TCM Prescription: Lung-Ventilating-Regulating Bolus



Prescription Description
Prescription IDTCMF2337
Pinyin NameTong Xuan Li Fei Wan
Chinese Name通宣理肺丸
English NameLung-Ventilating-Regulating Bolus
Function Description感冒风寒引起的咳嗽气喘, 发烧头疼, 鼻塞不通, 周身作疼
IndicationsCommon cold disorder, Common cold, Upper respiratory infection(uri)
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung, Blood, Nose
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2046 folium perillae 苏叶 TCMH2046
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH78 Platycodon grandiflorum 白桔梗 TCMH78 ITSAJ4293-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PPARA, TBXAS1, TRPV1 12.6462
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 9.75488
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 9.47968
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.33343
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 9.15621
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR, XDH 8.33181
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.05682
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 7.82447
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MCL1, MET, MIF, POLA1, POLB, PPARA, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 7.67262
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 7.61225
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, TBXAS1 7.25966
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, SRC, TRPV1, TYR 7.1415
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, SRC, TRPV1, TYR 7.03693
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, SRC, TERT, TRPV1, TYR 7.01684
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, MET, MIF, PPARA, TBXAS1 6.90412
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.68675
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.62224
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.62224
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MCL1, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, SRC, TERT, TNKS2, TYR 6.46761
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 6.36431
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.06434
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.02686
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PPARA, TBXAS1 6.02686
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.02686
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.99318
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 5.94345
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.81484
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.76252
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, PTPRS, SRC, TYR 5.64743
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 5.46284
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TRPV1, XDH 5.44742
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 5.33669
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 5.33426
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.32154
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC, TRPV1 5.31536
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.83836
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TRPV1, TYR 4.80904
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 4.75379
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.73899
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.72458
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MCL1, MMP9, PIM1, POLB, PPARA, PTPRS, SRC, TYR 4.70239
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR 4.70239
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1 4.68751
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MIF, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TRPV1, TYR 4.66493
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT 4.65447
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TERT 4.55267
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.53857
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.52833
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, MIF, SRC, TNKS, TNKS2, TRPV1 4.40073
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.40073
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MCL1, MIF, MMP2, MMP9, POLA1, POLB, PTPN1, SRC, TERT, TRPV1 4.2536
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.2536
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR 4.19161
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR 4.09961
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.09045
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.07478
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.05312
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, POLB, SRC, TRPV1 4.04398
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PTPN1, SRC, TERT 4.04398
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, POLA1, SRC, TYR 3.82397
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.77217
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MCL1, MET, MIF, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.74144
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.67746
[BP] GO:0032845 None ADORA1, BCL2, MIF, SRC, TNKS, TNKS2, TRPV1 3.66642
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT, TRPV1 3.66642
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.66642
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SRC, TERT 3.61862
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.6107
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TRPV1, TYR 3.6107
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MCL1, MET, POLA1, POLB, SRC, TERT, TRPV1 3.58107
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MIF, MMP9, PTPN1, SRC 3.55981
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.55458
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.46476
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.46476
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.46476
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MCL1, MET, MIF, PTPN1, SRC, XDH 3.42417
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37185
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.32092
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TRPV1 3.25784
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.20194
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.19287
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.19287
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.167
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.13035
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 3.09117
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, PTPN1, SRC, XDH 3.08152
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF 3.08116
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.01232
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.01232
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 3.01232
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC, TRPV1 3.0004
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.0004
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.99084
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.96165
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.96165
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.93074
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.89372
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.81002
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.7755
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.74597
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MCL1, MIF, MMP9, PTPN1, SRC, TERT 2.74154
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.73553
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, MIF 2.72392
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SRC, TERT, TRPV1, TYR 2.70836
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.70524
[BP] GO:0009115 None AOX1, XDH 2.70524
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, XDH 2.68183
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 2.67141
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.61896
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MCL1, MET, MIF, MMP9, PTPN1, SRC, XDH 2.6186
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.60693
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.60074
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.58495
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.55627
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 2.55313
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.54635
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MIF, MMP9, PTPN1, SRC 2.48723
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.46568
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46568
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.43677
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, XDH 2.43297
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.41751
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.39341
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.37087
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MCL1, MET, MIF, MMP2, MMP9, PTPRS, SRC, TERT 2.36026
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.35841
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.32602
[BP] GO:0046110 None AOX1, XDH 2.29652
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.29652
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.28669
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.28248
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 2.28124
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.27951
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.27056
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.25309
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.25309
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.25309
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.24062
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MET, MIF, MMP12, MMP9, PIM1, PTPRS, SRC, TERT, TNKS2, TRPV1, XDH 2.204
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, TRPV1 2.17085
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.16713
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.16713
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13 2.16713
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.13781
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.12502
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.12502
[BP] GO:0090344 None CDK6, MIF, TERT 2.12502
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.12502
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.12502
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, SRC, TRPV1 2.0987
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSD11B2, MCL1, MIF, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TRPV1 2.08543
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.08543
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.08543
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.08543
[BP] GO:0070213 None TNKS, TNKS2 2.08543
[BP] GO:0006145 None AOX1, XDH 2.08543
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08543
[BP] GO:0009968 negative regulation of signal transduction BCL2, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.08543
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.04507
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.03676
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.02403
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, MCL1, MIF, MMP9, POLA1, POLB, PTPN1, SRC, TERT, TRPV1 2.02403
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MCL1, MIF, MMP2, MMP9, PIM1, POLA1, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 2.9912
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 2.22326
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MET, MMP2, PIM1, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR 2.11398
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2, TBXAS1 1.96222
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.77214
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 14.7028
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 14.6263
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 10.3954
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.78218
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 7.85484
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 7.70606
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.62224
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.47974
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.30409
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.1112
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.02686
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.02686
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.97131
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS 5.7605
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH 5.14411
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.13188
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.07805
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.83836
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.53302
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.13588
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.04398
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.80492
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.75304
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 3.68856
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.66642
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.66642
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 3.37597
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.32092
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.27548
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.22524
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.17014
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.93959
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.78714
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.70524
[MF] GO:0003845 None HSD11B1, HSD11B2 2.70524
[MF] GO:0008389 None CYP2A13, CYP2A6 2.70524
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.55677
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.25309
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.22599
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.22326
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.22326
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, TERT, TRPV1, TYR, XDH 2.19412
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, SRC, TERT 2.14318
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.08543
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, POLA1, SRC, TRPV1, TUBB3, XDH 2.00271


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9087
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.7657
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7149
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.7713
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.7518
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.4738
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 4.8016
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0161
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0313
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.573
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.1764
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8435
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8377
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3.1877
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KDR, BCL2, MET, MCL1, IGF1R 2.8413
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.165
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5226
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0897
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3507
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9863
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 1.9311
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9614
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9614
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7445
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 1.9792
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2 2.4345
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7585
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.5715
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.5563
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3169
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4814
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1, TRPV1 1.2346
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 1.0126
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, PPARA 1.0364
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2346
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9582
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2311
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1652
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1967
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1504
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9944
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2135
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9851
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 0.9582
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0561
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0048
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1479
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9582
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 0.9952
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1224
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8979
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9344
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9759
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8735
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.094
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15 0.8911
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8655
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8778
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.7889
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8778
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8778
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7964
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7889
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8595
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7883
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6988
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6747
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6156
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6747
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.5875
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6586
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2267
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT 0.5258
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6733
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3135
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.3188
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3355
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3134
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3655
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3622
Phagosome_Homo sapiens_hsa04145 TUBB3 0.359
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.354
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.376
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3799
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3915
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3915
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4052
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4052
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4096
Axon guidance_Homo sapiens_hsa04360 MET 0.4004
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4368
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6173
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5563
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4603
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4603
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4499
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4806
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4716
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4715
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4798
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4713
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.48
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4806
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4806
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4803
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5258
Peroxisome_Homo sapiens_hsa04146 XDH 0.4905
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.505
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5258
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5346
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8428
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5487
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5487
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5487
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5358
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5591
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5487
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.551
Shigellosis_Homo sapiens_hsa05131 SRC 0.5487
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5817
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.584
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6045
Malaria_Homo sapiens_hsa05144 MET 0.6156
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6176
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6156
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6176
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.634
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6747
DNA replication_Homo sapiens_hsa03030 POLA1 0.6942
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7392
Base excision repair_Homo sapiens_hsa03410 POLB 0.719
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.761
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7889
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7849
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8911
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8798
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9504
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1751


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)