TCM Prescription: Da Huang Gan Cao Decoction



Prescription Description
Prescription IDTCMF2893
Pinyin NameDa Huang Gan Cao Tang
Chinese Name大黄甘草汤
English NameDa Huang Gan Cao Decoction
Function Description各类疾病并发的呕吐或便秘, 重症急性胰腺炎, 脓毒症肠功能障碍, 急性五官科疾病如急性喉炎, 扁桃体炎, 鼻衄, 牙龈炎, 急性中耳炎等属于胃中积热者
IndicationsConstipation disorder, Acute pancreatitis, Pharyngitis, Pharyngotonsillitis
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
DC31 [Acute pancreatitis, 急性胰腺炎 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
CA0Y [Other specified upper respiratory tract disorders, 其他特指的上呼吸道疾患 ];
Human Tissues Associated with IndicationLung, Stomach, Intestine, Nose
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, TYR 8.43667
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2, TNKS, TNKS2, XDH 8.31505
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PTGS2, TYR 7.97645
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.95738
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.57445
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.22452
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.12896
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PTGS2, TYR 7.06103
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.80703
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.79718
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.79718
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.78097
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.67532
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 6.67322
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, PTGS2, TYR 6.64438
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, HTR2B, HTR2C, PIK3CA, PTGS1, PTGS2, TYR, XDH 6.61764
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.27223
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.27223
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.16355
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.42902
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, PIK3CA, PTGS2, TYR 5.42902
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.40797
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.15634
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, CNR1, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2, TNKS, TNKS2 5.10182
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 4.8704
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.86807
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 4.84095
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.79337
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.76843
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP2, MMP9, PIK3CA, PTGS2, TNKS2, TYR 4.76843
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.76843
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, PTGS2 4.53782
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.43432
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.43432
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39931
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.39166
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.38334
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.29866
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.2906
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.27487
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS1, PTGS2, XDH 4.18225
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.0965
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.08879
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.07113
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.07113
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS2 4.02775
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.01217
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, TNKS, TNKS2 3.91985
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.91563
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HTR1A, TYR 3.91563
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TYR 3.91213
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.90929
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.88862
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.82045
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.72972
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.71006
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 3.69402
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.65237
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, F3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 3.60702
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, MMP2, PTGS2 3.57952
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS2, TYR 3.53958
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 3.52771
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.49022
[BP] GO:0071073 None HTR2A, HTR2B, HTR2C 3.3238
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.31732
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.31732
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.25381
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.25381
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.24107
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20622
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D 3.18951
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.17936
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.17936
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.17936
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.09217
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, TNKS, TNKS2 3.04299
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.01477
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.00792
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.90521
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88303
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.88014
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.8441
[BP] GO:0007208 None HTR2A, HTR2C 2.82668
[BP] GO:0009115 None AOX1, XDH 2.82668
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.80007
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PIK3CA, TYR 2.78991
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, MMP9, PTGS2 2.78991
[BP] GO:0007154 None BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 2.78991
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 2.78692
[BP] GO:0003008 None AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, TYR 2.7036
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.68003
[BP] GO:0071071 None HTR2A, HTR2B, HTR2C 2.65503
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.63968
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PTGS2, PTPN1 2.58157
[BP] GO:0007267 None CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.58086
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.54886
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, ESR1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.53757
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.51674
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.4988
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.4988
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.47784
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.47157
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.45766
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.45766
[BP] GO:0046110 None AOX1, XDH 2.4355
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4355
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.38099
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.34283
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.32878
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.30593
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.28788
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C 2.28362
[BP] GO:0046889 None HTR2A, HTR2B, HTR2C, PTGS2 2.25907
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.25907
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.25265
[BP] GO:0022414 reproductive process AKR1B1, ALPL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTGS2 2.2459
[BP] GO:0023052 None CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.2459
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.24576
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, MMP9, PTGS2 2.20025
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19362
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, HSD11B2, HTR1B, PTGS2 2.1903
[BP] GO:0070213 None TNKS, TNKS2 2.1903
[BP] GO:0006145 None AOX1, XDH 2.1903
[BP] GO:0038171 None CNR1, CNR2 2.1903
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1903
[BP] GO:0014827 None HTR1D, HTR2B 2.1903
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, HTR5A, MMP9, PIK3CA, PTGS2, TYR 2.18129
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.03987
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.01659
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR 4.31704
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TYR 4.09133
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F3, GBA2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTPN1 3.28453
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, CA4, CNR1, CNR2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.00792
[CC] GO:0005887 integral component of plasma membrane ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 2.10926
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, CA2, CA4, CA9, CNR1, CNR2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2 2.05247
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.6154
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.6154
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.5493
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.4405
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.9595
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PTPN1, TNKS, TYR, XDH 11.3933
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.6687
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.5114
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.385
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 9.26685
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 8.43667
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.45045
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.66082
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PTPN1, TNKS 6.00373
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.77937
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.54372
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.38996
[MF] GO:0038023 signaling receptor activity ADORA3, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.20171
[MF] GO:0060089 molecular transducer activity ADORA3, CDK6, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.9193
[MF] GO:0004872 receptor activity ADORA3, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.45965
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.18225
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.10819
[MF] GO:0004930 None ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.08879
[MF] GO:0004871 signal transducer activity ADORA3, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.93255
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.91563
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.84526
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.77838
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.65237
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.5875
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.5325
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.50358
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.44564
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.4249
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.28453
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 3.26225
[MF] GO:0099600 transmembrane receptor activity ADORA3, CNR1, CNR2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.15723
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, CNR1, CNR2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.15723
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.14254
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.82668
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82668
[MF] GO:0003845 None HSD11B1, HSD11B2 2.82668
[MF] GO:0071886 None HTR2A, HTR2C 2.82668
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.80441
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.78694
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.78692
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.65299
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.65299
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.4355
[MF] GO:0004949 None CNR1, CNR2 2.4355
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.38099
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1903


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7 16.7174
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 11.6176
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7535
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.6851
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1 6.6962
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.8567
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4 5.6267
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.1004
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.8239
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB, F3 3.9274
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 3.9594
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.1785
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.7231
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.2257
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1785
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, CYP1B1, PTGS2, MMP9, CDC25B 3.6733
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 PIK3CA, PIK3CB, PTGS2, PTGS1 3.7147
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, BCL2, PIK3CB, MMP9 3.3126
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1, ESR2 3.3337
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.3336
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.1793
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.7742
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.7742
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7742
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.6842
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6966
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.5084
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, AOX1, PIK3CB 2.3657
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.5556
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.9066
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8601
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.4804
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB 2.4454
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4804
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.04
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.4381
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB 2.3657
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.4804
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.345
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.1294
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B 2.04
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.4454
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, HTR2A 2.1332
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 2.0027
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0851
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB 1.9547
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.8914
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.8668
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.8914
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.8788
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.7245
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.7256
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB 1.7149
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6799
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.6167
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.5719
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, BCL2, PIK3CB 1.4828
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.4245
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, PIK3CB 1.4185
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB 1.3914
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.3203
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2745
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3778
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3882
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.371
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.3769
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3773
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4488
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4447
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6813
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.7991
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 1.0122
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0436
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0956
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3056
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2646
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.923
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.0956
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.1363
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.3021
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2646
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.8788
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0884
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2406
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.3488
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4878
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 1.0956
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2739
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2509
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.1363
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2509
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2646
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.4939
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5653
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4585
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.5002
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5777
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.5194
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5772
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5906
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5914
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5664
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.4211
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4756
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.5896
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5923
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.453
Peroxisome_Homo sapiens_hsa04146 XDH 0.6153
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.4876
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6527
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5719
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.631
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6544
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6527
Bile secretion_Homo sapiens_hsa04976 CA2 0.6617
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6692
PPAR signaling pathway_Homo sapiens_hsa03320 MMP1 0.6692
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.731
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7058
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7783
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0027
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8965
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7991
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.0137
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8011
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.8
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9562
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8914
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1548
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9512
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9747
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0122
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0005
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.1363
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2526
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.23
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4876


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)