TCM Prescription: Nü Zhen Granules



Prescription Description
Prescription IDTCMF225
Pinyin NameNü Zhen Ke Li 
Chinese Name女珍颗粒
English NameNü Zhen Granules
Function Description更年期综合征属肝肾阴虚, 心肝火旺证者, 可改善烘热汗出, 五心烦热, 心悸, 失眠
IndicationsKidney yin deficiency pattern, Liver and kidney yin deficiency pattern, Climacteric states
Disease ICD-11 Category SF93 [Kidney yin deficiency pattern (TM1), 肾阴虚证 (TM1) ];
SF5H [Liver and kidney yin deficiency pattern (TM1), 肝肾阴虚证 (TM1) ];
GA30.00 [Menopausal or female climacteric states, 更年期或女性更年期状态 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH2609 Margarita 珍珠粉 TCMH2609
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1276 Nelumbo nucifera 莲子心 TCMH1276 ITSAI3109-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.0431
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2551
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GLO1, HMGCR, PIM1, PPARA, SOAT1, SOAT2, TYR, XDH 10.6356
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 10.6356
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, SOAT1, SOAT2 10.4991
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 9.67284
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 9.0827
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, HMGCR, HSD17B1, HSD17B2, SOAT1, SOAT2 8.84166
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MCL1, MMP2, PPARA, RORC, SRC, TYR 8.32165
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FDPS, HMGCR, HTR1A, SOAT1, SOAT2, TYR 7.24258
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 7.20964
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR 7.01702
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, RORC, SRC, TYR 6.95285
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA, SOAT1, SOAT2 6.93066
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.58278
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, SRC 6.39514
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 6.23574
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, RORC, SRC, TYR 6.10796
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 6.08713
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.8686
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 5.74143
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP4, HMGCR, HSD17B2, HTR1A, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SOAT1, SOAT2, SRC, TYR 5.69235
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.43795
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC 5.40209
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, HTR1A, KDR, MCL1, MET, PPARA, SOAT1, SOAT2, SRC, XDH 5.40209
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.33016
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC 5.12517
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SRC, TOP2A, XDH 5.08775
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, XDH 4.91987
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.89369
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH 4.84911
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH 4.82755
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MCL1, MET, SOAT1, SOAT2, SRC 4.73466
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, XDH 4.59978
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.53697
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MCL1, MET, MMP2, MMP9, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A 4.52927
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 4.48688
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC 4.48033
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, HMGCR, HTR1A, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SRC, TOP2A, XDH 4.48033
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HMGCR, HSD17B1, HSD17B2, HTR1A 4.48033
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, KDR, SRC 4.4705
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, TYR 4.42335
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 4.32603
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.28198
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.23329
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, SRC 4.1952
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, TYR 4.12065
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 3.924
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, RORC, SRC, TOP2A 3.92326
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.89524
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 3.86988
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 3.78673
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 3.77443
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FLT3, HMGCR, HTR1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 3.70003
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.61773
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, XDH 3.61773
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FLT3, HMGCR, HTR1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 3.61315
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.61315
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TOP2A, XDH 3.61154
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 3.58352
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 3.57851
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.53508
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53173
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A 3.50533
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 3.45834
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.42653
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.42653
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.39272
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SRC 3.30253
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.28297
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.28297
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, FLT3, HMGCR, KDR, MCL1, MET, PTPN1, SRC, XDH 3.22102
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HMGCR, PPARA, RORC, SRC 3.20769
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 3.18604
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, HMGCR, KDR, SRC 3.15951
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.1527
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, FLT3, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.13411
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSD17B2, KDR, MCL1, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TYR 3.13411
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MCL1, MMP12, PPARA, SOAT1, SOAT2 3.13411
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS, HMGCR 3.13411
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.1286
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD17B1, HSD17B2 3.1286
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.1286
[BP] GO:0016125 None CYP19A1, CYP1B1, FDPS, HMGCR, SOAT1, SOAT2 3.09618
[BP] GO:0016311 None ALPI, ALPL, APEX1, BCL2, CA3, CDC25B, PTPN1, PTPRS 3.09465
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.09247
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09176
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 3.04143
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FLT3, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.01683
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.00237
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 2.99054
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTPRS 2.84274
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.82546
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.75763
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, MET, SOAT1, SOAT2 2.75763
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TOP2A, XDH 2.75763
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, ESR1, FLT3, FUT7, GLO1, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TOP2A, TYR, XDH 2.69838
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD17B1, HSD17B2 2.698
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.68261
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MMP2, MMP9, RORC, SOAT1, SOAT2, TOP2A 2.67962
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MCL1, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, XDH 2.63248
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTPN1, SRC 2.61338
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 2.61338
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.60857
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 2.60758
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.58324
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.56481
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HMGCR, MMP2, PPARA, SRC, TYR 2.54752
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.54752
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.54752
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.49296
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.47456
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 2.47367
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.47367
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.47367
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.44713
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.43097
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.43097
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.4286
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TOP2A, XDH 2.41829
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.41243
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.3941
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, RORC, SRC 2.3941
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MCL1, MMP2, MMP9, PPARA, PTPN1, SRC, TOP2A 2.38132
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.38132
[BP] GO:0034433 None SOAT1, SOAT2 2.38132
[BP] GO:0034434 None SOAT1, SOAT2 2.38132
[BP] GO:0034435 None SOAT1, SOAT2 2.38132
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38132
[BP] GO:0006066 None AKR1B1, AKR1B10, CYP1B1, FDPS, HMGCR, SOAT1, SOAT2 2.38132
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.38132
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.38132
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.37056
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, HMGCR, PPARA, PTPRS 2.35937
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.3527
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.3527
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, SRC 2.3375
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.29432
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.28713
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FABP4, FLT3, HMGCR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 2.28713
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28254
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC 2.27202
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.27202
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.27077
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.26549
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.26015
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.26015
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.26015
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.26003
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.26003
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24987
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.24987
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.24987
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2 2.24064
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.21088
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.20472
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20472
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.20324
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.17892
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TOP2A, XDH 2.17367
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17367
[BP] GO:0042632 None FABP3, FABP4, SOAT1, SOAT2 2.17367
[BP] GO:0055092 None FABP3, FABP4, SOAT1, SOAT2 2.17367
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.17367
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.17367
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17367
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.16454
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.16454
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TOP2A, XDH 2.14823
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TOP2A, XDH 2.13104
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.10004
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.09514
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.02119
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, HSD17B2, MMP2, MMP9, SRC, TOP2A 2.00749
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, KDR, MCL1, MMP2, MMP9, PIM1, PTPN1, PTPRS, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 2.68847
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 2.50252
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, HMGCR, KDR, PTPN1, SOAT1, SOAT2, XDH 2.26015
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.87109
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 1.82016
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2845
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 15.4591
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.3133
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 13.3133
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2297
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SOAT1, SOAT2, SRC, TOP2A, TYR, XDH 12.2154
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 10.3617
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 10.064
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, FDPS, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TOP2A, TYR, XDH 8.038
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TOP2A, TYR, XDH 5.69235
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.48688
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 3.96668
[MF] GO:0005496 steroid binding ESR1, ESR2, HSD17B1, RORC, SOAT1, SOAT2 3.89585
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58668
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.4129
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.34063
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.22102
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, SOAT1, SOAT2, SRC, XDH 3.1286
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.93428
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 2.90072
[MF] GO:0034736 None SOAT1, SOAT2 2.71767
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.71767
[MF] GO:0004772 None SOAT1, SOAT2 2.71767
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.6312
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.62451
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.61338
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.60827
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.51817
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.51817
[MF] GO:0042578 None ADORA1, ALPI, ALPL, APEX1, CA3, CDC25B, PTPN1, PTPRS 2.44871
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.41243
[MF] GO:0016788 None ACHE, ADORA1, ALPI, ALPL, APEX1, CA1, CA2, CA3, CDC25B, PTPN1, PTPRS 2.3941
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.28863
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.26015
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, TOP2A, TYR, XDH 2.2498
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.17367
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, FABP3, FABP4, HSD17B1, PPARA, RORC, SOAT1, SOAT2 2.17367
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17367
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.05182
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A 2.02119


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.7093
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8851
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9176
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, AKR1B1, HMGCR, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 4.4868
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0985
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0985
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.6024
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8024
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 3.225
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.6334
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0002
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0547
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, HTR1A, DRD1, DRD2, PPARA 2.4694
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.8758
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.466
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.4046
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6196
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, HTR1A, DRD1, DRD2 1.9646
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9948
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.7199
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, MCL1, IGF1R 1.6968
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8761
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 1.8595
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4402
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5725
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.379
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, MCL1 1.3116
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3116
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0502
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3116
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2779
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0511
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0511
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2324
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2943
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.3889
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2145
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0177
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.934
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0511
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.945
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2303
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.247
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9867
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9504
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.2752
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1476
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0502
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2145
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR1A 0.945
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.8315
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.934
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.934
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.934
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8798
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9031
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8274
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8315
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7199
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7452
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6438
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7183
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7183
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6084
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8821
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2524
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2524
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3008
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3107
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6944
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3519
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3456
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3417
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3363
Influenza A_Homo sapiens_hsa05164 FDPS 0.3456
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3858
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3362
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4004
Platelet activation_Homo sapiens_hsa04611 SRC 0.4179
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3826
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3965
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3708
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3965
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4045
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3965
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4179
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4045
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4179
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4454
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4179
Axon guidance_Homo sapiens_hsa04360 MET 0.4132
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4726
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4909
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4757
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4726
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4793
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4951
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4793
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4793
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4909
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4909
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4909
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4909
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4909
Peroxisome_Homo sapiens_hsa04146 XDH 0.4951
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.53
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 1.9646
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5567
Glioma_Homo sapiens_hsa05214 IGF1R 0.5567
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.547
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.558
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5556
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5567
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5546
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5567
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5479
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5567
Shigellosis_Homo sapiens_hsa05131 SRC 0.5567
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.902
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6174
Malaria_Homo sapiens_hsa05144 MET 0.628
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6394
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6426
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.2167
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6882
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7256
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7577
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7731
Base excision repair_Homo sapiens_hsa03410 APEX1 0.744
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8058
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7652
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7964
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9682


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)