TCM Prescription: Huqian Bolus



Prescription Description
Prescription IDTCMF2133
Pinyin NameHu Qian Wan
Chinese Name虎潜丸
English NameHuqian Bolus
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH743 Plastrum testudinis 龟板 TCMH743
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2056 Cynomorium songaricum 锁阳 TCMH2056 ITSAO3649-14
TCMH904 Os tigris 虎骨 TCMH904
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH1059 Glycine max TCMH1059 ITSAJ4675-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.4718
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5903
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, IGF1R, MAOB, MMP2, MMP9, PPARA, RORC, SRC, TRPV1 8.81329
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, TRPV1 8.63657
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, MCL1, MMP2, PPARA, RORC, SRC, TRPV1 8.3785
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 8.21982
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FDPS, FUT7, PDE5A, PIM1, PPARA, XDH 8.16399
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, MAOB, RORC, SRC, TRPV1 7.54377
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MCL1, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 7.30085
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, TRPV1 7.30085
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, MCL1, MMP2, MMP9, PPARA, RORC, SRC, TRPV1 7.22581
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, KDR, MAOB, MCL1, MET, PPARA, SRC, TRPV1, XDH 7.1102
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F2, F3, FLT3, HCAR2, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 6.99281
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F2, F3, FLT3, HCAR2, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 6.97444
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, ESR1, FABP3, FABP4, FDPS, FUT7, HSD17B1, MET, PPARA, TRPV1 6.91737
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, PDE5A, PIM1, PPARA, RORC, SRC, XDH 6.60541
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, MAOB, MMP2, PPARA, SRC, TRPV1 6.60541
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MCL1, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 6.49674
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, F2, KDR, SRC, TRPV1 6.37501
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, PPARA, SRC, TRPV1 6.32183
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MAOB, MMP9, SRC 6.22922
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, MAOB, SRC 5.85658
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, RORC, SRC 5.84312
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F2, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 5.57294
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 5.5615
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SRC, TRPV1, XDH 5.38631
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, F2, HCAR2, KDR, SRC, TRPV1 5.17159
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F10, F2, F3, FLT3, KDR, MCL1, MET, PDE5A, SRC, XDH 5.06023
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F10, F2, F3, FABP4, IGF1R, MCL1, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1 4.93445
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, MAOB, SRC, TRPV1 4.93445
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F10, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 4.90981
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.84623
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MCL1, MMP9, PIM1, SRC, TRPV1, XDH 4.77052
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.70636
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FDPS, HSD17B1 4.70636
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.70598
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, FABP4, FLT3, MCL1, MET, SRC, TRPV1 4.70598
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, MCL1, MMP2, MMP9, PPARA, RORC, SRC, TRPV1 4.69723
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 4.58467
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.551
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 4.4839
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4435
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.43582
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, KDR, MAOB, MCL1, MMP9, PIM1, PPARA, RORC, SRC 4.43566
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FDPS, FLT3, HCAR2, PPARA, RORC, SRC 4.42609
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.40838
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 4.24962
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F2, F3, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, PPARA, SRC, TRPV1 4.23296
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC, TRPV1 4.22682
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, KDR, MAOB, MCL1, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC 4.12222
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F10, F2, F3, FLT3, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 4.11982
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.08542
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HSD17B1 4.08395
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.07933
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC, TRPV1 3.98922
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, MAOB 3.9826
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IGF1R, KDR, MAOB, MCL1, MET, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 3.98118
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1 3.9398
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F10, F2, F3, FABP4, FLT3, KDR, MCL1, MET, MMP2, MMP9, PDE5A, SRC, XDH 3.80137
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SRC 3.79426
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.77151
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, MET, PPARA 3.73409
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.73031
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA, TRPV1 3.64543
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SRC, TRPV1 3.63954
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, F2, PPARA 3.5985
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, IGF1R, KDR, MAOB, MCL1, MET, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 3.5623
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PPARA, RORC, SRC, TRPV1, XDH 3.49815
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SRC 3.49493
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.49396
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, TRPV1 3.49396
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, PPARA, SRC 3.46744
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 3.42926
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.38054
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, RORC, SRC 3.36828
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.34317
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.29442
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PPARA, RORC, SRC, TRPV1, XDH 3.25804
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PPARA, RORC, SRC, TRPV1, XDH 3.22766
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21698
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, F3, MET, SRC, XDH 3.20514
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, RORC, SRC, TRPV1 3.17862
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, MAOB 3.17547
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, FABP4, MET, TRPV1 3.16868
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOB 3.15988
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1 3.09196
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PDE5A, PPARA, SRC, XDH 3.06187
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 3.06187
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, F2, HCAR2 3.04631
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.94888
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MMP9, PIM1, SRC 2.88522
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PDE5A, PIM1, SRC, TRPV1 2.86255
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.84479
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.84479
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.84479
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.84479
[BP] GO:0009115 None AOX1, XDH 2.82514
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.82405
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.81861
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, F2, FLT3, IGF1R, KDR, MET, SRC 2.80644
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.77692
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, FDPS, FLT3, IGF1R, KDR, MET, PDE5A, PIM1, SRC, XDH 2.77692
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HCAR2, HSD17B1, IGF1R, KDR, MAOB, MCL1, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 2.77254
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.72065
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, RORC, SRC, TRPV1 2.69614
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.67923
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.67613
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.67447
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.67447
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67447
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MCL1, PPARA, TRPV1 2.66876
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.65962
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 2.6342
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.6342
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.60488
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, MAOB 2.60415
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 2.59664
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.59664
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.59664
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F2, F3, FABP4, KDR, MET, PPARA 2.59209
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, PDE5A, SRC, XDH 2.59209
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, PDE5A, SRC, XDH 2.59209
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, FDPS, FLT3, IGF1R, KDR, MET, PDE5A, PIM1, SRC, XDH 2.57301
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.57301
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC, TRPV1 2.54918
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.54182
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MCL1, MET, MMP9, SRC, XDH 2.53837
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, ESR1, F10, F2, F3, FLT3, FUT7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, SRC, XDH 2.51548
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.51279
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD1, DRD2, ESR1, ESR2, F2, IGF1R, MCL1, MET, MMP9, PPARA, SRC, XDH 2.50999
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.50636
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, F2, HCAR2, SRC, TRPV1 2.50636
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F10, F2, F3, MET, XDH 2.50428
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.48789
[BP] GO:0046110 None AOX1, XDH 2.47882
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47882
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.47114
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, TRPV1 2.47114
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.41838
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.39794
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.396
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC 2.396
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.396
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.396
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.396
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, MMP2, PPARA, SRC, TRPV1 2.3725
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, DRD1, DRD2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.37197
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.37197
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HSD17B1 2.3588
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.3588
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, PPARA, RORC, SRC, XDH 2.34928
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, SRC, TRPV1 2.34474
[BP] GO:1901575 None ACHE, ADORA1, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MAOB, PDE5A, XDH 2.34474
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, DRD1, DRD2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.34474
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, IGF1R, KDR, MAOB, MCL1, MET, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 2.34474
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.34299
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.31924
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31924
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F10, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PDE5A, SRC, XDH 2.31172
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PDE5A, PIM1, SRC, TRPV1, XDH 2.28849
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, MAOB, SRC 2.2742
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.27086
[BP] GO:0006145 None AOX1, XDH 2.25405
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25405
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, PPARA, RORC, SRC, TRPV1 2.20743
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, MAOB, PDE5A, XDH 2.20473
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, F2, FABP3, MCL1, MMP9, PPARA, SRC, TRPV1, XDH 2.20133
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, MAOB, XDH 2.18585
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.18493
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, MAOB, MMP9 2.17879
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PPARA, RORC, SRC, TRPV1, XDH 2.17403
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PDE5A, PIM1, PPARA, SRC, TRPV1, XDH 2.16927
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TRPV1 2.14222
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, ESR1, F10, F2, FABP3, MCL1, MMP9, PPARA, SRC, TRPV1, XDH 2.14222
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 2.14108
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, MCL1, MMP9, SRC, TRPV1, XDH 2.1183
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F2, MCL1, MMP2, MMP9, PPARA, SRC, TRPV1 2.11781
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, DRD1, DRD2, F2, MAOB, MMP9 2.11755
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.11033
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.11033
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1 2.10752
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, F2, HCAR2, MAOB, MMP9, PPARA, SRC, TRPV1 2.10429
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, F2, FABP3, MCL1, MMP9, PPARA, SRC, TRPV1, XDH 2.10289
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, MCL1, MMP9, SRC, TRPV1, XDH 2.10199
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, ESR1, F2, F3, FABP4, IGF1R, MCL1, MET, MMP2, PPARA, SRC, XDH 2.09893
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.09893
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.09547
[BP] GO:0021853 None DRD1, DRD2 2.09547
[BP] GO:0010641 None F3, SRC 2.09547
[BP] GO:0007598 None F10, F3 2.09547
[BP] GO:1904936 None DRD1, DRD2 2.09547
[BP] GO:0042321 None ADORA1, DRD2 2.09547
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, IGF1R, MCL1, MET, MMP9, SRC, XDH 2.08702
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.07875
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.07875
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, IGF1R, MCL1, MET, MMP9, SRC, XDH 2.07875
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.07535
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.06144
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.06144
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, MAOB, SRC 2.05208
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 2.02514
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.02514
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, MAOB, TRPV1 2.00764
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.00224
[CC] GO:0031233 None CA4, F10, F3 2.45908
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, SRC, TRPV1 2.32797
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, IGF1R, KDR, MAOB, MCL1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, XDH 1.87168
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, ESR1, F10, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TRPV1 1.81346
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, KDR, MAOB, MCL1, MMP2, MMP9, PDE5A, PIM1, SRC, TRPV1, XDH 1.67631
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.7161
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, XDH 15.5158
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 14.3604
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5903
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0646
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FDPS, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, TRPV1, XDH 9.39093
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, RORC 8.63045
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 8.01232
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F2, F3, FDPS, FLT3, FUT7, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 7.80042
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FDPS, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, TRPV1, XDH 7.54961
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD17B1, PPARA, RORC, TRPV1 6.19827
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.41227
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 5.41227
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.41227
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.41227
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC, TRPV1 5.32043
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.18741
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97486
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.93485
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC, TRPV1 4.60979
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC, TRPV1 4.43566
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.15519
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC, TRPV1 4.06381
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 4.01459
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.67767
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.5623
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, MAOB, SRC, XDH 3.46744
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.34636
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.32199
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.16793
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.13624
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82514
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, MAOB, XDH 2.81086
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.80469
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KDR, MAOB, MCL1, MET, MMP9, TRPV1, XDH 2.62757
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.61196
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP2, MMP9 2.542
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.47882
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25405
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.25405
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.25405
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CSNK2A1, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, SRC, TRPV1, XDH 2.1183
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09547
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09547
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.09547
[MF] GO:0004252 None F10, F2, F3, MMP1, MMP2, MMP9 2.06165
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.05208


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.1408
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.36
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.1378
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.4583
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2871
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.7217
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8798
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOB, AKR1B1, CYP3A4, CYP19A1, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.2378
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2378
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4 3.2378
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.9367
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.1909
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1909
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2378
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.821
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, DRD1, F2, DRD2 2.9367
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, MCL1 2.821
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA 2.7347
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.0787
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.7258
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.6592
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 2.1988
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1957
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, MCL1, IGF1R 1.8674
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0419
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.6492
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 2.0965
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 2.0096
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5914
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 1.6119
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6861
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.5013
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.3775
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.3182
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1425
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3947
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3913
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3568
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.3102
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1425
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3102
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1425
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0318
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0995
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3004
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0318
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3078
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1425
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0678
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2328
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1332
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3004
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5 1.0318
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.9094
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0122
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0122
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0122
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9094
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5358
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9094
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9094
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8022
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7242
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1 1.7162
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7994
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.6938
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2761
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3432
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3899
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3699
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3755
Influenza A_Homo sapiens_hsa05164 FDPS 0.3815
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3697
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.425
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4215
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4093
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4359
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4477
Platelet activation_Homo sapiens_hsa04611 SRC 0.4664
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4521
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.467
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4521
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8636
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4664
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4664
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4951
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4951
Axon guidance_Homo sapiens_hsa04360 MET 0.4613
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5267
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5193
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5433
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5305
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5305
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5305
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5429
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5433
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5433
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5433
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5432
Peroxisome_Homo sapiens_hsa04146 XDH 0.5488
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5891
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6064
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6267
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6267
Glioma_Homo sapiens_hsa05214 IGF1R 0.6267
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6251
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.02
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6267
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6267
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6267
Shigellosis_Homo sapiens_hsa05131 SRC 0.6267
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6278
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6267
Malaria_Homo sapiens_hsa05144 MET 0.6874
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6813
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6842
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6938
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6908
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7442
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8294
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8216
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8142
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.782
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8318
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8655
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8294
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8557
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8928
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.9094
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1075
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9996
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0318
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3015


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)