TCM Prescription: Aifu Nuangong Pills



Prescription Description
Prescription IDTCMF2100
Pinyin NameAi Fu Nuan Gong Wan
Chinese Name艾附暖宫丸
English NameAifu Nuangong Pills
Function Description妇人子宫虚寒, 经水不调, 小腹时痛, 赤白带下
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationUterus
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6067
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7774
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, HTR2B, HTR2C, PIM1, PPARA, PTGS1, PTGS2, XDH 10.8974
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 8.58465
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 8.54235
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 8.54235
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, HSD17B1, MET, PPARA, PTGS1, PTGS2 7.42809
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CXCL8, CYP1B1, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 6.95464
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.82875
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HTR2A, HTR2B, HTR2C, KDR, MET, MTNR1B, PPARA, PTGS1, PTGS2, SRC, XDH 6.82875
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.63816
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 6.6264
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.45149
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PTGS2, SRC, XDH 6.37797
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, HCAR2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PPARA, PTGS2, SRC 6.25002
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, SRC, XDH 6.11961
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PTGS2, SRC, XDH 6.11916
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.09146
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 6.07445
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PTGS2, SRC, XDH 6.03658
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.9917
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.92595
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.79173
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, F10, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTGS2, SRC, XDH 5.72422
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.69455
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, SRC, XDH 5.61099
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 5.59489
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 5.58153
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FABP4, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, SRC, XDH 5.50617
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.48605
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 5.47415
[BP] GO:0042221 response to chemical AKR1B1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, SRC 5.47415
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.3536
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.32474
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 5.21364
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.03922
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1 5.03813
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC 4.99156
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, BCL2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP3, IGF1R, MMP2, MMP9, PPARA, PTGS2, SRC 4.9409
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, MET, PPARA, PTGS1, PTGS2 4.93794
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC, XDH 4.93784
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.93127
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 4.8492
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.80307
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, HSD17B1, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, XDH 4.80307
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC, XDH 4.69366
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC 4.68126
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 4.65348
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, MTNR1B, SRC 4.65049
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.60317
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.58663
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.57489
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.56053
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HTR2A, HTR2C, MTNR1B 4.49582
[BP] GO:0010033 response to organic substance AKR1B1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, PPARA, PTGS2, SRC 4.42832
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.25438
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, HSD17B1, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS1, PTGS2, SRC, XDH 4.19161
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.10084
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, XDH 4.09559
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 4.02381
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC 3.99439
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.98056
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, FABP3, FLT3, PTGS2, SRC 3.94
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.89942
[BP] GO:0007210 None HTR2A, HTR2B, HTR2C, HTR6 3.89942
[BP] GO:0098664 None HTR2A, HTR2B, HTR2C, HTR6 3.89942
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 3.86512
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 3.84266
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PTGS1, PTGS2, XDH 3.81412
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, F10, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS1, PTGS2, SRC 3.81346
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.81346
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.81346
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.81346
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.79682
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.72092
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.69249
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, F10, FABP4, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC 3.68327
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.6564
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PTGS2, SRC, XDH 3.64178
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PTGS2, SRC, XDH 3.64178
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, HTR2A, HTR2B, HTR2C, MMP12, MMP9, MTNR1B, PPARA, PTGS2, SRC 3.6312
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, MTNR1B 3.6202
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC 3.55763
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.55763
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, PTGS2, SRC 3.55763
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA 3.55763
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, SRC, XDH 3.55352
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 3.40035
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CXCL8, CYP1B1, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 3.39529
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PPARA, PTGS2, SRC, XDH 3.38338
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SRC 3.37048
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.37048
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.36575
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PPARA, PTGS2, SRC, XDH 3.35334
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC 3.32347
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, SRC 3.22181
[BP] GO:0014070 response to organic cyclic compound APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGS2, SRC 3.21524
[BP] GO:0097756 None ADORA1, HTR2A, HTR2B, PTGS2 3.18507
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.96676
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.9511
[BP] GO:0007208 None HTR2A, HTR2C 2.93029
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 2.9204
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.90622
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.90603
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 2.89151
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.88056
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, HTR2B, MMP12, PTGS2, SRC 2.85776
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, F10, FABP3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PPARA, SRC, XDH 2.85508
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, HTR2A, HTR2B, HTR2C, KDR, SRC, XDH 2.8547
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, PTGS2, SRC 2.8091
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.78144
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.77969
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.77969
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.77969
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.77969
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 2.77763
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, MTNR1A, MTNR1B, PPARA, SRC 2.77763
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 2.77763
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, F10, FABP3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PPARA, SRC, XDH 2.77763
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.76484
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.72669
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, HCAR2, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC 2.72517
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, PPARA, SRC 2.72014
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PTGS2, SRC, XDH 2.7097
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, PTGS1 2.70583
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.67882
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, HTR2A, PTGS2 2.65038
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, HTR2A, PTGS2 2.65038
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2 2.64684
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.6396
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.60378
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.60378
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.5972
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, SRC, XDH 2.57249
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57249
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.54982
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.52328
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SRC, XDH 2.52102
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, HCAR2, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC 2.50378
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, F10, FABP3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PPARA, SRC, XDH 2.47812
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, HTR2A, PTGS2 2.47812
[BP] GO:0002791 None ACHE, ADORA1, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, SRC 2.46051
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.45606
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41838
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, IGF1R, MMP2, MMP9, PTGS2, SRC 2.41838
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CXCL8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B, SRC 2.40905
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CXCL8, CYP1B1, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, XDH 2.39165
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.37118
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37118
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC 2.3604
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.35429
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, HTR2A, MMP9, PTGS2 2.3382
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC 2.3382
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, SRC, XDH 2.33685
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32401
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2 2.32401
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC 2.32173
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PTGS2, SRC, XDH 2.30334
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CXCL8, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, SRC 2.30212
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.30082
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, FABP3, FABP4, HCAR2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SRC, XDH 2.27345
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2 2.27089
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.26686
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.25804
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.24439
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, HTR2C, MMP2, MMP9, PPARA, PTGS1, PTGS2, SRC 2.23156
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.22156
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.18846
[BP] GO:0003018 None ADORA1, HTR2A, HTR2B, PTGS2, SRC 2.18754
[BP] GO:0002793 None ACHE, ADORA1, HCAR2, HTR2B, MMP12, SRC 2.173
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.15186
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, HCAR2, HTR2B, MMP12, PTGS2, SRC 2.13752
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, FABP3, HTR2A, HTR2B, HTR2C 2.12111
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, HTR2B, MMP12, SRC 2.11734
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.11718
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, HCAR2, HTR2B, MET, PPARA 2.11252
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, HCAR2, HTR2A, HTR2C, MTNR1B 2.11252
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PTGS2, SRC, XDH 2.11061
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.10448
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 2.09526
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 2.08265
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.07314
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.07191
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.06483
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.03153
[BP] GO:0007610 None APP, BCL2, HTR2A, HTR2B, HTR2C, MTNR1A, PPARA, PTGS2 2.02272
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.01107
[BP] GO:0032496 response to lipopolysaccharide AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.01107
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.01083
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.01083
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00793
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 3.6202
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTGS2, SRC 2.76484
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 2.6396
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, SRC 2.33328
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGS1, PTGS2, SRC 2.22601
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.1973
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, XDH 12.1746
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.846
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6543
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, HSD17B1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, XDH 9.32655
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.99102
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.99102
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.99102
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.82875
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 6.77084
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, HTR2A, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, XDH 6.6264
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.61182
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.3536
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.26376
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA 4.97932
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PTGS1, PTGS2, XDH 4.68126
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PTGS1, PTGS2, SRC, XDH 4.66881
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, SRC 4.65348
[MF] GO:0046872 metal ion binding ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, XDH 4.50187
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.37847
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.19161
[MF] GO:0004993 None HTR2A, HTR2B, HTR2C, HTR6 3.89942
[MF] GO:0099589 None HTR2A, HTR2B, HTR2C, HTR6 3.89942
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.78595
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.38338
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.35087
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 3.31568
[MF] GO:0043176 None HTR2A, HTR2B, HTR2C 3.25805
[MF] GO:0051378 None HTR2A, HTR2B, HTR2C 3.25805
[MF] GO:0099528 None HTR2A, HTR2B, HTR2C, HTR6 3.22181
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 3.09249
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 3.09249
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93029
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93029
[MF] GO:0071886 None HTR2A, HTR2C 2.93029
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.82966
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.77965
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 2.77763
[MF] GO:0042165 neurotransmitter binding ACHE, HTR2A, HTR2B, HTR2C 2.76994
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 2.64767
[MF] GO:0008227 None HTR2A, HTR2B, HTR2C, HTR6 2.64439
[MF] GO:0008502 None MTNR1A, MTNR1B 2.57249
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 2.36796
[MF] GO:0070405 ammonium ion binding ACHE, HTR2A, HTR2B, HTR2C 2.30082
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, SRC 2.27231
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.18988
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A 2.08922
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00793


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.7796
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.4587
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, ALOX5, HTR2B, HTR2C, HTR2A, PTGS2, PTGS1 7.6482
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9 5.712
Pathways in cancer_Homo sapiens_hsa05200 CXCL8, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 4.9055
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.712
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, MTNR1A, MTNR1B, ADORA3, HTR2B, ADORA1, HTR2C, HTR2A 5.0052
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.1011
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.7535
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7873
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2, PTGS1 3.7873
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.4051
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4928
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.0612
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 CXCL8, MMP2, BCL2, PIM1 3.0328
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, HTR2A 3.0612
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 3.1401
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 3.0806
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, BCL2, PTGS2 3.0806
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.9586
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AKR1B1, PTGS2, CYP19A1, XDH, PTGS1 2.7364
Hepatitis B_Homo sapiens_hsa05161 CXCL8, SRC, BCL2, MMP9 2.5367
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.5367
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR2B, HTR2C, HTR2A 2.2458
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0158
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.5367
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, PPARA 2.1151
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0499
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET 2.4583
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4998
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0499
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7932
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET 1.7696
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8611
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4381
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, IGF1R 1.4462
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2624
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2518
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5255
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4014
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1223
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4307
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2503
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.2626
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.1223
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.2235
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1666
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3333
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1 1.251
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 1.0698
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.507
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4159
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PPARA 0.9255
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0888
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9045
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA 1.0095
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0888
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9045
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.4462
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9821
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8758
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.6419
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7597
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8404
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.8102
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6844
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3615
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.372
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4229
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4027
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4161
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4694
Influenza A_Homo sapiens_hsa05164 CXCL8 0.4161
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4229
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4735
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4694
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4621
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4694
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4778
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8 0.4681
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5438
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4998
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4957
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4957
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5571
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5274
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.502
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.5339
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5459
Axon guidance_Homo sapiens_hsa04360 MET 0.4908
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5438
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.5438
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.553
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 CXCL8 0.5369
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5459
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5571
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5438
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5459
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5571
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.5571
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5914
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5571
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5923
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5907
Peroxisome_Homo sapiens_hsa04146 XDH 0.5605
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5911
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6064
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9784
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.605
Glioma_Homo sapiens_hsa05214 IGF1R 0.6057
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.575
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6155
Bile secretion_Homo sapiens_hsa04976 CA2 0.5919
Pertussis_Homo sapiens_hsa05133 CXCL8 0.5904
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.5923
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.608
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6064
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.6302
Legionellosis_Homo sapiens_hsa05134 CXCL8 0.6388
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8589
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6635
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9355
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1543
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8719
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8891


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)