TCM Prescription: Added Flavor BHDH Decoction



Prescription Description
Prescription IDTCMF2254
Pinyin NameJia Wei Bai He Di Huang Tang
Chinese Name加味百合地黄汤
English NameAdded Flavor BHDH Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH2573 Ziziphus jujuba var. spinosa 枣仁 TCMH2573 ITSAM943-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH2681 Caulis bambusae in taeniam 竹茹 TCMH2681
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 11.7475
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MAOB, MMP2, MMP9, PPARA, PTGES, RELA, SRC, TYR 11.3778
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 10.8679
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, MAOB, PTGES, RELA, SRC, TYR 9.96712
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, PPARA, PTGES, RELA, SRC, TYR 9.38604
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 9.38604
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.1856
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, MAOB, PTGES, RELA, SRC, TYR 9.03122
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GBA2, GLO1, HMGCR, HSD17B3, PDE5A, PIM1, PPARA, PTGES, TYR, XDH 8.62931
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, PTGES, RELA, SRC 8.08392
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAOB, MET, PPARA, SRC, TNKS, TNKS2, XDH 7.95756
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HSD17B3, KDR, MAOB, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, RELA, SRC, TNKS2, TOP2A, TYR 7.95756
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC, TYR 7.95756
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, PPARA, PTGES, RELA, SRC, TYR 7.95756
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, MAOB, PPARA, RELA, SRC 7.92808
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MAOB, MMP2, PPARA, RELA, SRC 7.79269
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TOP2A, XDH 7.63319
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.61119
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.58857
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SRC, TOP2A, XDH 7.57566
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 7.49355
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.39372
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.11555
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MMP2, MMP9, PDE5A, PIM1, PTGES, RELA, SRC, XDH 6.98267
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SRC, TOP2A, XDH 6.93495
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, HMGCR, HSD17B3, MAOA, MAOB, TYR 6.90787
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.90787
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, MAOB, TYR, XDH 6.88686
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.56749
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.50879
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, SRC 6.4815
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 6.4815
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.47047
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.01656
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.90763
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86932
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.68677
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.67225
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MET, PDE5A, PTPN1, RELA, SRC, XDH 5.57819
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.54007
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, MAOB, MAP2K1, MMP9, PIM1, PPARA, RELA, SRC, TYR 5.46509
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, MAOB, RELA, SRC 5.17306
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 4.98889
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.98889
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTPN1, SRC, TNKS, XDH 4.94373
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, XDH 4.89299
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.89299
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, MAOB, RELA, SRC 4.89299
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.77553
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, RELA, SRC 4.77553
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, RELA 4.68599
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 4.68599
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 4.64785
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTPN1, SRC, TNKS, XDH 4.64019
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, MAOB, RELA, SRC 4.61895
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MET, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 4.61895
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 4.5204
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 4.49775
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 4.49775
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PTPN1, RELA, SRC, TOP2A 4.46044
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RELA, SRC 4.41565
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.41565
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, HSD17B3 4.36014
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 4.36014
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36014
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, SRC, TOP2A 4.36014
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RELA, SRC 4.35566
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 4.32529
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RELA, SRC, TNKS2, TYR 4.32166
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, MET, PPARA, PTGES 4.28772
[BP] GO:0009893 positive regulation of metabolic process APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 4.23699
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC 4.19801
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MET, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 4.11091
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 4.03178
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.95783
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, SRC, TOP2A, TYR 3.93925
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 3.79025
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MAOA, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 3.68752
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PIM1, RELA, SRC 3.60617
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, SRC 3.57745
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 3.57745
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 3.57745
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51502
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.51502
[BP] GO:0042327 positive regulation of phosphorylation APP, AR, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 3.46592
[BP] GO:0043410 positive regulation of MAPK cascade APP, AR, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, XDH 3.44365
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, PTGES 3.41986
[BP] GO:0032879 regulation of localization ACHE, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MET, MMP9, PPARA, PTPN1, SRC 3.40559
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.37873
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, RELA, SRC 3.36493
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.36493
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.35522
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.33343
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 3.25853
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, MAOB, RELA, SRC 3.23479
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.21723
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.19417
[BP] GO:0048583 regulation of response to stimulus AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PDE5A, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 3.19417
[BP] GO:0042325 regulation of phosphorylation APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 3.19277
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, RELA, SRC 3.17619
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, SRC 3.15932
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.14415
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.14208
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.09951
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.08763
[BP] GO:0001934 positive regulation of protein phosphorylation APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 3.07306
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS, HMGCR 3.05752
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 3.03755
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.01218
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGES, RELA, SRC 3.01218
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.97208
[BP] GO:0019220 regulation of phosphate metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.96741
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, RELA, SRC 2.96741
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MAP2K1, MET, MMP2, MMP9, SRC, TOP2A 2.95995
[BP] GO:0044093 positive regulation of molecular function APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, XDH 2.95103
[BP] GO:0051174 regulation of phosphorus metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.92887
[BP] GO:0043408 regulation of MAPK cascade APP, AR, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, XDH 2.92879
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.9136
[BP] GO:0018958 None AKR1B1, BCL2, MAOA, MAOB, TYR 2.90641
[BP] GO:0051239 regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PIM1, RELA, SRC, TNKS2, XDH 2.88497
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.85055
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGES, RELA, SRC 2.84291
[BP] GO:0051247 positive regulation of protein metabolic process APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, RELA, SRC, XDH 2.82721
[BP] GO:0080134 regulation of response to stress APP, CDK6, CYP19A1, ESR1, F3, FABP4, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTPN1, RELA, SRC, XDH 2.81012
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.80133
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.79096
[BP] GO:0019222 regulation of metabolic process ACHE, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.7903
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP2A 2.7903
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78925
[BP] GO:0009115 None AOX1, XDH 2.7826
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.78017
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.76417
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.76417
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 2.74084
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.73569
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.73569
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71399
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.68828
[BP] GO:0007165 signal transduction AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2 2.68641
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.6778
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APEX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, MAOB, MAP3K7, PDE5A, PPARA, RELA, TOP2A, TYR, XDH 2.66671
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, MAP2K1, RELA 2.65594
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 2.6458
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, SRC 2.64248
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, MAP2K1, PIM1, TNKS, TOP2A 2.61985
[BP] GO:0001932 regulation of protein phosphorylation APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 2.58868
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, RELA, SRC, TYR 2.58868
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.58077
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57188
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD17B3, TYR 2.55936
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.55936
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.55848
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 2.55489
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.51342
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50423
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.49454
[BP] GO:0065007 biological regulation ACHE, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.48764
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.4792
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.47112
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.47112
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, KDR, MAP2K1, PDE5A, PIM1, RELA, SRC 2.47112
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.44537
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 2.43674
[BP] GO:0046110 None AOX1, XDH 2.41272
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41272
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.40765
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.38764
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.38622
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES 2.38264
[BP] GO:0080090 regulation of primary metabolic process APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.37732
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, SRC 2.35959
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, MAOA, MAOB 2.3368
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, PPARA, RELA, SRC, TNKS, TNKS2, TOP2A 2.3368
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, MMP2, PPARA, RELA, SRC, TYR 2.32464
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.32084
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PPARA, PTGES 2.32084
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, FUT7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A 2.29716
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MMP9, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.28397
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, TNKS 2.28397
[BP] GO:0042135 None ACHE, MAOA, MAOB 2.28397
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28397
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, PPARA, RELA, SRC, TNKS, TNKS2, TOP2A 2.26838
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.26396
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.23702
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.22884
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.22156
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.20661
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, SRC, TOP2A 2.20661
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.20661
[BP] GO:0051090 regulation of DNA binding transcription factor activity APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.19424
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18081
[BP] GO:0070213 None TNKS, TNKS2 2.18081
[BP] GO:0006145 None AOX1, XDH 2.18081
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18081
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.18018
[BP] GO:0065009 regulation of molecular function APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, XDH 2.1719
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 2.16667
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.15708
[BP] GO:0031401 positive regulation of protein modification process APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, XDH 2.15639
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, MAOA, MAOB, PDE5A, SRC, XDH 2.15639
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, KDR, MAP2K1, PDE5A, PIM1, PPARA, RELA, SRC, TNKS2, XDH 2.15639
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.1477
[BP] GO:0006081 None AKR1B10, CYP1B1, GLO1, RELA 2.13919
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.13438
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 2.12836
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A 2.12432
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.1183
[BP] GO:1901575 None ACHE, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MAOA, MAOB, PDE5A, XDH 2.11049
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, FDPS, HMGCR 2.10962
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HMGCR, HSD11B2, RELA, SRC, TYR 2.10761
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PTPN1, RELA, SRC 2.10422
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, RELA, SRC 2.09672
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.09672
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, MAOA, MAOB 2.07246
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.07202
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.069
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTPN1, RELA, SRC 2.069
[BP] GO:0050790 regulation of catalytic activity APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, SRC, TNKS, XDH 2.06829
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.02536
[BP] GO:0043696 None CDK6, ESRRB 2.01576
[BP] GO:0043697 None CDK6, ESRRB 2.01576
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.01576
[BP] GO:0010641 None F3, SRC 2.01576
[BP] GO:0031399 regulation of protein modification process APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTPN1, RELA, SRC, XDH 2.01143
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MMP2, MMP9, PDE5A, PIM1, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.36014
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.35522
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SHBG, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.68928
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, HMGCR, HSD17B3, KDR, MAP2K1, PTPN1, XDH 2.55341
[CC] GO:0016020 membrane ACHE, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR 2.43511
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1 2.38264
[CC] GO:0043226 organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SHBG, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.18081
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES 2.11686
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, AKR1B1, AKR1B10, APEX1, APP, AR, AURKB, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MMP2, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.0633
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 12.7094
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 12.4208
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PTGES, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 12.4
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.9739
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, MAOB, TYR, XDH 8.07384
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 7.39372
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.81973
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 6.70593
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, MAP3K7, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, TNKS, TNKS2, TOP2A, TYR, XDH 6.66115
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 6.42495
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, MAP3K7, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, TNKS, TNKS2, TOP2A, TYR, XDH 6.36315
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.3321
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.39454
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.14545
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.11122
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.11122
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.89299
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.74818
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.69066
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, MAOB, PTGES, SRC, XDH 4.46044
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG 3.82053
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57745
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.47933
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.39278
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.35522
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MAOB, MAP3K7, MET, MMP9, RELA, TOP2A, TYR, XDH 3.30776
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.30529
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.26184
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTGES, RELA, SRC, TOP2A, XDH 3.19707
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.19707
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP2A 3.00487
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.88489
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.7826
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7826
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.76688
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.6579
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.6309
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.63054
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.58292
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, TOP2A, XDH 2.57805
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, TOP2A, XDH 2.49454
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, TOP2A, XDH 2.49454
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 2.38264
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, RELA, SRC 2.36113
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.3368
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18081
[MF] GO:0005497 None AR, SHBG 2.18081
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.10962
[MF] GO:0032403 protein complex binding ACHE, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, RELA, SRC 2.06059
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01576


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 10.4763
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8438
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6494
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOB, MAOA, HSD17B3, AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 7.6043
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 6.7742
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, RELA, IGF1R 5.4996
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 5.0201
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.2765
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.1947
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.679
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOB, MAOA, ALOX5, CACNA1C 4.4064
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 4.1355
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.9817
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.8761
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.808
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.5675
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MAOA, AOX1, TYR 4.0666
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.1858
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3551
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, CDK6, KDR, BCL2, MET, RELA, IGF1R 2.9129
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 3.0671
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, MAOA, CYP1A2, AOX1 3.0954
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.7392
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0954
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0578
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.4849
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.6165
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.486
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, CACNA1C, PPARA, RELA 2.4743
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.5797
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.7187
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.8969
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.3975
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.2676
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.424
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 2.2416
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.1489
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 2.1966
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2416
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.7711
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 2.1966
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, MAOA, CACNA1C 2.1966
Cocaine addiction_Homo sapiens_hsa05030 MAOB, MAOA, RELA 2.4707
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.8013
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 2.1176
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1966
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.1966
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1876
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.7433
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7587
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.95
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.7172
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4983
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.6312
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.637
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.6153
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, BCL2, RELA 1.6312
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.4955
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, MAOA, CACNA1C 1.5724
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, MAP3K7, IGF1R 1.6124
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.5518
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.4913
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3916
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.3916
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PDE5A, CACNA1C 1.3562
Influenza A_Homo sapiens_hsa05164 FDPS, MAP2K1, RELA 1.3292
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOB, MAOA 1.317
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.317
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.3021
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 1.2057
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9706
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2982
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.3328
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3504
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.8784
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8784
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.9034
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4006
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8703
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.9034
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.8511
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.7585
HTLV-I infection_Homo sapiens_hsa05166 FDPS, RELA 0.5658
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.42
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.6596
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9735
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9481
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8511
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7881
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.969
Axon guidance_Homo sapiens_hsa04360 MET 0.4385
Platelet activation_Homo sapiens_hsa04611 SRC 0.45
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0883
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4713
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.1324
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.1802
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5017
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5098
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5098
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5098
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5191
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5166
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5105
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5154
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5166
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5098
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1799
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5286
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5287
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.1799
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5286
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5423
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5346
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5361
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5286
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.3021
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3803
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3399
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.4082
Peroxisome_Homo sapiens_hsa04146 XDH 0.5423
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.543
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.3399
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2581
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.317
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5514
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5423
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.3645
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5496
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.3021
Pertussis_Homo sapiens_hsa05133 RELA 0.5635
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3995
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5658
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3104
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.342
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5862
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3885
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.317
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5658
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5837
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.3645
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6036
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.6036
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6036
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.6007
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB, MAOA 1.4913
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6467
Legionellosis_Homo sapiens_hsa05134 RELA 0.6505
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6666
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.671
Malaria_Homo sapiens_hsa05144 MET 0.6836
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8013
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6887
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6906
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6887
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB, MAOA 1.6312
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6925
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6906
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.762
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7523
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6919
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7881
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7455
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9965
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8511
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8639
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8289
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8066
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8511
Histidine metabolism_Homo sapiens_hsa00340 MAOB, MAOA 1.9682
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8511
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8703
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MAOA 2.1966
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8639
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.0262
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9859
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0578
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.088
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3512


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)