TCM Prescription: Di Huang Decoction



Prescription Description
Prescription IDTCMF2842
Pinyin NameDi Huang Yin Zi
Chinese Name地黄饮子
English NameDi Huang Decoction
Function Description喑痱证, 主肾虚内夺而厥, 舌喑不能言, 二足废不为用肾脉虚弱, 其气厥不至, 舌不仁经云∶喑痱, 足不履用, 音声不出者地黄饮子主之, 治喑痱, 肾虚弱厥逆, 语声不出, 足废不用
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH716 Cinnamomum cassia 官桂 TCMH716 GQ255631
TCMH57 Wolfiporia cocos 白茯苓 TCMH57 GBPOL314-13
TCMH1428 Ophiopogon japonicus 麦门冬 TCMH1428 ITSAJ4140-14
TCMH237 Acorus calamus 菖蒲 TCMH237 ITSAI4402-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1B1, CYP3A4, DRD3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSPA1A, INSR, KDR, MET, PPARA, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 11.1745
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.29404
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.29404
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 9.11756
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 9.03895
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 9.02158
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 9.02158
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 8.72729
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.38446
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.346
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 8.31781
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 8.28322
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 8.28322
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 8.28322
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.20165
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 8.20165
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1 8.20165
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 8.20165
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 8.12917
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.46987
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 7.46987
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC, TRPV1 7.46966
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 7.33648
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.29135
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, FABP3, GRIK5, GRM5, HMGCR, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TRPV1 7.14671
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, BCL2, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1 7.00859
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD11B1, MET, PPARA, TRPV1 6.7722
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.76483
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, DRD3, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, TRPV1 6.76483
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.61462
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, BCL2, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1 6.52167
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD3, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.29365
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.27848
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.15512
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 6.136
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.07193
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.07193
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 5.99039
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.94278
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.85702
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.85702
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.77463
[BP] GO:0009719 response to endogenous stimulus AKR1B1, BCL2, CA2, CSNK2A1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 5.77178
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.70325
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.70019
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.64634
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 5.58485
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.55892
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.5427
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.53998
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.53998
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.53998
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.4932
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.4191
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.39014
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, DRD3, EGFR, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, INSR, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 5.35782
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, F10, INSR, MET, SRC, TEK, XDH 5.30563
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 5.29451
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.28985
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.28985
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.26841
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.19636
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.14609
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 5.14609
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 5.10519
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.0538
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.0538
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.04607
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.04607
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.0175
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, DRD3, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 4.97548
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.97548
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 4.97177
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 4.88771
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, PPARA, SLC1A1, TRPV1 4.88771
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD3, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.88649
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CYP19A1, DRD3, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.8602
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD3, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.74692
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.74692
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.73568
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 4.73568
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, GRIK5, INSR, SLC1A1, SMAD3, TRPV1 4.73568
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.72624
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, CSNK2A1, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 4.72624
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.69421
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, FABP3, FUT7, HMGCR, HSPA1A, PIM1, PPARA, XDH 4.64159
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.63962
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.62967
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.62111
[BP] GO:0007193 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 4.60282
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.57249
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.53212
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA 4.47502
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD3, EGFR, HMGCR, KDR, SRC, TRPV1 4.41894
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.36065
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 4.35443
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 4.35293
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD3, KDR, SRC, TRPV1 4.34671
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.3201
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.2241
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 4.2241
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.2241
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 4.2241
[BP] GO:0042391 None ADORA1, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.17665
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.17257
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 4.12623
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 4.10348
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 4.10222
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.0601
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1B1, CYP3A4, DRD3, HMGCR 4.0601
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, HMGCR, HSPA1A, KDR, MET, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1 4.05273
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.04269
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.04269
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.03859
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC 3.95243
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, PPARA, SLC1A1, TRPV1 3.91164
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.90558
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.89805
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 3.86627
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.81505
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.79599
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 3.79204
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.75906
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD3, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.74829
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD3, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.73336
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, EGFR, PPARA, SMAD3 3.72783
[BP] GO:0001503 ossification ALOX15, BCL2, EGFR, MMP2, MMP9, TEK 3.70277
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, DRD3, FABP3, FLT3, HMGCR, PPARA, RORC, SRC, TEK 3.63771
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.63107
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 3.61017
[BP] GO:0014070 response to organic cyclic compound BCL2, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, FLT3, NR3C1, RORC, SRC, TEK, TRPV1 3.58115
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 3.57582
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.55648
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CYP1B1, DRD3, EGFR, FABP3, HMGCR, KDR, NR3C1, SRC, TRPV1 3.52787
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.52787
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD3, HMGCR, PPARA, SMAD3, TEK 3.52787
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.52178
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 3.52178
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.51949
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, EGFR, FLT3, HSD11B1, INSR, KDR, PPARA, SMAD3, SRC, TEK 3.50883
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 3.50861
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, EGFR, PPARA, RORC, SRC 3.49019
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.49019
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD3, DUSP3, EGFR, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 3.47488
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 3.42713
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.39012
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 3.33922
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.32357
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD3, EGFR, FABP4, HMGCR, KDR, MET, PPARA, SMAD3, TEK 3.28774
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 3.2622
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.2433
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.23363
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 3.16978
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.12705
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.12705
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 3.09826
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.09071
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 3.06793
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 3.06793
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 3.02281
[BP] GO:0007188 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 3.02281
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.00082
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.00082
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.00082
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.00082
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.99536
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.96698
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.9659
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.96257
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR 2.95011
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1 2.94577
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.93916
[BP] GO:0007154 None ADORA1, AXL, BCL2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK, TRPV1 2.90445
[BP] GO:0045936 None DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.8853
[BP] GO:0010563 None DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.88293
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, DRD3, EGFR, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 2.87679
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.83355
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, MMP2, PPARA, SMAD3, SRC, TEK 2.83302
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.83302
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.83302
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.83302
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.83302
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.83145
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.79732
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.79386
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, MMP2, PPARA, SMAD3, SRC, TEK 2.76412
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1B1 2.75792
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 2.73845
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.72784
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.71049
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD3, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.70546
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.70546
[BP] GO:0007187 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 2.70532
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1B1, CYP3A4, HSD11B1 2.68228
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.67677
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.67677
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.6651
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.65
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1B1, CYP3A4, EGFR, HMGCR, HSD11B1 2.64918
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.63603
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CSNK2A1, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.63291
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.63291
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.62627
[BP] GO:0099566 None GRM1, GRM5 2.6219
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.6219
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 2.62053
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.62053
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.62053
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.61565
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.61565
[BP] GO:0044057 None ADORA1, ADORA3, DRD3, EGFR, GPR35, GRM1, SLC1A1, SMAD3, TRPV1 2.61177
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HMGCR, HSD11B1, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK 2.61023
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD3, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 2.60843
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.60112
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, MMP2, PPARA, SMAD3, SRC, TEK 2.58716
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CYP1B1, DRD3, HMGCR, KDR, SRC 2.58716
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.58716
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.58716
[BP] GO:0007268 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.58716
[BP] GO:0098916 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.58716
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HMGCR, KDR, SRC, TEK 2.58535
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC, TRPV1 2.5845
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD3, EGFR, INSR, SMAD3, SRC, TRPV1 2.57153
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.56126
[BP] GO:0051172 None AURKB, CSNK2A1, DRD3, DUSP3, EGFR, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.53782
[BP] GO:0099536 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.53723
[BP] GO:0099537 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.53723
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1 2.53349
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.51979
[BP] GO:0007610 None BCL2, DRD3, EGFR, GRM1, GRM5, HMGCR, INSR, PPARA, TRPV1 2.51514
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.50889
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD3, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.49523
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1B1, CYP3A4, EGFR, HMGCR 2.49523
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.49523
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1 2.4831
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.45398
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP3A4, HMGCR, HSD11B1 2.45127
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD3, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 2.44221
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.43772
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.41559
[BP] GO:0051894 None KDR, SMAD3, TEK 2.40723
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.40723
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 2.38927
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD3, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.38171
[BP] GO:0048545 response to steroid hormone BCL2, CA2, EGFR, FLT3, NR3C1, SRC 2.37961
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP3A4, DRD3, DUSP3, EGFR, F10, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.37754
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.36149
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.35196
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK 2.34356
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 2.32498
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CSNK2A1, EGFR, FABP3, FLT3, NR3C1, RORC, SRC 2.32498
[BP] GO:1900543 None DRD3, GRM3, GRM8, PPARA 2.32498
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CYP1B1, DRD3, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, SRC, TEK, TRPV1 2.32498
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.32498
[BP] GO:1903393 None KDR, SMAD3, TEK 2.32498
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, GRIK5, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.32228
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD3, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.32219
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.32
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.3106
[BP] GO:0045980 None DRD3, GRM3, GRM8, PPARA 2.3106
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD3, GPR35, MMP9 2.29775
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, PTPN1, SRC 2.2799
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.27808
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.27055
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TRPV1 2.26099
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1, XDH 2.24845
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.23727
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.23301
[BP] GO:0051262 protein tetramerization ACHE, HMGCR, IGF1R, INSR, TRPV1 2.22638
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.22402
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.22402
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.21719
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.21271
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, HMGCR, MMP9, SMAD3, SRC, TRPV1, XDH 2.20003
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3 2.1905
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.19004
[BP] GO:0071407 cellular response to organic cyclic compound CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 2.19004
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.1865
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GRIK5, HMGCR, MMP9, SMAD3, SRC, TRPV1, XDH 2.17495
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.17495
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.17495
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.14514
[BP] GO:0031960 response to corticosteroid BCL2, EGFR, FLT3, NR3C1, SRC 2.13911
[BP] GO:0003018 None ADORA1, EGFR, HMGCR, SRC, TEK 2.13911
[BP] GO:1901890 None KDR, SMAD3, TEK 2.13898
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.13898
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.13433
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.13433
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.13433
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.13433
[BP] GO:0007267 None ADORA1, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.12074
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.11081
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.10671
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.09994
[BP] GO:0045927 positive regulation of growth ALOX12, BCL2, CSNK2A1, EGFR, INSR, PIM1 2.094
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.08627
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, DRD3, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 2.08208
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.07674
[BP] GO:0010907 None INSR, PPARA, SRC 2.07674
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, DRD3, DUSP3, EGFR, INSR, SRC 2.0744
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.04942
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, MET, PPARA, SMAD3 2.03369
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.02395
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD3, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.01017
[BP] GO:0040008 regulation of growth ALOX12, BCL2, CSNK2A1, DRD3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.00626
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, SRC, TRPV1 2.00543
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, EGFR, FLT3, MET, PIM1, SRC, TEK 2.00355
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CSNK2A1, DRD3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.88908
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 5.78219
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, DRD3, DUSP3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK, TRPV1 5.7598
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD3, F10, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 5.55892
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 4.54816
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, EGFR, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 3.8278
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.71585
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.46188
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.12705
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, PTPN1, SLC1A1, SRC, TEK, TRPV1 3.09381
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 3.03795
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.57804
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.57804
[CC] GO:0005783 None ADORA1, BCL2, CA4, CYP19A1, FLT3, GRIK5, HMGCR, HSPA1A, KDR, PTPN1, XDH 2.09798
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.08627
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.40044
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.28322
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 8.28322
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 8.20165
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.84261
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 7.27166
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 7.27166
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.11123
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 7.0502
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 6.69237
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.56031
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.56031
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, HMGCR, HSD11B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.99039
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.77463
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.29451
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP3A4, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 5.21755
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.74692
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.62967
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, XDH 4.00486
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.98034
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.94189
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, MMP1, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3 3.83683
[MF] GO:0030594 None DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.79599
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.68501
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.61287
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.52178
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 3.23861
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TRPV1, XDH 3.20745
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, NR3C1 3.12705
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, TRPV1, XDH 3.10747
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.00082
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.94914
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, TRPV1, XDH 2.94282
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1, XDH 2.88301
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.83885
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.80295
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.7624
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.69377
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.63603
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.63603
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.6219
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.6219
[MF] GO:0099583 None GRM1, GRM5 2.6219
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.58716
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.58535
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, FABP3, FABP4, NR3C1, PPARA, RORC, TRPV1 2.51514
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.49314
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, F10, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TRPV1, XDH 2.48785
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.46448
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP3A4 2.45398
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.44665
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.42984
[MF] GO:0004971 None GRIA2, GRIA4 2.39699
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, XDH 2.35196
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP3A4 2.32498
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.32498
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.28407
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.25035
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.2449
[MF] GO:0043559 insulin binding IGF1R, INSR 2.22402
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.20984
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.13898
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.10671
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08627
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.04942
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.0482


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD3, GRIA4 9.6519
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.5892
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.1919
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2983
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3783
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, CYP1B1, CYP19A1, IGF1R 5.0151
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.9682
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 4.3622
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.3622
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3292
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 4.212
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8256
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.7875
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.5402
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5378
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.2855
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.3298
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.369
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, CYP1B1, CYP3A4, CYP19A1 3.5402
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.8105
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3472
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.8105
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1, EGFR 3.0016
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, FUT7, AKR1B10, ALOX5, ALOX15, AKR1B1, ALOX12, HMGCR, CYP3A4, CYP19A1, XDH 2.2953
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.2953
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4068
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3368
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2953
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.3123
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2953
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2906
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2577
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0779
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2858
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.965
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 2.0357
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0193
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.9492
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.2577
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1B1, CYP3A4 2.2355
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1B1, CYP3A4 2.1025
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8589
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12 1.8353
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.7049
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7905
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6552
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7788
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.7481
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD3, GRIA4 1.7174
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4746
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1, EGFR 1.4353
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.3198
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0798
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9446
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9566
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1722
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9439
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2379
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.0048
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1938
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9378
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9014
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9378
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0377
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9439
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1912
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8867
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.2168
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1965
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2662
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8508
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8867
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7077
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8213
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3328
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4624
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3491
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3567
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3701
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4369
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3701
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3198
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3563
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4966
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4112
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4195
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4358
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4481
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4353
Platelet activation_Homo sapiens_hsa04611 SRC 0.4722
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4747
Axon guidance_Homo sapiens_hsa04360 MET 0.4639
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4722
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4624
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.4313
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4776
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4753
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4999
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5173
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5249
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5249
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4369
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5376
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5372
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5505
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5607
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5527
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5597
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5527
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5544
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5519
Peroxisome_Homo sapiens_hsa04146 XDH 0.5607
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5511
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5916
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5931
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5724
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5901
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5784
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.5817
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6003
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.6075
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6155
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP3A4 0.6021
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6176
Retinol metabolism_Homo sapiens_hsa00830 CYP3A4 0.6176
Shigellosis_Homo sapiens_hsa05131 SRC 0.6176
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6529
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6645
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6676
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7385
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6859
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9112
Malaria_Homo sapiens_hsa05144 MET 0.7058
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7077
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP3A4 1.9303
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8655
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7932
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7815
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0771
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1B1 0.7755
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8213
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8969
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8582
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9014
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8671
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8969
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9439
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.4624


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)