TCM Prescription: Left-Over Cleansing Decoction



Prescription Description
Prescription IDTCMF2543
Pinyin NameXiao Yi Tang
Chinese Name
English NameLeft-Over Cleansing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2227 Succinus 西琥珀 TCMH2227
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH1689 NA 青龙齿 TCMH1689
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH357 Pericarpium arecae 大腹皮 TCMH357
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2634 Rhizoma cyperi preparata 制香附 TCMH2634
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 8.8734
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.7389
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.7389
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 8.31822
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PPARA 8.21191
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 8.01871
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, PPARA, RORC, SMAD3, SRC, TEK, TYR 7.83268
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 7.72189
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MET, PPARA, SMAD3, SRC, TEK, XDH 7.50817
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, SRC 7.50817
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.50817
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 7.47647
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.47647
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 7.47647
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.36445
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.36445
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 7.36445
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 7.32608
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 7.32608
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 7.24464
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.03909
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.98507
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.91172
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 6.83061
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PTPN1, SRC, TEK, XDH 6.74824
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.73007
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.73007
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.70398
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 6.70275
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 6.69558
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 6.60623
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SRC, TEK, TYR 6.52314
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.51122
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.46314
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 6.24261
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 6.13945
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.10596
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, KIT, MMP2, PPARA, SMAD3, SRC, TEK 5.96744
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM4, CHRM5, CYP1A1, EGFR, FLT3, KIT, MET, PIM1, SRC, TEK, TYR 5.8591
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR 5.8591
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.77207
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.74975
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.62464
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, XDH 5.51638
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, RORC, SMAD3, SRC 5.51638
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.51428
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 5.48048
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.48048
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 5.40145
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 5.40145
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.38216
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, FABP3, FABP4, FUT7, KIT, MET, PPARA 5.37959
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.30197
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, XDH 5.21999
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.1653
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.1653
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 5.1653
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.13757
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.12146
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.12146
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 5.12146
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 5.11811
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, PPARA, SRC, TEK 5.08434
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, RORC, SRC, TEK 5.08028
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, KIT, MET, SRC, TEK, XDH 5.05146
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.05146
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.05146
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.99314
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, KIT, MET, SRC, TEK 4.991
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, PPARA, SMAD3, SRC, TEK, TYR 4.96873
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 4.94497
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.86998
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, RORC, SMAD3, SRC 4.82305
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 4.79553
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.77472
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 4.69577
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 4.6725
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 4.66249
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 4.61749
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 4.54804
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 4.54472
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, KIT, SRC, TEK 4.52565
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TOP1, TOP2A 4.49849
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.48119
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TEK 4.46548
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 4.41109
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 4.40399
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.29482
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.23735
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, KIT, PPARA, RORC, SRC, TOP1, TOP2A 4.10845
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.05012
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.03287
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.03287
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA 3.972
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.94357
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.9393
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.885
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.84392
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, KIT, MMP2, PPARA, SMAD3, SRC, TEK, TYR 3.8353
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.80383
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.80383
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.78283
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9 3.75037
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.74568
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.72775
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.68153
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.65423
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.61035
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.60212
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.59934
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.59934
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.59934
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.56794
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 3.56012
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.53159
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.52833
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.49716
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.481
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.48086
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.46711
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, KIT 3.45862
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.45862
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.42093
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.4165
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.41335
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC, TEK 3.34066
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.34066
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.32814
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 3.30328
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC, TEK 3.28448
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GLO1, PPARA 3.28448
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.28448
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28229
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.26992
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.26386
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, KIT, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.24127
[BP] GO:0019538 protein metabolic process ACHE, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.19531
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC, TEK 3.17412
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.16694
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.14682
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.09879
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 3.0897
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 3.04299
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, KIT, SMAD3 3.02476
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.01746
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 3.01278
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CHRM3, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, KIT, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 3.01278
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, XDH 2.9888
[BP] GO:0044267 cellular protein metabolic process APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.98193
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 2.97273
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96502
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.9568
[BP] GO:0015711 organic anion transport CA1, CA12, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 2.9568
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.94087
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 2.93791
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 2.93609
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.91435
[BP] GO:0006464 cellular protein modification process APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.91435
[BP] GO:0036211 protein modification process APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.91435
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.90134
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.88066
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, SRC, TEK 2.86879
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 2.85686
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.84878
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, FLT3, IGF1R, INSR, KIT, MMP2, SMAD3, SRC 2.80934
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC 2.79617
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.75727
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.75488
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.74552
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 2.74205
[BP] GO:0043412 macromolecule modification APEX1, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.70037
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 2.67362
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.67362
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.67362
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.67362
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.67362
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.65957
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.64713
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.6385
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.62735
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.62645
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.60961
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.60477
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.5987
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PTPN1, SRC 2.58329
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.57073
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.5573
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.55664
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, SRC, TOP1 2.55664
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.54751
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.54751
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53999
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.53856
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.53112
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 2.5294
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.51377
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.50242
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.50242
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9 2.50009
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.47458
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.47447
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.47447
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.47447
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 2.4729
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.4626
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.46224
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.44847
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 2.44483
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.44394
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.41975
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 2.41975
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.3897
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.3897
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, SRC, TEK 2.3897
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.38843
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.38843
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.37952
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.379
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET 2.33418
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.33187
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.3223
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.3223
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, SRC, TEK 2.31353
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.31353
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.31305
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31114
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31114
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT 2.31114
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT 2.31114
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.30671
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.30575
[BP] GO:0051894 None KDR, SMAD3, TEK 2.29705
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.29705
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.29467
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.28788
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, TYR 2.28788
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, RORC, SMAD3, SRC 2.26809
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.26809
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.2657
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, EGFR, HCAR2, MMP12, PTPN1, SMAD3, SRC 2.26526
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.26526
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.26108
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.25356
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.25333
[BP] GO:0006820 anion transport CA1, CA12, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 2.24216
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.23495
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.23169
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK 2.22808
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.22794
[BP] GO:1903393 None KDR, SMAD3, TEK 2.21687
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.21096
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK 2.20927
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CBR1, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TOP2A 2.20169
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, SRC, TEK 2.17748
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.16977
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.1508
[BP] GO:0046541 None CHRM1, CHRM3 2.14264
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.14264
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, SMAD3 2.12026
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.09567
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.09567
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.07615
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.07615
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, HCAR2, HSPA1A, KIT, MMP12, MMP2, PTPN1, SMAD3, SRC 2.06556
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.05628
[BP] GO:0022414 reproductive process AKR1B1, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, KIT, MMP2, MMP9, SRC, TOP2A 2.0525
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MET, MMP1, MMP12, MMP9, SRC, TEK 2.04974
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.04048
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.04048
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC 2.02566
[BP] GO:1901890 None KDR, SMAD3, TEK 2.02314
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.02314
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.00461
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.00351
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.00186
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 3.92205
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, EGFR, F10, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 3.8739
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.78591
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR 3.46796
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.41335
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, INSR, MET, SRC, TEK 3.32814
[CC] GO:0009330 None TOP1, TOP2A 2.93609
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.8976
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, HCAR2, HSPA1A, KDR, KIT, TEK 2.48253
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, APP, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, F10, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TYR 2.15071
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, TOP2A, TYR, XDH 13.1809
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 12.7375
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA2, CA4, CA6, CA7, CA9 9.79555
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 9.30767
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 8.8734
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.76811
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.01871
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 7.69313
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.98087
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.60623
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.50881
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 5.87597
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.8591
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 5.52285
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, GLO1 5.43108
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 5.38216
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 5.34917
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.34497
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 5.30197
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.17002
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.02965
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, XDH 4.83669
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, SMAD3, TEK 4.67657
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 4.67657
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, TEK 4.6725
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, TEK 4.6725
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.60656
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.60656
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 4.52383
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 4.50099
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 4.48864
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.25119
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR 4.13836
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 3.885
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80383
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.80383
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1 3.73495
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 3.69619
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.41335
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 3.30561
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, SRC 3.26514
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 3.21074
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.13197
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, SRC 3.09879
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 3.09335
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 3.05978
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 3.05403
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 2.86879
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.8649
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.81293
[MF] GO:0042578 None ADORA1, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.56982
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 2.54428
[MF] GO:0016788 None ACHE, ADORA1, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.48253
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.47447
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.47447
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.40269
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.36348
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.3393
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.3223
[MF] GO:0051425 None APP, INSR 2.31114
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.27754
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.26809
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.17748
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.17481
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.15051
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.14322
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14264
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.09567
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.02314


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.5735
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9 11.1407
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.3277
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9404
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 5.0947
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2291
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.6033
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM4, CHRM5 4.6033
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.5795
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, KIT, MMP9, MET, EGFR, IGF1R 4.2843
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.3443
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM4, CHRM5, ADORA1 4.4043
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM4, CHRM5, EGFR 4.2558
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.1427
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 4.3443
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 3.588
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8687
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 4.2176
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.3334
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, EGFR 2.7445
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.6488
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3044
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 2.5979
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6895
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5847
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3682
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.183
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7445
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3994
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3921
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2884
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9893
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1971
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.3147
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8416
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2385
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9367
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2822
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1218
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5507
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7696
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.7464
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4779
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.4853
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3479
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1271
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1251
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0757
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3193
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3479
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.237
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0954
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0663
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1271
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9504
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1271
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8726
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9504
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9439
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9307
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3147
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.202
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8837
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.123
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8677
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0854
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.863
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9307
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.863
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8677
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8386
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3659
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3193
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2862
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8156
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6745
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2437
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3079
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3497
Purine metabolism_Homo sapiens_hsa00230 XDH 0.343
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3335
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3427
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.343
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3497
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3653
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3333
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3727
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4147
Platelet activation_Homo sapiens_hsa04611 SRC 0.4378
Axon guidance_Homo sapiens_hsa04360 MET 0.4299
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4378
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4456
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4674
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4843
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4913
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4913
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4953
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5031
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5117
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5233
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5074
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5227
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5163
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5163
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5163
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5222
Peroxisome_Homo sapiens_hsa04146 XDH 0.5233
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5563
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5462
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5575
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.534
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5399
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.56
Bile secretion_Homo sapiens_hsa04976 CA2 0.5588
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5786
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.582
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5986
Shigellosis_Homo sapiens_hsa05131 SRC 0.5804
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5901
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6214
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6242
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6419
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8416
Malaria_Homo sapiens_hsa05144 MET 0.6609
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8579
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6647
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8052
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7342
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7345
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0242
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7739
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7289
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8456
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7739
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8088
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7881
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8505
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8156
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8456


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)