Prescription Description
| Prescription ID | TCMF1903 |
| Pinyin Name | Dang Gui Si Ni Tang |
| Chinese Name | 当归四逆汤 |
| English Name | Chinese Angelica Decoction for Restoring Yang |
| Function Description | 手足厥寒, 脉细欲绝者, 当归四逆汤主之下利脉大者, 虚也, 以强下之故也设脉浮革, 因尔肠鸣者, 属当归四逆汤 |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | Blood |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH761 | Cinnamomum cassia | 桂枝 | TCMH761 | GQ255631 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH2239 | Asarum sieboldii | 细辛 | TCMH2239 | ITSAI1576-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH1531 | Akebia quinata | 木通 | TCMH1531 | ITSAJ4440-14 |
| TCMH388 | Ziziphus jujuba | 大枣 | TCMH388 | ITSAM869-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
Showing 1 to 10 of 118 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 72 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.24873 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.24238 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3 | 3.15067 |
| [BP] GO:0001659 | None | ADORA1, ADRB1, DRD1, DRD2 | 3.22255 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 4.86467 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 | 3.51469 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.72177 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, DRD2, EGFR, ERBB2, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.35389 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 3.45882 |
| [BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.69285 |
Showing 1 to 10 of 535 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2956 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R | 9.0186 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5067 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, ADRB1, CACNA1C | 1.3038 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.4542 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.643 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.4729 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.5249 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP, CACNA1C | 0.6749 |
| Amphetamine addiction_Homo sapiens_hsa05031 | CACNA1C, DRD1 | 1.2132 |
Showing 1 to 10 of 165 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples