TCM Prescription: Plus and Minus DG and Four Adversary Decoction



Prescription Description
Prescription IDTCMF1969
Pinyin NameJia Jian Dang Gui Si Ni Tang
Chinese Name加减当归四逆汤
English NamePlus and Minus DG and Four Adversary Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1301 Sulfur 硫磺 TCMH1301
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5234
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5462
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA 10.6161
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.6161
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 10.3064
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, PPARA, TYR, XDH 8.51632
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 7.71535
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.82494
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.8034
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, TYR 6.70151
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, TYR 5.88643
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.71396
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.53488
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TNKS, TNKS2, XDH 5.44029
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, HSD11B2, MMP2, PPARA 5.08216
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MMP2, PPARA, TYR 5.05443
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, HSD11B2, TYR 5.03578
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH 5.00723
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH 4.98904
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.8733
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, TYR 4.8604
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.84753
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.8385
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, PPARA 4.68929
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.66573
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, MMP1, MMP2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 4.65253
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, PPARA 4.4773
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.34107
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, TYR 4.20243
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, MMP2, MMP9, PPARA, TNKS2, TYR 3.81199
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, MMP2, MMP9, XDH 3.73906
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.70129
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.5851
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, HCAR2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH 3.54142
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, MMP9 3.54142
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.52914
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.52914
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 3.5236
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, MMP9, PPARA, TYR 3.51147
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, HCAR2, TNKS, TNKS2 3.47634
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.44379
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, MMP9 3.39197
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.27062
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, XDH 3.1477
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 3.0972
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0972
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, MMP9 3.02868
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, APP, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, MMP1, MMP2, MMP9, PPARA, TNKS2, TYR 3.02868
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.00711
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, F3, MMP9, PTPN1, TNKS, TNKS2, XDH 2.97155
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HCAR2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH 2.92596
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F10, F3, FABP4, MMP2, MMP9, PTPN1, TNKS, TNKS2, XDH 2.79075
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78078
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, MMP9 2.71935
[BP] GO:0009115 None AOX1, XDH 2.70494
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH 2.70494
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.67742
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.63872
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH 2.63104
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.63104
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.60145
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.59794
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.5612
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.50543
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APP, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F10, F3, FABP3, FABP4, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, PTPN1, TYR 2.49434
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.42169
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, BCL2, CYP1B1, EGFR, ERBB2, F10, F3, PTPN1, XDH 2.40929
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR 2.40785
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.40105
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.34644
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9 2.32001
[BP] GO:0046110 None AOX1, XDH 2.32001
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.32001
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CYP1A1, EGFR, HSD11B2, MMP2, PPARA, TYR 2.32001
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.30334
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, HCAR2, MMP9, PPARA, PTPN1 2.30051
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.28858
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.24655
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.16845
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14762
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, MMP2, MMP9 2.14067
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.12113
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.10404
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.10404
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.07936
[BP] GO:0070213 None TNKS, TNKS2 2.07936
[BP] GO:0006145 None AOX1, XDH 2.07936
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.07936
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 3.0972
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AOX1, APP, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 2.80486
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2 2.63104
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.47473
[CC] GO:0031233 None CA4, F10, F3 2.31398
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.9361
[MF] GO:0046914 transition metal ion binding AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TYR, XDH 17.3083
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5873
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4547
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 8.90296
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 8.52787
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 8.03153
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 7.05362
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.86967
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.82494
[MF] GO:0046872 metal ion binding ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 6.70151
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.84037
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.37359
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.36759
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.09925
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.93087
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.07612
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.05355
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.88214
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.88214
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.86697
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.53817
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.44379
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, XDH 3.43127
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.39664
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34058
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.23693
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.0972
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.08249
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.04374
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.70494
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.70494
[MF] GO:0003845 None HSD11B1, HSD11B2 2.70494
[MF] GO:0008389 None CYP2A13, CYP2A6 2.70494
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.49432
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.07936


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.4884
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.5874
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.6185
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, ERBB2, MMP9, EGFR 5.5355
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.2772
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.7673
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.5355
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, EGFR, ESR2 3.9488
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1575
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, BCL2, CYP1B1, MMP9, EGFR, CDC25B 3.648
Pathways in cancer_Homo sapiens_hsa05200 CDK6, MMP1, MMP2, ERBB2, BCL2, MMP9, EGFR 2.9863
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.4353
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, ERBB2, EGFR 3.2801
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3675
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, ERBB2, MMP9, ESR1, EGFR 2.6929
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, ADRB1, CACNA1C, PPARA 2.7066
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.4366
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4366
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.1453
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.271
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, EGFR 2.0441
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.2888
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.235
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR 1.9889
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 1.8645
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2, CACNA1C, EGFR 1.9776
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.8069
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR 1.8557
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.54
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.751
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.5354
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3349
Focal adhesion_Homo sapiens_hsa04510 ERBB2, BCL2, EGFR 1.2566
Glioma_Homo sapiens_hsa05214 CDK6, EGFR 1.3301
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.0579
Melanoma_Homo sapiens_hsa05218 CDK6, EGFR 1.2882
Central carbon metabolism in cancer_Homo sapiens_hsa05230 ERBB2, EGFR 1.3156
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2864
ErbB signaling pathway_Homo sapiens_hsa04012 ERBB2, EGFR 1.1695
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4939
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRB1 1.0005
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3996
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1699
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0318
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1596
Gap junction_Homo sapiens_hsa04540 ADRB1, EGFR 1.1692
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2296
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2, EGFR 0.8422
Serotonergic synapse_Homo sapiens_hsa04726 APP, CACNA1C 1.0262
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1418
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9194
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9296
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0005
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9694
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8422
Oxytocin signaling pathway_Homo sapiens_hsa04921 CACNA1C, EGFR 0.8422
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5621
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7016
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8184
Endocytosis_Homo sapiens_hsa04144 ADRB1, EGFR 0.567
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8468
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7562
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 EGFR 0.2784
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 EGFR 0.3374
Rap1 signaling pathway_Homo sapiens_hsa04015 EGFR 0.3386
Ras signaling pathway_Homo sapiens_hsa04014 EGFR 0.3221
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3446
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3813
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3916
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.3806
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3748
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3809
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4415
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4415
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4415
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.427
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4415
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9974
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR 0.4467
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4415
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.4401
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4893
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8069
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5173
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4765
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.48
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4541
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4765
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.751
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5173
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5173
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5173
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5325
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4765
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5173
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4765
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5325
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5538
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5237
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5173
GABAergic synapse_Homo sapiens_hsa04727 CACNA1C 0.5237
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5237
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5173
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5237
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5278
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5237
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5173
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5538
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5583
Peroxisome_Homo sapiens_hsa04146 XDH 0.5325
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5577
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5558
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5379
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5325
Bile secretion_Homo sapiens_hsa04976 CA2 0.5552
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 EGFR 0.5571
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5564
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5724
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5538
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6453
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6643
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6643
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6643
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6643
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7206
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8422
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8094
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8251
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8251
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8422
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8422
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9586
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0277
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2882


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)