TCM Prescription: Bolus of Olibanum for Alleviating Pain



Prescription Description
Prescription IDTCMF2047
Pinyin NameRu Xiang Ding Tong Wan
Chinese Name乳香定痛丸
English NameBolus of Olibanum for Alleviating Pain
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH296 Radix aconiti 川乌 TCMH296
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 12.0631
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4529
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TYR 10.7345
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7345
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 10.1786
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 9.95355
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.94356
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.92323
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FLT3, NR3C1, RORC, SRC, TEK, TYR 9.56383
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.45871
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 9.38868
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 9.28462
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA 8.91339
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 8.52354
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.47028
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.42961
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PPARA, SMAD3, SRC, TEK, XDH 8.39093
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK 8.17827
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 8.17827
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, MIF, PIM1, PPARA, TYR, XDH 8.11379
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.82249
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.68312
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.57991
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.5468
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.45368
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.32018
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD17B1, HSD17B2 7.08871
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.08871
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.04684
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.87897
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK 6.78824
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 6.72179
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.72179
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 6.72179
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.71794
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.65674
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 6.6229
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.62023
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC 6.61333
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.58522
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, AR, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, NR3C1, RORC, SRC 6.58522
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 6.31792
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 6.31792
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 6.29951
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 6.26768
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 6.15748
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.08132
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.04179
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC 5.99811
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 5.98014
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.95025
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 5.81807
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 5.76357
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.76357
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.76357
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.76357
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F10, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.76357
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.73796
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.73796
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.73796
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PGR, PPARA, RORC, SRC, TOP2A 5.56414
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.50916
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.49993
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.49993
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.46672
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.45182
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 5.44936
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.40747
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA 5.40308
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.40308
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AR, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.3994
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 5.35509
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC 5.34191
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.33926
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, PIM1, PPARA, RORC, SRC 5.31356
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 5.30337
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 5.30337
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.20897
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 5.15245
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.14598
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.12969
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, SRC 5.12652
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.10282
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.08132
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.97767
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.97121
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.94721
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.90734
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.83903
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.83903
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.77699
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.76636
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, KDR, NR3C1, SRC 4.74647
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.72894
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AR, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 4.71503
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.69482
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.66668
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.66668
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 4.64532
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.62687
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.59217
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SRC 4.59072
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, RORC 4.55257
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA 4.54262
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.54262
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.54262
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.48348
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 4.47101
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.46736
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, MIF, SRC 4.45319
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.42595
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.41343
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, AR, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC 4.3997
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 4.39409
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.35769
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.34831
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.24805
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 4.23032
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 4.19616
[BP] GO:0043408 regulation of MAPK cascade ADORA1, AR, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.15857
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, AR, DRD2, EGFR, FLT3, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.15204
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.15204
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.13829
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 4.1274
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 4.10701
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.07533
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.06789
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 4.06539
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.99515
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.89901
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 3.88573
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.85916
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.8352
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, RORC 3.8352
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA, SMAD3, TEK 3.8343
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 3.82651
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC 3.80082
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 3.79774
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.76741
[BP] GO:0044093 positive regulation of molecular function ADORA1, AR, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.74146
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.74146
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.73852
[BP] GO:0008217 None ADORA1, AR, DRD2, DRD3, DRD5, PPARA, SMAD3 3.70756
[BP] GO:0009968 negative regulation of signal transduction AR, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 3.65575
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 3.65144
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PPARA 3.63511
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63511
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.6281
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 3.62698
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 3.62631
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.60904
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR 3.60757
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR 3.60757
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.60523
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.58915
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.57271
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.56957
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, PGR, SRC, TOP2A 3.53512
[BP] GO:0042325 regulation of phosphorylation ADORA1, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.52794
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.51854
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.493
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.493
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, MIF, MMP12, SMAD3, SRC 3.47367
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.45015
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.44733
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.44144
[BP] GO:0051240 positive regulation of multicellular organismal process AR, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 3.42121
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.42121
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.37543
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.37371
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 3.33067
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.33067
[BP] GO:0050678 None AR, EGFR, F3, KDR, MMP12, PGR, SMAD3, TEK, XDH 3.33067
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, RORC 3.30421
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.27375
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.27293
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3 3.2377
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MIF, MMP12, SRC 3.2377
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 3.2377
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.21736
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.21123
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21123
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.19962
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.19962
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR 3.17615
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TOP2A 3.17093
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.16448
[BP] GO:0051130 positive regulation of cellular component organization AR, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.1513
[BP] GO:0031399 regulation of protein modification process ADORA1, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.15084
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.13802
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, AR, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.13278
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.11997
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.11343
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, SMAD3 3.11343
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AR, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, TOP2A 3.10215
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.10215
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.07114
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.07009
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 3.05261
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.99718
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.98236
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.98236
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, TYR 2.97421
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.97421
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, AR, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.96413
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.94223
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, AR, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.91475
[BP] GO:0046960 None DRD1, DRD5 2.9146
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.90979
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90706
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.90706
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.90706
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.89918
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.89294
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PGR, SRC 2.86357
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 2.82019
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.81578
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.81489
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.81489
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC 2.80617
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, NR3C1 2.78823
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, AR, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.78751
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, NR3C1, SRC 2.78751
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, XDH 2.78437
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.78277
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.7709
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.7709
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.7709
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.70907
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.6962
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.68919
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 2.68241
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, TYR 2.6722
[BP] GO:0003018 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 2.66772
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66261
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.66261
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.64776
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3 2.63028
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.6298
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, MIF, MMP12, SRC 2.6232
[BP] GO:0051254 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.58315
[BP] GO:0051172 None APEX1, AR, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.57771
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC 2.57572
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.54786
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.53123
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.52217
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.52217
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.51966
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.51966
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.51966
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.51966
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AR, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, XDH 2.51966
[BP] GO:0060748 None AR, PGR 2.51966
[BP] GO:0060160 None DRD2, DRD3 2.51966
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51966
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 2.51966
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.51777
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 2.50823
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AR, AXL, CYP1A1, DRD1, DRD5, EGFR, ESR1, PGR, SRC 2.50723
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AR, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.47642
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.47226
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, EGFR, ESR1, FLT3, INSR, NR3C1, SRC 2.47226
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.46918
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 2.45451
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AR, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.44752
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, AR, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.44188
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.44188
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.44188
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 2.43138
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.43138
[BP] GO:0050679 None AR, EGFR, F3, KDR, MMP12, TEK 2.42885
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.42548
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, PTPN1, SMAD3, SRC 2.42514
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.42002
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.42002
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.42002
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.42002
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.42002
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.3925
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, MIF, MMP12, SRC 2.38651
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, NR3C1, RORC, SRC 2.38651
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.36855
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.36588
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.3641
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.3581
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.3549
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.35363
[BP] GO:0045893 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.34092
[BP] GO:1903508 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.34092
[BP] GO:1902680 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.33852
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.32456
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.32329
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.32329
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.31962
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.31962
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.31652
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.31512
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR 2.30444
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.30054
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.2876
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2876
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2876
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.28251
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF 2.28251
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.27405
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.27377
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.27377
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.2715
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.25218
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.24768
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.24598
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AR, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.24288
[BP] GO:0051894 None KDR, SMAD3, TEK 2.22856
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22856
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, PPARA 2.21207
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, KDR, MIF, SRC, TEK 2.20949
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.20732
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP4, GLO1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 2.1979
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.19773
[BP] GO:0010638 positive regulation of organelle organization AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.18886
[BP] GO:0050927 None F3, KDR, SMAD3 2.18637
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.18637
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.18325
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.16806
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 2.15684
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.15578
[BP] GO:0050926 None F3, KDR, SMAD3 2.14228
[BP] GO:1903393 None KDR, SMAD3, TEK 2.14228
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.13508
[BP] GO:0003013 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 2.13377
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3 2.12792
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.12548
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.12548
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.12049
[BP] GO:0021853 None DRD1, DRD2 2.12049
[BP] GO:0010641 None F3, SRC 2.12049
[BP] GO:0090325 None DRD2, DRD3 2.12049
[BP] GO:0007598 None F10, F3 2.12049
[BP] GO:1904936 None DRD1, DRD2 2.12049
[BP] GO:0042321 None ADORA1, DRD2 2.12049
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.10874
[BP] GO:1903507 None APEX1, AR, AURKB, DRD3, ESR1, ESR2, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC 2.10827
[BP] GO:0010628 positive regulation of gene expression AR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.10605
[BP] GO:1902679 None APEX1, AR, AURKB, DRD3, ESR1, ESR2, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC 2.10272
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTPN1, SRC 2.08567
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5 2.08445
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.0687
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.06397
[BP] GO:0007189 None DRD1, DRD2, DRD3, DRD5 2.06397
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC 2.0465
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, INSR 2.0465
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.04586
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.04586
[BP] GO:0031401 positive regulation of protein modification process ADORA1, AR, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.04231
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.03385
[BP] GO:0040008 regulation of growth AR, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SMAD3 2.02492
[BP] GO:0000122 None AR, AURKB, DRD3, ESR1, ESR2, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3 2.02184
[BP] GO:0051128 regulation of cellular component organization AR, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, TOP2A 2.01334
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3 2.01334
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.01046
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 3.03441
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SMAD3, SRC, TOP2A, TYR, XDH 3.01877
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SMAD3, SRC, TEK, TYR 2.74719
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC 2.687
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.63334
[CC] GO:0031233 None CA4, F10, F3 2.42002
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.31629
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, FLT3, HSD11B1, HSD17B2, NR3C2, PTPN1 2.24771
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, HSD11B1, HSD17B2, NR3C2 2.03385
[MF] GO:0046914 transition metal ion binding ALOX5, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 19.5702
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.9341
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 15.6879
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3 11.2297
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP2A, TYR, XDH 11.2297
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.88
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7345
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 10.6232
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.3689
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.34375
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 7.85383
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 7.69101
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, RORC 7.45483
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 7.37481
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.32018
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.92355
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 6.89666
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK 6.78272
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 6.67717
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.61333
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, HSD17B1, NR3C1, NR3C2, PGR, RORC 6.33581
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.04043
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.57176
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.49993
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.37468
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.2037
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.1923
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, PGR, PPARA, RORC 5.1923
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, PGR, PPARA, RORC 5.1923
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.15245
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.97767
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.76982
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.64532
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.64532
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.54262
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 4.44498
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.96979
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 3.92202
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.86401
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.70759
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.3906
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.3906
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.34113
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.13003
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5 3.09844
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.93206
[MF] GO:0019899 enzyme binding AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F3, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.9146
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.9146
[MF] GO:0008389 None CYP2A13, CYP2A6 2.9146
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, SRC, XDH 2.90706
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.78751
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.68756
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.47938
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.45745
[MF] GO:0001588 None DRD1, DRD5 2.2876
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2876
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.26139
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.24116
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.22292
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.19773
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, PGR, SMAD3, TOP2A, TYR, XDH 2.19667
[MF] GO:0000978 None AR, ESR1, ESR2, NR3C1, PGR, PPARA, RORC, SMAD3 2.14603
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.12049
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12049
[MF] GO:0043559 insulin binding IGF1R, INSR 2.12049
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.10944
[MF] GO:0000987 None AR, ESR1, ESR2, NR3C1, PGR, PPARA, RORC, SMAD3 2.04586
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.03385
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.03385


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.1578
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.0934
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.8517
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.1828
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.565
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.7165
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.9237
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0787
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.8389
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.0317
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.7693
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, DRD1, NR3C1, DRD2, DRD3, DRD5 4.0014
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.306
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA, DRD5 3.043
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 2.8804
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.8105
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.4364
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9539
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.6205
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.2978
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4245
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.263
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.0758
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3, DRD5 2.1322
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0997
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.5068
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1741
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0708
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0426
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0106
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0379
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0059
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.0661
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.7739
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7739
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.0331
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7657
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.6977
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6033
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3734
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4868
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3318
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.3318
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.2248
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR, DRD5 1.1579
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0282
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.988
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5 0.8726
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0066
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8517
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0085
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8517
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8517
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7865
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2248
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.845
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8321
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7865
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2531
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1005
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7865
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8321
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2923
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7865
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7865
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2198
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0974
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7865
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7865
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.7812
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.763
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2089
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6052
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2723
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7438
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6698
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2248
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2693
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.584
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2936
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3089
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3027
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3023
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3027
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2935
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3271
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3342
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3747
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.3827
Platelet activation_Homo sapiens_hsa04611 SRC 0.4
Axon guidance_Homo sapiens_hsa04360 MET 0.3896
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4296
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4296
Melanogenesis_Homo sapiens_hsa04916 TYR 0.453
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.446
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.453
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.453
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4535
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4577
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4574
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4618
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4748
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4748
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4847
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4743
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4261
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.5455
Peroxisome_Homo sapiens_hsa04146 XDH 0.4853
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5222
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0632
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5209
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5096
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5303
Bile secretion_Homo sapiens_hsa04976 CA2 0.5289
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.545
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5432
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5488
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5613
Shigellosis_Homo sapiens_hsa05131 SRC 0.5468
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7069
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5569
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.6075
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.584
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5569
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.584
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6003
Malaria_Homo sapiens_hsa05144 MET 0.6151
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6731
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6187
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6227
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6033
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8891
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6782
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7277
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7865
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.763
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7438
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7757
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7865
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7667
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7865
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8911
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9666


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)