Prescription Description
| Prescription ID | TCMF2221 |
| Pinyin Name | Zhuang Yao Jian Shen Wan |
| Chinese Name | 壮腰健肾丸 |
| English Name | Loins-Strengthening and Kidney-Invigorating Bolus |
| Function Description | 腰痛, 痹病, 遗精 |
| Indications | Involuntary ejaculation disorder, Lumbago disorder, Arthritis, Rheumatoid arthritis |
| Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
| Human Tissues Associated with Indication | SkeletalMuscle, Kidney |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH693 | Cudrania cochinchinensis | 狗脊 | TCMH693 | |
| TCMH1133 | Rosa laevigata | 金樱子 | TCMH1133 | ITSAJ4477-14 |
| TCMH843 | radix kadsurae coccineae | 黑老虎根 | TCMH843 | |
| TCMH1791 | Loranthus parasiticus | 桑寄生 | TCMH1791 | |
| TCMH1036 | Spatholobus suberectus | 鸡血藤 | TCMH1036 | ITSAK2607-14 |
| TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
| TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
| TCMH967 | Polygonatum sibiricum | 黄精 | TCMH967 | ITSAH4762-14 |
| TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
| TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
Showing 1 to 10 of 89 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 66 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, SRC | 2.03284 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGS2, SRC | 2.4783 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, INSR, PTGS2, SMAD3 | 2.18209 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, PIK3CA, PIK3CB, PTGS2, TEK | 2.17613 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK | 2.93703 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 4.0555 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, PIK3CA, PIK3CB, RORC, SMAD3, SRC | 2.75479 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.26597 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, CDC25B, EGFR, FLT3, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.07296 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | KDR, PIK3CB, SMAD3, SRC, TEK | 2.87605 |
Showing 1 to 10 of 392 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.9014 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.7359 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6653 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 1.0119 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, PIM1, PIK3CB | 3.1087 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 3.1219 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4049 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.2535 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, IGF1R | 2.838 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.6407 |
Showing 1 to 10 of 162 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples