Prescription Description
| Prescription ID | TCMF2565 |
| Pinyin Name | Lu Si Ka Wan |
| Chinese Name | 鹭鸶咯丸 |
| English Name | Lusika Pills |
| Function Description | 咳嗽, 百日咳 |
| Indications | Upper respiratory infection(uri) |
| Disease ICD-11 Category |
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的
]; |
| Human Tissues Associated with Indication | Lung |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1398 | Ephedra sinica | 麻黄 | TCMH1398 | ITSAM882-14 |
| TCMH1219 | Semen armeniacae amarum | 苦杏仁 | TCMH1219 | |
| TCMH1931 | Gypsum fibrosum | 石膏 | TCMH1931 | |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH2239 | Asarum sieboldii | 细辛 | TCMH2239 | ITSAI1576-14 |
| TCMH2047 | Fructus perillae | 苏子 | TCMH2047 | |
| TCMH79 | Sinapis alba | 白芥子 | TCMH79 | ITSAD4265-14 |
| TCMH1562 | Arctium lappa | 牛蒡子 | TCMH1562 | ITSAI1776-14 |
| TCMH706 | Trichosanthes kirilowii | 瓜蒌皮 | TCMH706 | ITSAO4359-14 |
| TCMH1870 | Belamcanda chinensis | 射干 | TCMH1870 | |
| TCMH1678 | Indigo naturalis | 青黛 | TCMH1678 | |
| TCMH626 | Concha meretricis seu cyclinae | 蛤壳 | TCMH626 | |
| TCMH923 | Radix trichosanthis | 花粉 | TCMH923 | |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
Showing 1 to 10 of 131 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 74 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.86542 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.92982 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9 | 2.07657 |
| [BP] GO:0001516 | None | MIF, PTGS1, PTGS2 | 2.74392 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT | 2.77655 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 3.2582 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, KIT, MIF, MMP9, PIK3CA, PIK3CB, RORC, SRC | 2.26658 |
| [BP] GO:0001816 | cytokine production | APP, FABP4, IDO1, KIT, PTGS2 | 2.60393 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.65404 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.82415 |
Showing 1 to 10 of 464 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6686 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, KIT, PIM1, PIK3CB | 4.4503 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R | 6.348 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, ADRB1, CACNA1C, PIK3CB | 2.8173 |
| African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.7537 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 4.4503 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.4795 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB | 2.6934 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP, CACNA1C | 1.2272 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9952 |
Showing 1 to 10 of 178 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples