TCM Prescription: Appetite Opening Qi Fries



Prescription Description
Prescription IDTCMF2188
Pinyin NameKai Wei Qi Cao
Chinese Name
English NameAppetite Opening Qi Fries
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH173 Lablab niger 扁豆 TCMH173
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH53 Amomum kravanh 白豆蔻 TCMH53 KT898257
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT108 GRIA1 Glutamate receptor ionotropic, AMPA 1 Ion channel P42261
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, INSR, KDR, MET, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, XDH 12.2556
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, SLC6A3, SMAD3, SRC, TEK, TYR 11.1508
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, SLC6A3, SRC, TEK, TYR 10.9623
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 10.4324
[BP] GO:0007215 None GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1644
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA1, GRIK5, GRM1, GRM5, INSR, MET, POLA1, POLB, SMAD3, SRC 8.10832
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, GRIK5, HTR1A, INSR, SLC1A1, SLC6A2, SLC6A3, SMAD3 7.95458
[BP] GO:0007193 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HTR1A 7.93691
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, POLB, SLC6A3, SRC 7.77065
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, GRIA1, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 7.58266
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, GRIA1, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 7.44989
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR 7.43586
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 7.43586
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP4, GRIA1, GRM1, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 7.43586
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 7.42366
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIA1, GRIK5, GRM1, GRM3, GRM5, GRM8 7.35367
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIA1, GRIK5, GRM1, GRM3, GRM5, GRM8 7.35367
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, SLC6A3, SRC, TEK, TYR 7.27023
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SLC6A3, SRC 7.20646
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, HMGCR, KDR, POLB, SLC6A2, SLC6A3, SRC 7.20357
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.86284
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.86284
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, HTR1A, SLC6A3, TYR 6.61656
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, GPR35, GRIA1, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 6.46494
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TYR 6.24825
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 6.24825
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 6.24355
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 6.16137
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TOP2A, XDH 6.13664
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 6.10482
[BP] GO:0032879 regulation of localization ACHE, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK 6.08274
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.06994
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 5.94951
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.91316
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TYR 5.8286
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.8202
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.75974
[BP] GO:0007188 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HTR1A 5.75974
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 5.73689
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX5, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 5.70256
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 5.70256
[BP] GO:0007268 None CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.60401
[BP] GO:0098916 None CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.60401
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 5.60125
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD4, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 5.60125
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, TOP2A, XDH 5.58582
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 5.54248
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, SMAD3, SRC, TOP2A 5.54063
[BP] GO:0099536 None CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.54063
[BP] GO:0099537 None CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.54063
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 5.50022
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, EGFR, GRM1, HMGCR, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.46076
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, DRD3, EGFR, FLT3, HMGCR, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 5.46076
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 5.42301
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.27171
[BP] GO:0007187 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HTR1A 5.27007
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.21414
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.15921
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.15069
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, HTR1A, SLC6A3, TYR 5.14784
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.1368
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 5.04511
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.97533
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 4.96922
[BP] GO:0099566 None GRIA1, GRM1, GRM5 4.96231
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 4.92063
[BP] GO:0007610 None BCL2, DRD2, DRD3, DRD4, EGFR, GRIA1, GRM1, GRM5, HMGCR, HTR1A, INSR, PPARA, SLC6A3 4.85003
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 4.81044
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, INSR, MET, SRC, TEK, XDH 4.81044
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD2, EGFR, GRM1, GRM3, GRM5, GRM8 4.80068
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, XDH 4.79982
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, PPARA, SRC, TOP2A 4.79151
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 4.72124
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.71715
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.71496
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, FABP3, GPR35, GRIA1, GRM1, GRM5, SMAD3 4.66546
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 4.65749
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.6311
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA1, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 4.61613
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, SRC 4.6129
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.59931
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.51589
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR 4.47934
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46304
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.41953
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.41953
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.40204
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.40204
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 4.38746
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.37272
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 4.34383
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, TBXAS1 4.32985
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.3292
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD2, DRD3, DRD4, HTR1A, SLC6A3 4.27749
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, HTR1A, INSR, MMP12, MMP9, PPARA, SMAD3, SRC 4.22219
[BP] GO:0060078 None DRD4, GRIA1, GRIA2, GRIA4, GRIK5, GRM5 4.22219
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GPR35, GRIA1, GRM1, GRM5, SMAD3 4.12248
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.12248
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.11606
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.11606
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.09306
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.07137
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TEK, TYR 4.05221
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRIA1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 4.04478
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK 4.04478
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.04478
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.99768
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, GRIA1, GRIK5, GRM1, GRM5, POLA1, SMAD3 3.95907
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.95907
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.91548
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.89747
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.87901
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.87901
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.83994
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.83483
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.70464
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SLC6A3, SMAD3, SRC, TEK 3.69639
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.67114
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.67114
[BP] GO:0043408 regulation of MAPK cascade DRD2, DRD4, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, SRC, TEK, XDH 3.66995
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.66995
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.65307
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.65307
[BP] GO:0042391 None BCL2, DRD4, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.64916
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SLC6A2, SMAD3, SRC, TEK, TOP2A 3.60785
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRIA1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.60785
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 3.59035
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HMGCR, HSD17B1, HSD17B2, HTR1A 3.59035
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, DRD4, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, SRC, TEK, XDH 3.57641
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, SLC6A3 3.56408
[BP] GO:0035235 None GRIA1, GRIA2, GRIA4, GRIK5 3.56252
[BP] GO:0007267 None CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.54433
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, HMGCR, HSPA1A, IGF1R, MET, MMP9, SRC, XDH 3.54433
[BP] GO:0007154 None AXL, BCL2, CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.54433
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GPR35, GRIA1, GRM1, GRM5, SMAD3 3.53862
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD2, DRD3, DUSP3, EGFR, GPR35, GRIA1, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 3.53862
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.53253
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.53253
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, GPR35, GRIA1, GRM1, GRM5, SMAD3 3.53253
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD2, DRD3, DUSP3, EGFR, GPR35, GRIA1, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 3.53202
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.52506
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.52506
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, PPARA, SLC6A3, SMAD3, SRC, TEK, TYR 3.48708
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, HSPA1A, SLC6A3 3.48704
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.47119
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2 3.47119
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.404
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, GRIA1, GRIK5, GRM1, GRM5, SMAD3 3.40034
[BP] GO:0043405 regulation of MAP kinase activity DRD4, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, SRC 3.39372
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.3684
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.3684
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CYP19A1, DRD2, DRD3, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, SLC6A3, SMAD3, SRC, TEK, XDH 3.35968
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.35503
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD2, DRD3, EGFR, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SLC6A3, SMAD3, TEK 3.355
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.34268
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.34015
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.34015
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 3.32506
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, SLC6A3, SMAD3, SRC, TEK, XDH 3.32506
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.32363
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.31589
[BP] GO:0042325 regulation of phosphorylation BCL2, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 3.31347
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.29986
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.27894
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.2764
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.2764
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2764
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.27589
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.25909
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.25909
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, GRIA1, GRM1, GRM5, SMAD3 3.25824
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, SRC, TEK, XDH 3.21195
[BP] GO:0001932 regulation of protein phosphorylation BCL2, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 3.21195
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.19032
[BP] GO:0003008 None AKR1B1, BCL2, CYP1B1, DRD2, DRD3, EGFR, GRIA1, GRM1, GRM5, GRM8, HMGCR, HTR1A, INSR, SLC6A3, SRC, TEK, TYR 3.1866
[BP] GO:0023052 None CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.17297
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, GRIA1, GRM1, GRM5, SMAD3 3.1713
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.16998
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.16503
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD2, DRD3, HMGCR, PPARA, SLC6A3, SMAD3, TEK 3.16503
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.16503
[BP] GO:0032413 None DRD2, DRD3, DRD4, GPR35, MMP9 3.15598
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD2, DRD3, EGFR, HMGCR, KDR, SRC 3.15072
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 3.13126
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.11471
[BP] GO:0045936 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, XDH 3.10775
[BP] GO:0010563 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, XDH 3.10265
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, GPR35, GRIA1, GRM1, GRM5, SMAD3 3.08674
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.06272
[BP] GO:0043549 regulation of kinase activity DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, SRC, TEK 3.06103
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC 3.04959
[BP] GO:0042327 positive regulation of phosphorylation BCL2, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, SRC, TEK, XDH 3.03688
[BP] GO:0031399 regulation of protein modification process BCL2, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 2.99479
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, GPR35, GRIA1, GRM1, GRM5, SMAD3 2.99479
[BP] GO:0043271 negative regulation of ion transport BCL2, DRD2, DRD3, DRD4, GPR35, MMP9 2.98591
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, BCL2, CA2, CHRM2, CYP1B1, DRD2, DRD3, EGFR, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SLC6A3, SMAD3, SRC, TEK, XDH 2.98378
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.9789
[BP] GO:0032410 None DRD2, DRD3, DRD4, GPR35, MMP9 2.97651
[BP] GO:1904063 None DRD2, DRD3, DRD4, GPR35, MMP9 2.97651
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97651
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.97651
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.96986
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, GPR35, GRIA1, GRM1, GRM5, SMAD3 2.96615
[BP] GO:0080134 regulation of response to stress CYP19A1, DRD2, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.94542
[BP] GO:0051338 regulation of transferase activity AURKB, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, SRC, TEK 2.93798
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.93798
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.90722
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, SRC 2.90496
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.88918
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.88918
[BP] GO:0080090 regulation of primary metabolic process ADORA3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.87671
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.85614
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 2.85614
[BP] GO:0022898 None BCL2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.8361
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.8361
[BP] GO:0051588 None DRD2, DRD3, DRD4, GRIK5, HTR1A 2.83551
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, POLB, SLC6A3 2.80406
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.79034
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, INSR, PPARA 2.7742
[BP] GO:0007611 None DRD2, DRD3, EGFR, GRIA1, GRM5, HMGCR, INSR 2.76383
[BP] GO:0034766 None DRD2, DRD3, DRD4, GPR35, MMP9 2.7561
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.75494
[BP] GO:0045859 regulation of protein kinase activity DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, SRC 2.73437
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.73218
[BP] GO:0055065 metal ion homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, GPR35, GRIA1, GRM1, GRM5, SMAD3 2.71892
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.71779
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.71457
[BP] GO:0006140 None DRD2, DRD3, DRD4, GRM3, GRM8, INSR, PPARA 2.70715
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.70199
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.70185
[BP] GO:0032409 None BCL2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.70185
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.69065
[BP] GO:0042752 None DRD2, DRD3, DRD4, PPARA, TOP2A 2.69065
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, DRD3, DRD4, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, POLA1, SMAD3, SRC 2.69015
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.68586
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.67373
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.67373
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.66754
[BP] GO:0034763 None DRD2, DRD3, DRD4, GPR35, MMP9 2.65825
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.65272
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HMGCR, HTR1A, MMP12, SRC 2.64868
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.64851
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.64851
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.64851
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.64851
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.64489
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.63612
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.63199
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.62757
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.6143
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.61288
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.59737
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CYP19A1, DRD2, DRD3, DRD4, EGFR, INSR, MMP12, SMAD3, SRC 2.59737
[BP] GO:0045927 positive regulation of growth BCL2, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 2.59625
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.59625
[BP] GO:0051944 None DRD2, DRD4 2.59625
[BP] GO:0060160 None DRD2, DRD3 2.59625
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.59625
[BP] GO:0051586 None DRD2, DRD4 2.59625
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.57964
[BP] GO:0042069 None DRD4, HTR1A, SLC6A3 2.56395
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56395
[BP] GO:0042053 None DRD4, HTR1A, SLC6A3 2.56395
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.55638
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD4, HTR1A, SLC6A2 2.55638
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.55638
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.55638
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.52794
[BP] GO:0031623 None ACHE, DRD2, DRD3, GRIA1 2.52731
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, DRD3, FABP3, FLT3, HMGCR, PPARA, SRC, TEK 2.50739
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.50466
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CSNK2A1, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.49552
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.47216
[BP] GO:0050890 None DRD2, DRD3, EGFR, GRIA1, GRM5, HMGCR, INSR 2.44908
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.44841
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.44841
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, HMGCR, KDR, SRC, TEK 2.4352
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD2, DRD3, DRD4, GPR35, GRIA1, GRM1, GRM5, SMAD3 2.4244
[BP] GO:0051046 None ACHE, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HMGCR, HTR1A, MMP12, SRC 2.41722
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.41316
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, GRM5, HTR1A, MMP9 2.40365
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.39473
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.38698
[BP] GO:0009056 catabolic process ACHE, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 2.38142
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.37898
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.37898
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.37898
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.37582
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.37582
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.37582
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.36094
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.35822
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.35514
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.35514
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35514
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD2, DRD3, EGFR, HMGCR, TYR 2.35514
[BP] GO:0051582 None DRD2, DRD4 2.3546
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3546
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DRD3, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 2.3546
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD2, DRD4, EGFR 2.35419
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, HMGCR, KDR, SRC, TEK 2.34494
[BP] GO:0050877 None CYP1B1, DRD2, DRD3, EGFR, GRIA1, GRM1, GRM5, GRM8, HMGCR, INSR, SLC6A3, TYR 2.33934
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DRD4, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, SRC 2.33835
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.32607
[BP] GO:0051894 None KDR, SMAD3, TEK 2.31074
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31074
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC 2.30418
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 2.3014
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.3014
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3014
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, DRD4, GPR35 2.3014
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD3, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, POLB, SRC, TEK 2.29933
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.28869
[BP] GO:0032270 positive regulation of cellular protein metabolic process BCL2, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.28814
[BP] GO:0031401 positive regulation of protein modification process BCL2, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, SRC, TEK, XDH 2.28395
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 2.27918
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.27186
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.26287
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, SLC6A3 2.26074
[BP] GO:0044057 None ADORA3, CHRM2, DRD2, DRD3, EGFR, GPR35, GRM1, SLC1A1, SMAD3 2.25685
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.25494
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.25119
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GRM5, IGF1R, INSR, SRC 2.24365
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.23856
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.23128
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23128
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.23128
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, BCL2, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.22493
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HMGCR 2.22352
[BP] GO:0060079 None GRIA1, GRIA2, GRIA4, GRIK5 2.22352
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.2149
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIM1, SLC6A3, SMAD3 2.2149
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 2.21387
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.1834
[BP] GO:0090325 None DRD2, DRD3 2.1834
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.16598
[BP] GO:0007612 None DRD2, DRD3, GRM5, HMGCR, INSR 2.16598
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.16585
[BP] GO:0009314 response to radiation AURKB, BCL2, DRD2, DRD3, EGFR, HMGCR, POLB, TYR 2.15149
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.14707
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.14657
[BP] GO:0050708 None ACHE, DRD2, DRD3, DRD4, EGFR, HMGCR, MMP12, SRC 2.1414
[BP] GO:0032412 None DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.11888
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC 2.11627
[BP] GO:0033674 positive regulation of kinase activity DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, SRC, TEK 2.11627
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.11627
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.11627
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.09757
[BP] GO:0009893 positive regulation of metabolic process AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.09757
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, SRC, TYR 2.09594
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.09594
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2 2.09343
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.09343
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, EGFR 2.08944
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, SMAD3, SRC 2.08906
[BP] GO:0002209 None BCL2, DRD4, HTR1A 2.0842
[BP] GO:0001662 None BCL2, DRD4, HTR1A 2.0842
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.0842
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.0842
[BP] GO:0051347 positive regulation of transferase activity AURKB, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, SRC, TEK 2.08356
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1 2.07909
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CYP1A1, DRD3, DUSP3, INSR 2.0781
[BP] GO:0009892 negative regulation of metabolic process APEX1, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, XDH 2.07558
[BP] GO:0034762 None BCL2, CA2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.06245
[BP] GO:0009410 None DRD2, DRD3, DRD4, EGFR, SLC6A3 2.05732
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM2, DRD2, DRD3, DRD4, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, INSR, SRC 2.05732
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.05732
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05732
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05732
[BP] GO:0045744 None DRD2, DRD3, MET 2.05732
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.05732
[BP] GO:0032415 None DRD3, DRD4 2.05732
[BP] GO:0051934 None SLC6A2, SLC6A3 2.05732
[BP] GO:0021984 None DRD2, SLC6A3 2.05732
[BP] GO:0090494 None SLC6A2, SLC6A3 2.05732
[BP] GO:0090493 None SLC6A2, SLC6A3 2.05732
[BP] GO:0051583 None SLC6A2, SLC6A3 2.05732
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.0555
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.05273
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.0485
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.04386
[BP] GO:0040018 None BCL2, DRD2, SLC6A3 2.02718
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.02718
[BP] GO:0042596 None BCL2, DRD4, HTR1A 2.02718
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.02079
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.00292
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.00292
[BP] GO:0002791 None ACHE, DRD2, DRD3, DRD4, EGFR, HMGCR, MMP12, SRC 2.00287
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALPI, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, FLT3, GLO1, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, MMP2, PIM1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK 6.50396
[CC] GO:0044459 plasma membrane part ADORA3, AXL, CA2, CA4, CA9, CHRM2, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TEK 6.50396
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK 6.36268
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM2, DRD2, EGFR, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 6.2668
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK 6.03833
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, FUT7, GLO1, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, MMP2, PIM1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TYR 4.92724
[CC] GO:0044456 None ACHE, CHRM2, DRD2, DRD4, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 4.49558
[CC] GO:0044425 membrane part ACHE, ADORA3, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, FUT7, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TBXAS1, TEK, TYR 4.47934
[CC] GO:0097060 None CHRM2, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.87901
[CC] GO:0043235 receptor complex EGFR, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.54433
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.47562
[CC] GO:0043005 None CA2, CHRM2, DRD2, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.31589
[CC] GO:0014069 None DRD2, GRIA1, GRIK5, GRM1, GRM3, GRM5, SRC 3.16503
[CC] GO:0099572 None DRD2, GRIA1, GRIK5, GRM1, GRM3, GRM5, SRC 3.16503
[CC] GO:0098794 None DRD2, DRD4, GRIA1, GRIA2, GRIA4, GRM3 2.8361
[CC] GO:0008328 None GRIA1, GRIA2, GRIA4, GRIK5 2.75659
[CC] GO:0098878 None GRIA1, GRIA2, GRIA4, GRIK5 2.70185
[CC] GO:0042995 cell projection AKR1B1, CA2, CHRM2, DRD2, DRD3, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC, TEK 2.69065
[CC] GO:0031224 None ACHE, ADORA3, ALPI, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TBXAS1, TEK, TYR 2.59625
[CC] GO:0098802 None GRIA1, GRIA2, GRIA4, GRIK5, GRM1, INSR 2.58513
[CC] GO:0120025 None AKR1B1, CA2, CHRM2, DRD2, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC, TEK 2.44841
[CC] GO:0043197 None DRD2, GRIA1, GRIA2, GRIA4, GRM3 2.38503
[CC] GO:0044309 None DRD2, GRIA1, GRIA2, GRIA4, GRM3 2.36094
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 2.30022
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 2.28617
[CC] GO:0097458 None CA2, CHRM2, DRD2, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, SLC6A2, SLC6A3, SRC 2.1965
[CC] GO:0032281 None GRIA1, GRIA2, GRIA4 2.19162
[CC] GO:0009986 cell surface ACHE, AXL, CA4, EGFR, GRIA1, MET, SLC6A2, SLC6A3, TEK 2.14567
[CC] GO:0016021 None ADORA3, ALPI, ALPL, AXL, CA12, CA14, CA9, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TBXAS1, TEK, TYR 2.07261
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 10.4324
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.89056
[MF] GO:0008066 None GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 9.89056
[MF] GO:0030594 None CHRM2, DRD2, DRD3, DRD4, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A 9.30817
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 8.44149
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.95458
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PPARA, TEK 7.43586
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, TEK 7.43586
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, TEK 7.43586
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.3376
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A3, SRC, TEK, TOP2A 7.12544
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.58452
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PPARA, TEK 6.58452
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 6.50396
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 6.50396
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, TBXAS1, TOP2A, TYR, XDH 6.46494
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PPARA, TEK 6.38292
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.28729
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.2668
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.30066
[MF] GO:0099583 None GRIA1, GRM1, GRM5 4.96231
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.64063
[MF] GO:0004971 None GRIA1, GRIA2, GRIA4 4.46304
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, HTR1A, SLC6A3 4.34383
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, TBXAS1, TOP2A, TYR, XDH 4.13144
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.05652
[MF] GO:0004970 None GRIA1, GRIA2, GRIA4, GRIK5 4.04478
[MF] GO:0005234 None GRIA1, GRIA2, GRIA4, GRIK5 4.04478
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.95907
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3 3.82614
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.76337
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73156
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.62327
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.61219
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC 3.59035
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, SLC6A3, SMAD3 3.57218
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.56252
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.53253
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.5083
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.38681
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.35109
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SLC6A3, SMAD3, SRC 3.31589
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.18025
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.09637
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.06372
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.03244
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.02455
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.93798
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.79268
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.79034
[MF] GO:0005231 None GRIA1, GRIA2, GRIA4, GRIK5 2.70185
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SLC1A1, SRC, TEK, TOP2A, XDH 2.67373
[MF] GO:0022824 None GRIA1, GRIA2, GRIA4, GRIK5 2.64951
[MF] GO:0022835 None GRIA1, GRIA2, GRIA4, GRIK5 2.64951
[MF] GO:0005330 None SLC6A2, SLC6A3 2.59625
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, DRD2, DRD4, EGFR, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, SMAD3, TOP2A, TYR, XDH 2.47325
[MF] GO:0098960 None GRIA1, GRM1, GRM5 2.44841
[MF] GO:0001540 amyloid-beta binding ACHE, GRIA1, GRIA2, INSR 2.3977
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, SLC6A3 2.38503
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.34238
[MF] GO:0099094 None GRIA1, GRIA2, GRIA4, GRIK5 2.3014
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.23856
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.1965
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.19483
[MF] GO:0043559 insulin binding IGF1R, INSR 2.1834
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, HMGCR, HSD17B1, HSD17B2, XDH 2.16598
[MF] GO:0051721 None BCL2, HMGCR, SLC6A3 2.15165
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.11627
[MF] GO:0005230 None GRIA1, GRIA2, GRIA4, GRIK5 2.10989
[MF] GO:0005329 None SLC6A2, SLC6A3 2.05732
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05732
[MF] GO:0004035 alkaline phosphatase activity ALPI, ALPL 2.05732
[MF] GO:0019899 enzyme binding ALPI, AURKB, BCL2, CYP1A1, CYP1A2, DUSP3, EGFR, GRM5, HMGCR, HSPA1A, MET, POLA1, POLB, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A 2.02814
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.01354


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA1, GRIA2, GPR35, GRIK5, HTR1A, GRM1, GRM3, GRM5, ADORA3, GRM8, DRD2, DRD3, DRD4, GRIA4 11.296
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.4401
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1651
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA1, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 8.0668
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.6649
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.8791
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA1, GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 5.1905
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.9097
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.1905
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.7077
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 3.9401
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.0505
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA1, GRIA2, HTR1A, DRD2, PPARA, GRIA4 4.0693
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.9097
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP19A1, POLA1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 3.719
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.6576
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1, EGFR 3.8389
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6101
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA1, GRIA2, GRM5, GRM1, GRIA4 3.6511
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.6323
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.2992
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.6576
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1219
Long-term depression_Homo sapiens_hsa04730 GRIA1, GRIA2, GRM1, IGF1R 3.3952
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.2329
Amphetamine addiction_Homo sapiens_hsa05031 GRIA1, GRIA2, SLC6A3, GRIA4 3.2624
Long-term potentiation_Homo sapiens_hsa04720 GRIA1, GRIA2, GRM5, GRM1 3.2703
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.6819
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR 2.5539
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2329
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.1637
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, GRM1, EGFR 1.9045
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2048
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1637
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9045
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1208
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1637
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9027
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.672
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8851
Circadian entrainment_Homo sapiens_hsa04713 GRIA1, GRIA2, GRIA4 1.8419
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.097
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA1, GRIA2, BCL2 2.4671
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3949
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.6078
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 1.9739
Nicotine addiction_Homo sapiens_hsa05033 GRIA1, GRIA2, GRIA4 2.7387
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.5575
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7387
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.0935
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.0491
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.8993
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.919
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0628
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.0935
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8626
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR1A 0.9041
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0276
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7981
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.8693
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8091
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2788
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8761
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7937
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7937
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0491
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2551
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0297
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7937
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1294
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3311
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7937
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.768
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3246
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2499
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7577
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7577
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2788
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7366
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.1979
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR 0.7366
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7151
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2551
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3068
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3141
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.7151
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7151
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6413
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.2788
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3136
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3286
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5385
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3691
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3771
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3928
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3928
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4016
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4223
Axon guidance_Homo sapiens_hsa04360 MET 0.417
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4223
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4276
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4304
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4522
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4747
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.466
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4734
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4734
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4747
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4734
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4761
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4657
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4756
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4943
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5013
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4943
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4959
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4935
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4927
Peroxisome_Homo sapiens_hsa04146 XDH 0.5022
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5385
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5385
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5385
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.527
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5452
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5604
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5468
Shigellosis_Homo sapiens_hsa05131 SRC 0.5624
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5624
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5924
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6091
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6123
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6304
Malaria_Homo sapiens_hsa05144 MET 0.6459
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6501
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6629
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7151
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.7314
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7366
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.765
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7937
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7151
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7577
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9743
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7366
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7693
DNA replication_Homo sapiens_hsa03030 POLA1 0.7366
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7577
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7366
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7937
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7937
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8309
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.3302
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1835


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)