TCM Prescription: Recipe No.II for Removing Gallstones



Prescription Description
Prescription IDTCMF2260
Pinyin Namedan dao pai shi er hao fang
Chinese Name
English NameRecipe No.II for Removing Gallstones
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH767 Herba lysimachiae 过路黄 TCMH767
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1450 Natrii sulfas 芒硝 TCMH1450
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.101
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.101
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, NR3C1, PTGES, PTGS2, RELA, RORC, SRC, TYR 13.1683
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, POLA1, POLB, PTGS1, PTGS2, SRC, XDH 12.8785
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, POLB, PTGES, PTGS2, RELA, RORC, SRC, TYR 12.6719
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, TBXAS1 12.4906
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, POLB, PTGES, PTGS2, RELA, RORC, SRC, TYR 12.2966
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, POLB, PTGES, PTGS2, RELA, RORC, SRC, TYR 11.3951
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PTGES, PTGS2, RELA, RORC, SRC, TYR 11.2296
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 11.2211
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, PGR, PIM1, PTGES, PTGS1, PTGS2, RELA, SRC, XDH 10.729
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 10.6604
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 10.6491
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 10.5154
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TYR 9.70674
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 9.45671
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 9.32293
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 9.18808
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC 9.0781
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 8.89504
[BP] GO:0019371 None AKR1C3, CBR1, PTGES, PTGS1, PTGS2, TBXAS1 8.79023
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 8.67746
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.5107
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, NR3C1, PTGS2, RELA, SRC 8.48023
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 8.4674
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RELA, RORC, SRC, TYR 8.44278
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 8.13427
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSD17B3, HTR2B, HTR2C, PIK3CA, PIM1, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.13427
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 8.04634
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA 7.99726
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.99726
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, NR3C1, PTGS2, RELA, SRC 7.9717
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.9593
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.93408
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.93129
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.9283
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, NR3C1, POLB, PTGS2, RELA, SRC 7.75681
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.75681
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.68663
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLB, PTGES, PTPN1, RELA, RORC, SRC 7.67376
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.53949
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, RELA, RORC, SRC, TYR 7.30861
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.24599
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PIK3CA, POLB, RELA, SRC, TYR 7.24134
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, RELA, SRC 7.14846
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 7.10032
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.09962
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PTGS2, RELA, RORC, SRC 7.05376
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, TYR, XDH 7.05171
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.97024
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RELA, RORC, SRC 6.78889
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.77074
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 6.71266
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.69518
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 6.68756
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 6.65881
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, TBXAS1 6.65176
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64374
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.52893
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.46861
[BP] GO:0007193 None ADORA1, CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.42374
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.42374
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.42374
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RELA, RORC, SRC 6.40638
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, RELA, SRC 6.2559
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.2012
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, AKR1C3, APP, CA2, CHRM2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.95048
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 5.94825
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, KIT, MAP2K1, MMP9, PGR, PIK3CA, PIM1, POLB, PTGS2, RELA, RORC, SRC, TYR 5.94308
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 5.90992
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PTGS2, RORC, SRC 5.85874
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGES, PTGS1, PTGS2, TBXAS1 5.85653
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.64809
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 5.59097
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.59097
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 5.58755
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 5.56555
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.53905
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, PTGS2 5.53519
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 5.50033
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.48276
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.47633
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, TYR, XDH 5.46529
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 5.45893
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIK3CB, PIM1, POLA1, SRC, TYR 5.38032
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 5.35845
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, SRC 5.33176
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 5.33176
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.33176
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SRC 5.32605
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 5.32229
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.3178
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.30947
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, HTR1A, MAOA, TYR 5.29208
[BP] GO:0007154 None ADORA1, AKR1C3, AR, AXL, BCL2, CACNA1C, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PTGS2 5.23853
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 5.15302
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.15302
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.15302
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, PGR, PTGS2, SRC 5.10226
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, RELA 5.06031
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, PGR, PTGS2, SRC 4.98997
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PTGS2, SRC 4.96533
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.94415
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.94415
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, NR3C1, PGR, PIM1, RELA, RORC, SRC 4.92864
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.89619
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 4.89594
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 4.89594
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.88058
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.75918
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC 4.75918
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.75828
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.7434
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 4.64713
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RELA, RORC, SRC 4.64713
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, XDH 4.63038
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.50925
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.49379
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.48426
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.41843
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.40866
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, POLB, PTGS2, RELA, SRC, TYR 4.40211
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 4.39863
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 4.39357
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37785
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 4.37785
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, TYR, XDH 4.37785
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.36184
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 4.35313
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.33309
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.33113
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.32799
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 4.31122
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, XDH 4.29639
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 4.23235
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.16779
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.16741
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 4.16624
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.14359
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 4.11974
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.09089
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.06028
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.05796
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.05796
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, POLB, PTGS2, RELA 4.03945
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.03528
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.03528
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.95896
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.942
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGES, PTGS1, PTGS2, TBXAS1 3.87881
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.84322
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 3.79592
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, NR3C1, PTGS2, RELA, SRC 3.77357
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.76814
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.76814
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.76208
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, RELA, SRC 3.7592
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, RORC, SRC 3.75863
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, TYR, XDH 3.75863
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.72979
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.72979
[BP] GO:0003008 None ADORA1, AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC, TYR 3.72979
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR 3.68799
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SRC 3.65351
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 3.6535
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.62975
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.62552
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 3.61256
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.61256
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.55867
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.5508
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TYR 3.54468
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.51117
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PTPN1, SRC 3.50655
[BP] GO:0007267 None ADORA1, AR, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR 3.49368
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48539
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SRC 3.4786
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.42434
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.42187
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, NR3C1, PTGS2, RELA, SRC 3.416
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, KIT, PGR, RORC, SRC 3.39291
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.3859
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.3859
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.3859
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, XDH 3.38382
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.36559
[BP] GO:0006693 None AKR1C3, PTGES, PTGS1, PTGS2 3.36559
[BP] GO:0006692 None AKR1C3, PTGES, PTGS1, PTGS2 3.36559
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.35924
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.31843
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.31843
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC, TYR 3.31622
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.27746
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.2422
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.2341
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.21068
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.20671
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.19343
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.19305
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.19305
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, POLB, PTPN1, RELA, SRC 3.17714
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.17714
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.17253
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CNR1, CYP1B1, ESR1, F3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, XDH 3.16222
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, KIT, MMP12, PTGES, PTGS2, RELA, SRC, TYR 3.15124
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.14394
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, POLB, TYR 3.14135
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, RORC, SRC 3.14135
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.14135
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.14135
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.13715
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.13715
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11521
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.08505
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.06901
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.06035
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, TYR, XDH 3.06035
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TYR 3.05466
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 3.05466
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.03266
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.01357
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.00111
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3 2.99882
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.99882
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.99882
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC, TYR 2.99882
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, RELA, SRC 2.99213
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.99001
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.98165
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, HTR1A, MAOA 2.93404
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PTGS2, PTPN1, RELA, SRC, XDH 2.92869
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.92583
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.92072
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.86676
[BP] GO:0071383 None AKR1C3, AR, FLT3, NR3C1, SRC 2.86588
[BP] GO:0007208 None HTR2A, HTR2C 2.86588
[BP] GO:0016488 None AKR1B10, AKR1C3 2.86588
[BP] GO:0016487 None AKR1B10, AKR1C3 2.86588
[BP] GO:0016107 None AKR1B10, AKR1C3 2.86588
[BP] GO:0006714 None AKR1B10, AKR1C3 2.86588
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 2.82472
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.82472
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.81237
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, PTGES, PTGS1, PTGS2 2.80251
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80251
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.80251
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.80251
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, PTGS2, RELA, TYR 2.80251
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.80008
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.79973
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 2.7922
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, NR3C1, PGR, SRC 2.78752
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.78752
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.78752
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.77282
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, ESR1, FLT3, NR3C1, RELA, RORC, SRC 2.7459
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.73834
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, KIT, PGR, PTGS2, SRC 2.7169
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71562
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.71562
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, KIT, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, RELA, SRC 2.7123
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.7123
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.69431
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC 2.69129
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.67088
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.65588
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.65202
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.65167
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.64136
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 2.63885
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.63885
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PTGS2, RELA 2.62489
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.61253
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.60855
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MAP3K7, MMP12, MMP2, PTGS2, PTPN1, RELA, SRC 2.60595
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, XDH 2.60591
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.6032
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.60187
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.59976
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC 2.59694
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.59418
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.59116
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC 2.58866
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PTGS2, SRC 2.58156
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.578
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.56988
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56988
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.56988
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 2.56988
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC 2.5513
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PTGS1, PTGS2 2.51792
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, PTGS2, RELA, SRC 2.51471
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, KIT, MAP3K7, PIM1, RELA 2.50712
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.48021
[BP] GO:0060748 None AR, PGR 2.47482
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47482
[BP] GO:0016095 None AKR1B10, AKR1C3 2.47482
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.46569
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.44104
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.43479
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.4335
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.42878
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.42622
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.39209
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, KIT, PTPN1, SRC 2.3902
[BP] GO:0032147 activation of protein kinase activity ADORA1, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.38502
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, NR3C1, NR3C2, PGR, RORC 2.37156
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.36822
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, PTGS2, RELA, SRC 2.35549
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.35549
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, HSD17B3, TYR 2.34621
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.31378
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.30084
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.2767
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.2703
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.25435
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.24459
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.24459
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.23949
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.22848
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.22239
[BP] GO:0038171 None CNR1, CNR2 2.20979
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20979
[BP] GO:0014827 None HTR1D, HTR2B 2.20979
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.20979
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, KIT, PTPN1, SRC 2.20772
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.20456
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.1953
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PTGS2 2.16534
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.15264
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, ESR1, FLT3, KIT, NR3C1, RELA, SRC 2.14903
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.14522
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.14234
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14234
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, MAP2K1, PTGS2, RELA 2.12092
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.11692
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.11436
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.11292
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PTGS2, RELA, SRC 2.10662
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.10662
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.10153
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09406
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.09296
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MET, PIK3CA, RELA 2.08528
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, HTR1A, HTR2A, HTR2C 2.08528
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.08528
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1 2.06956
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CYP1A1, ESR1, FABP4, FLT3, FUT7, HTR2B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC 2.0569
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA 2.05399
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.05003
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, HTR2A, HTR2B, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PTPN1, RELA 2.04768
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.03876
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C 2.03876
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.02489
[BP] GO:0010641 None F3, SRC 2.02338
[BP] GO:0071502 None HTR1B, HTR2B 2.02338
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.02338
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.02329
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.02158
[BP] GO:0006940 None ADORA1, CHRM2, KIT, PTGS2 2.02158
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, RELA 2.02158
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.01699
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR 7.07915
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 5.90992
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.61664
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, NR3C2, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR 5.53064
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.75918
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, SRC 4.69062
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.3859
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR4, HTR5A, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TYR, XDH 3.12778
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 2.59418
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, PTGES, PTGS1, PTGS2, TBXAS1 2.55667
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES, TBXAS1, TYR 2.02288
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.101
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.101
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.101
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.101
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7441
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.414
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, TYR, XDH 13.1683
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TBXAS1, TYR, XDH 12.0754
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.6526
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.3237
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.86889
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 9.52378
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.4302
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TYR, XDH 9.27369
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.27369
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NR3C1, NR3C2, PGR, RORC 8.8261
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR, XDH 8.48023
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 8.42271
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 8.11493
[MF] GO:0005496 steroid binding AR, ESR1, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 7.30861
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.88769
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.45613
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.38425
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.2012
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.2012
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 6.18172
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 6.18172
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.01137
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PTPN1, RORC 5.60097
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC 5.58918
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.3754
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 5.33176
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1, SHBG 4.85808
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.85801
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.63074
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.55775
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, NR3C1, NR3C2, PGR, RORC 4.50925
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.39843
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TYR, XDH 4.30692
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.20275
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, TBXAS1, XDH 3.97722
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.9104
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.84516
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.8431
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 3.81964
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.79592
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.76814
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TBXAS1, XDH 3.75532
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.55169
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.36559
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 3.32574
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC 3.19305
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 3.17978
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.99882
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.86588
[MF] GO:0045550 None AKR1B10, AKR1C3 2.86588
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86588
[MF] GO:0071886 None HTR2A, HTR2C 2.86588
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.82215
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.58982
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.56064
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.47482
[MF] GO:0047718 None AKR1B10, AKR1C3 2.47482
[MF] GO:0004949 None CNR1, CNR2 2.47482
[MF] GO:0047045 None AKR1C3, HSD17B3 2.47482
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, PGR, RORC 2.43479
[MF] GO:0004879 nuclear receptor activity AR, ESR1, PGR, RORC 2.43479
[MF] GO:0005497 None AR, SHBG 2.20979
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.20979
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, TBXAS1, TYR, XDH 2.01213
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.01213
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.01213
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.00078


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 22.7317
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, NR3C1, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 12.7215
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 11.5346
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.6447
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, MAP2K1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HTR6, PIK3CA, ADORA1 10.1311
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, AKR1C3, PTGS2, PTGES, PTGS1 8.2658
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 7.6099
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 7.6099
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7886
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 7.1126
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.6146
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, CACNA1C, HTR2A, HTR5A, HTR4 5.9682
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 5.8579
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.595
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.6003
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 5.5563
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.7655
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.5979
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 5.406
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, RELA, IGF1R 5.3762
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.4117
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET 5.4267
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 4.9333
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.3224
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB, RELA 5.2519
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.8444
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.2698
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 4.7592
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.6755
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.5896
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 4.6755
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.0562
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.5761
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.2482
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.2519
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.1967
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.6313
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 3.9115
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, ADORA1, CACNA1C, PIK3CB 3.5077
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1494
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.8474
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.4719
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.5018
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A 3.8097
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.7044
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.2446
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.2701
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 3.1511
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.2367
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.1085
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.0197
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.0707
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.2367
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5586
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.2832
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.5043
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB, RELA 2.3529
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.7683
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.098
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, RELA 2.5043
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.7219
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.2367
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.8353
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, PIK3CA, SRC, PIK3CB 2.2891
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 3.098
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.2367
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, PGR, IGF1R 2.345
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3931
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.2387
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.3379
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB, NR3C2 3.9809
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, PIK3CB 2.1807
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0091
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.1674
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0088
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, KIT, PIK3CB 2.1522
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.0324
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 2.1149
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.0324
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2885
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 1.8881
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.9477
Axon guidance_Homo sapiens_hsa04360 MET 0.3756
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.381
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB, RELA 1.3939
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4066
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3722
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6782
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4323
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.67
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, RELA 1.3722
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.4765
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7066
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4622
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4609
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, RELA 1.4895
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8142
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4622
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8052
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4724
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4737
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.1965
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4737
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8526
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.7865
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2345
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4737
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4823
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.7865
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.7836
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4839
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.8592
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8976
Peroxisome_Homo sapiens_hsa04146 XDH 0.4899
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4934
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.7577
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.7836
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4899
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5017
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4998
Pertussis_Homo sapiens_hsa05133 RELA 0.5134
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5157
Adipocytokine signaling pathway_Homo sapiens_hsa04920 RELA 0.528
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.1748
Bile secretion_Homo sapiens_hsa04976 CA2 0.5255
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5157
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.042
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.1137
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2334
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1174
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1174
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5589
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1748
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.3649
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1674
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.4459
Legionellosis_Homo sapiens_hsa05134 RELA 0.614
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2711
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2788
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3146
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6404
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3063
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.3242
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.2866
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.528
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6451
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3231
Malaria_Homo sapiens_hsa05144 MET 0.6501
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3722
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3722
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3231
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.3231
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6637
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3939
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3722
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6692
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5007
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7126
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7602
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5666
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8176
DNA replication_Homo sapiens_hsa03030 POLA1 0.7518
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.803
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8438
Base excision repair_Homo sapiens_hsa03410 POLB 0.7809
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8526
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8102
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8614
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8438
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.763
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8162
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8854
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7479
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8791
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0595
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0159
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0907
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2367


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)