Prescription Description
| Prescription ID | TCMF187 |
| Pinyin Name | Er Mu An Sou Wan |
| Chinese Name | 二母安嗽丸 |
| English Name | Er Mu An Sou Pills |
| Function Description | 咳嗽 |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | Lung |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2624 | Anemarrhena asphodeloides | 知母 | TCMH2624 | GBVA3255-11, GBVU1201-13 |
| TCMH2343 | Scrophularia ningpoensis | 玄参 | TCMH2343 | ITSAO4295-14 |
| TCMH2515 | Papaver somniferum | 罂粟壳 | TCMH2515 | ITSAD207-14 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH1223 | Tussilago farfara | 款冬花 | TCMH1223 | ITSAH4326-14 |
| TCMH2728 | Aster tataricus | 紫菀 | TCMH2728 | ITSAI2445-14 |
| TCMH1219 | Semen armeniacae amarum | 苦杏仁 | TCMH1219 | |
| TCMH62 | Lilium brownii | 百合 | TCMH62 | ITSAO2415-14 |
| TCMH2596 | Fritillaria verticillata | 浙贝母 | TCMH2596 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT113 | OPRD1 | Delta opioid receptor | GPCR | P41143 |
| TCMT116 | OPRM1 | Mu opioid receptor | GPCR | P35372 |
| TCMT117 | OPRK1 | Kappa opioid receptor | GPCR | P41145 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
Showing 1 to 10 of 100 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1191 | Bacillus megaterium |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1214 | Enterococcus faecium |
Showing 1 to 10 of 54 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.60799 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, GRIK5, HTR1A, MAOB, SLC1A1 | 3.46289 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A | 3.35241 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC | 2.6052 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 2.6875 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH | 5.139 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, XDH | 5.26571 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CYP1A1, CYP1A2, MAOB, OPRK1, OPRM1, SRC | 3.09641 |
| [BP] GO:0003008 | None | ADORA1, AKR1B1, APP, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, SRC, TYR | 4.50314 |
| [BP] GO:0003013 | None | ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC | 3.15292 |
Showing 1 to 10 of 401 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3823 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SRC, MET, IGF1R | 3.1733 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5289 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.0408 |
| Alcoholism_Homo sapiens_hsa05034 | MAOB, DRD1, DRD2 | 1.2896 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3432 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, MAOB, DRD1, GRIA4 | 3.2752 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4162 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.6284 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5 | 1.3396 |
Showing 1 to 10 of 127 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples