TCM Prescription: Pellet of Poria and Cuscutae



Prescription Description
Prescription IDTCMF1755
Pinyin NameFu Tu Dan
Chinese Name茯菟丹
English NamePellet of Poria and Cuscutae
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, KDR, MET, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 11.9656
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 9.93485
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, SLC6A3, SRC, TRPV1, TYR 9.56605
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, SLC6A3, SRC, TRPV1, TYR 9.56605
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, HMGCR, HTR1A, SLC6A3, TYR 9.1705
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, SLC6A2, SLC6A3, SRC, TRPV1, TYR 8.95256
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 8.55265
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.5463
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, NR3C1, SLC6A3, SRC, TRPV1, TYR 6.84021
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC6A2, SLC6A3, SRC, TRPV1, TYR 6.84021
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HMGCR, KDR, NR3C1, SLC6A2, SLC6A3, SRC, TRPV1 6.83341
[BP] GO:0007193 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HTR1A 6.83341
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, HTR1A, SLC6A3, TYR 6.76325
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.66932
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.66932
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HMGCR, PIM1, PPARA, TYR, XDH 6.59723
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 6.42939
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, SLC6A3, SRC 6.39514
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, HTR1A, SLC1A1, SLC6A2, SLC6A3, TRPV1 6.31741
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 6.22188
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TRPV1 6.1547
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, HMGCR, MET, PPARA 6.11623
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A3, SRC, TOP2A, TRPV1, XDH 6.08718
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SRC, TOP2A, TRPV1, XDH 5.90919
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TRPV1, TYR 5.88761
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.79356
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, GRIK5, GRM5, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, SRC, TRPV1 5.79356
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, TRPV1, XDH 5.59809
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, SRC, XDH 5.58601
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, SRC, XDH 5.56371
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 5.52818
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TRPV1, TYR 5.52818
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.51424
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC, TOP2A, TRPV1, XDH 5.48659
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.39738
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.25427
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.18965
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, SLC6A2, SLC6A3, SRC, TOP2A, TRPV1, TYR 5.18965
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 5.13563
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.09187
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 5.09187
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, ALOX12, APP, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 5.06249
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TRPV1 5.03035
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 5.00057
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC, TOP2A, TRPV1, XDH 4.94745
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, SRC, XDH 4.91238
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, SRC, TRPV1 4.89058
[BP] GO:0007188 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HTR1A 4.89058
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.84257
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.84256
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, SRC, XDH 4.83496
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, SLC6A3, TYR 4.79391
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.77025
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, BCL2, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 4.70325
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 4.68125
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A 4.68125
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.58483
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3, TRPV1 4.55753
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.55723
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.54273
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CSNK2A1, DRD2, DRD3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 4.53812
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.51594
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, SRC 4.51594
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.5035
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD2, DRD3, DRD4, HTR1A, SLC6A3 4.5035
[BP] GO:0007187 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HTR1A 4.49453
[BP] GO:0007610 None APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, HMGCR, HTR1A, PPARA, SLC6A3, TRPV1 4.47706
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.40924
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TOP2A, TRPV1, TYR, XDH 4.39131
[BP] GO:0060078 None DRD4, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.38652
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, SRC, XDH 4.36731
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.23607
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.23607
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 4.20714
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.19723
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, PPARA, SRC, TOP2A 4.16732
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, SRC, XDH 4.16207
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC, TRPV1 4.13729
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 4.12188
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, SRC, XDH 4.12188
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, MET, SRC, XDH 4.09732
[BP] GO:0007268 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.09732
[BP] GO:0098916 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.09732
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 4.05156
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 4.05041
[BP] GO:0099536 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.02963
[BP] GO:0099537 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.02963
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 4.01923
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 4.01923
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, GRM1, HMGCR, MMP2, PPARA, SRC, TRPV1, TYR 3.98233
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.98162
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, SRC, TRPV1 3.97609
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.97294
[BP] GO:0042391 None APP, BCL2, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.97144
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.95526
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.92805
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.92805
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, SRC, TRPV1 3.89589
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TOP2A, TRPV1, XDH 3.88132
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, SRC, TOP2A, TRPV1, XDH 3.88132
[BP] GO:0040012 regulation of locomotion ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, DRD3, IGF1R, KDR, MET, MMP9, SRC 3.8735
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.85152
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, SLC6A3 3.81221
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HMGCR, HTR1A, MMP12, MMP9, PPARA, SRC, TRPV1 3.80958
[BP] GO:0030334 regulation of cell migration ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.8004
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79445
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TOP2A, TRPV1 3.76552
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, HMGCR, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SLC6A3, SRC, TRPV1 3.7341
[BP] GO:0009725 response to hormone AKR1B1, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 3.72723
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD2, GRM1, GRM3, GRM5, GRM8 3.68591
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.68536
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.68536
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, GRM1, GRM5, TRPV1 3.67227
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.67227
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, SLC6A3, SRC, TOP2A, TYR, XDH 3.66239
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.65262
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.59565
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.59565
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 3.59565
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.59565
[BP] GO:0007626 None APP, DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 3.59565
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.57145
[BP] GO:2000145 regulation of cell motility ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.55558
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, SLC6A3 3.46799
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.46799
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SLC6A3, SRC, TOP2A, TYR 3.45422
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, SRC, XDH 3.43566
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD2, DRD3, HMGCR, KDR, SRC, TRPV1 3.42617
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.4142
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, SRC, TYR 3.40389
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC 3.40389
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 3.40389
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.37299
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.36979
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, SRC, TRPV1 3.35244
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.32825
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.32825
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32825
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.27837
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.26614
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.25273
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TOP2A, TRPV1, XDH 3.22585
[BP] GO:0051270 regulation of cellular component movement ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.22495
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1, TRPV1 3.22204
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.20974
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, SRC, XDH 3.19522
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.19522
[BP] GO:0098657 import into cell ACHE, ALOX15, APP, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3, TRPV1 3.16567
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 3.13832
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM5, TRPV1 3.07343
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM5, TRPV1 3.07343
[BP] GO:0022898 None APP, BCL2, DRD2, DRD3, DRD4, GRM5, MMP9 3.00178
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.00178
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 3.00178
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.99119
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.97758
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.97758
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.96434
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.96434
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.96434
[BP] GO:0051588 None DRD2, DRD3, DRD4, GRIK5, HTR1A 2.93907
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.92108
[BP] GO:0032409 None APP, BCL2, DRD2, DRD3, DRD4, GRM5, MMP9 2.86325
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.85717
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.85717
[BP] GO:0009056 catabolic process ACHE, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 2.82975
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.82417
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.82082
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.78083
[BP] GO:0042752 None DRD2, DRD3, DRD4, PPARA, TOP2A 2.78083
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.77807
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, FLT3, NR3C1, SRC, TRPV1 2.76557
[BP] GO:0008542 None APP, DRD2, DRD3, HMGCR 2.76557
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.76557
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.76557
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DRD2, DRD4, FLT3, GRM1, HMGCR, IGF1R, KDR, SRC, XDH 2.7536
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, TYR 2.75305
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.74628
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, XDH 2.71899
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.71752
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, XDH 2.71644
[BP] GO:0007154 None AXL, BCL2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TRPV1 2.71271
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TOP2A, TRPV1, TYR, XDH 2.70272
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.69908
[BP] GO:0051046 None ACHE, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HMGCR, HTR1A, MMP12, SRC, TRPV1 2.68199
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD2, DRD3, DRD4, FLT3, FUT7, GLO1, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC6A3, SRC, TOP2A, TYR, XDH 2.65274
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.64953
[BP] GO:0043269 regulation of ion transport APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GRM5, HTR1A, MMP9 2.63842
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, SRC, TOP2A, TRPV1, XDH 2.62615
[BP] GO:0007632 None APP, DRD2, DRD3, HMGCR 2.62615
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.62615
[BP] GO:0046942 None DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 2.62615
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TOP2A, TRPV1, TYR, XDH 2.60527
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, SRC, XDH 2.60259
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD4, HTR1A, SLC6A2 2.60133
[BP] GO:0003008 None AKR1B1, APP, BCL2, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HMGCR, HTR1A, SLC6A3, SRC, TRPV1, TYR 2.5908
[BP] GO:0042069 None DRD4, HTR1A, SLC6A3 2.5908
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.5908
[BP] GO:0042053 None DRD4, HTR1A, SLC6A3 2.5908
[BP] GO:0099566 None GRM1, GRM5 2.5908
[BP] GO:0051944 None DRD2, DRD4 2.5908
[BP] GO:0060160 None DRD2, DRD3 2.5908
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.5908
[BP] GO:0051586 None DRD2, DRD4 2.5908
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.58772
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.58524
[BP] GO:0015849 None DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 2.58371
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.56703
[BP] GO:0032102 negative regulation of response to external stimulus ALOX12, CYP19A1, DRD2, DRD3, HMGCR, PPARA, SLC6A3 2.56703
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.55682
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.53913
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, SRC, XDH 2.53624
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.52011
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD2, DRD3, HMGCR, TYR 2.51621
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.50413
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.50284
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.49619
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, GRM5, IGF1R, MMP2, SRC, TRPV1 2.4955
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, ALOX12, DRD2, MET, TRPV1 2.4955
[BP] GO:0032101 regulation of response to external stimulus ALOX12, CYP19A1, DRD2, DRD3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SLC6A3 2.4955
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.49035
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, HMGCR, IGF1R, MET, MMP9, SRC, XDH 2.48398
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.48398
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.48097
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HMGCR, KDR, SRC 2.48097
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.47469
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.4628
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.4628
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD2, DRD4 2.4628
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.45803
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, FABP3, FABP4, MET 2.4498
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, TYR 2.44234
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.44105
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, SRC, TRPV1 2.42986
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.40408
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.39756
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.39756
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39756
[BP] GO:0051050 positive regulation of transport ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD2, DRD3, DRD4, MMP12, SRC, TRPV1 2.38677
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, TYR 2.37953
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, SRC 2.37743
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.37442
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.36686
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, SRC, TRPV1, XDH 2.36686
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, SRC, TOP2A, TRPV1, XDH 2.36686
[BP] GO:0051582 None DRD2, DRD4 2.36686
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36686
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.36476
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.36414
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36285
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, MET, SRC, XDH 2.36232
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.36134
[BP] GO:0046683 response to organophosphorus APEX1, APP, SLC6A3, TRPV1, TYR 2.35494
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.35494
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, SRC, XDH 2.34778
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HMGCR, HTR1A, MMP12, SRC 2.34778
[BP] GO:0048585 negative regulation of response to stimulus ALOX12, ALOX15, BCL2, CYP19A1, DRD2, DRD3, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, SLC6A3, SRC, XDH 2.34755
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, FLT3, GRM5, IGF1R, MMP2, NR3C1, SRC, TRPV1 2.34514
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, BCL2, DRD2, DRD3, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, SRC, TOP2A, TRPV1, XDH 2.34321
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.33141
[BP] GO:0048169 None APP, DRD2, GRM5 2.32303
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, GRM5, IGF1R, MMP2, SRC, TRPV1 2.32252
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HMGCR 2.30759
[BP] GO:0060079 None GRIA2, GRIA4, GRIK5, TRPV1 2.30759
[BP] GO:0007612 None APP, DRD2, DRD3, GRM5, HMGCR 2.28244
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.28244
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.28244
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.28244
[BP] GO:0008306 None APP, DRD2, DRD3, HMGCR 2.26794
[BP] GO:0032412 None APP, DRD2, DRD3, DRD4, GRM5, MMP9 2.26794
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR 2.26122
[BP] GO:0034762 None APP, BCL2, CA2, DRD2, DRD3, DRD4, GRM5, MMP9 2.26122
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD2, DRD3, IGF1R, KDR, MET, MMP1, MMP9, SRC 2.2534
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, IGF1R, KDR, MET, MMP9, SRC 2.24365
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.24365
[BP] GO:0030534 None APP, DRD2, DRD3, DRD4, PPARA 2.23594
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.23205
[BP] GO:0043271 negative regulation of ion transport BCL2, DRD2, DRD3, DRD4, MMP9 2.22382
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.21057
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.19875
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.19875
[BP] GO:0090325 None DRD2, DRD3 2.19875
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.19722
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, SLC6A3 2.19658
[BP] GO:0032845 None BCL2, DRD2, HMGCR, SRC, TRPV1 2.19287
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.1784
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.17298
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.17298
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.17298
[BP] GO:0014074 response to purine-containing compound APEX1, APP, SLC6A3, TRPV1, TYR 2.17298
[BP] GO:0009410 None DRD2, DRD3, DRD4, NR3C1, SLC6A3 2.17298
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, SRC, TRPV1, XDH 2.17141
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, IGF1R, KDR, MET, MMP9, SRC 2.16669
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.15043
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.14987
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, DRD2, DRD3, DRD4, MMP9, SLC1A1, SLC6A3, TRPV1, XDH 2.147
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.14589
[BP] GO:0043086 negative regulation of catalytic activity APP, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, HMGCR, IGF1R, MMP9, SRC 2.14493
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, HTR1A, MMP2, MMP9, PPARA, SLC6A2, SRC, TOP2A, TRPV1 2.14238
[BP] GO:0002209 None BCL2, DRD4, HTR1A 2.14238
[BP] GO:0001662 None BCL2, DRD4, HTR1A 2.14238
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.14238
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TOP2A, TRPV1, XDH 2.14224
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, SLC6A3, SRC, TYR 2.14202
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.13741
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, SLC6A3, SRC, XDH 2.13444
[BP] GO:0006810 None ACHE, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 2.12925
[BP] GO:0006140 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.12614
[BP] GO:0050877 None APP, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HMGCR, SLC6A3, TRPV1, TYR 2.12308
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.11154
[BP] GO:0045744 None DRD2, DRD3, MET 2.11154
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.11154
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, IGF1R, KDR, MET, MMP9, SRC 2.10811
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.10642
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, HMGCR, MMP9, SRC, TOP2A, TRPV1, XDH 2.08701
[BP] GO:0040018 None BCL2, DRD2, SLC6A3 2.08459
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.08459
[BP] GO:0042596 None BCL2, DRD4, HTR1A 2.08459
[BP] GO:0032410 None DRD2, DRD3, DRD4, MMP9 2.08459
[BP] GO:1904063 None DRD2, DRD3, DRD4, MMP9 2.08459
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.08459
[BP] GO:0032415 None DRD3, DRD4 2.08459
[BP] GO:0051934 None SLC6A2, SLC6A3 2.08459
[BP] GO:0021984 None DRD2, SLC6A3 2.08459
[BP] GO:0090494 None SLC6A2, SLC6A3 2.08459
[BP] GO:0090493 None SLC6A2, SLC6A3 2.08459
[BP] GO:0051583 None SLC6A2, SLC6A3 2.08459
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.08459
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.08459
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TOP2A, TRPV1, XDH 2.08032
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GRIK5, HMGCR, MMP9, SRC, TOP2A, TRPV1, XDH 2.07542
[BP] GO:0051234 None ACHE, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 2.06067
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.05627
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.0489
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, DRD3, FABP3, FLT3, HMGCR, PPARA, SRC 2.04226
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.03451
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, IGF1R, KDR, MET, MMP9, SRC 2.03374
[BP] GO:0045927 positive regulation of growth ALOX12, BCL2, CSNK2A1, DRD2, PIM1, SLC6A3 2.03148
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, SRC, TOP2A, XDH 2.02856
[BP] GO:0007267 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.01978
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, HTR1A, SLC6A3 2.00314
[BP] GO:0060359 None DRD2, DRD3, DRD4, SLC6A3 2.00314
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.00204
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1 5.67321
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1 5.3304
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX12, ALOX15, ALPI, APP, AXL, CA12, CA14, CA2, CA4, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, MMP2, PIM1, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1 5.13563
[CC] GO:0044456 None ACHE, APP, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC, TRPV1 4.89058
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX12, ALOX15, ALOX5, ALPI, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP2, PIM1, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, TYR 4.89058
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, APP, AXL, CA2, CA4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1 4.66625
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPI, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, TYR 3.8654
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.60387
[CC] GO:0098590 plasma membrane region CA2, CA4, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 3.47632
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.30823
[CC] GO:0043005 None APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.03681
[CC] GO:0098794 None APP, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.97176
[CC] GO:0043197 None APP, DRD2, GRIA2, GRIA4, GRM3 2.4955
[CC] GO:0044309 None APP, DRD2, GRIA2, GRIA4, GRM3 2.47469
[CC] GO:0014069 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.47469
[CC] GO:0099572 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.47469
[CC] GO:0042995 cell projection AKR1B1, APP, CA2, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.14968
[CC] GO:0097458 None APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3, SRC, TRPV1 2.11732
[CC] GO:0031224 None ACHE, ADORA3, ALPI, APP, AXL, CA12, CA14, CA4, CYP3A4, DRD2, DRD3, DRD4, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1, TYR 2.06067
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, TYR, XDH 10.9771
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TOP2A, TRPV1, TYR, XDH 9.56605
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.33266
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.07739
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, TOP2A, TRPV1, TYR, XDH 7.14015
[MF] GO:0030594 None DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A 6.92651
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.84021
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.8068
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.58601
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 5.47188
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.3304
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC, TOP2A, TRPV1 5.31168
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.11046
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPI, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TOP2A, TYR, XDH 5.09187
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.05752
[MF] GO:0004872 receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 4.79391
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, TOP2A, TRPV1, TYR, XDH 4.77181
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, TRPV1 4.7707
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, TRPV1 4.7707
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.70325
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 4.62309
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, HTR1A, SLC6A3 4.49885
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.48092
[MF] GO:0004871 signal transducer activity ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 4.23848
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.21286
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.15929
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 4.05041
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.95526
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA 3.60387
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.60387
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.59565
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.48382
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.44977
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.338
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.18206
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.17844
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.10161
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.96434
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.93575
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, DRD4, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, TOP2A, TRPV1, TYR, XDH 2.90649
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.76557
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, SRC, XDH 2.64063
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.62041
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.5908
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.5908
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.5908
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.5908
[MF] GO:0005330 None SLC6A2, SLC6A3 2.5908
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.5908
[MF] GO:0099583 None GRM1, GRM5 2.5908
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.37442
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.36686
[MF] GO:0004971 None GRIA2, GRIA4 2.36686
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.36686
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SLC6A3, SRC 2.3225
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.28244
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.24365
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.24365
[MF] GO:0051721 None BCL2, HMGCR, SLC6A3 2.20162
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.19875
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.19722
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.17298
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.08459
[MF] GO:0005329 None SLC6A2, SLC6A3 2.08459
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08459
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NR3C1 2.05103
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.02541
[MF] GO:0019902 phosphatase binding BCL2, HMGCR, MET, PPARA, SLC6A3 2.00212


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, HTR1A, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, DRD2, DRD3, DRD4, GRIA4 10.7357
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.3446
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1925
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.1679
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.3446
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPI, XDH 5.4865
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.6174
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4387
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.329
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3905
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9638
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, HTR1A, ALOX12 3.5255
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.6929
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.3905
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.7951
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1464
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2374
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.7924
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.9285
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.7815
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR1A, DRD2, PPARA, GRIA4 2.6521
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.6402
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.5709
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.2912
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3614
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET 2.029
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7924
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.2821
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2868
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.8505
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.029
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1266
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2912
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8752
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5193
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.2231
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4543
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, IGF1R 1.2207
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0812
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3259
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0924
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2587
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.083
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.1397
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2395
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9527
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3718
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9735
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2562
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0728
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0168
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.181
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.2536
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0812
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9477
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9477
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8768
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.9416
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9234
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.8468
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7862
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8564
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4538
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.7433
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6722
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.7433
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7433
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5188
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6142
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3073
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3172
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3327
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3395
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3521
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.362
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3995
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3 0.362
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.362
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3888
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4033
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3394
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3856
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3995
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3739
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3995
Platelet activation_Homo sapiens_hsa04611 SRC 0.4274
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4074
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4284
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.452
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.452
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4274
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4305
Axon guidance_Homo sapiens_hsa04360 MET 0.4199
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4782
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4932
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4752
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4752
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4817
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4817
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4932
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4932
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4817
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4932
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4932
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4932
Peroxisome_Homo sapiens_hsa04146 XDH 0.4932
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4932
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5379
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5319
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5441
Glioma_Homo sapiens_hsa05214 IGF1R 0.5634
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5634
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5622
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.567
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.5971
Shigellosis_Homo sapiens_hsa05131 SRC 0.5634
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5815
Malaria_Homo sapiens_hsa05144 MET 0.6453
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.029
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7841
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7169
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.744
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7765
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7693
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7625
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7433
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8251
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8156
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8755
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 1.0105
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1266


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)