TCM Prescription: Shi'erwei Yishou Powder



Prescription Description
Prescription IDTCMF2408
Pinyin NameShi Er Wei Yi Shou San
Chinese Name十二味翼首散
English NameShi'erwei Yishou Powder
Function Description流行性感冒, 痢疾, 热病发烧
IndicationsDysentery disorder, Common cold disorder, Common cold, Influenza, Upper respiratory infection(uri)
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
1E32 [Influenza, virus not identified, 季节性流行性感冒，病毒尚未鉴定 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung, Intestine, Stomach, Blood
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2143 Sophora flavescens 土苦参 TCMH2143 ITSAK2609-14
TCMH133 Aconitum naviculare 榜嘎 TCMH133 KM09800
TCMH1000 Foeniculum vulgare 茴香 TCMH1000 ITSAM886-14
TCMH2102 Concretio silicea bambusae 天竺黄 TCMH2102
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH25 Styrax benzoin 安息香 TCMH25 CRCZ1380-16, CRCZ1353-16
TCMH538 Oxytropis falcata 莪大夏 TCMH538 MH258179
TCMH2104 Folium aconiti szechenyiani 铁棒锤叶 TCMH2104
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1350 Penicillium roqueforti
TCMT1352 Colletotrichum truncatum
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 8.41209
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PPARA 8.15415
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KDR, MET, MIF, PPARA, SLC1A1, SRC, TNKS, TNKS2, XDH 7.74385
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, GRIK5, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 7.36995
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, GRIK5, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 7.29166
[BP] GO:0033993 response to lipid AKR1C3, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, IDO1, RORC, SRC, TYR 7.19036
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.19036
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, IDO1, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 7.19036
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HSD17B3, IDO1, MIF, PIM1, PPARA, TYR, XDH 7.15419
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.15366
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.8238
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, GRIK5, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 6.8238
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.8148
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.8148
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRIK5, GRM1, GRM5, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 6.8148
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR 6.38013
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, RORC, SRC 6.36008
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 6.36008
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 6.2311
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, TYR, XDH 6.01249
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 6.01249
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.93359
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.77914
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, PPARA, SRC, TYR 5.73646
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, GPER1, RORC, SRC, TYR 5.67358
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, HSD17B3, IDO1 5.60383
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, GPER1, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, XDH 5.59975
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.54896
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.52343
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC 5.49447
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 5.44562
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, PPARA, SRC 5.40634
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.11836
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TOP2A, TYR 5.07111
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, GPER1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.00396
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GRM3, GRM8, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.98951
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC 4.98159
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.98159
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.86622
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.83564
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GPER1, GRM1, GRM5, GRM8, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 4.76397
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC 4.75564
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, AR, AXL, CYP1B1, ESR1, GPER1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 4.7554
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF 4.74832
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.60916
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF 4.57014
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.48474
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.48474
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 4.47488
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A 4.43241
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 4.38738
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.38636
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, APEX1, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SRC 4.30327
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, AR, AXL, CSNK2A1, CYP1B1, FLT3, GPER1, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.26814
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PPARA 4.23177
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, AR, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GPER1, GRM1, IDO1, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.20863
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC 4.14334
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.09342
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.07076
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GRM3, GRM8, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.0672
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, CDC25B, CSNK2A1, ESR1, FLT3, GPER1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 3.97339
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 3.969
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APEX1, AR, CYP1A1, CYP1B1, ESR1, FLT3, GPER1, RORC, SRC 3.95481
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALPI, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF 3.89147
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.81043
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.70361
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.68647
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.67875
[BP] GO:0032787 None AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MIF, PPARA 3.67119
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 3.64279
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.60996
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF 3.55524
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1 3.54147
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, AR, AXL, CYP1B1, FLT3, GPER1, GRM1, KDR, MET, MIF, PTPN1, SRC, XDH 3.52499
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51906
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.4873
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 3.46991
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 3.45527
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 3.4236
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD17B2, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, TYR 3.3971
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.39124
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.38746
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.36246
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.36246
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.36246
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.32407
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.32407
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 3.30021
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, GRM1, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH 3.21984
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.2085
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APEX1, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.16873
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, MET, SRC 3.13818
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.06818
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.06818
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, SRC 3.06526
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.06526
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, GPER1, PPARA, RORC, SRC 3.04436
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 3.02176
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.99789
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.99789
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.99789
[BP] GO:0071383 None AKR1C3, AR, FLT3, GPER1, SRC 2.98559
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, GPER1, KDR, MIF, SRC, TNKS, TNKS2 2.98327
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.97208
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.94147
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.91649
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.9116
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.90781
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 2.90226
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, AR, CDC25B, ESRRB, FLT3, GPER1, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.89517
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MIF, PIM1, PPARA, TYR 2.86952
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.85335
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.81384
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.77998
[BP] GO:0016488 None AKR1B10, AKR1C3 2.77998
[BP] GO:0016487 None AKR1B10, AKR1C3 2.77998
[BP] GO:0016107 None AKR1B10, AKR1C3 2.77998
[BP] GO:0009115 None AOX1, XDH 2.77998
[BP] GO:0006714 None AKR1B10, AKR1C3 2.77998
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.77756
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, AR, FLT3, GPER1, GRM1, KDR, MIF, PTPN1, SRC, XDH 2.77438
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.74206
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70133
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.68406
[BP] GO:0042325 regulation of phosphorylation ADORA1, AR, CDC25B, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.68406
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.66782
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, IDO1 2.6671
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, HSD17B3, IDO1, MMP2, MMP9, SRC, TOP2A 2.64538
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 2.62554
[BP] GO:0007188 None ADORA1, GPER1, GRM1, GRM3, GRM5, GRM8 2.61379
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.5663
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.54764
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.54764
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.53401
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GPER1, GRIK5, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC 2.53165
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 2.51312
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, AR, CDC25B, FLT3, GPER1, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.50448
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MIF, PIM1, PPARA, TYR 2.49726
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, AR, ESR1, FLT3, GPER1, GRM5, IGF1R, MMP2, SRC 2.482
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.482
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1 2.482
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 2.4657
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.44706
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MIF, PIM1, PPARA, TYR 2.43531
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GPER1, GRM5, IGF1R, PPARA, SRC 2.43053
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.42492
[BP] GO:0051172 None APEX1, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, IGF1R, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.42492
[BP] GO:0045934 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, MMP12, PPARA, RORC, SRC, TNKS, TNKS2 2.42337
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.41645
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.41645
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GPER1, GRM1, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.4086
[BP] GO:0099566 None GRM1, GRM5 2.4086
[BP] GO:0046110 None AOX1, XDH 2.4086
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4086
[BP] GO:0016095 None AKR1B10, AKR1C3 2.4086
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.40731
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.40561
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.40536
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, ESR1, FLT3, GPER1, RORC, SRC 2.40536
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.39024
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.37732
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.37732
[BP] GO:0043408 regulation of MAPK cascade ADORA1, AR, FLT3, GPER1, GRM1, IGF1R, KDR, MIF, PTPN1, SRC, XDH 2.35458
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.3382
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TNKS, TNKS2, TOP2A 2.3368
[BP] GO:0007187 None ADORA1, GPER1, GRM1, GRM3, GRM5, GRM8 2.32688
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, SRC 2.31149
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.29521
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28021
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TNKS, TNKS2, TOP2A 2.26463
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.26224
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.2621
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.23517
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.22699
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.22183
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.21424
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.20842
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP2A 2.20842
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.20842
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.20309
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.19806
[BP] GO:0010675 None ESRRB, GPER1, PPARA, RORC, SRC 2.18953
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18948
[BP] GO:0070213 None TNKS, TNKS2 2.18948
[BP] GO:0006145 None AOX1, XDH 2.18948
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.18948
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18948
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.18808
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.16222
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1477
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.14506
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.14256
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1 2.14256
[BP] GO:0042391 None ADORA1, GPER1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.13512
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, AR, CDC25B, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.1328
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, GPER1, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 2.1293
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A 2.1293
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, FABP4, GPER1, IDO1, KDR, MET, MIF, MMP12, PPARA 2.09185
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GPER1, GRM5, IGF1R, SRC 2.09185
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, GPER1, KDR, SRC 2.09185
[BP] GO:0045913 None ESRRB, GPER1, PPARA, SRC 2.07905
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, GPER1, IDO1, MMP12, MMP2, PPARA, PTPN1, SRC 2.07691
[BP] GO:0044093 positive regulation of molecular function ADORA1, AR, AURKB, CDC25B, ESR1, ESR2, FLT3, GPER1, GRM1, GRM5, MET, MIF, MMP9, PTPN1, SRC, TNKS, XDH 2.069
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.069
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.069
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, GPER1, MET, SRC, XDH 2.069
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, IGF1R, MIF, MMP9, PTPN1, SRC, TNKS, XDH 2.06829
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.06711
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, GRM1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.06379
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, CYP19A1, CYP1A1, CYP1B1, HSD17B3, TYR 2.0592
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, GPER1, GRIK5, GRM1, GRM5, MET 2.02848
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.02848
[BP] GO:0030263 None GPER1, TOP2A 2.01267
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.57014
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 3.51906
[CC] GO:0014069 None ADORA1, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 2.98559
[CC] GO:0099572 None ADORA1, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 2.98559
[CC] GO:0097060 None GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.91467
[CC] GO:0044456 None ACHE, ADORA1, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.43084
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM5, HSD17B3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SHBG, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.3095
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPI, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 2.2173
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HSD17B3, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SHBG, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.18948
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 14.9226
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.42984
[MF] GO:0008270 zinc ion binding ALPI, AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.54129
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.78174
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.77112
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.77112
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.77112
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, RORC, SHBG 7.39385
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.28352
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 7.19036
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IDO1, TYR, XDH 7.18637
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.88308
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.72282
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.1974
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 6.14136
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TOP2A, TYR, XDH 5.99737
[MF] GO:0046872 metal ion binding ALOX5, ALPI, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TOP2A, TYR, XDH 5.68125
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.36111
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 5.34014
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.11836
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 5.11494
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.86622
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.74175
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 4.69776
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.969
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.92673
[MF] GO:0042562 hormone binding ACHE, AR, GPER1, HSD17B1, IGF1R, SHBG 3.86012
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, PPARA, RORC, SHBG 3.80243
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.70361
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.61456
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57648
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.4873
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.3971
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.36246
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.31236
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, SRC 2.99789
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.90226
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.88206
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, SRC 2.85775
[MF] GO:0045550 None AKR1B10, AKR1C3 2.77998
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77998
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.62554
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.61379
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.5701
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 2.482
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 2.482
[MF] GO:0047718 None AKR1B10, AKR1C3 2.4086
[MF] GO:0047045 None AKR1C3, HSD17B3 2.4086
[MF] GO:0099583 None GRM1, GRM5 2.4086
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.39024
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.39024
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.36106
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.34766
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, SRC, XDH 2.29521
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18948
[MF] GO:0004971 None GRIA2, GRIA4 2.18948
[MF] GO:0005497 None AR, SHBG 2.18948
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.069


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 9.5494
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 10.5996
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.967
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7392
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, GRM1, ESR2 5.8791
Metabolic pathways_Homo sapiens_hsa01100 CBR1, HSD17B3, AKR1C3, AKR1B1, TYR, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPI, XDH, IDO1 5.5245
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.3154
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 5.1214
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1123
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1208
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1208
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9805
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9101
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.4935
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0426
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.4935
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0442
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0841
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7011
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, AKR1C3 2.065
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.957
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0442
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0442
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.762
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.762
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.654
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.6453
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6062
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.762
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3468
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9477
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.248
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2447
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2108
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1651
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 0.9846
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9759
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9355
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1651
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9508
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9431
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1468
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2274
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.848
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1628
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8844
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0804
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.1605
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3468
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.848
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.848
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.8365
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.848
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8074
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7916
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.755
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7627
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7655
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.708
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7279
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4923
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6546
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.708
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.6645
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2305
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2875
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.277
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2864
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3132
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2981
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3044
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3131
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3044
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.356
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3445
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3805
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3729
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3766
Platelet activation_Homo sapiens_hsa04611 SRC 0.4014
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3845
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8187
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4224
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4014
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4538
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4014
Axon guidance_Homo sapiens_hsa04360 MET 0.3969
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4224
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5686
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4409
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4077
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4575
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4441
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4441
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4471
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4224
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4506
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4538
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4538
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4538
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4506
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4538
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4506
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4506
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4538
Peroxisome_Homo sapiens_hsa04146 XDH 0.4575
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6423
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4538
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4919
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5038
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5229
Glioma_Homo sapiens_hsa05214 IGF1R 0.5229
Bile secretion_Homo sapiens_hsa04976 CA2 0.5031
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5217
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5229
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5229
Shigellosis_Homo sapiens_hsa05131 SRC 0.5229
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5935
Malaria_Homo sapiens_hsa05144 MET 0.6041
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6103
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6073
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6137
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.708
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6645
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7291
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7445
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7151
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7445
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7627
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7366
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7552
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8722
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 0.9355
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9825
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1839


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)