TCM Prescription: Bitter Shen Decoction for Promoting Urine



Prescription Description
Prescription IDTCMF1856
Pinyin NameKu Shen Tong Lin Tang
Chinese Name苦参通淋方
English NameBitter Shen Decoction for Promoting Urine
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH1396 Portulaca oleracea 马齿苋 TCMH1396 ITSAK4834-14
TCMH1953 Pyrrosia lingua 石韦 TCMH1953 GBVQ3369-13
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT572 EPHX1 Epoxide hydrolase 1 Hydrolase P07099
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX1, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TYR 13.6895
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 12.8576
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, SLC6A3, SMAD3, SRC, TEK, TYR 12.4836
[BP] GO:0010647 positive regulation of cell communication ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, SMAD3, SRC, TEK, TERT, XDH 12.2239
[BP] GO:0023056 positive regulation of signaling ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, SMAD3, SRC, TEK, TERT, XDH 12.2239
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, ESRRA, FLT3, SLC6A3, SRC, TEK, TYR 10.8432
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, SLC6A3, SRC, TEK, TYR 10.4671
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 10.24
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.0512
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.90177
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, APP, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, TERT, XDH 9.90177
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, SMAD3, SRC, TEK, TERT, XDH 9.86224
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 9.66451
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, SRC, TEK, XDH 9.66451
[BP] GO:0032501 multicellular organismal process ADRA2A, ADRA2C, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESRRB, F10, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP1, TYR 9.62072
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SLC6A3, SRC, TERT 9.28236
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, XDH 9.23254
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, XDH 9.08008
[BP] GO:0050896 response to stimulus ACHE, ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX1, EPHX2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR 8.95891
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, FABP3, FUT7, GLO1, HSPA1A, MIF, PIM1, PPARA, TYR, XDH 8.76939
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AXL, CYP1B1, DRD2, DRD4, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, SRC, TEK, XDH 8.76939
[BP] GO:0030334 regulation of cell migration ADRA2A, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 8.76939
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, EPHX2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA 8.76158
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 8.76144
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, TERT, XDH 8.70431
[BP] GO:0040012 regulation of locomotion ADRA2A, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 8.66643
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, HSPA1A, SLC6A3 8.56531
[BP] GO:2000145 regulation of cell motility ADRA2A, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 8.36198
[BP] GO:0048583 regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 8.28234
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 8.12063
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK, TERT 7.83022
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TERT 7.79284
[BP] GO:0051270 regulation of cellular component movement ADRA2A, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.77389
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.73832
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.64677
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.64677
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.45007
[BP] GO:0032879 regulation of localization ACHE, ADRA2A, ADRA2C, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT 7.43772
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 7.42677
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.30832
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SRC, TEK 7.20617
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TYR 7.19025
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EPHX1, EPHX2, KDR, SLC6A3, SRC 7.18465
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.12876
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 7.11607
[BP] GO:0009966 regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, XDH 7.09397
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.08469
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, SLC6A3, TYR 7.05784
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.05031
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 6.87724
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.82432
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TYR 6.74505
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR 6.67218
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 6.65605
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 6.64905
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, FABP3, KDR, SLC6A2, SLC6A3, SRC, TOP1 6.60713
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, DRD3, DRD4, SLC6A3 6.47459
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC, TERT 6.46147
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ADRA2C, AKR1C3, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.45371
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.43031
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, INSR, SLC6A2, SLC6A3, SMAD3 6.26122
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.25928
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC6A3, SMAD3, SRC, TEK, TERT 6.22469
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.21606
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ADRA2C, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, SMAD3, SRC, TERT, XDH 6.1107
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.09763
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ADRA2C, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, SMAD3, SRC, TERT, XDH 6.09763
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ADRA2C, AKR1C3, APP, AURKB, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.06818
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.06818
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HSD17B1, HSD17B2 6.06818
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ADRA2C, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.02165
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 6.00115
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.98157
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.92073
[BP] GO:0080134 regulation of response to stress ADRA2A, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, TERT, XDH 5.92073
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 5.90011
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TERT 5.89659
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, PPARA, SRC, TOP1, TOP2A 5.86698
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.86228
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, EPHX2, FABP3, FABP4, FUT7, MET, MIF, PPARA 5.82388
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 5.82388
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SRC, TERT 5.73243
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, SMAD3, SRC, TEK, TERT 5.68685
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, SMAD3, SRC, TERT, TOP2A 5.68257
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.67144
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.67144
[BP] GO:0051940 None DRD1, DRD2, DRD3, DRD4 5.63974
[BP] GO:0051584 None DRD1, DRD2, DRD3, DRD4 5.63974
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 5.60398
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3, TYR 5.57337
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 5.53678
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, SLC6A3, SMAD3, TEK 5.51593
[BP] GO:0010038 response to metal ion AKR1C3, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, SLC6A3, TERT 5.42685
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.35341
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.29704
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA 5.23321
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ADRA2C, APP, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MIF, SRC, TEK, XDH 5.22146
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 5.21027
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ADRA2C, APP, DRD2, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, SRC, TEK, XDH 5.20747
[BP] GO:0033993 response to lipid AKR1C3, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 5.18729
[BP] GO:0065009 regulation of molecular function ADRA2A, ADRA2C, APP, AURKB, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TERT, XDH 5.17078
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 5.14086
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 5.14086
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, DRD4, EGFR, INSR, MIF, MMP12, SMAD3, SRC, TERT 5.12819
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA2A, ADRA2C, AKR1C3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, XDH 5.08775
[BP] GO:0050790 regulation of catalytic activity ADRA2A, ADRA2C, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, XDH 5.08775
[BP] GO:0042417 None DRD1, DRD2, DRD3, DRD4, SLC6A3 5.07212
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 5.06942
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 5.06942
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, SMAD3, SRC, TEK, TERT 5.06942
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, MIF 5.00864
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ADRA2C, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, DRD4, EGFR, GPR35, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TERT 4.91919
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TERT, TYR 4.91919
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1, HSD17B2 4.87487
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, MIF 4.82732
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, GPR35, SMAD3 4.80796
[BP] GO:0060134 None DRD1, DRD2, DRD3, SLC6A3 4.7778
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 4.7541
[BP] GO:0044092 negative regulation of molecular function ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC 4.7468
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, APP, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 4.71863
[BP] GO:0051580 None DRD1, DRD2, DRD3, DRD4 4.65634
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.59368
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, XDH 4.54198
[BP] GO:0080090 regulation of primary metabolic process ADRA2A, ADRA2C, AKR1C3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.53741
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TYR 4.52241
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.52241
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD4, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PPARA, SRC, TEK, XDH 4.50243
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 4.45428
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2, DRD4, EGFR 4.42988
[BP] GO:0032225 None DRD1, DRD2, DRD3, DRD4 4.42675
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.39564
[BP] GO:0051952 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3, DRD4 4.36382
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 4.34413
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.25712
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, SRC 4.24497
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 4.23309
[BP] GO:0009987 cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 4.23309
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, XDH 4.22942
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP1, TOP2A 4.22942
[BP] GO:0006950 response to stress ACHE, AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD4, EGFR, EPHX2, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, SLC6A2, SMAD3, SRC, TEK, TERT, TOP2A 4.18451
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, SRC 4.18351
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA 4.17255
[BP] GO:0044093 positive regulation of molecular function ADRA2A, ADRA2C, APP, AURKB, DRD2, DRD4, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT, XDH 4.17255
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.17086
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.17086
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADRA2A, ADRA2C, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, XDH 4.14638
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.14274
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 4.14025
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TERT, TOP2A 4.11079
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, AKR1C3, CYP1A1, DRD3, EPHX2, FABP3, FLT3, PPARA, SRC, TEK 4.08429
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA, SLC6A3, SMAD3, TEK 4.07635
[BP] GO:0048148 None DRD1, DRD2, DRD3, DRD4 4.07347
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.07347
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, SMAD3, SRC, TERT, XDH 4.03478
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CYP1A1, DRD3, DUSP3, INSR, TERT 3.99342
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.99267
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 3.96245
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADRA2A, ADRA2C, AKR1C3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.94448
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, KDR, MIF, SRC 3.94321
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.89899
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, MIF, PPARA 3.88987
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR 3.83403
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR 3.83403
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 3.81978
[BP] GO:0065007 biological regulation ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, XDH 3.81837
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, MIF 3.81133
[BP] GO:0003018 None ADRA2A, ADRA2C, DRD1, EGFR, EPHX2, SRC, TEK 3.81133
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.80708
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, AKR1C3, APEX1, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TERT, XDH 3.79504
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.78266
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.7666
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.7666
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.7666
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9, TERT 3.73986
[BP] GO:0043549 regulation of kinase activity ADRA2A, ADRA2C, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, SRC, TEK 3.73716
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 3.71319
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, DRD4, ESRRB, INSR, PPARA 3.69187
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ADRA2C, APP, DRD2, DRD4, EGFR, ESRRB, FLT3, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 3.68511
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, ADRA2C, APP, AURKB, DRD2, DRD4, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, MIF, SMAD3, SRC, TEK, TERT, XDH 3.66878
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD4 3.65905
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, SRC, XDH 3.6397
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 3.63003
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 3.62618
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.62618
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.62618
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.62618
[BP] GO:0072507 divalent inorganic cation homeostasis APP, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 3.62618
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, DRD4, ESRRB, INSR, PPARA 3.62552
[BP] GO:0050793 regulation of developmental process ADRA2C, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, INSR, KDR, MIF, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 3.6147
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.58526
[BP] GO:0051338 regulation of transferase activity ADRA2A, ADRA2C, APP, AURKB, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, SRC, TEK 3.58213
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 3.58213
[BP] GO:0031399 regulation of protein modification process ADRA2A, ADRA2C, APP, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, SRC, TEK, XDH 3.56921
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APEX1, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TERT, XDH 3.54437
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 3.53906
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ADRA2C, APP, CSNK2A1, DRD2, DRD4, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 3.53428
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.53172
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.53172
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.51023
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2 3.50223
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.49132
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, SRC 3.49107
[BP] GO:0051172 None ADRA2A, APEX1, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TERT, XDH 3.49061
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.49061
[BP] GO:0001666 response to hypoxia CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.43495
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.42994
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, ADRA2C, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, SRC 3.41888
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.41603
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.41393
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.41393
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 3.40591
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.38335
[BP] GO:0002791 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 3.38126
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1 3.37985
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, AKR1C3, APP, AXL, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, SRC, TOP2A 3.37797
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, DRD4 3.36862
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.36337
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.36337
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.36251
[BP] GO:0030003 cellular cation homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.34063
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, DRD4, PPARA 3.33168
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.33168
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.32489
[BP] GO:0090087 None ACHE, ADRA2A, ADRA2C, APP, CA2, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SMAD3, SRC 3.31387
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ADRA2C, APP, DRD2, DRD4, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 3.31387
[BP] GO:0007189 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3 3.3107
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, DRD4, PPARA 3.3107
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.30508
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ADRA2C, APP, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 3.30484
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, FABP3, FABP4, HSPA1A, SLC6A3, SRC, XDH 3.30198
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CYP1A1, DRD2, DRD3, INSR, TERT 3.30046
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, DUSP3, EGFR, KDR, MIF, SRC, TEK 3.30046
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.28875
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, DRD4 3.28875
[BP] GO:0006873 cellular ion homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.26808
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, EGFR, KDR, MIF, SRC, TEK 3.26808
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.25873
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.24665
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.24665
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 3.22712
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 3.22281
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.21768
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PPARA 3.21582
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, DRD4 3.20947
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, INSR, KDR, PIM1, SLC6A3, SMAD3, SRC, TEK, TERT 3.18864
[BP] GO:1904062 None ADRA2A, APP, DRD1, DRD2, DRD3, DRD4, GPR35, MMP9 3.18166
[BP] GO:0006874 cellular calcium ion homeostasis APP, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.17868
[BP] GO:0003013 None ADRA2A, ADRA2C, DRD1, EGFR, EPHX2, SRC, TEK 3.17847
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.17847
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD4 3.16954
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF, TERT 3.16828
[BP] GO:0007165 signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK 3.16427
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A3 3.16285
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, APP, AXL, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, SMAD3, SRC, TEK, TERT, TOP2A 3.16285
[BP] GO:0070482 response to oxygen levels CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.15067
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 3.1472
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD4 3.13323
[BP] GO:0043269 regulation of ion transport ADRA2A, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, GPR35, MIF, MMP9 3.11591
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, DRD4, PPARA 3.09911
[BP] GO:1901020 None ADRA2A, DRD2, DRD4, GPR35 3.09476
[BP] GO:0055074 calcium ion homeostasis APP, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.09476
[BP] GO:0043271 negative regulation of ion transport ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.08553
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 3.0799
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.07235
[BP] GO:0033604 None ADRA2A, ADRA2C, DRD2 3.07235
[BP] GO:0016488 None AKR1B10, AKR1C3 3.07235
[BP] GO:0016487 None AKR1B10, AKR1C3 3.07235
[BP] GO:0016107 None AKR1B10, AKR1C3 3.07235
[BP] GO:0009115 None AOX1, XDH 3.07235
[BP] GO:0006714 None AKR1B10, AKR1C3 3.07235
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.06829
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ADRA2C, APP, CSNK2A1, DRD1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.04681
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD4, EGFR, SLC6A3 3.01904
[BP] GO:0042058 None ADRA2A, ADRA2C, APP, EGFR, MMP9 3.01628
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 3.01628
[BP] GO:0032412 None ADRA2A, APP, DRD2, DRD3, DRD4, GPR35, MMP9 3.0004
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.0004
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.99183
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.9899
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, CSNK2A1, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SMAD3, SRC, TERT 2.9853
[BP] GO:0051254 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 2.9833
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD4, SLC6A3 2.97648
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR 2.96207
[BP] GO:1903170 None ADRA2A, DRD2, DRD4, GPR35 2.96207
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.96207
[BP] GO:2001023 None DRD1, DRD2, DRD3, DRD4, MET 2.95882
[BP] GO:0022898 None ADRA2A, APP, DRD2, DRD3, DRD4, GPR35, MMP9 2.93999
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, SMAD3, XDH 2.93768
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, DRD4 2.92904
[BP] GO:0010628 positive regulation of gene expression APP, DRD1, DRD2, DRD3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 2.92904
[BP] GO:0019933 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3 2.91924
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.91392
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A3 2.91392
[BP] GO:0050730 None ADRA2A, ADRA2C, APP, EGFR, FLT3, MIF, SRC 2.9132
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.89846
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, DRD4 2.89846
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD4 2.89846
[BP] GO:0007188 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3, DRD4 2.88954
[BP] GO:0040008 regulation of growth APP, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SLC6A3, SMAD3 2.88954
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.88954
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SMAD3, SRC 2.87616
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, ADRA2C, DRD1, DRD2, DRD3, EGFR, KDR 2.87483
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.87326
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, HSD17B2, HSPA1A, PPARA, SLC6A3, SMAD3, TERT, TOP1, TOP2A, TYR, XDH 2.87013
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, DRD4 2.8696
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.86558
[BP] GO:0019725 cellular homeostasis APEX1, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.86142
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 2.85716
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, SRC, TEK 2.85191
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.84727
[BP] GO:0070920 None EGFR, ESR1, TERT 2.84727
[BP] GO:0050433 None ADRA2A, ADRA2C, DRD2, DRD3 2.84142
[BP] GO:0055065 metal ion homeostasis APP, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 2.83486
[BP] GO:0051591 None APEX1, APP, SLC6A3, TEK, TYR 2.83486
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, SLC6A3, TYR 2.81905
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, ADRA2C, DRD2, DRD4, EGFR, FLT3, INSR, MIF, SRC, TEK 2.81905
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.81763
[BP] GO:0032409 None ADRA2A, APP, DRD2, DRD3, DRD4, GPR35, MMP9 2.81501
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.81501
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, DRD4 2.81501
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, DRD4 2.80189
[BP] GO:0042752 None DRD2, DRD3, DRD4, PPARA, TOP2A 2.80189
[BP] GO:0051704 multi-organism process ADRA2C, APP, AXL, CYP1A1, DRD3, DRD4, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC, TOP1 2.80189
[BP] GO:0034762 None ADRA2A, APP, CA2, DRD1, DRD2, DRD3, DRD4, GPR35, MMP9 2.80189
[BP] GO:0003008 None ADRA2A, ADRA2C, AKR1B1, AKR1C3, APP, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, INSR, SLC6A3, SRC, TEK, TYR 2.79928
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, MIF 2.79665
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, DRD4 2.78923
[BP] GO:2000351 None AKR1C3, KDR, TEK, TERT 2.78923
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, DRD4 2.78923
[BP] GO:1901184 None ADRA2A, ADRA2C, APP, EGFR, MMP9 2.78923
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.78756
[BP] GO:1901575 None ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FABP4, FUT7, HSPA1A, SLC6A3, XDH 2.78255
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.77251
[BP] GO:0019935 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3 2.77251
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.76666
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, DRD4 2.76174
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, INSR, KDR, PIM1, SMAD3, SRC, TEK, TERT, XDH 2.76166
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, ADRA2C, CYP19A1, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 2.76166
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.76024
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.76024
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.76024
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.76024
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.75846
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, AKR1C3, APEX1, EGFR, ESR1, FLT3, INSR, SRC 2.75846
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, ADRA2C, AURKB, DRD2, DRD4, EGFR, FLT3, INSR, MIF, SRC, TEK 2.75171
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, EGFR, INSR, SMAD3, XDH 2.75038
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2 2.74593
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.7412
[BP] GO:0045893 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 2.73273
[BP] GO:1903508 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 2.73273
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.73179
[BP] GO:1902680 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TOP2A 2.73107
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, SMAD3, SRC 2.73001
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.73001
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, EPHX2, HSPA1A, SLC6A3, XDH 2.72213
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.71887
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SMAD3, SRC 2.71887
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.71792
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.71528
[BP] GO:0051944 None DRD2, DRD4 2.71528
[BP] GO:0046110 None AOX1, XDH 2.71528
[BP] GO:0060160 None DRD2, DRD3 2.71528
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.71528
[BP] GO:0051586 None DRD2, DRD4 2.71528
[BP] GO:0016095 None AKR1B10, AKR1C3 2.71528
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.69805
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.69805
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.69188
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, SMAD3, SRC, TERT 2.6867
[BP] GO:0042069 None DRD1, DRD4, SLC6A3 2.68339
[BP] GO:0042053 None DRD1, DRD4, SLC6A3 2.68339
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.67267
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.67267
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.65982
[BP] GO:0009611 response to wounding ACHE, CYP1A1, DRD2, EGFR, PPARA, SMAD3 2.64683
[BP] GO:0007626 None APP, DRD1, DRD2, DRD3, DRD4, SLC6A3 2.64683
[BP] GO:0032922 None DRD2, DRD3, PPARA, TOP1 2.64589
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, DRD4, EGFR, FLT3, INSR, MIF, SRC 2.64297
[BP] GO:0071880 None ADRA2A, ADRA2C, DRD2 2.62454
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.61234
[BP] GO:0007187 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3, DRD4 2.60004
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.59115
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.58798
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, DRD4, FABP3, PPARA, SLC6A2, SLC6A3 2.58583
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.57962
[BP] GO:0009889 regulation of biosynthetic process ADRA2A, AKR1C3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TERT, TOP2A 2.57667
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A3 2.56815
[BP] GO:0006875 cellular metal ion homeostasis APP, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.54505
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.5432
[BP] GO:0051046 None ACHE, ADRA2A, ADRA2C, CYP19A1, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 2.5385
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, DRD3, DRD4 2.53414
[BP] GO:0051246 regulation of protein metabolic process ADRA2A, ADRA2C, APP, CSNK2A1, DRD1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.53096
[BP] GO:0051234 None ACHE, ADRA2A, AKR1C3, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, DRD4, EGFR, F10, FABP3, HSPA1A, MIF, MMP12, MMP9, PPARA, SLC6A2, SLC6A3, SRC, TERT, XDH 2.52714
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.51574
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.51574
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.51504
[BP] GO:0051179 None ACHE, ADRA2A, AKR1C3, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FABP3, HSPA1A, MIF, MMP12, MMP9, PPARA, SLC6A2, SLC6A3, SRC, TERT, XDH 2.51504
[BP] GO:0051047 None ACHE, CYP19A1, DRD2, DRD3, EGFR, MIF, MMP12, SRC 2.49618
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.49618
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, DRD4 2.49618
[BP] GO:0010638 positive regulation of organelle organization AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.49308
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, DRD3, DRD4 2.49308
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.49308
[BP] GO:0051051 negative regulation of transport ADRA2A, ADRA2C, APP, DRD2, DRD3, DRD4, GPR35, HSPA1A, MMP9 2.48579
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.47855
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, DRD4 2.47795
[BP] GO:0051953 None ADRA2A, ADRA2C, DRD2 2.47795
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.47795
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.47795
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.47795
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, EGFR, TYR 2.47795
[BP] GO:0035625 None ADRA2A, ADRA2C 2.47795
[BP] GO:0032811 None ADRA2A, ADRA2C 2.47795
[BP] GO:0006145 None AOX1, XDH 2.47795
[BP] GO:0097176 epoxide metabolic process EPHX1, EPHX2 2.47795
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.47795
[BP] GO:0051582 None DRD2, DRD4 2.47795
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.47795
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, SRC 2.45925
[BP] GO:0050789 regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, XDH 2.45925
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.44678
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, DRD2, DRD3, DRD4, HSPA1A, MIF, MMP9, SLC6A3, XDH 2.44123
[BP] GO:0097746 None ADRA2A, ADRA2C, DRD1, EGFR, EPHX2 2.43512
[BP] GO:0035296 None ADRA2A, ADRA2C, DRD1, EGFR, EPHX2 2.43512
[BP] GO:0051894 None KDR, SMAD3, TEK 2.43512
[BP] GO:0071875 None ADRA2A, ADRA2C, DRD2 2.43512
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.43512
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, HSPA1A, MIF, MMP12, SMAD3, SRC 2.42828
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.4233
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.4233
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, DRD2, DRD4, GPR35 2.4233
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1 2.4233
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ADRA2C, APP, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 2.40121
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, ADRA2C, DRD2, DRD4, EGFR, FLT3, INSR, MIF, SRC 2.40121
[BP] GO:0050927 None F3, KDR, SMAD3 2.38821
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.37912
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.3784
[BP] GO:0040014 regulation of multicellular organism growth APP, DRD2, DRD3, SLC6A3 2.37756
[BP] GO:1900371 None ADRA2A, DRD1, DRD2, DRD3, DRD4 2.36563
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.35783
[BP] GO:0031326 regulation of cellular biosynthetic process ADRA2A, AKR1C3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, IGF1R, INSR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TERT, TOP2A 2.35766
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.3563
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, APP, AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.3563
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, SMAD3, SRC, TERT 2.3563
[BP] GO:0046683 response to organophosphorus APEX1, APP, SLC6A3, TEK, TYR 2.3563
[BP] GO:0030808 None ADRA2A, DRD1, DRD2, DRD3, DRD4 2.3563
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, TERT, XDH 2.35068
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.35068
[BP] GO:0050926 None F3, KDR, SMAD3 2.35068
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.35068
[BP] GO:1903393 None KDR, SMAD3, TEK 2.35068
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.33146
[BP] GO:0050880 None ADRA2A, ADRA2C, DRD1, EGFR, EPHX2 2.33146
[BP] GO:0010468 regulation of gene expression APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HSPA1A, INSR, KDR, MET, MIF, MMP12, PIM1, PPARA, SMAD3, SRC, TERT, TOP1, TOP2A, XDH 2.31938
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.31938
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.31938
[BP] GO:0035150 None ADRA2A, ADRA2C, DRD1, EGFR, EPHX2 2.31919
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.31132
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.30808
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.30808
[BP] GO:0021853 None DRD1, DRD2 2.30808
[BP] GO:0035624 None ADRA2A, ADRA2C 2.30808
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.30808
[BP] GO:0010641 None F3, SRC 2.30808
[BP] GO:0090325 None DRD2, DRD3 2.30808
[BP] GO:0007598 None F10, F3 2.30808
[BP] GO:1904936 None DRD1, DRD2 2.30808
[BP] GO:0014060 None ADRA2A, ADRA2C 2.30808
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, TOP1 2.28915
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, INSR 2.28915
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.28877
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, DRD4, EGFR, INSR, PPARA, SLC6A3 2.27641
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.27569
[BP] GO:0032147 activation of protein kinase activity ADRA2A, ADRA2C, DRD2, DRD4, EGFR, INSR, SRC 2.27569
[BP] GO:0045944 None APP, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, MET, MMP12, PPARA, SMAD3, TERT, TOP2A 2.27312
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.26926
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.26689
[BP] GO:0034765 None ADRA2A, APP, DRD1, DRD2, DRD3, DRD4, GPR35, MMP9 2.25035
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.24931
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.23777
[BP] GO:0007176 None ADRA2A, ADRA2C, APP 2.23777
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.23777
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TOP2A 2.23177
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TERT, XDH 2.22461
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, DRD3, DRD4 2.21552
[BP] GO:1903169 None ADRA2A, DRD1, DRD2, DRD4, GPR35 2.21552
[BP] GO:0007193 None ADRA2A, DRD2, DRD3, DRD4 2.21327
[BP] GO:1904035 regulation of epithelial cell apoptotic process AKR1C3, KDR, TEK, TERT 2.21327
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.21327
[BP] GO:0006357 None APP, AURKB, CA9, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GLO1, HSPA1A, MET, MMP12, PPARA, SMAD3, TERT, TOP2A 2.20898
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.20766
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.20194
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.20194
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.20194
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, SMAD3, SRC, TEK 2.17647
[BP] GO:0008344 None APP, DRD1, DRD2, DRD4 2.17586
[BP] GO:0014074 response to purine-containing compound APEX1, APP, SLC6A3, TEK, TYR 2.17586
[BP] GO:0007568 aging APEX1, AURKB, CYP1A1, MIF, SLC6A3, TERT 2.17586
[BP] GO:0050678 None EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.17586
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.17586
[BP] GO:1901890 None KDR, SMAD3, TEK 2.17586
[BP] GO:2000352 None KDR, TEK, TERT 2.17586
[BP] GO:0010039 response to iron ion CYP1A1, DRD2, SLC6A3 2.17586
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.17586
[BP] GO:0021843 None DRD1, DRD2 2.17586
[BP] GO:0046113 None AOX1, XDH 2.17586
[BP] GO:1990535 None APP, INSR 2.17586
[BP] GO:0021830 None DRD1, DRD2 2.17586
[BP] GO:0032415 None DRD3, DRD4 2.17586
[BP] GO:0051934 None SLC6A2, SLC6A3 2.17586
[BP] GO:0021984 None DRD2, SLC6A3 2.17586
[BP] GO:0090494 None SLC6A2, SLC6A3 2.17586
[BP] GO:0090493 None SLC6A2, SLC6A3 2.17586
[BP] GO:0051583 None SLC6A2, SLC6A3 2.17586
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.17586
[BP] GO:0021826 None DRD1, DRD2 2.17586
[BP] GO:0016115 None AKR1B10, AKR1C3 2.17586
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.17586
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.17381
[BP] GO:0008217 None DRD2, DRD3, EPHX2, PPARA, SMAD3 2.14723
[BP] GO:0050714 None ACHE, DRD2, EGFR, MIF, MMP12, SRC 2.14486
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, INSR 2.14486
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.14331
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.14331
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.13746
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.13746
[BP] GO:0019538 protein metabolic process ACHE, APP, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP1, TOP2A 2.13746
[BP] GO:2001257 None APP, DRD2, DRD4, GPR35, MMP9 2.12578
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.1189
[BP] GO:0031327 None ADRA2A, AKR1C3, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, SMAD3, SRC 2.11428
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.10916
[BP] GO:1902893 None PPARA, SMAD3, TERT 2.10916
[BP] GO:0106027 None APP, IGF1R, INSR 2.10916
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADRA2A, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HSPA1A, IGF1R, INSR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TERT, TOP2A 2.09393
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, TEK, TERT 2.09086
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, CA2, CA9, CYP1B1, DRD2, EGFR, ESR1, INSR, MET, MMP2, SMAD3, SRC, TEK 2.08904
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.08635
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.08469
[BP] GO:0050794 regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.0648
[BP] GO:0009890 None ADRA2A, AKR1C3, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, SMAD3, SRC 2.06284
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.0616
[BP] GO:0040016 embryonic cleavage TOP1, TOP2A 2.0543
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP3A4 2.0543
[BP] GO:0032226 None DRD2, DRD4 2.0543
[BP] GO:0098810 None SLC6A2, SLC6A3 2.0543
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRA2A, DRD4, EGFR, FLT3, INSR, MIF, SRC 2.04297
[BP] GO:0045936 None ADRA2A, DRD2, DRD3, DRD4, DUSP3, FABP4, IGF1R, PPARA, XDH 2.03985
[BP] GO:0007200 None ADRA2A, DRD1, DRD2, ESR1 2.03936
[BP] GO:1901019 None ADRA2A, DRD2, DRD4, GPR35 2.03936
[BP] GO:0010563 None ADRA2A, DRD2, DRD3, DRD4, DUSP3, FABP4, IGF1R, PPARA, XDH 2.03641
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.03055
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.01838
[BP] GO:1901385 None DRD2, DRD4, GPR35 2.01678
[BP] GO:1900087 None APEX1, CYP1A1, TERT 2.01678
[BP] GO:0045124 None CA2, EGFR, SRC 2.01678
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, MIF, MMP12, SRC 2.01357
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.01016
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AXL, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.01013
[CC] GO:0031226 intrinsic component of plasma membrane ADRA2A, ADRA2C, APP, AXL, CA4, DRD1, DRD2, DRD3, DRD4, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, TEK 4.65758
[CC] GO:0005886 plasma membrane ACHE, ADRA2A, ADRA2C, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT 3.65905
[CC] GO:0044459 plasma membrane part ADRA2A, ADRA2C, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, SRC, TEK 3.50735
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, F3, MET, MIF, SLC6A2, SLC6A3, TEK 3.49061
[CC] GO:0005887 integral component of plasma membrane ADRA2A, ADRA2C, APP, AXL, DRD1, DRD2, DRD3, DRD4, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, TEK 3.22281
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 3.13323
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 3.11591
[CC] GO:0009330 None TOP1, TOP2A 3.07235
[CC] GO:0043227 membrane-bounded organelle ACHE, ADRA2C, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TERT, TOP1, TOP2A, TYR, XDH 2.75038
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 2.69188
[CC] GO:0031233 None CA4, F10, F3 2.62454
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.56815
[CC] GO:0044444 cytoplasmic part ACHE, ADRA2C, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, PIM1, SMAD3, SRC, TERT, TOP1, TOP2A, TYR, XDH 2.56815
[CC] GO:0016020 membrane ACHE, ADRA2A, ADRA2C, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, TYR 2.16691
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 14.5523
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, TYR, XDH 12.988
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1246
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, EPHX1, EPHX2, F10, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TERT, TOP1, TOP2A, TYR, XDH 9.92818
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1, DRD2, DRD3, DRD4, SLC6A3 9.30958
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, TERT, TOP2A, TYR, XDH 9.06973
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A3, SRC, TEK, TOP1, TOP2A 8.76144
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.54969
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.98773
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.82432
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD4, SLC6A3 6.64905
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.47293
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, TERT, TOP2A, TYR, XDH 6.34289
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3 6.06153
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, CSNK2A1, DRD2, DRD4, EGFR, EPHX2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, SMAD3, TERT, TOP2A, TYR, XDH 5.833
[MF] GO:0038023 signaling receptor activity ADRA2A, ADRA2C, AXL, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 5.68928
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.46173
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.44443
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.39026
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.20872
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 5.13859
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 5.06829
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SLC6A3, SMAD3, SRC 5.00384
[MF] GO:0004872 receptor activity ADRA2A, ADRA2C, AXL, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.91919
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.91919
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD4 4.91919
[MF] GO:0004871 signal transducer activity ADRA2A, ADRA2C, AXL, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 4.8853
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.76822
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SLC6A3, SMAD3, SRC 4.73223
[MF] GO:0060089 molecular transducer activity ADRA2A, ADRA2C, AXL, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.72101
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD4, SLC6A3 4.45532
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.18159
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.14638
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD17B1, HSD17B2, XDH 4.14025
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 4.09593
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.08429
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.99267
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.99267
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.81133
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.69355
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.64392
[MF] GO:0051379 None ADRA2A, ADRA2C, DRD4 3.62618
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.62618
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT, TOP1 3.59833
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.49061
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.49061
[MF] GO:0097159 organic cyclic compound binding ADRA2A, ADRA2C, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, SLC6A3, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, XDH 3.46426
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, PPARA 3.37682
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.2764
[MF] GO:0005102 receptor binding ADRA2A, ADRA2C, APP, DRD2, DRD3, EGFR, EPHX2, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, SLC6A3, SMAD3, SRC 3.27596
[MF] GO:0099600 transmembrane receptor activity ADRA2A, ADRA2C, AXL, DRD1, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.22712
[MF] GO:0004888 transmembrane signaling receptor activity ADRA2A, ADRA2C, AXL, DRD1, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.22712
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.13073
[MF] GO:0045550 None AKR1B10, AKR1C3 3.07235
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.07235
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.03722
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.96918
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, MIF, PPARA, SLC6A3, SMAD3, SRC, TEK, TOP2A 2.92904
[MF] GO:0004935 None ADRA2A, ADRA2C, DRD2 2.84727
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRA2C, AOX1, DRD2, EPHX2, FLT3, SMAD3, TERT, TOP2A, TYR, XDH 2.834
[MF] GO:0047718 None AKR1B10, AKR1C3 2.71528
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.71528
[MF] GO:0004938 None ADRA2A, ADRA2C 2.71528
[MF] GO:0005330 None SLC6A2, SLC6A3 2.71528
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.65982
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.62454
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.55616
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.55616
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TOP1 2.54505
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD17B1, HSD17B2 2.49308
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.48523
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.47795
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.47795
[MF] GO:0051425 None APP, INSR 2.47795
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.47795
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.46973
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.46391
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.44092
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.40121
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.3563
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.35068
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.31318
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.31132
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.30855
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.30808
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.30808
[MF] GO:0043559 insulin binding IGF1R, INSR 2.30808
[MF] GO:0051380 None ADRA2A, DRD4 2.30808
[MF] GO:0046983 protein dimerization activity ACHE, ADRA2A, ADRA2C, AOX1, AXL, DRD2, EGFR, EPHX2, FLT3, SMAD3, TERT, TOP2A, TYR, XDH 2.26496
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.23777
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.23777
[MF] GO:0005329 None SLC6A2, SLC6A3 2.17586
[MF] GO:0004936 None ADRA2A, ADRA2C 2.17586
[MF] GO:0004064 arylesterase activity CA1, CA2 2.17586
[MF] GO:0043546 None AOX1, XDH 2.17586
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.17586
[MF] GO:0004301 None EPHX1, EPHX2 2.17586
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.07486
[MF] GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen AKR1C3, CYP1A1, CYP3A4 2.07486
[MF] GO:0003916 None TOP1, TOP2A 2.0543
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.0543
[MF] GO:0001758 None AKR1B10, AKR1C3 2.0543
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1 2.0543
[MF] GO:0004032 None AKR1B1, AKR1C3 2.0543
[MF] GO:0008134 transcription factor binding APEX1, ESR1, ESRRB, FLT3, PIM1, PPARA, SMAD3, SRC, TERT 2.05411
[MF] GO:0004252 None F10, F3, MMP1, MMP12, MMP2, MMP9 2.04115
[MF] GO:0035258 None ESR1, FLT3, SMAD3, SRC 2.02228


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 11.1314
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1314
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 8.9263
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.5974
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.8066
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.957
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.8881
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.1334
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 EPHX1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.0451
Metabolic pathways_Homo sapiens_hsa01100 EPHX2, AKR1C3, AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 3.6234
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.4311
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.161
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.828
Chemical carcinogenesis_Homo sapiens_hsa05204 EPHX1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.8422
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, DRD1, ADRA2C, DRD2, DRD3, DRD4, ADRA2A 3.2783
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3, SLC6A3, DRD4 3.124
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.9897
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1495
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.5678
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0991
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.777
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.5541
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.4078
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.2012
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2012
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.155
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.777
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2, SLC6A3 2.4139
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR 1.8508
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2, AKR1C3 2.1801
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1119
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1071
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0922
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8604
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.087
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.1023
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8444
Bile secretion_Homo sapiens_hsa04976 CA2, EPHX1, CYP3A4 2.0922
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3812
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.3703
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2, SLC6A3 1.3844
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.3844
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR, ADRA2C, ADRA2A 1.2666
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2, SLC6A3 1.219
cAMP signaling pathway_Homo sapiens_hsa04024 DRD1, DRD2, PPARA 1.1231
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9169
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9296
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3271
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0676
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0788
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2823
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0379
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2545
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9212
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3211
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8162
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9055
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1376
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8271
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2498
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9055
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8739
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0655
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9055
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8066
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8066
Amphetamine addiction_Homo sapiens_hsa05031 DRD1, SLC6A3 1.2451
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1345
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8066
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7823
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3013
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7645
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.1092
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7645
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR 0.6955
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6371
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6082
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2887
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3297
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3137
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3231
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.5303
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3227
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3231
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3297
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3135
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3556
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3843
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3935
Platelet activation_Homo sapiens_hsa04611 SRC 0.4136
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4136
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4136
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4442
Axon guidance_Homo sapiens_hsa04360 MET 0.4086
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4425
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4425
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4666
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4661
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4666
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.459
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4661
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4661
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4671
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4669
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.4756
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4712
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4806
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4806
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4903
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.48
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5303
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5303
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5191
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5397
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5583
Shigellosis_Homo sapiens_hsa05131 SRC 0.5602
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5789
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5602
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5702
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6017
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.618
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6045
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7749
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6402
Malaria_Homo sapiens_hsa05144 MET 0.6371
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6371
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6371
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7934
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6371
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7303
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6968
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9485
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7361
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6955
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8066
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.766
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7552
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7833
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8066
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8066
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9212
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0445
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2666


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)