Prescription Description
| Prescription ID | TCMF2090 |
| Pinyin Name | Wu Jia Qiang Xin Tang |
| Chinese Name | |
| English Name | Five Plus Heart Strengthening Decoction |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH228 | Bupleurum chinense | 柴胡 | TCMH228 | ITSAM2218-14 |
| TCMH2618 | Citrus aurantium | 枳壳 | TCMH2618 | ITSAA1279-14 |
| TCMH241 | Plantago asiatica | 车前子 | TCMH241 | ITSAB3641-14 |
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH865 | Carthamus tinctorius | 红花 | TCMH865 | ITSAI2447-14 |
| TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
| TCMH706 | Trichosanthes kirilowii | 瓜蒌皮 | TCMH706 | ITSAO4359-14 |
| TCMH150 | Cortex acanthopanacis radicis | 北五加皮 | TCMH150 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 104 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1168 | Trichomonas vaginalis |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
Showing 1 to 10 of 56 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.39205 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT | 2.39379 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2C19, TBXAS1 | 2.45887 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR | 2.547 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.10801 |
| [BP] GO:0006286 | base-excision repair, base-free sugar-phosphate removal | APEX1, POLB | 2.69394 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.10801 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.55732 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, PRKCA, SRC, TOP1 | 2.65947 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 | 7.29781 |
Showing 1 to 10 of 202 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3408 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 3.9846 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5397 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PRKCA | 0.3984 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCA | 0.7003 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1, PRKCA | 1.6824 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCA | 0.4973 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PRKCA | 0.6772 |
| Amoebiasis_Homo sapiens_hsa05146 | PRKCA | 0.4782 |
| Amphetamine addiction_Homo sapiens_hsa05031 | PRKCA | 0.5397 |
Showing 1 to 10 of 148 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples