TCM Prescription: Kidney Nourishing Bolus



Prescription Description
Prescription IDTCMF2174
Pinyin NameZi Shen Rong Jing Wan
Chinese Name滋肾蓉精丸
English NameKidney Nourishing Bolus
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1237 Mycobacterium kansasii
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 14.3386
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, NR3C1, PIK3CA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 12.5273
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, ESR1, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, NR3C1, PIK3CA, PTGS2, RORC, SLC6A3, SRC, TEK, TRPV1, TYR 10.7905
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, NR3C1, PIK3CA, PTGS2, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 10.7905
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A3, SRC, TEK, TRPV1, TYR 10.4297
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 9.73184
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, SMAD3, TRPV1 9.2661
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.2661
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.26082
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 9.14752
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, DRD4, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 9.14752
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1 9.12496
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC, TRPV1 8.85639
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.62079
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.47467
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.3638
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, NR3C1, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 8.20851
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.95215
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.81611
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC, TRPV1 7.49795
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.49795
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.43893
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC, TRPV1 7.43406
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.42642
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.33279
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.33279
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.28107
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SRC, TYR 7.23026
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, PIK3CA, PIM1, PTGS2, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 7.21803
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, PTGS2, SLC6A3, SRC 7.1818
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, KDR, NR3C1, PTGS2, SLC6A2, SLC6A3, SRC, TRPV1 7.14909
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HSPA1A, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 7.03618
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 7.0104
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PTGS2, SRC, TEK, TRPV1 6.98906
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 6.9644
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.96089
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 6.93792
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, NR3C1, PTGS2, SMAD3, SRC, TEK, TRPV1 6.93792
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, SLC6A3, TYR 6.89316
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, SLC1A1, TRPV1 6.85504
[BP] GO:0007193 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 6.85504
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 6.83395
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.81451
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HSPA1A, IGF1R, KDR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.81173
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.61759
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1 6.52497
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, GPR35, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 6.52299
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.46165
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.21447
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.21249
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.21249
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 6.21249
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 6.15947
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.11697
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.10942
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 6.03395
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.93549
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.90162
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.88502
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TRPV1 5.84797
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.79652
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, SMAD3, SRC, TEK, TYR 5.72479
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.71426
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 5.6853
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.67014
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, SLC1A1, TRPV1 5.57378
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 5.57378
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 5.57378
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.5073
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3, TRPV1 5.48765
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TYR, XDH 5.47277
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PTGS2, SLC6A3, SRC, TEK, TRPV1, TYR 5.47165
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.46568
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 5.46568
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.43158
[BP] GO:0030334 regulation of cell migration ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 5.39387
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.35836
[BP] GO:0040012 regulation of locomotion ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 5.35836
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.34818
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.33094
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B2 5.2911
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, KDR, SLC6A3, SRC 5.26508
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B2 5.26399
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.24755
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.19127
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 5.10186
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 5.10176
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PTGS2, SLC6A3, SRC, TEK, TRPV1, TYR 5.09
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.09
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, DRD2, DRD4, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.09
[BP] GO:2000145 regulation of cell motility ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 5.08574
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DRD2, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.05086
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.0155
[BP] GO:0031399 regulation of protein modification process ALOX15, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.0084
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, HSPA1A, SLC6A3 4.94524
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.9401
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1 4.9401
[BP] GO:0043549 regulation of kinase activity CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.92741
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.89496
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.8893
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.83424
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 4.81094
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, RORC, SRC 4.80978
[BP] GO:0033674 positive regulation of kinase activity CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.78758
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.783
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.7655
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.75034
[BP] GO:0007188 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.75004
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PIM1, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 4.74248
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, PIM1, PTGS2, TEK 4.73414
[BP] GO:0007268 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.73414
[BP] GO:0098916 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.73414
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.68268
[BP] GO:0051270 regulation of cellular component movement ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.68029
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.65999
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B2 4.65999
[BP] GO:0099536 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.65999
[BP] GO:0099537 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.65999
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.65999
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.65999
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3, TRPV1 4.63886
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD2, DRD3, EGFR, KDR, PIK3CB, PTGS2, SRC, TRPV1 4.62897
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.62897
[BP] GO:0045859 regulation of protein kinase activity CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.62577
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, PIM1, PTGS2, PTPN1, SRC 4.58724
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, SLC1A1, SLC6A2, SLC6A3, TRPV1 4.58703
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.58263
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.58263
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.57872
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.55493
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 4.55241
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1, RORC 4.54294
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 4.54278
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.54278
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.53696
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.51795
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.51023
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.47415
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, PTGS2, SLC6A3 4.45649
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.45072
[BP] GO:0032225 None DRD2, DRD3, DRD4, PTGS2 4.42534
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.42534
[BP] GO:0031401 positive regulation of protein modification process ALOX15, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.41092
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, SMAD3 4.39851
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 4.38233
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 4.34818
[BP] GO:0007187 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.33264
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.33264
[BP] GO:0060078 None DRD4, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.31804
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.31791
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.31791
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SRC, XDH 4.31724
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.24562
[BP] GO:0043405 regulation of MAP kinase activity DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 4.24466
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.22513
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.22513
[BP] GO:0007154 None AXL, BCL2, CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, SLC6A2, TEK, TRPV1 4.18186
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HSPA1A, INSR, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TRPV1 4.18056
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.18056
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, EGFR, GRM1, HSPA1A, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 4.13386
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 4.12705
[BP] GO:0043085 positive regulation of catalytic activity AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 4.1034
[BP] GO:0055065 metal ion homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 4.1034
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.10235
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 4.09898
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.08836
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.05879
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.05879
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 4.01518
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.99892
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, PTGS2, SRC, TRPV1 3.99015
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC, TRPV1 3.97977
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.97977
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.97977
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.97927
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.96447
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, NR3C1, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.94435
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.94316
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.86085
[BP] GO:0048585 negative regulation of response to stimulus ALOX12, ALOX15, BCL2, CYP19A1, DRD2, DRD3, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 3.85444
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 3.83963
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.83187
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 3.79264
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.77341
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ALOX12, AXL, BCL2, CA2, CHRM2, CYP1B1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIM1, PTGS2, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.74936
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, EGFR, PIK3CB, PTGS2 3.73733
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.72472
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.72472
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.72472
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 3.692
[BP] GO:0042391 None BCL2, DRD4, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.69154
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.68634
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, NR3C1, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.68245
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, HSPA1A, KDR, MET, PIM1, PTGS2, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1 3.67643
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.67631
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, SLC6A3, TYR 3.66756
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.66381
[BP] GO:0032147 activation of protein kinase activity DRD2, DRD4, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.66026
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HSD11B1, HSD17B2 3.62125
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.61987
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.61987
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.59659
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 3.56364
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.55421
[BP] GO:0044057 None ADORA3, CHRM2, DRD2, DRD3, EGFR, GPR35, GRM1, PTGS2, SLC1A1, SMAD3, TRPV1 3.55405
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.54876
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.53943
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.50349
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 3.4945
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.48293
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, DRD4, GPR35, PTGS2 3.44635
[BP] GO:0007610 None BCL2, DRD2, DRD3, DRD4, EGFR, GRM1, GRM5, INSR, PTGS2, SLC6A3, TRPV1 3.40824
[BP] GO:0045927 positive regulation of growth ALOX12, BCL2, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 3.40824
[BP] GO:0040008 regulation of growth ALOX12, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIK3CA, PIM1, SLC6A3, SMAD3 3.39741
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, PTGS1, PTGS2, SRC 3.38911
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, PIK3CA, SLC6A3 3.38911
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, ALOX12, DRD2, MET, PIK3CA, TRPV1 3.38215
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.38122
[BP] GO:0032101 regulation of response to external stimulus ALOX12, CYP19A1, DRD2, DRD3, EGFR, ESR1, FABP4, KDR, MET, PTGS2, SLC6A3, SMAD3, TEK 3.33603
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, INSR, PTGS2, SRC, TEK, TRPV1 3.33592
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.33592
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.33592
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33592
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.33397
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD2, DRD4, EGFR, PTGS2 3.33181
[BP] GO:0043406 positive regulation of MAP kinase activity DRD4, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 3.31835
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, SMAD3, SRC, TEK 3.31137
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.30526
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8 3.28642
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.261
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8 3.261
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.261
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.24134
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, NR3C1, PTGS2, SMAD3, SRC, TRPV1 3.23425
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.22027
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.21859
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD3, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.16834
[BP] GO:0051246 regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.16172
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.15607
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.15333
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.13645
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1, TRPV1 3.13524
[BP] GO:0003008 None AKR1B1, BCL2, CYP1B1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, INSR, PIK3CA, PTGS2, SLC6A3, SRC, TEK, TRPV1, TYR 3.12772
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.11358
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CYP19A1, DRD2, DRD3, DRD4, EGFR, INSR, PTGS2, SMAD3, SRC, TRPV1 3.10073
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.06531
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 3.04066
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2 3.03205
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.02495
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 3.02495
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.02495
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.02495
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.02495
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 3.02374
[BP] GO:0043271 negative regulation of ion transport BCL2, DRD2, DRD3, DRD4, GPR35, PTGS2 3.01052
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SMAD3, SRC, XDH 2.95884
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.95371
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.95136
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SMAD3, SRC, XDH 2.94618
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, INSR, PIK3CA, PIK3CB, SRC 2.94336
[BP] GO:0009410 None DRD2, DRD3, DRD4, EGFR, NR3C1, SLC6A3 2.93254
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.93229
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.93229
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, EGFR, HSPA1A, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC6A2, SMAD3, SRC, TEK, TRPV1 2.92026
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.90432
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.9017
[BP] GO:0007267 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 2.89585
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.89533
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.89452
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.89314
[BP] GO:0080134 regulation of response to stress ALOX12, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.8757
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.85263
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.84607
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.83478
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.82531
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.77206
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.77206
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.75667
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.71747
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.71657
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR 2.7101
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.70006
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.70006
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.70006
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, MET, PIK3CA, PIK3CB 2.68945
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.67235
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.66923
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 2.66664
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.65036
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.65036
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.65036
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.65036
[BP] GO:0009892 negative regulation of metabolic process AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.64092
[BP] GO:0099566 None GRM1, GRM5 2.62553
[BP] GO:0051944 None DRD2, DRD4 2.62553
[BP] GO:0060160 None DRD2, DRD3 2.62553
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.62553
[BP] GO:0051586 None DRD2, DRD4 2.62553
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.59837
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.58613
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.58287
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TYR, XDH 2.58287
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, SRC 2.57829
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity DRD4, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 2.57091
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.56521
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.56521
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, PIK3CA, PIK3CB, RORC, SMAD3, SRC, TRPV1 2.56202
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, PTGS2, SMAD3, SRC, TEK 2.55315
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.54724
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.54724
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.54724
[BP] GO:0023052 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 2.54559
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, INSR, KDR, NUAK1, PIK3CA, PIM1, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.54559
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.53875
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.53206
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.52738
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.48703
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, DRD3, FABP3, FLT3, PTGS2, RORC, SRC, TEK 2.48703
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, PTGS2, SMAD3, SRC, TEK 2.484
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.47273
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47273
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.45775
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.45775
[BP] GO:0045936 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, IGF1R, PTPN1, XDH 2.45093
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, TEK 2.45023
[BP] GO:0010563 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, IGF1R, PTPN1, XDH 2.44695
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 2.43368
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.41849
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.38634
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.38634
[BP] GO:0032102 negative regulation of response to external stimulus ALOX12, CYP19A1, DRD2, DRD3, SLC6A3, SMAD3, TEK 2.38
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.38
[BP] GO:0051582 None DRD2, DRD4 2.3776
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3776
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.3772
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MET, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.37658
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.37658
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.37658
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.37658
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.37658
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37658
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.37391
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.36713
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.33853
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD2, DRD3, EGFR, PTGS2, TYR 2.33853
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, KDR, SRC, TEK 2.33342
[BP] GO:0051894 None KDR, SMAD3, TEK 2.32772
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.32772
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32772
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PTGS2, SRC, TEK 2.32619
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PTGS2, SRC, TEK 2.29504
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, PTGS2, SMAD3, SRC, TEK 2.29205
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SMAD3, SRC, XDH 2.28463
[BP] GO:0050877 None CYP1B1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, INSR, PTGS2, SLC6A3, TRPV1, TYR 2.28356
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 2.28356
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, PTGS2, SRC, TRPV1 2.27964
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3 2.26067
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.23964
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.23964
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.23964
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.23964
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.23964
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23964
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.23964
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 2.23659
[BP] GO:0098657 import into cell ACHE, ALOX15, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3, TRPV1 2.23474
[BP] GO:0046683 response to organophosphorus PTGS2, SLC6A3, TEK, TRPV1, TYR 2.23292
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.23292
[BP] GO:0060079 None GRIA2, GRIA4, GRIK5, TRPV1 2.22409
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR 2.21998
[BP] GO:0090325 None DRD2, DRD3 2.20511
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.20511
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.20511
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.19896
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.19836
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.16546
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.16504
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.16282
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, PTGS2, PTPN1, SMAD3, SRC, TEK 2.16163
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.16106
[BP] GO:0007612 None DRD2, DRD3, GRM5, INSR, PTGS2 2.16106
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.15259
[BP] GO:0048638 regulation of developmental growth BCL2, DRD2, DRD3, INSR, PIK3CA, PIM1, SLC6A3 2.15259
[BP] GO:0030100 regulation of endocytosis ALOX15, AXL, DRD2, PIK3CB, PTPN1, SRC 2.1318
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.1296
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.12899
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.12899
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.12899
[BP] GO:0032413 None DRD2, DRD3, DRD4, GPR35 2.11228
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.10228
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.09322
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.09221
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09221
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09221
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.09166
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, PTGS2, SRC, TRPV1 2.09166
[BP] GO:0000187 activation of MAPK activity DRD4, GRM1, INSR, PIK3CB, PTPN1 2.07845
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGS2, SRC 2.07827
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.07187
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.07187
[BP] GO:0032415 None DRD3, DRD4 2.07187
[BP] GO:0051934 None SLC6A2, SLC6A3 2.07187
[BP] GO:0021984 None DRD2, SLC6A3 2.07187
[BP] GO:0090494 None SLC6A2, SLC6A3 2.07187
[BP] GO:0090493 None SLC6A2, SLC6A3 2.07187
[BP] GO:0051583 None SLC6A2, SLC6A3 2.07187
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.07187
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.07187
[BP] GO:0022898 None BCL2, DRD2, DRD3, DRD4, GPR35, GRM5 2.07097
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.07097
[BP] GO:1901890 None KDR, SMAD3, TEK 2.07097
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.07097
[BP] GO:0045744 None DRD2, DRD3, MET 2.07097
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.07097
[BP] GO:0051094 positive regulation of developmental process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD2, INSR, KDR, PIM1, PTGS2, SLC6A3, SMAD3, SRC, TEK 2.07051
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.06554
[BP] GO:0014074 response to purine-containing compound PTGS2, SLC6A3, TEK, TRPV1, TYR 2.05816
[BP] GO:0040018 None BCL2, DRD2, SLC6A3 2.03426
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.03426
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, PTGS1, PTGS2 2.03395
[BP] GO:0008217 None DRD2, DRD3, PTGS1, PTGS2, SMAD3 2.02118
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, INSR 2.01921
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.01921
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.0109
[BP] GO:0007611 None DRD2, DRD3, EGFR, GRM5, INSR, PTGS2 2.0109
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, INSR, KDR, PIK3CA, PTGS2, RORC, SMAD3 2.00672
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.0027
[BP] GO:0008286 None IGF1R, INSR, PIK3CA, PTPN1 2.0027
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.00204
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1 7.82741
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, DRD2, DRD3, DRD4, DUSP3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTGS2, SLC1A1, SLC6A2, SLC6A3, SRC, TEK, TRPV1 7.43893
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 7.21803
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TEK, TRPV1, TYR 7.21803
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM2, DRD2, DRD3, DRD4, F10, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1 6.96089
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM2, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK, TRPV1 6.96089
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1 5.94606
[CC] GO:0044456 None ACHE, CHRM2, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC, TRPV1 4.52793
[CC] GO:0097060 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.94274
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.53691
[CC] GO:0043005 None CA2, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A3, SRC 3.29234
[CC] GO:0042995 cell projection AKR1B1, CA2, CHRM2, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SRC, TEK 3.1345
[CC] GO:0097458 None CA2, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, SLC6A2, SLC6A3, SRC, TRPV1 3.08041
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SRC, TEK 3.03205
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SRC, TEK 3.02374
[CC] GO:0120025 None AKR1B1, CA2, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SRC, TEK 2.8757
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.7853
[CC] GO:0031224 None ACHE, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM2, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1, TYR 2.6077
[CC] GO:0098589 membrane region EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SRC, TEK 2.55158
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, GRIA2, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.43426
[CC] GO:0014069 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.32627
[CC] GO:0099572 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.32627
[CC] GO:0044463 None AKR1B1, CA4, CA9, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.2188
[CC] GO:0120038 None AKR1B1, CA4, CA9, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.2188
[CC] GO:0045211 None CHRM2, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 2.20511
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, GRIA2, HSD11B1, HSD17B2, PTGS1, PTGS2 2.19369
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.07187
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B2, HSPA1A, INSR, KDR, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TRPV1, TYR, XDH 2.07149
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.9427
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 9.73735
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, NQO2, NR3C1, PIM1, PTPN1, RORC, SMAD3, TYR, XDH 9.20866
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC6A3, SRC, TEK, TRPV1 8.95658
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.20851
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, RORC, TEK, TRPV1 8.02493
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.67128
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.33681
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, RORC, TEK, TRPV1 7.1599
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, RORC, SMAD3, TEK, TRPV1 7.04881
[MF] GO:0030594 None CHRM2, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.96089
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NR3C1, RORC, TEK, TRPV1 6.96089
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.88734
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR, XDH 6.81451
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.79037
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.79037
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.76581
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.49031
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, ESR1, F10, NQO2, NR3C1, NUAK1, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1, TYR, XDH 6.22497
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.71426
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.37904
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.33058
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.30518
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.13912
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.09
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.0069
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.7655
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TYR 4.7655
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.73414
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.65033
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F10, NQO2, NR3C1, NUAK1, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1, TYR, XDH 4.45475
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 4.31902
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.24696
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.13386
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, NQO2, NR3C1 4.10182
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 4.06955
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.85444
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.65449
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.61987
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.59659
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.48213
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.4687
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.4687
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3 3.23446
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, NQO2, NR3C1, PTPN1, RORC, SMAD3 3.20289
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.11358
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1, PTGS2, SRC, XDH 3.08001
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.02495
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.02495
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, DRD2, DRD4, EGFR, ESR1, FLT3, GRIK5, IGF1R, KDR, MET, NQO2, PTGS2, SMAD3, TRPV1, TYR, XDH 2.85903
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.85903
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TRPV1 2.84025
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.71988
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TRPV1 2.71988
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TRPV1 2.69198
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PTPN1, SLC6A3, SMAD3 2.68945
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.62553
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.62553
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.62553
[MF] GO:0005330 None SLC6A2, SLC6A3 2.62553
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.62553
[MF] GO:0099583 None GRM1, GRM5 2.62553
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.58287
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.58287
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TRPV1, XDH 2.58287
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TRPV1, XDH 2.56618
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.54724
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, MET, PTPN1, SLC6A3 2.38634
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3776
[MF] GO:0004971 None GRIA2, GRIA4 2.3776
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3776
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.30437
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.28356
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.23292
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.22409
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.20511
[MF] GO:0043559 insulin binding IGF1R, INSR 2.20511
[MF] GO:0051721 None BCL2, PTPN1, SLC6A3 2.16282
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B2, XDH 2.16106
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, PTPN1, SMAD3, SRC 2.14524
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.1296
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12899
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.11228
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TRPV1, XDH 2.09419
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TRPV1, XDH 2.09322
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, F10, FABP3, FABP4, NR3C1, RORC, TRPV1 2.07415
[MF] GO:0005329 None SLC6A2, SLC6A3 2.07187
[MF] GO:0004064 arylesterase activity CA1, CA2 2.07187
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.07097
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.03426


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GPR35, GRIK5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, DRD2, DRD3, DRD4, GRIA4 11.3784
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.1399
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.3138
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.0201
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.9469
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7503
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.3105
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 6.0495
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, PIK3CB, ESR1, GRM1, EGFR, HSPA1A 5.9674
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 6.0495
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 5.2873
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.8897
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, KDR, PIK3CB, MET, ESR1, EGFR, IGF1R 5.1664
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.1664
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.8834
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 5.2337
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.8526
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.2337
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.6426
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, BCL2, PIK3CB, PTGS2, MET, EGFR, IGF1R 4.1309
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.582
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 4.6295
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.3394
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MET, EGFR, CDC25B 4.1523
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.3975
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.5031
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.3563
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.0165
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.8283
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, BCL2, PIM1, PIK3CB 3.8066
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7144
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1, EGFR 4.0252
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.6362
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.8066
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 3.6362
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, PIK3CA, PIK3CB, DRD2, GRIA4 3.4816
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.5441
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB 3.2007
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.0594
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6362
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.4561
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.8204
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.515
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.3133
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.4406
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.6386
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.9352
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.0513
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8874
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0594
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2007
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB 2.7208
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, EGFR 2.5699
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6212
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5825
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.6022
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.5699
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.4423
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.414
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.4012
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.2603
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, GRM1, EGFR 2.0745
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PIK3CB 2.1852
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.624
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2983
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3085
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3212
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2 1.8496
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5824
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.9359
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6101
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3632
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7615
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4045
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.9115
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, EGFR 1.6603
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB 1.5414
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5599
Axon guidance_Homo sapiens_hsa04360 MET 0.4201
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4283
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.398
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0249
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2545
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3855
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 1.0454
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.2937
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8245
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4988
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.9333
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7913
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.7905
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9352
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5117
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5107
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3512
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.95
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9333
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.963
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5287
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5287
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4824
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5287
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5414
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.0063
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.6212
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5399
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5287
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.4012
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5287
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, PIK3CB 1.04
Peroxisome_Homo sapiens_hsa04146 XDH 0.5414
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1145
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4012
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.3885
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1254
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5538
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4015
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1931
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5605
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5745
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.5626
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1519
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1601
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5724
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.2063
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1804
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.376
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.7005
Shigellosis_Homo sapiens_hsa05131 SRC 0.6158
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.398
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3692
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3855
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3855
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.9352
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4 1.398
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.398
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6778
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.49
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4292
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9108
Malaria_Homo sapiens_hsa05144 MET 0.7203
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4994
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7338
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.601
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2595
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6811
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6676
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.754
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8398
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7647
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8398
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8831
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9333
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9767
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9326
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9352
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8483
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8931
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9333
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1852
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1588
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3205


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)