TCM Prescription: Muscle Relaxing Decoction



Prescription Description
Prescription IDTCMF2334
Pinyin NameShu Jin Huo Xue Tang
Chinese Name舒筋活血汤
English NameMuscle Relaxing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2013 Hirudo medicinalis 水蛭 TCMH2013 GBAN0017-06
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 14.6739
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 12.8727
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 11.8206
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 11.8206
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, KCNH2, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 11.3324
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 11.3324
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 11.0746
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 11.05
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3056
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 9.8385
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, HCAR2, HTR2A, HTR2B, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 9.8385
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.71027
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 9.70431
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.59942
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 9.54513
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.45761
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 9.44249
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, GBA2, GLO1, HTR2B, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.37687
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TRPV1 9.13621
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.08324
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.75082
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR 8.7443
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.47738
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 8.13791
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TRPV1 8.09973
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SIGMAR1, SRC, TERT, TOP2A, TRPV1, XDH 8.08343
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 7.97393
[BP] GO:0015872 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.96731
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SIGMAR1, SRC, TERT, TOP2A, TRPV1, XDH 7.95866
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SRC, TERT, TRPV1 7.91121
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 7.8367
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 7.83462
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, PRKCA, PRKCE, SLC22A1 7.78982
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PRKCE, PTGS2, RORC, SLC6A4, SRC, TYR 7.71458
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 7.66726
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.63827
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 7.63581
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SIGMAR1, SRC, TERT, TOP2A, TRPV1, XDH 7.62566
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, PRKCD, PRKCE, SLC6A4, SRC 7.60434
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, XDH 7.5592
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 7.5592
[BP] GO:0051937 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.41208
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, PRKCE, SRC, TRPV1 7.40789
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 7.40789
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.40789
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 7.23499
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC6A2, SLC6A4, TRPV1 7.10534
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TERT 6.95245
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HTR2A, HTR2B, PRKCE, SRC, TNKS, TNKS2, TRPV1 6.9264
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.88767
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.87665
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.87665
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT 6.73439
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 6.63324
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.6184
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TRPV1, TYR 6.61043
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PPARA, PTGS1, PTGS2, TBXAS1 6.61043
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TERT, TRPV1 6.57952
[BP] GO:0015844 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.53662
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.53662
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC 6.49744
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 6.46005
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 6.45131
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 6.45131
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.43811
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT 6.40718
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SIGMAR1, SLC6A4, SRC, TERT, TNKS2, TOP2A, TYR 6.29967
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 6.27343
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT 6.27286
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 6.23108
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.23108
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.23108
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 6.21264
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.17667
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 6.17096
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT, TRPV1, TYR 6.0858
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC, TERT 6.06217
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KCNH2, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.03412
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 6.01433
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, PRKCG, RORC, SLC6A4, SRC, TOP2A 6.00469
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, HTR2A, KCNH2, MMP9, PRKCE, PTGS2 6.00013
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.94073
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 5.91627
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.88791
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, KCNH2, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 5.88453
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 5.8801
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 5.83356
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM2, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.82224
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 5.81175
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.76283
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.75584
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.72038
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.6622
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.62172
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 5.61808
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, PTGS2, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TRPV1 5.58831
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 5.56292
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2, SLC6A4 5.52373
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2, PRKCE 5.52078
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.41739
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.41739
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.41739
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, PRKCD, PRKCE, PTGS2, SRC 5.41576
[BP] GO:0007200 None ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, ESR1, HTR2A, HTR2B 5.40788
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.40788
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.36092
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.36092
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TRPV1, TYR 5.35904
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.34641
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, XDH 5.27811
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 5.27811
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.19402
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 5.18436
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.16145
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR2B, KCNH2, MMP12, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TERT, TRPV1 5.1266
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.10721
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, PTGS2, SLC6A4 5.09034
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.02096
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.00152
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1 4.95028
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, ESRRB, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.94767
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, PRKCE, PTGS2, SLC6A4 4.88977
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, PRKCE, PTGS2, SLC6A4 4.88977
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TRPV1, TYR 4.88277
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, TRPV1 4.88109
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, XDH 4.87124
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PRKCD, SRC 4.80726
[BP] GO:0015893 None CA2, DRD1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 4.80256
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.76696
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 4.76696
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 4.72056
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.69463
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.66844
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.6297
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.61182
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR1A, HTR2A, KCNH2, MMP9, PRKCD, PRKCE, PTGS2, SLC6A4 4.60099
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.59867
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 4.55275
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.54858
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 4.53591
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HCAR2, HTR2A, HTR2B, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TERT, TNKS2, TRPV1, XDH 4.52877
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA, TRPV1 4.50104
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.47926
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 4.46527
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, PRKCE, PTGS2 4.42372
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 4.37069
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, PRKCD, PRKCE 4.3668
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.36658
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD 4.36076
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 4.35787
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 4.33703
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 4.33336
[BP] GO:0015696 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.33197
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.33197
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.32427
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.27783
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.27783
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, ESRRB, HCAR2, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1 4.26941
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, BCL2, CYP1A1, HTR2A, POLB, PRKCD, PTGS2, TERT 4.23444
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7, PRKCE 4.22791
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.22131
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SRC, TERT, TRPV1 4.20418
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.20418
[BP] GO:0015874 None SLC22A1, SLC22A2, SLC6A2 4.20418
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.20418
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.17767
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.17767
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, HTR2A, HTR2B, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, XDH 4.12167
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2, SLC6A4 4.08761
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.08112
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.06853
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.02062
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PRKCG, RORC, TOP2A 3.98313
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.96112
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.95492
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, MMP12, PRKCE, SLC6A4, SRC, TRPV1 3.94485
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, TRPV1 3.92454
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP2A 3.92365
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.91724
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 3.9123
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, PRKCE, TRPV1 3.9123
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.83769
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2 3.83447
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 3.83344
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.83247
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3, PRKCE 3.82388
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 3.81978
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 3.79026
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.78245
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1 3.781
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, TRPV1 3.781
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.77026
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.73861
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.73861
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.73861
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3, SLC6A4 3.68418
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, PRKCA, PRKCE, SLC6A4, SRC, TRPV1 3.68392
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.65735
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, TRPV1 3.64469
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PRKCD, SRC 3.64469
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.63895
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.58852
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.58852
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.54463
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 3.51621
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, PRKCE, TRPV1 3.51621
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.50958
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, HCAR2, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.50958
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.45892
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.45801
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 3.45427
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, PRKCE, TRPV1 3.44237
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, PRKCE, TRPV1 3.44237
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SRC, TERT, XDH 3.43548
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, PRKCA, PRKCE, SLC6A4, SRC 3.43548
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.40496
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.39483
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.39244
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM2, DRD2, DRD3, HCAR2, HTR2A, KCNH2, PRKCA, PTGS2, TRPV1 3.39244
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, PRKCG, PTGS2, SLC6A4, SRC, TRPV1, TYR 3.39244
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.38254
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2 3.36446
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.36446
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, CA2, CHRM2, DRD1, DRD2, DRD3, ESR1, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SIGMAR1, SRC 3.34457
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34457
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, PRKCA, PRKCE, SLC6A4, SRC, TERT 3.33914
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, KCNH2, MMP9, PRKCE 3.3279
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3 3.3244
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TERT, TNKS, XDH 3.32347
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B, PRKCE 3.30205
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.27364
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.27352
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.26678
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, MMP12, PPARA, PRKCB, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC6A2, SLC6A4, TNKS, TRPV1 3.23937
[BP] GO:0007610 None BCL2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA, PRKCE, PRKCG, PTGS2, SLC6A4, TRPV1 3.22988
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.22148
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.22148
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.20243
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.20243
[BP] GO:0055065 metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 3.19423
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.11651
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, ESR1, F10, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.11189
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, PRKCG, SLC6A2 3.09053
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.08695
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 3.07444
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, XDH 3.06484
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC22A1, SLC22A2, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.06484
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 3.06484
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.06394
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TNKS, TRPV1, XDH 3.05338
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, KCNH2, MMP9, PRKCE 3.05062
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.04886
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, POLA1, PRKCD, SRC, TYR 3.03279
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.03188
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TNKS, TRPV1, XDH 3.03188
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B, PRKCE 3.03182
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, PIK3CB, PRKCB, PRKCE, TRPV1 3.02359
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, HCAR2, HTR2B, MET, PIK3CA, PPARA, PRKCG 3.01557
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, PRKCA, PRKCE 3.01557
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.01283
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, PRKCE, TRPV1 3.00279
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.99908
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 2.96543
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 2.94548
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SIGMAR1, SRC, TYR 2.94073
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, IGF1R, PIK3CB, PRKCD, PTPN1, SRC 2.93804
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.93804
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A, PTGS2 2.93804
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, BCL2, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 2.92813
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 2.92684
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, KCNH2, MMP9, PRKCE 2.92684
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.92195
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.91713
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, SRC 2.91659
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SRC, TERT, TNKS 2.91659
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 2.88948
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, PRKCG, PTGS2, SLC6A2, TRPV1 2.88642
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 2.88575
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.88575
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.88575
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, DRD1, ESR1, FLT3, IGF1R, MMP2, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TRPV1 2.86486
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, PTGS2, SRC, TRPV1 2.86448
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TERT 2.86267
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TNKS 2.85573
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 2.83845
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, ESRRB, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.82853
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.82009
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.81892
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.81729
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.81729
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, HTR2A, KCNH2, PRKCE, PTGS2 2.8157
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 2.8139
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SRC, TERT, TNKS, XDH 2.80875
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, PRKCD, PTGS2 2.80875
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.80875
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.80875
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.80228
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, PRKCA 2.80228
[BP] GO:0043278 None DRD2, DRD3, PRKCE, PRKCG 2.80228
[BP] GO:0014072 None DRD2, DRD3, PRKCE, PRKCG 2.80228
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM2, DRD2, HTR2A, KCNH2, PTGS2 2.80158
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.79076
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA2A, CHRM2, PTGS2 2.78697
[BP] GO:0035408 None PRKCA, PRKCB 2.78064
[BP] GO:0009115 None AOX1, XDH 2.78064
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.78064
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.76489
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG, SLC6A2 2.73767
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG, SLC6A2 2.73767
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, PIK3CA, TNKS2 2.73767
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.73767
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.73257
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.73257
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, PRKCA 2.7222
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.71895
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, PRKCE, SRC 2.71505
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.71505
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, PRKCE, TRPV1 2.70009
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, DRD2, DRD3, HCAR2, HTR2B, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.69797
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.69482
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, HCAR2, HTR2B, MMP12, PRKCA, PRKCE, SRC 2.68859
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.67988
[BP] GO:0099536 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG, SLC6A2 2.67635
[BP] GO:0099537 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG, SLC6A2 2.67635
[BP] GO:0050730 None ADORA1, ADRA2A, FLT3, HTR2A, PRKCD, PRKCE, PTPN1, SRC 2.66792
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.63994
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, PRKCA 2.63994
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.63994
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.63994
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, PPARA, PRKCA 2.63994
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA, PRKCA 2.63555
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 2.6235
[BP] GO:0006812 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, KCNH2, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC6A2, SLC6A4, TRPV1 2.61827
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.61775
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, PPARA, PRKCA 2.61775
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.61775
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.61775
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TERT 2.58735
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.58398
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.55793
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA, PRKCA 2.5565
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.55271
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.55271
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.55271
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, MMP9, PRKCE 2.5413
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.51463
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 2.50682
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, PIM1, PRKCA, PRKCE, PTGS2, SLC6A4, SRC, TERT, TNKS, TOP2A 2.50374
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, IGF1R, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 2.50374
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.49133
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2, TERT 2.48969
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B, PRKCE, TRPV1 2.48116
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.47033
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.47033
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.47033
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.47033
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SLC6A4, SRC 2.46437
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.44195
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, BCL2, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SRC, TERT, XDH 2.4303
[BP] GO:0015850 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 2.42594
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.40835
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.40835
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, HTR2B, MMP12, PRKCE, SRC 2.40835
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.40407
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.39431
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.39431
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.39431
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, HTR2A, KCNH2, MMP9, PRKCB, PRKCE, PTGS2 2.38758
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.38758
[BP] GO:0046110 None AOX1, XDH 2.38758
[BP] GO:0060160 None DRD2, DRD3 2.38758
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38758
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.38758
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.387
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.387
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, MMP9, PRKCE 2.36953
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.35264
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, PRKCA 2.35107
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.33555
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.33555
[BP] GO:0001504 None SLC22A3, SLC6A2, SLC6A4 2.33555
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, PIK3CB, PTPN1, SRC 2.33324
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC, SLC6A4 2.33221
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.32395
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PRKCA, SRC 2.32319
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, PRKCA 2.32319
[BP] GO:0050708 None ACHE, ADRA2A, DRD2, DRD3, HCAR2, HTR2B, MMP12, PRKCA, PRKCE, SRC 2.29816
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, SLC22A2, SLC6A4 2.28815
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, PRKCA 2.28815
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, KCNH2, PRKCG, SLC6A2 2.2872
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.27378
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, IGF1R, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 2.27103
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.27103
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.27103
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, HTR1A, SLC22A2, SLC6A4 2.27103
[BP] GO:0060359 None DRD1, DRD2, DRD3, PRKCE, PRKCG 2.27103
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.26319
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.25918
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, HTR2A, PRKCG, PTGS2, SLC6A4 2.25865
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.25125
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.24428
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TNKS 2.24428
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, PRKCE, TERT 2.24105
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PRKCA, PTPN1, SRC 2.24105
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, SLC6A4 2.23258
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.23109
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, PRKCA 2.2309
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, PRKCA, TERT 2.21754
[BP] GO:0043279 None DRD2, DRD3, PRKCE, PRKCG, TRPV1 2.2133
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.21201
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.21201
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.21201
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.20966
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.20894
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.20875
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, PPARA, PRKCD, PTGS2, SRC, TRPV1 2.20796
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, PRKCA 2.20662
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, PRKCA 2.20662
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.20662
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.20662
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, HCAR2, HTR2B, MMP12, PRKCE, SLC6A4, SRC 2.20366
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, BCL2, CSNK2A1, DRD2, DRD3, HCAR2, HTR2B, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT 2.19778
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.18893
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, PRKCA 2.17634
[BP] GO:0070201 None ACHE, ADRA2A, BCL2, DRD2, DRD3, HCAR2, HTR2B, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.16403
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, PRKCG, SLC6A2 2.16403
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HTR2A, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.16206
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.15961
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.15961
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, IGF1R, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.15333
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B, PRKCE, TRPV1 2.15111
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.15111
[BP] GO:1901374 None SLC22A1, SLC22A2 2.15111
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.15111
[BP] GO:0070213 None TNKS, TNKS2 2.15111
[BP] GO:0006145 None AOX1, XDH 2.15111
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15111
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.13637
[BP] GO:0010676 None ESRRB, PPARA, PRKCE, SRC 2.12503
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.11883
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.10713
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.10713
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.09749
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, PRKCA 2.09608
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.09436
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, DRD3, HSD11B2, HTR2A, MMP12, PRKCD, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.08978
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, MET, PPARA, PRKCD, TNKS 2.08306
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.08306
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, ESR1, ESRRA, HCAR2, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC 2.06301
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.05832
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.05832
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.05832
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.05832
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.05832
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.04976
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.04876
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.04876
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.01773
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.01054
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.01054
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.00689
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.00689
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.00689
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.00689
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR 7.15366
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, GBA2, GLO1, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TRPV1 7.10338
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA4, CHRM2, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TRPV1 6.67645
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TRPV1 5.3617
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MPEG1, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TBXAS1, TRPV1, TYR 4.942
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1, TBXAS1 4.3423
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CA4, CA9, CHRM2, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PRKCG, PTGS2, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SRC, TRPV1 4.27508
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, HTR5A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SIGMAR1, XDH 4.10525
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR5A, KCNH2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.76112
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, SIGMAR1, TBXAS1 3.68001
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, ADRA2A, CA2, CA4, CA9, CHRM2, DRD1, DRD2, HTR2A, MET, PRKCG, PTGS2, SIGMAR1, SLC22A1, SRC, TRPV1 2.84448
[CC] GO:0031233 None CA4, F10, F3 2.15961
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.10274
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, KCNH2, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.06376
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 18.335
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 15.5445
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.4667
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 14.8103
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.8206
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.9211
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SIGMAR1, SLC6A4, SRC, TOP2A, TRPV1 9.8385
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TNKS 9.70431
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.65273
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.47768
[MF] GO:0008227 None ADRA1A, ADRA2A, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.37687
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 8.46471
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, SLC6A4 8.34426
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.33326
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 8.12207
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 7.91121
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.90228
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, TRPV1 7.8367
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1, TYR 7.66726
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.56355
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TBXAS1, XDH 7.5592
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TBXAS1, TYR 7.4194
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 7.36293
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CDK6, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, TRPV1 7.06376
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.90322
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.81674
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, TRPV1 6.77101
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.49693
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, PRKCE, RORC, SIGMAR1, TRPV1 6.46301
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.35317
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.35317
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.32098
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.23108
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.23108
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.05171
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.52373
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.37466
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.89091
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TERT 4.80837
[MF] GO:0005333 None SLC22A1, SLC22A2, SLC6A2 4.70171
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 4.53899
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 4.53899
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.52852
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.50686
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.50686
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.50686
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.3668
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.31772
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TRPV1, XDH 4.29126
[MF] GO:0008519 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.23444
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.20418
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.10125
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.09626
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 4.09499
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.06086
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.50958
[MF] GO:1901618 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 3.44237
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TRPV1, XDH 3.06528
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.04886
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.03502
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.92963
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 2.90433
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC22A1, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 2.89227
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.8792
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.85723
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.81729
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.80875
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, TERT, TOP2A, TYR, XDH 2.78832
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.78832
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.78697
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.78064
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78064
[MF] GO:0003845 None HSD11B1, HSD11B2 2.78064
[MF] GO:0008389 None CYP2A13, CYP2A6 2.78064
[MF] GO:0035403 None PRKCA, PRKCB 2.78064
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.73257
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.73257
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, ESR1, ESR2, ESRRB, F3, KCNH2, MET, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SRC, TNKS2, TOP2A 2.67635
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.63994
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.59672
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.50475
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.44669
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.39431
[MF] GO:0015307 None SLC47A1, SLC47A2 2.38758
[MF] GO:1901375 None SLC22A1, SLC22A2 2.38758
[MF] GO:0005330 None SLC6A2, SLC6A4 2.38758
[MF] GO:0005277 None SLC22A1, SLC22A2 2.38758
[MF] GO:0008513 None SLC22A1, SLC22A2 2.38758
[MF] GO:0004699 None PRKCD, PRKCE 2.38758
[MF] GO:0047374 None CES1, CES2 2.38758
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.35107
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.33926
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.33555
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.33555
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.33555
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA1A, ADRA2A, AOX1, AXL, BCL2, DRD2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, TERT, TOP2A, TYR, XDH 2.17709
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.15961
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15111
[MF] GO:0032795 None ADORA1, ADRA2A 2.15111
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.11405
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.08985
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.08978
[MF] GO:0005326 None SLC22A1, SLC22A2, SLC6A2, SLC6A4 2.07209


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, HTR2B, HTR1A, PRKCA, HTR2A, PTGS2, HTR5A, CYP2C19, PTGS1, SLC6A4, HTR6, HTR7, CYP2D6, ALOX5 14.63
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.4303
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, PRKCA, PIK3CB, TRPV1, HTR2A 9.6173
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR2B, HTR1A, TRPV1, HTR2A, HTR5A, ADRA1A, ADRA2A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 9.0819
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 8.2942
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.2101
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PIK3CA, PRKCB, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 7.7464
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.6678
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, HTR6, HTR7, PRKCB, HTR2B, PRKCA, HTR2A, DRD1, HTR5A, ADRA1A 7.2738
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.7464
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 7.0165
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, IGF1R, CDK6, PIK3CA, BCL2, MET 6.5613
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.6972
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, IGF1R 6.2764
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, HTR2B, PRKCA, HTR2A, DRD1, DRD2 6.5719
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 6.7496
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, ESR2 6.2764
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB 6.2317
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.143
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, PIK3CA, ADORA1, HTR1A, PIK3CB, DRD1, DRD2, PPARA 6.0585
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 6.0126
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 6.0373
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, DRD2, MET, IGF1R 5.8969
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 5.5197
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.0373
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, PRKCA, PIK3CB 6.2764
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.4248
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB 5.5049
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB, IGF1R 5.1379
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, HTR7, PIK3CA, PRKCB, KDR, PRKCA, PIK3CB, MET, IGF1R 4.7755
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, PRKCE, PRKCD, PIK3CB, PPARA 5
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5049
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.7953
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.7953
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2 4.0335
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB 4.4799
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.3616
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PRKCE, ADORA1, PIK3CB, ADRA1A, ADRA2A 3.8894
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 3.5327
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, ADRA1A 3.7788
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.1225
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA, DRD1, DRD2, DRD3 3.6373
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 3.8187
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.7994
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, CYP2C19, PTGS1 4.0637
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 3.869
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.7612
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 3.4171
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.493
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA, DRD1 3.4171
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.2731
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.2395
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.8824
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.7025
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB, ADRA1A 2.5487
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.4523
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2023
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.1727
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2236
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 2.0304
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.5187
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.3928
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2264
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.7696
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.647
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.3661
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA, DRD1 2.9133
Axon guidance_Homo sapiens_hsa04360 MET 0.3031
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3104
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.1063
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 2.9133
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.5251
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, ADRA1A, IGF1R 2.0607
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA, ADRA1A 2.5187
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.1273
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.454
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.6962
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, PTGS2 2.3558
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.4145
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3579
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3682
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 1.9578
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.0762
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.568
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3858
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5637
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.563
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9496
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7001
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4014
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.1551
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4038
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6855
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.4552
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 1.9194
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4026
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.3822
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4214
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 1.9194
Peroxisome_Homo sapiens_hsa04146 XDH 0.4214
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.1725
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6119
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB 1.6436
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7275
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8781
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7582
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.186
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.1741
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2575
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.1868
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.2617
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.2342
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.3062
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8598
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.3062
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.8703
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8703
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4761
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.4552
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4786
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.6484
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4977
Shigellosis_Homo sapiens_hsa05131 SRC 0.4974
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.4362
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.6436
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4974
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCE, PRKCD, PIK3CB 3.4171
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6373
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.7496
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.9194
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 1.9194
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.9759
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.551
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.6621
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.4648
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0612
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.0074
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.0074
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.1182
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0074
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5682
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5682
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.0304
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.9329
Malaria_Homo sapiens_hsa05144 MET 0.5777
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.1363
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1363
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.0593
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5827
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1629
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5877
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2531
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.3316
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6472
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.4094
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.3755
DNA replication_Homo sapiens_hsa03030 POLA1 0.6855
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7331
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.6755
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7535
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7883
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.743
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7762
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7314
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6273
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.66
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6815
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.7513
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6119
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9255
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9263
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0277
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0937
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3309


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)