[CC] GO:0098793 None ADORA1, APP, DRD2, GRIK5, OPRD1, OPRK1 2.70529
[CC] GO:0043204 None DRD2, GRIK5, OPRK1, OPRM1, PDE10A 2.45761
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, DRD1, DRD2, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SLC1A1, TYR 2.36301
[CC] GO:0045211 None GRIA2, GRIA4, GRIK5, GRM3, OPRD1, SIGMAR1 2.24867
[CC] GO:0031253 None ADORA1, CA4, DRD1, DRD2, OPRD1, OPRM1, SRC 2.1839
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01374
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR7, OPRM1 9.10242
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 8.39154
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 8.39154
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 8.39154
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.17562
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.9459
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 7.55315
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 7.45275
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 7.41565
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 6.8634
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, SRC, TOP2A, TYR, XDH 6.29967
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, GLO1, HTR1A, HTR2A, HTR7, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, TOP2A, TYR, XDH 5.93214
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, FUT7, GLO1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PTPN1, SENP6, SRC, TOP2A, TYR, XDH 5.76123
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.55209
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.47116
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.32066
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.12017
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 5.03406
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.03002
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B, PDE5A 4.54741
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2, MAOB, TYR, XDH 4.47385
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.40998
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FLT3, HTR2A, IGF1R, KDR, MET, PDE10A, PIM1, PPARA, SIGMAR1, SRC, TOP2A 4.40991
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.34782
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.09041
[MF] GO:0008081 None ADORA1, APEX1, PDE10A, PDE3A, PDE3B, PDE5A 3.92406
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.82945
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B, PDE5A 3.70449
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 3.70379
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B, PDE5A 3.64443
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.51052
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, PDE10A, PDE3A, PDE3B, PDE5A, PTPN1 3.29695
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.24389
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.17869
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.17869
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GLO1, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, TOP2A, TYR, XDH 3.17546
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.10679
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.09608
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 3.06729
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, PDE10A, PDE3A, PDE3B, PDE5A, PTPN1 3.03391
[MF] GO:0004119 None PDE3A, PDE3B 2.96298
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 2.85486
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.82098
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.6052
[MF] GO:0099583 None GRM1, GRM5 2.56589
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.56073
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.55901
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.55901
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.54403
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.48717
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.39797
[MF] GO:0004971 None GRIA2, GRIA4 2.33837
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.31421
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.31421
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, HTR2A, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.27837
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP2, MMP9, PPARA, PTPN1 2.20435
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B2, XDH 2.18191
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, FLT3, HTR2A, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.10774
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0275
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01374


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, GRIA2, GRIK5, HTR1A, OPRK1, OPRM1, HTR2A, GRM1, GRM3, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 14.447
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, PPARA, GRIA4 7.313
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.8665
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.0666
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.3935
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR7, MAOB, CYP2D6, ALOX5, HTR1A, HTR2A 5.7003
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 5.0604
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2A, DRD1, DRD2, GRM1 5.0604
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 5.0604
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.7354
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.2781
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A, PDE5A 3.7642
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, GRM1 3.7642
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 3.9931
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3182
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9846
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, DRD1, DRD2, GRIA4 3.2752
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, DRD1, GRIA4 3.2752
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 2.9465
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.1733
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, HTR7, HTR2A, DRD1, GRM1 2.7582
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2486
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, PDE5A, XDH 2.7854
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.7455
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.4776
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0204
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.1014
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.2509
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.4002
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3281
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9618
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 2.2615
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9618
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2509
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8248
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.8368
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP2D6, CYP1A2 2.2085
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6891
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5217
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, ADORA1 1.6668
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.2896
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0408
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2A 1.0504
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9539
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0942
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0676
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.1598
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 1.0408
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3444
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9952
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3823
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2931
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2699
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8697
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8333
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8392
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2019
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PDE3B 0.8489
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7667
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9539
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2896
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3629
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3094
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3396
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2386
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2854
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2949
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3099
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3282
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3161
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3597
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3674
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3432
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3597
Tight junction_Homo sapiens_hsa04530 SRC 0.3881
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3845
Platelet activation_Homo sapiens_hsa04611 SRC 0.4162
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4319
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3995
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4162
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4319
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4181
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4162
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4508
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4162
Axon guidance_Homo sapiens_hsa04360 MET 0.4117
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4181
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4574
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4793
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4681
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4793
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4681
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4793
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4793
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4681
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4793
Peroxisome_Homo sapiens_hsa04146 XDH 0.4828
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4793
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5275
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5217
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5289
Bile secretion_Homo sapiens_hsa04976 CA2 0.5283
Glioma_Homo sapiens_hsa05214 IGF1R 0.5479
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5479
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5468
Shigellosis_Homo sapiens_hsa05131 SRC 0.5479
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.659
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8315
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.7324
Malaria_Homo sapiens_hsa05144 MET 0.634
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6284
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6312
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.654
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7187
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7981
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7053
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0133
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7053
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7875
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7675
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8094
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8374
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8333
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8523
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9718
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0405
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1733


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)