TCM Prescription: Liver Controlling Wind Extinguishing Decoction



Prescription Description
Prescription IDTCMF2427
Pinyin NameZhen Gan Xi Feng Tang
Chinese Name镇肝熄风汤
English NameLiver Controlling Wind Extinguishing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH394 Haematitum 代赭石 TCMH394
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH743 Plastrum testudinis 龟板 TCMH743
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH284 Melia toosendan 川楝子 TCMH284 KY197925
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PPARA, PTGS2, SRC, TYR 10.548
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.0378
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, PTGS2, SLC1A1, SRC, TNKS, TNKS2, XDH 9.94445
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGS2 9.77508
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MPO, PPARA, PTGS2, SRC, TYR 9.69054
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGS2, SRC, TYR 9.69054
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1132
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, MPO, PPARA, PTGS2, SRC, TYR 8.07641
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GRM1, HCAR2, HTR6, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.85489
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GRM1, HCAR2, HTR6, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.84428
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.74269
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GBA2, IDO1, MPO, PIM1, PPARA, PTGS2, TYR, XDH 7.53245
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.4609
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.44607
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 7.26492
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 7.18673
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.14883
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 7.03071
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SLC1A1, SRC, TNKS, TNKS2, XDH 6.93714
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.84709
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, PTGS2, SRC 6.84231
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.74714
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.74279
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 6.67475
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, SRC, TNKS2, TYR 6.64702
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, SRC, TYR 6.28637
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 6.23816
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 6.23816
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, F10, F3, FLT3, GRM1, HTR6, KDR, KIT, MET, PTGS2, PTPN1, SRC, XDH 6.07488
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 5.96901
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, GRM1, HTR6, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.9299
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.88835
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 5.87585
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.76518
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, GRM1, HTR6, IDO1, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.67476
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PPARA, SRC, TYR 5.58615
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.58615
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC 5.52985
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, SRC 5.42856
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, PTGS2, SRC 5.42856
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 5.33115
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, GRM1, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.262
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.23881
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 5.14502
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.13715
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.12168
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.90577
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.90052
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, GBA2, KIT, MET, PPARA, PTGS2 4.75893
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 4.62169
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FDPS, FLT3, HCAR2, KIT, PPARA, PTGS2, SRC 4.5945
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, SRC, TNKS2, TYR 4.55585
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 4.52723
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2 4.52355
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.50678
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.5008
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.48652
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, MPO, PPARA, PTGS2, PTPN1, SRC, TYR 4.4183
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2 4.39994
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.35798
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30269
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2 4.1914
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, PTPN1, SRC 4.18768
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 4.14618
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, TYR 4.11525
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, SRC, TYR 4.11436
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, IDO1, MMP1, MMP2, MMP9, MPO, SRC, XDH 4.04915
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 4.01674
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.9704
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.96468
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS2, SRC 3.96468
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 3.96026
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PTGS2, SRC 3.93823
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HSD11B2, KIT, MMP2, MPO, PPARA, PTGS2, SRC, TYR 3.91635
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.89808
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.89683
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.88454
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.86303
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.82134
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.81806
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.79756
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.79349
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.78306
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F10, F3, GRIK5, GRM5, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, PTPN1, SRC 3.71789
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, SRC, XDH 3.70291
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.68427
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.63346
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 3.60365
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, SRC 3.59993
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.57657
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.56591
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.5604
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 3.5604
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.54956
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.54956
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 3.53962
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.50344
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.50344
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.4392
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.42963
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.40863
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.39741
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.39741
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.39741
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, FDPS 3.39186
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.37428
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.37043
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.29512
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.2844
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.2844
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, MPO, PTGS2, SRC, TYR 3.26084
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.25589
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.25589
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.19866
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.19822
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.18663
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PTGS2, SRC 3.16294
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 3.14619
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.14619
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, IDO1 3.14619
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.13868
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13868
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SLC1A1, SRC, TNKS, TNKS2, XDH 3.12462
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.12277
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.12277
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.12277
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.12277
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.09195
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 3.09195
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, FDPS 3.0898
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.0834
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.03506
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.03506
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.0339
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.02608
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.02447
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.01099
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.98837
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.96278
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.95945
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PPARA, PTGS2 2.95884
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRM1, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.93685
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.93259
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.89355
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GRIK5, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.84713
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 2.84713
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.84713
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84713
[BP] GO:0016488 None AKR1B10, AKR1C3 2.84713
[BP] GO:0016487 None AKR1B10, AKR1C3 2.84713
[BP] GO:0016107 None AKR1B10, AKR1C3 2.84713
[BP] GO:0009115 None AOX1, XDH 2.84713
[BP] GO:0006714 None AKR1B10, AKR1C3 2.84713
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.84293
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.84217
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GRIK5, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.83581
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, PTGS2, SRC 2.83092
[BP] GO:0007154 None ADORA1, AKR1C3, AXL, BCL2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PTGS2, SLC1A1 2.80765
[BP] GO:0042391 None ADORA1, APP, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.79851
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MMP9, PTGS2, PTPN1, SRC, TNKS, XDH 2.79109
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 2.78712
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76442
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, HSD11B2, MPO, PTGS2, SRC, TYR 2.76398
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.75462
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.72797
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PTGS2, TNKS, TNKS2 2.71379
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.70749
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.67471
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO 2.66061
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, KIT, PTPN1, SRC 2.66061
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.65679
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.64388
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F10, F3, FLT3, FUT7, GBA2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.61872
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 2.61618
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60918
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.60575
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR, XDH 2.59145
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SLC1A1, SRC, TNKS2, XDH 2.59145
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.58941
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GRIK5, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.58515
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.57112
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.57112
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.5414
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SLC1A1, SRC 2.5414
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, FDPS, IDO1, MPO, PTGS2 2.53501
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.52875
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.51856
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.50812
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.49068
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.48433
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.48433
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, PTGS2, SRC 2.47885
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 2.47885
[BP] GO:0099566 None GRM1, GRM5 2.46281
[BP] GO:0046110 None AOX1, XDH 2.46281
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46281
[BP] GO:0016095 None AKR1B10, AKR1C3 2.46281
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.45745
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.44849
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, PTPN1, SRC 2.44849
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.44849
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.44023
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43319
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, GRM1, GRM5, KIT, MET, MMP9, PTPN1, SRC, TNKS, XDH 2.43227
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 2.42845
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.40103
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.40103
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, XDH 2.39681
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.36363
[BP] GO:0007187 None ADORA1, GRM1, GRM3, GRM5, GRM8, HTR6 2.33398
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.31748
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.31748
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.31748
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.30906
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS2, TYR 2.29164
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.28931
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, ESR1, F3, FABP4, IDO1, IGF1R, MET, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 2.28931
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2644
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.26438
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC, TNKS 2.2352
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PTGS2, SRC 2.22462
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.22462
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS 2.22462
[BP] GO:0070213 None TNKS, TNKS2 2.22462
[BP] GO:0006145 None AOX1, XDH 2.22462
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22462
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22462
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.2212
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.21768
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, KIT, PPARA, SRC 2.21738
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.21387
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.18422
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.1794
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.15571
[BP] GO:0007268 None GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 2.15516
[BP] GO:0098916 None GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 2.15516
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, KDR, KIT, PTPN1, SRC, XDH 2.13513
[BP] GO:0048169 None APP, GRM5, KIT 2.13374
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.10757
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.10614
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.10528
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.10528
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, ESR1, F3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.10528
[BP] GO:0099536 None GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 2.10528
[BP] GO:0099537 None GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 2.10528
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.09835
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.09835
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, IDO1, MPO, SRC, XDH 2.09638
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.08452
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.06043
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.06043
[BP] GO:0043696 None CDK6, ESRRB 2.06043
[BP] GO:0043697 None CDK6, ESRRB 2.06043
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.06043
[BP] GO:0010641 None F3, SRC 2.06043
[BP] GO:0007598 None F10, F3 2.06043
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.06043
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, IDO1, XDH 2.05481
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC 2.0477
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.03245
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, HSD11B2, IDO1, KIT, MPO, PTGS2, SRC, TYR 2.02211
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F10, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 3.68427
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTGS2, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR 3.65256
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 3.45251
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.33036
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, KDR, MET, SLC1A1 3.22861
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, KDR, KIT, MET, PTGS2, SLC1A1, SRC 3.19281
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, KIT, MET, PTGS2, PTPN1, SLC1A1, SRC, TYR 3.02209
[CC] GO:0044456 None ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.43319
[CC] GO:0031233 None CA4, F10, F3 2.37363
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1 2.32371
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.24303
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.22462
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.19181
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.19062
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.19062
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.10684
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 2.03109
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, KDR, MET, SLC1A1 2.00633
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, GRIK5, KDR, PTGS2, PTPN1, XDH 2.00429
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 10.548
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.77508
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.5724
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.99272
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR, XDH 7.4609
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 7.04407
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA 6.64702
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA 6.16199
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.15815
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.02894
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA 5.76518
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, IDO1, KIT, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 5.63327
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.35387
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, IDO1, KIT, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 5.35387
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC 5.10211
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA 5.10211
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 4.97527
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC 4.8762
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.84389
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.69153
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.52048
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, IDO1, MPO, PTGS2, SRC, XDH 4.33255
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.16418
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET 3.99497
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, KIT, MET 3.99497
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.98457
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.91438
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.82134
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.72483
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.72483
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.61558
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59995
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 3.5604
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.48819
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.42963
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.40863
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.37428
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR6 3.35685
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.20177
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.16835
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.12277
[MF] GO:0045550 None AKR1B10, AKR1C3 2.84713
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.84713
[MF] GO:0003845 None HSD11B1, HSD11B2 2.84713
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.66046
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.61872
[MF] GO:0047718 None AKR1B10, AKR1C3 2.46281
[MF] GO:0099583 None GRM1, GRM5 2.46281
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43319
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43319
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MMP9, PTGS2, TYR, XDH 2.28931
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22462
[MF] GO:0004971 None GRIA2, GRIA4 2.22462
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.09835
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.09835
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.06043
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.06043
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06043
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 2.05435


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.0555
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 10.6128
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0555
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.5926
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1C3, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 5.9408
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, HTR6, GRM5, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 5.9194
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, IGF1R 4.6368
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.2067
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.6368
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.983
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.908
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0133
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.5299
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.908
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, HTR6, ADORA1, PPARA, GRIA4 3.1542
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8468
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, KIT, GRM8, GRM1 2.9226
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5072
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9855
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0324
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.5072
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.327
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.2598
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, ALOX5, PTGS2 2.357
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 2.1797
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.1126
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.2254
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2194
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0495
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1797
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1797
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2 2.1735
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1222
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.1164
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0689
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0635
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.128
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.5651
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.8781
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.8608
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8038
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3774
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5651
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2876
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, GRM1 1.1863
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9763
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0319
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0212
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.994
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9735
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9194
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9176
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9187
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2251
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.957
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.034
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2082
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1155
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8941
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8153
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8941
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8941
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8265
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8438
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8623
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1124
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2038
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8047
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7994
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2876
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.1995
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.7462
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2198
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.22
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.716
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6198
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6803
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.614
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.266
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2937
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3007
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3131
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3198
Influenza A_Homo sapiens_hsa05164 FDPS 0.3131
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3003
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3198
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3504
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3469
Phagosome_Homo sapiens_hsa04145 MPO 0.3435
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3625
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3625
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3609
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3734
Platelet activation_Homo sapiens_hsa04611 SRC 0.3908
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3922
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3908
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3908
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3833
Axon guidance_Homo sapiens_hsa04360 MET 0.3858
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4078
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.45
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4575
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4623
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4712
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4619
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4616
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4707
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4712
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4829
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4712
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4712
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4712
Peroxisome_Homo sapiens_hsa04146 XDH 0.4829
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.52
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.52
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5187
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5243
Bile secretion_Homo sapiens_hsa04976 CA2 0.5229
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5391
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5391
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5259
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5391
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5391
Shigellosis_Homo sapiens_hsa05131 SRC 0.5391
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5427
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5651
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5782
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7555
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.644
Malaria_Homo sapiens_hsa05144 MET 0.6198
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6258
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6218
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6299
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6258
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7104
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6258
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6826
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7172
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9416
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7572
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7799
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7799
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8047
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7994
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8477
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9034
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9735
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.991
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2426


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)