TCM Prescription: Vaginal Bleeding Decoction



Prescription Description
Prescription IDTCMF2208
Pinyin NameGu Chong Tang
Chinese Name固冲汤
English NameVaginal Bleeding Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH789 Lonicera japonica 海螵蛸 TCMH789 ITSAI3881-14
TCMH2217 NA 茜草 TCMH2217
TCMH2739 Carbonized vagina trachycarpus wagnerianus 棕榈炭 TCMH2739
TCMH2175 Galla chinensis 五倍子 TCMH2175
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD17B1, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, SLC1A1, SMAD3, SRC, TEK, XDH 8.99563
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.49477
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.49477
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, RORC, SMAD3, SRC, TEK 7.40578
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HMGCR, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, RORC, SRC, TEK 7.26348
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.22853
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.11457
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.90154
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.90154
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, PPARA, RORC, SMAD3, SRC, TEK 6.30893
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.30893
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, MET, PPARA 6.24876
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.24625
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.24625
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.24625
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.22344
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.12722
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.12518
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.01819
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.95118
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.95118
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC 5.94326
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.92605
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 5.82109
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.71176
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 5.65602
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, POLA1, POLB, SMAD3, SRC 5.58144
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 5.55408
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, HMGCR, HSD11B1, HSD17B1 5.48609
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.40529
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.40529
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 5.40529
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.38364
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.37961
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.2558
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 5.1636
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 5.06863
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.03312
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 4.98864
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.85803
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 4.85803
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 4.84115
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.84115
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.84115
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK 4.84115
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, HMGCR, HSPA1A, PIM1, PPARA, XDH 4.84115
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.74747
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.50177
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.41089
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 4.41089
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK 4.4062
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 4.37731
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS, HMGCR 4.35235
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.28172
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 4.28172
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HMGCR, PPARA, RORC, SRC, TEK 4.20543
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.20543
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.15115
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.15072
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.15072
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 4.13198
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.13198
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.11659
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.04969
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.04969
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 4.04969
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 4.03922
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.02413
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.9649
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.96241
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.91065
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.90761
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.89905
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 3.88465
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 3.88385
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 3.87725
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.84645
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.83739
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.83739
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.82816
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.79014
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.69874
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.69086
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC 3.68429
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 3.68429
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS 3.64775
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.6422
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.63143
[BP] GO:0030335 positive regulation of cell migration EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.61709
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 3.60996
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.60596
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.54366
[BP] GO:2000147 positive regulation of cell motility EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.49968
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HMGCR, HSD11B1, INSR, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK 3.48122
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.47159
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1 3.4511
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.44033
[BP] GO:0051272 positive regulation of cellular component movement EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.41056
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.41056
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.39485
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, RORC, SRC 3.3716
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.36029
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK 3.35022
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.34991
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD11B1, HSD17B1 3.31453
[BP] GO:0040017 positive regulation of locomotion EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.3061
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.29521
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.25301
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25301
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.22158
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.21061
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 3.21061
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.18663
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 3.18663
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HMGCR, HSD11B1, HSD17B1 3.17383
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.16429
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 3.13983
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.03982
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.01566
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, INSR, KDR, MMP9, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK 2.95492
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.94384
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.92571
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.91702
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.88344
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.87316
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.87251
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.85351
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.81701
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.7783
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.76743
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 2.72469
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3 2.67593
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.6627
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.6627
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.6627
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.6627
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.6627
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.65051
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, F10, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.65051
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.64875
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.64064
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.63928
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.63928
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, POLB, SRC 2.63928
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.61225
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.5853
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.58469
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.58283
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, FDPS, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.56316
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.56316
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.55857
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.55432
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.53676
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.53676
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 2.53676
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK 2.53676
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.50943
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.50892
[BP] GO:0099566 None GRM1, GRM5 2.50419
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50419
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.47726
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.46591
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.4631
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.44345
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.4389
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.42324
[BP] GO:0042391 None ADORA1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.40231
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.40231
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK 2.39883
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1 2.37486
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.35607
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.35059
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.32711
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.3228
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30103
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.29684
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK 2.29388
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.2848
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.2848
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.2789
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.27067
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27067
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27067
[BP] GO:0051894 None KDR, SMAD3, TEK 2.27067
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.27067
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.27067
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27067
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.26663
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.26555
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD11B1, HSD17B1 2.25667
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.24981
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.24038
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.21973
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.21973
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.1884
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1884
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, EGFR, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK 2.18054
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.15903
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13724
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.12098
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, PTPN1, SRC 2.10473
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.07545
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.07094
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK 2.06468
[BP] GO:0045936 None DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.06311
[BP] GO:0010563 None DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.05946
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.05523
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.05523
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.05389
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, XDH 2.03089
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.03089
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.03089
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03089
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.03047
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.00657
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 2.00657
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 5.40748
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, DUSP3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 4.16849
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 4.13198
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, F10, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.95237
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.54366
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.03987
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.94384
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.51085
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.43814
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.39883
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.39883
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 2.37562
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.2306
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, PTPN1, SLC1A1, SRC, TEK 2.21668
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.4689
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, SRC, TEK, XDH 8.64386
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.94408
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 7.51956
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 7.51956
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.34351
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.86361
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.70496
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.30893
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.5344
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.48311
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 4.84115
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.84115
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 4.80139
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 4.80139
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.64096
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.4062
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.40375
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 4.20543
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 4.19713
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.03701
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.92785
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.78493
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.7011
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.66529
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, XDH 3.65684
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.60996
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, XDH 3.40447
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.37265
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.36904
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SLC1A1, SRC, TEK, XDH 3.30114
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, XDH 3.16097
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.97223
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.97223
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.80178
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.78146
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.75084
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, XDH 2.66127
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, POLA1, SRC, XDH 2.59699
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.54363
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.50943
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.50943
[MF] GO:0099583 None GRM1, GRM5 2.50419
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1 2.40231
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.32711
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.2848
[MF] GO:0004971 None GRIA2, GRIA4 2.27067
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.27067
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, XDH 2.22623
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.21973
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.2187
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.1748
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08697
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.06311


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2638
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0649
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2946
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.0749
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 6.4286
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2148
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4521
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.9404
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.2971
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.232
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 4.1279
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7303
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, HMGCR, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.6421
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.5021
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2006
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.2456
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.195
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2398
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.7338
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.7555
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1, EGFR 2.9462
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.45
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0437
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.6366
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.7414
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7602
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4322
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2928
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3597
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2682
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.263
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2165
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.8918
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0255
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8526
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2577
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9562
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7897
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5947
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5465
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.6576
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.5064
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3753
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1, EGFR 1.3432
HTLV-I infection_Homo sapiens_hsa05166 POLB, FDPS, SMAD3 1.0121
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1424
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0922
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1537
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3463
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1122
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1104
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.375
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4062
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9718
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8925
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1401
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9718
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.965
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9212
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9038
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9458
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8871
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8821
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3432
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8536
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8821
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8871
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2344
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.3432
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3861
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3463
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8333
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.699
Influenza A_Homo sapiens_hsa05164 FDPS, HSPA1A 0.7833
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3463
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7833
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6964
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3036
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6807
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3445
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3521
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3757
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3617
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3516
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5146
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3952
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4031
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4459
Platelet activation_Homo sapiens_hsa04611 SRC 0.4701
Axon guidance_Homo sapiens_hsa04360 MET 0.4617
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4701
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4944
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4786
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4944
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5085
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.516
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4943
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.516
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5206
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5082
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5253
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5249
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5346
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5299
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5482
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5367
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5367
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5471
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.536
Peroxisome_Homo sapiens_hsa04146 XDH 0.5482
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5354
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5789
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6576
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5804
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5597
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5774
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5658
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5875
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6026
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5892
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6068
Shigellosis_Homo sapiens_hsa05131 SRC 0.6047
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6153
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8526
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6153
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6474
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6503
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6686
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7277
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6722
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8077
Malaria_Homo sapiens_hsa05144 MET 0.6807
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6836
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6964
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0255
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7501
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7833
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8536
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8162
DNA replication_Homo sapiens_hsa03030 POLA1 0.7783
Base excision repair_Homo sapiens_hsa03410 POLB 0.7951
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8333
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.0519
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8536
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8248
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8536
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0397
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1354


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)