Prescription Description
| Prescription ID | TCMF2761 |
| Pinyin Name | Gui Ma Ge Ban Tang |
| Chinese Name | 桂麻各半汤 |
| English Name | Combined Cinnamon Twig and Ephedra Decoction |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Current Kampo Medicine |
| Reference Book/link | ISSN 1559-033X |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH761 | Cinnamomum cassia | 桂枝 | TCMH761 | GQ255631 |
| TCMH388 | Ziziphus jujuba | 大枣 | TCMH388 | ITSAM869-14 |
| TCMH1398 | Ephedra sinica | 麻黄 | TCMH1398 | ITSAM882-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH2322 | Prunus armeniaca | 杏仁 | TCMH2322 | ITSAJ4486-14 |
| TCMH1903 | Zingiber officinale | 生姜 | TCMH1903 | ITSAO3969-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 118 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1188 | Leishmania braziliensis |
| TCMT1189 | Pseudomonas fluorescens |
Showing 1 to 10 of 78 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.19427 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC | 2.50439 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.19285 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, MAOA, SMAD3, TRPV1 | 4.82813 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, TRPV1 | 3.18162 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 4.77234 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 | 3.45623 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC, TRPV1 | 2.17736 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH | 3.11759 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH | 2.72565 |
Showing 1 to 10 of 498 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2736 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.6908 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5364 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3357 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.2971 |
| Alcoholism_Homo sapiens_hsa05034 | MAOA, DRD1, DRD2 | 1.1285 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.5064 |
| Amphetamine addiction_Homo sapiens_hsa05031 | MAOA, DRD1 | 1.1874 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.8274 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.618 |
Showing 1 to 10 of 162 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples