TCM Prescription: Stagnation Relieving Recipe



Prescription Description
Prescription IDTCMF2404
Pinyin NameDao Zhi Yun Pi Fang
Chinese Name
English NameStagnation Relieving Recipe
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH173 Lablab niger 扁豆 TCMH173
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH905 Picrorhiza kurrooa 胡黄连 TCMH905 GBVX6435-15, GBVX5995-15
TCMH1270 NA 连米 TCMH1270
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1077 NA 焦三仙 TCMH1077
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT108 GRIA1 Glutamate receptor ionotropic, AMPA 1 Ion channel P42261
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1268 Nocardia farcinica
TCMT1269 Mycobacterium ulcerans
TCMT1270 Streptomyces coelicolor
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1275 Erwinia chrysanthemi
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1279 Staphylococcus aureus subsp. aureus
TCMT1280 Salmonella sp.
TCMT1281 Clostridium difficile
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1311 Pseudomonas tolaasii
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1325 Mycobacterium gordonae
TCMT1326 Shigella
TCMT1328 Enterococcus avium
TCMT1329 Bacillus fortis
TCMT1330 Salmonella enterica subsp. enterica serovar Paratyphi B
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1408 Colletotrichum gloeosporioides
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1461 Salmonella enterica subsp. enterica serovar Gallinarum
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA1, GRIA2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 7.33633
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1, TRPV1 7.32949
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 7.32949
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, SRC, TEK, TRPV1, TYR 6.97979
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.97979
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 6.63916
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.39522
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GRIA1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 6.38624
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 6.38624
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.16849
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.99567
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 5.83038
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 5.64917
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.49024
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.49024
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.46355
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 5.46355
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 5.44451
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.39334
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK, TRPV1 5.38615
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA1, INSR, MET, POLA1, POLB, SMAD3, SRC, TRPV1 5.33265
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 5.1448
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.13984
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GRIA1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 5.12249
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.07694
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.88622
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 4.8713
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 4.8713
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.73772
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1, XDH 4.6579
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 4.62061
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRIA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.52139
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRIA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.43894
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.38551
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.38551
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 4.38551
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, ALPL, AXL, CHRM1, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, GRIA1, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 4.36425
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 4.26781
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 4.24676
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 4.24676
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.23921
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, SRC, TEK, TRPV1, TYR 4.23921
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, SMAD3, SRC, TRPV1 4.23921
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 4.23921
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TRPV1 4.23921
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC, TRPV1 4.23906
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 4.22556
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 4.18688
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1, XDH 4.18688
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 4.18688
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.16791
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 4.16791
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.16791
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.12617
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.03426
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.00554
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.99065
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.96369
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.91778
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 3.89919
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TRPV1 3.89881
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 3.89644
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.86039
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 3.80524
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.78643
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.78112
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 3.74603
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.74603
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.74603
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.73719
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.73719
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BACE1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 3.6929
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BACE1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GRIA1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 3.64027
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.59665
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 3.48616
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.47033
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.4488
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.44177
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC, TRPV1 3.41356
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.40488
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.36855
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 3.36855
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, XDH 3.32943
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28336
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.27117
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.26996
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 3.25043
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIA1, INSR, MET, SMAD3, TRPV1 3.23945
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.16967
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.14112
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 3.12303
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.12083
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.02143
[BP] GO:0030335 positive regulation of cell migration EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.02143
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.99255
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.99255
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97247
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.96291
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.91799
[BP] GO:2000147 positive regulation of cell motility EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.91799
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BACE1, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR, XDH 2.89693
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 2.88558
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, SRC, TRPV1 2.83885
[BP] GO:0051272 positive regulation of cellular component movement EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.83492
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA1, GRIA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 2.82894
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.8011
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 2.78487
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.78291
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TRPV1 2.78291
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.78291
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.76523
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.76523
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.76523
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.76523
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.75321
[BP] GO:0040017 positive regulation of locomotion EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.74459
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.74142
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.72316
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.69367
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.67869
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.64735
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1, HSD17B2 2.61811
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 2.61811
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, GRIA1, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 2.60788
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.60481
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.60481
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, GRIA1, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 2.60481
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, SMAD3, SRC, TRPV1 2.60481
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, SRC, TRPV1 2.60481
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TRPV1 2.571
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.56219
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC, TRPV1 2.55032
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.54852
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, POLB, SRC 2.53483
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.53363
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.53363
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52394
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.47951
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BACE1, CA2, CA7, EGFR, GRIA1 2.46004
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BACE1, CA2, CA7, EGFR, GRIA1 2.46004
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.43801
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.43801
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.43801
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.41188
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.41188
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.40973
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.37592
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.35298
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35298
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.35298
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35298
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.35298
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.34732
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CHRM1, CHRM2, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1, XDH 2.32392
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.31376
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 2.3099
[BP] GO:0051894 None KDR, SMAD3, TEK 2.3099
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.3099
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.29026
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29026
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29026
[BP] GO:0060079 None ADORA1, GRIA1, GRIA2, TRPV1 2.27818
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.24525
[BP] GO:1903393 None KDR, SMAD3, TEK 2.21653
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.21144
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRIA1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 2.21144
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 2.20044
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.1939
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.1939
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.17759
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.17369
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.16635
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, SRC, TRPV1 2.16339
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4 2.14142
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.14142
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.14142
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.13446
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, KDR, SRC, TRPV1 2.13305
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, FLT3, SRC, TRPV1 2.12736
[BP] GO:0060078 None ADORA1, GRIA1, GRIA2, TRPV1 2.12637
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.12421
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.12365
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BACE1, CHRM1, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK 2.12193
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.10292
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.09683
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.07699
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.07699
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, XDH 2.07277
[BP] GO:0003018 None ADORA1, CHRM1, EGFR, SRC, TEK 2.0675
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.06511
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, SRC, TEK 2.06511
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.06511
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.05724
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.05387
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.05387
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.05387
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05198
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05198
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, SMAD3, TRPV1 2.03437
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.0134
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.00217
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, EGFR, GRIA1, GRIA2, INSR, MET, SRC, TEK, TRPV1 4.31957
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, FLT3, GPR35, GRIA2, IGF1R, INSR, KDR, MET, TEK, TRPV1 3.74033
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DUSP3, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, SRC, TEK, TRPV1 3.68227
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK, TRPV1 3.47809
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CHRM1, CHRM2, CHRM4, FLT3, GPR35, GRIA2, IGF1R, INSR, KDR, MET, TEK, TRPV1 3.35597
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, FUT7, GPR35, GRIA1, GRIA2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR 3.28336
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, GPR35, GRIA1, GRIA2, HSD17B2, IGF1R, INSR, KDR, MET, SRC, TBXAS1, TEK, TRPV1, TYR 3.04469
[CC] GO:0032589 None ADORA1, GRIA1, INSR, TRPV1 2.99255
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.6144
[CC] GO:0031253 None ADORA1, CA4, CA9, GRIA1, INSR, SRC, TRPV1 2.35586
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GRIA1, GRIA2, HSD17B2, TBXAS1 2.14142
[CC] GO:0031256 None ADORA1, GRIA1, INSR, SRC, TRPV1 2.10912
[CC] GO:0044432 endoplasmic reticulum part BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, GRIA1, GRIA2, HSD17B2, TBXAS1 2.08776
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, SRC, TBXAS1, TEK, TYR, XDH 10.1627
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.99519
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 9.99519
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 8.29903
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.33633
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 7.03301
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.97979
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.82925
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.71672
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.42749
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.36406
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 5.98155
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.56197
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.48803
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.38615
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.33265
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.99383
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.62061
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 4.59392
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.50705
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, TEK, TRPV1 4.43894
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, TEK, TRPV1 4.43894
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TRPV1, TYR, XDH 4.31957
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.24676
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.23906
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 4.2243
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.18688
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.16791
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK, TRPV1 4.1016
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TRPV1, TYR, XDH 4.07467
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 4.03545
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.97306
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, GRIA1, GRIA2, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 3.88018
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 3.70717
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA1, GRIA2, INSR 3.70193
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.63365
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.41271
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.27117
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.25043
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TRPV1, XDH 3.21574
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3 3.16567
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.06087
[MF] GO:0008389 None CYP2A13, CYP2A6 2.89639
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, GRIA1, GRIA2 2.62495
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.60488
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.59694
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TRPV1, XDH 2.52394
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TRPV1, XDH 2.52394
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.50255
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.47347
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK 2.42023
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.39599
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.35098
[MF] GO:0004971 None GRIA1, GRIA2 2.29026
[MF] GO:0043559 insulin binding IGF1R, INSR 2.11327
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.11152


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.9698
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4857
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.0518
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2253
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA1, GRIA2, CHRM1, GPR35, ADORA3, CHRM4, ADORA1, TRPV1 5.5513
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.5414
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.4537
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.4391
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1395
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.4461
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.0152
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.0152
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.7854
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 4.0152
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.2827
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA1, GRIA2, CHRM1, ADORA1, PPARA 3.6946
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.423
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.7194
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.423
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.7194
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.8041
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 2.6313
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4751
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8136
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4768
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR 2.1314
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3562
Long-term depression_Homo sapiens_hsa04730 GRIA1, GRIA2, IGF1R 2.4223
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3281
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1045
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2831
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.908
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3237
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3517
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0245
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5664
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.5084
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3813
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, EGFR 1.3406
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.0532
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3406
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3597
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3962
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1492
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1467
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0997
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1182
Circadian entrainment_Homo sapiens_hsa04713 GRIA1, GRIA2 1.1172
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3406
Long-term potentiation_Homo sapiens_hsa04720 GRIA1, GRIA2 1.3406
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.321
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1479
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA1, GRIA2 1.083
Amphetamine addiction_Homo sapiens_hsa05031 GRIA1, GRIA2 1.3368
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2293
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 1.0436
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1455
Glutamatergic synapse_Homo sapiens_hsa04724 GRIA1, GRIA2 1.0152
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.3559
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9884
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 1.0014
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.321
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0014
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9948
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA1, GRIA2 1.4787
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9292
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9821
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA1, GRIA2 0.9574
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9401
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9136
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8784
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9136
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9087
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9183
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8661
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5441
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.817
Nicotine addiction_Homo sapiens_hsa05033 GRIA1, GRIA2 1.6398
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7459
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7402
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6317
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3768
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3977
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3865
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3891
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.3977
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3762
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4144
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4224
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4528
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4626
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.484
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.484
Axon guidance_Homo sapiens_hsa04360 MET 0.4786
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5147
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4955
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5372
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5363
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5113
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5287
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5363
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5363
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5418
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5286
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5415
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.551
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5464
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5564
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5564
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5669
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5558
Peroxisome_Homo sapiens_hsa04146 XDH 0.5677
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6061
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6075
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6045
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5929
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6107
Bile secretion_Homo sapiens_hsa04976 CA2 0.6091
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6299
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6317
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.634
Shigellosis_Homo sapiens_hsa05131 SRC 0.6317
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6317
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6494
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6659
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.669
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6872
Malaria_Homo sapiens_hsa05144 MET 0.7066
Cocaine addiction_Homo sapiens_hsa05030 GRIA2 0.7066
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7066
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0793
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.777
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8074
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8413
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8693
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8327
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8074
DNA replication_Homo sapiens_hsa03030 POLA1 0.8052
Base excision repair_Homo sapiens_hsa03410 POLB 0.817
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8248
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8502
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8052
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8742
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8693
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0436


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)