TCM Prescription: Shixiang Fansheng Pills



Prescription Description
Prescription IDTCMF2617
Pinyin NameShi Xiang Fan Sheng Wan
Chinese Name十香返生丸
English NameShixiang Fansheng Pills
Function Description中风
IndicationsStroke
Disease ICD-11 Category 8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH1693 Aristolochia debilis 青木香 TCMH1693 GBVE1975-11
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH1060 Bombyx batryticatus 僵蚕 TCMH1060
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MAOA, MET, MIF, PPARA, SLC1A1, SMAD3, SRC, TEK, XDH 11.0272
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 9.94951
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 9.94951
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, PTPN1, RELA, SRC, TEK, XDH 9.47774
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, EGFR, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PTGES, RELA, SMAD3, SRC, TEK, XDH 9.47407
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PTGES, RELA, RORC, SRC, TEK, TYR 8.83791
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.83791
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, XDH 8.83791
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, XDH 8.83791
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.71811
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.57335
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 8.57335
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PTGES, RELA, RORC, SMAD3, SRC, TEK, TYR 8.30801
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, XDH 8.26892
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 8.18126
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PPARA, PTGES 8.0125
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.98542
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 7.62265
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.62265
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 7.53815
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK 7.53656
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PTGES, RELA, RORC, SMAD3, SRC, TEK, TYR 7.44817
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALDH2, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HMGCR, HSD17B3, HSPA1A, MIF, PIM1, PPARA, PTGES, TYR, XDH 7.15953
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.04542
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.99251
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.92267
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK 6.90664
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 6.85567
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK, XDH 6.81809
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PPARA, RELA, SMAD3, SRC, TEK, TYR 6.80845
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, RELA, SRC 6.47
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK, XDH 6.47
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.40382
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP3K7, MET, MIF, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK 6.3891
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RELA, RORC, SMAD3, SRC, TOP2A 6.28116
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 6.1939
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.13641
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.05021
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, AR, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARA, RELA, SMAD3, SRC, TEK 6.01206
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.97102
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.97102
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, F3, FABP4, HMGCR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.9494
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.93086
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RELA, RORC, SMAD3, SRC 5.84614
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.77609
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.76059
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.7248
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, PTGES, RELA, RORC, SRC, TEK, TYR 5.7205
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.71606
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.71606
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.6017
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.58212
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 5.55481
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RELA, RORC, SRC 5.51596
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK 5.43141
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.40474
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RELA, RORC, SMAD3, SRC 5.36012
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 5.36012
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 5.36012
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.36012
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.35703
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.34125
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, EGFR, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, RELA, TEK 5.34125
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.30166
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 5.28686
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TYR 5.28582
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.28582
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.28578
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC 5.28578
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.28409
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 5.22936
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 5.21773
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.21773
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.21179
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.21179
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 5.15378
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.11192
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.10333
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, PTGES, RELA, RORC, SRC, TYR 5.10179
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 5.06447
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.03354
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.02503
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.02503
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, NR3C1, PGR, PIM1, PPARA, RELA, RORC, SRC 5.02475
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.99435
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.97343
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.91213
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.88409
[BP] GO:0009725 response to hormone AKR1B1, APEX1, AR, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, RELA, SRC, TEK 4.84034
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.81543
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.75418
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.69561
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 4.69561
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, HSD17B3, MAOA, TYR 4.62114
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 4.60314
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 4.59756
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.55031
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.53216
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, EGFR, F3, HMGCR, HSPA1A, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, RELA, SLC1A1, SMAD3, SRC, TEK 4.5209
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, HMGCR, KDR, MAP2K1, MIF, PTPN1, SRC, TEK 4.47632
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.47632
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, RELA, SRC, TEK 4.47113
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.42804
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 4.42753
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.41377
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 4.36835
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 4.36835
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.36763
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.36663
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 4.36119
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, MIF, PPARA, PTGES 4.25985
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.24469
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.24469
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 4.24351
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, CDC25B, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MAP2K1, MAP3K7, MET, MIF, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.24351
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.23741
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, HSD17B3 4.21461
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF, PTGES 4.21268
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, RELA, SRC, TEK, TYR 4.16717
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.12612
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.10706
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.09404
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MMP9, PGR, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TYR 4.08728
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, RELA, SMAD3, SRC, TEK, TYR 4.06744
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.06662
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.06486
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, F3, FABP4, HMGCR, KDR, MAP2K1, MET, MIF, MMP12, PPARA, RELA, SMAD3, TEK 4.04539
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3, TYR 4.03363
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, RELA, SMAD3, SRC 4.01463
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.01463
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.01274
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 4.00575
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.00575
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 3.96216
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.92626
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, INSR, MAP2K1, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.85719
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.85719
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, RELA, SRC, TEK, TYR 3.8272
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.804
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.75982
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.7472
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, HMGCR, KDR, MAP2K1, MIF, SRC, TEK 3.72839
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.70124
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.69789
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CACNA1C, CYP1B1, EGFR, F3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, RELA, SLC1A1, SMAD3, SRC, TEK, XDH 3.68086
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.67368
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC 3.67368
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, RELA, SRC 3.57072
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, NR3C1, RELA, SRC 3.55053
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, NUAK1, PTPN1, XDH 3.55053
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, FLT3, MAP2K1, MET, MIF, PIM1, SRC, TEK, TYR 3.52174
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.52174
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK, TOP2A 3.51412
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TOP2A 3.49329
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 3.48554
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES 3.48243
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.46381
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.43132
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.3956
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 3.38124
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 3.37567
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.37567
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SMAD3, SRC, TEK, XDH 3.37038
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.37038
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 3.3647
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES 3.33324
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, XDH 3.32515
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.32408
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.32387
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 3.29691
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, RELA, SRC 3.28783
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.28387
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.28187
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.28187
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.28187
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.26559
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.25893
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.25893
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.25477
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 3.16997
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.14178
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, RELA, SMAD3, SRC 3.14178
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.13704
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13704
[BP] GO:0050678 None AR, EGFR, F3, KDR, MMP12, PGR, SMAD3, TEK, XDH 3.09536
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, RELA, SRC, XDH 3.09287
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, EGFR, NR3C1, RELA, SRC 3.09144
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, NR3C1, RELA, SRC 3.06133
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.0321
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.0321
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, MAOA, SLC1A1, SMAD3 3.03135
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, RELA, SRC 3.03122
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A, MAOA 3.01955
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 2.92088
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.87103
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.87103
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 2.86893
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.86893
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.84835
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, RORC, SRC, TEK 2.80515
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80515
[BP] GO:0050801 ion homeostasis ABCG2, APP, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3 2.80384
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, MIF, PIM1, SMAD3, SRC, TOP2A 2.78309
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, RELA, SMAD3, SRC 2.78309
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.75761
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.73331
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, PGR, PPARA, RORC, SRC, TOP2A 2.73266
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, EGFR, HMGCR, KDR, MIF, SRC 2.68213
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.66733
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTPN1, RELA, SRC 2.66733
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 2.63614
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.63614
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES 2.62483
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.59421
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, PGR, SRC, TOP2A 2.59084
[BP] GO:0048545 response to steroid hormone AR, CA2, EGFR, FLT3, NR3C1, RELA, SRC 2.58262
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A 2.57462
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, EGFR, HSD17B2, HSD17B3, INSR, MAP2K1, PGR, SRC 2.57187
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, RELA, SRC 2.5027
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CACNA1C, CYP1B1, EGFR, GRM5, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, NUAK1, PTPN1, RELA, SRC, TEK 2.49963
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES 2.48369
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.46748
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, GRM1, INSR, MAP2K1, MAP3K7, PTPN1, SRC 2.46572
[BP] GO:0007568 aging APEX1, AURKB, CYP1A1, HMGCR, MAP2K1, MIF, RELA 2.45325
[BP] GO:0051591 None APEX1, APP, RELA, TEK, TYR 2.45002
[BP] GO:0099566 None GRM1, GRM5 2.44714
[BP] GO:0033590 None EGFR, RELA 2.44714
[BP] GO:0060748 None AR, PGR 2.44714
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44714
[BP] GO:0002520 None CACNA1C, SMAD3 2.44714
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES 2.43457
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.4296
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1 2.40233
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B3, TYR 2.40233
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.38767
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, XDH 2.38767
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, HSPA1A, IGF1R, INSR, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TOP2A 2.37945
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.37654
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.37654
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.37654
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.37654
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, XDH 2.37654
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.35838
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, CA12, CA2, CA7, CACNA1C, EGFR, GPR35, GRM1, GRM5, SMAD3 2.35423
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, MAP3K7, PTPN1 2.3193
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.3157
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES 2.3157
[BP] GO:0000186 activation of MAPKK activity ADORA1, EGFR, GRM1, MAP3K7 2.3157
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.3157
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.3002
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.27359
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B3, MIF, PTGES 2.27094
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.26902
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.2592
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, EGFR, FLT3, INSR, NR3C1, RELA, SRC 2.25711
[BP] GO:0050679 None AR, EGFR, F3, KDR, MMP12, TEK 2.255
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 2.24818
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.24115
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MAP3K7, MET, PPARA, PTPN1, RELA, SMAD3 2.22963
[BP] GO:0009968 negative regulation of signal transduction AR, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 2.22813
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.21121
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.21121
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.21121
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21121
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.19837
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.1823
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP3A4, MAOA 2.17629
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.17629
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, FLT3, NR3C1, RELA, RORC, SRC 2.17117
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16577
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.16197
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SMAD3, SRC, TOP2A 2.15563
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.14819
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MAP2K1, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, TOP2A 2.13968
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, HMGCR, MIF, MMP12, PTPN1, SMAD3, SRC 2.13274
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SMAD3, SRC, TOP2A 2.13006
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.12836
[BP] GO:0051894 None KDR, SMAD3, TEK 2.11984
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.11984
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, XDH 2.1082
[BP] GO:0023052 None ADORA1, AR, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1, TEK 2.09611
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.07581
[BP] GO:0006066 None AKR1B1, AKR1B10, ALDH2, APP, CYP1B1, CYP3A4, HMGCR 2.07581
[BP] GO:0050927 None F3, KDR, SMAD3 2.07581
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, SMAD3, XDH 2.07475
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06443
[BP] GO:0006081 None AKR1B10, CYP1B1, GLO1, RELA 2.06443
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, RELA, SRC, TEK 2.06179
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, HMGCR, MIF, PPARA, SMAD3, TEK 2.05443
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.05443
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.05227
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PPARA, PTGES 2.04833
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.03653
[BP] GO:0050926 None F3, KDR, SMAD3 2.03653
[BP] GO:1903393 None KDR, SMAD3, TEK 2.03653
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.03653
[BP] GO:0010641 None F3, SRC 2.03653
[BP] GO:0007598 None F10, F3 2.03653
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.03048
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTPN1, RELA, SMAD3, SRC 2.01238
[CC] GO:0043235 receptor complex ABCG2, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 4.7683
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, HSD17B3, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, NR3C2, PGR, PIM1, PTGES, PTPN1, SLC1A1, SMAD3, SRC, TEK, TYR 4.35238
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, EGFR, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 4.27334
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 4.19975
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, APP, AXL, CA2, CA4, CACNA1C, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 3.74813
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.72395
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGES, PTPN1, RELA, SMAD3, SRC, TOP2A, TYR, XDH 3.5327
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.39698
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.26218
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTGES, PTPN1 2.82435
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.82219
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.82219
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.65887
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, HSD17B3, IGF1R, INSR, KDR, MAOA, MET, NR3C2, PTGES, PTPN1, SLC1A1, SRC, TEK, TYR 2.65395
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, FLT3, GRIK5, HMGCR, HSD17B3, HSPA1A, KDR, MAP2K1, PTPN1, XDH 2.63614
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SLC1A1, SMAD3, SRC, TOP2A, TYR, XDH 2.49122
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 2.43351
[CC] GO:0031233 None CA4, F10, F3 2.31454
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, GRIA2, HMGCR, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTGES 2.21314
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.11984
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.09128
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 11.0272
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTPN1, SRC, TEK, TOP2A, TYR, XDH 9.47774
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 9.43908
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.86115
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.69791
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK 7.16793
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 7.01932
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.94835
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.3891
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.22017
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 6.10521
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1, SHBG 6.01206
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 5.98474
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 5.89766
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.84614
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3 5.80295
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 5.36012
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.21773
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.11192
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.88409
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.88017
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 4.75085
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.71046
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 4.55031
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TYR, XDH 4.24081
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC 4.15016
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.06662
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 4.06662
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 4.06662
[MF] GO:0043168 anion binding ABCG2, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTGES, RELA, SLC1A1, SRC, TEK, TOP2A, XDH 4.06486
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 4.05224
[MF] GO:0046872 metal ion binding ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TYR, XDH 4.04539
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.04172
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC 3.99773
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 3.9269
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.84854
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.62514
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.52174
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, ALDH2, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, TOP2A, XDH 3.49752
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.34184
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 3.3404
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, PTGES, SRC, XDH 3.32482
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F3, GRM5, HMGCR, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A 3.30384
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.26837
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.26837
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.25401
[MF] GO:0042802 identical protein binding ABCG2, ACHE, APP, CSNK2A1, EGFR, FLT3, GRIK5, HMGCR, IGF1R, KDR, MAP3K7, MET, MIF, MMP9, PGR, RELA, SMAD3, TOP2A, TYR, XDH 3.15332
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 2.99887
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.8832
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 2.88025
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.80515
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.7292
[MF] GO:0005524 ATP binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.67551
[MF] GO:0000166 nucleotide binding ABCG2, ALDH2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.63614
[MF] GO:1901265 nucleoside phosphate binding ABCG2, ALDH2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.63512
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.60153
[MF] GO:0032559 adenyl ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.56667
[MF] GO:0030554 adenyl nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.53037
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.48369
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.44714
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.44714
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44714
[MF] GO:0099583 None GRM1, GRM5 2.44714
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.3782
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.37326
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.37326
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.31066
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, GRM5, NR3C1, PTPN1, RELA, SMAD3, SRC, TOP2A 2.2688
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.26024
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.24759
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21121
[MF] GO:0004971 None GRIA2, GRIA4 2.21121
[MF] GO:0005497 None AR, SHBG 2.21121
[MF] GO:0051425 None APP, INSR 2.21121
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21121
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, GRM5, NR3C1, PTPN1, RELA, SMAD3, SRC, TOP2A 2.11068
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.1082
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.03653
[MF] GO:0043559 insulin binding IGF1R, INSR 2.03653
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.02965


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 9.5524
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.8739
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.8739
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.545
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, NR3C1, GRM1, GRIA4 6.4394
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.4394
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.7235
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, RELA, IGF1R 5.0023
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 5.4887
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, HMGCR, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 4.6251
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.6251
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, CYP1B1 5.0023
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.5666
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, INSR, GRM8, GRM1, EGFR 4.5929
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 4.3813
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 4.0687
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, TEK, EGFR, RELA, IGF1R 4.3813
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA, GRIA4 3.8598
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 4.1351
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, GRM1, EGFR, IGF1R 3.8598
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9674
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, EGFR, RELA, IGF1R 3.649
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3, RELA 3.4516
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 3.3738
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.6202
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, GRM1, EGFR 3.6542
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3165
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.7841
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.4516
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C 3.2956
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, EGFR, IGF1R 3.1175
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.0871
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3165
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, RELA 3.5011
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, EGFR, RELA 3.1175
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, SRC, MMP9, RELA 2.8948
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 3.1175
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 3.2571
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 3.1175
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, INSR, ADORA1, CACNA1C 2.6562
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.1175
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PGR, CDC25B, IGF1R 2.6002
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, EGFR, IGF1R 3.0871
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5272
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.4385
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA, RELA 2.4447
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1039
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA, HSPA1A 2.3339
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4, ABCG2 3.0871
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, PGR, IGF1R 2.2917
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.3152
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, MAP3K7, IGF1R 2.2866
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 2.2389
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA, HSPA1A 2.1885
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 1.9961
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, CACNA1C, GRM1, EGFR 1.8265
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA, HSPA1A 1.7055
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2943
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, EGFR 1.8758
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2256
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 1.8147
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, RELA 2.0645
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.0751
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.6564
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7124
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1885
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2673
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.7055
Glioma_Homo sapiens_hsa05214 MAP2K1, EGFR, IGF1R 2.1885
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.8097
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2921
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3021
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.8182
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4841
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3924
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR, RELA 1.4802
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3205
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3282
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, INSR 1.4408
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, IGF1R 1.4283
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.3363
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.4283
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2523
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3637
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3637
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA, RELA 1.3806
Axon guidance_Homo sapiens_hsa04360 MET 0.379
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, RELA 0.4887
Platelet activation_Homo sapiens_hsa04611 SRC 0.3901
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, CYP3A4 2.1211
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 2.1885
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA, HSPA1A 1.2493
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2004
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6077
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC, EGFR 1.071
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.6805
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6805
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1885
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7118
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8233
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.8213
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.453
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.1963
Amoebiasis_Homo sapiens_hsa05146 RELA 0.454
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4648
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4587
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4636
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4699
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 0.9108
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9161
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4752
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8931
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 0.9161
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.477
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4835
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4766
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9108
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4828
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4828
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4766
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4766
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.4828
Peroxisome_Homo sapiens_hsa04146 XDH 0.4852
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 1.0041
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0269
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4887
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 1.0229
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4852
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4972
Pertussis_Homo sapiens_hsa05133 RELA 0.5063
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4992
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5085
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5085
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1007
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5346
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1144
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.1563
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5375
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5519
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1963
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2385
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2385
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2601
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1913
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2601
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2991
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, MIF, TYR 2.8159
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.3157
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3073
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3 1.3371
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6264
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.631
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, EGFR 1.3982
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, EGFR 1.4408
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3924
Malaria_Homo sapiens_hsa05144 MET 0.6438
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7889
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.4085
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.3371
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.649
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.4637
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.4841
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6805
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6805
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5134
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.6358
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7064
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6245
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.706
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8179
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.8758
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8002
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8147
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.6245
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7778
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8265
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7708
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8002
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8465
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8072
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8374
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8374
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9952
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.9646
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.191
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9087
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1175


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)