TCM Prescription: Decoction for Changing Yellow Leukorrhea



Prescription Description
Prescription IDTCMF1739
Pinyin NameYi Huang Tang
Chinese Name易黄汤
English NameDecoction for Changing Yellow Leukorrhea
Function Description妇人有带下而色黄者, 宛如黄茶浓汁, 其气腥秽, 所谓黄带是也法宜补任脉之虚, 而清肾火之炎, 则庶几矣方用易黄汤
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationUterus
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH60 Ginkgo biloba 白果 TCMH60 ITSAJ4779-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT578 GLRA2 Glycine receptor subunit alpha-2 Ion channel P23416
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, KDR, MET, PPARA, PPARD, PRKCA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 10.5408
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLRA1, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, PPARA, PPARD, PRKCA, RORC, SLC6A3, SRC, TYR 9.24523
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, GLRA1, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PPARD, RORC, SLC6A3, SRC, TYR 9.15944
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLRA1, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PPARD, PRKCA, RORC, SLC6A2, SLC6A3, SRC, TYR 8.72026
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.96067
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLRA1, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TOP2A, XDH 6.96067
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, GLRA1, KDR, MMP9, SLC6A3, SRC 6.81958
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD1, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.81958
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD1, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.81958
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, MET, MMP12, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 6.55806
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, GLRA1, KDR, SLC6A3, SRC 6.55806
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, MET, MMP12, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 6.54395
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, PPARD, SLC6A3, TYR 6.46513
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, PPARA, PPARD, SLC1A1 6.43334
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP4, GLRA1, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SLC6A2, SLC6A3, SRC, TYR 6.28614
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD4, FABP3, FLT3, GLRA1, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 6.13835
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, DRD4, FABP3, GLRA1, PPARA, PPARD, SLC1A1 6.13733
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, GLRA1, GRIA2, GRIA4, GRIK5, PPARA, PPARD, SLC1A1, SLC6A2, SLC6A3 6.09784
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, TOP2A, XDH 6.09784
[BP] GO:0007268 None DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.03859
[BP] GO:0098916 None DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.03859
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, GRIK5, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, SRC, TOP2A, XDH 6.024
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 5.98029
[BP] GO:0099536 None DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.98029
[BP] GO:0099537 None DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.98029
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLRA1, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A2, SLC6A3, SRC, TOP2A, TYR 5.97935
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA, PRKCA 5.91884
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 5.90809
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, GRIK5, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PRKCA, PTPN1, SRC, TOP2A, XDH 5.90687
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA, PRKCA 5.90687
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD4, FABP3, FLT3, GLRA1, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 5.88533
[BP] GO:0007193 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 5.78118
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.7728
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.7728
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, FLT3, RORC, SLC6A3, SRC, TYR 5.75657
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, PPARD 5.75546
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3, TYR 5.75157
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.75157
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.75157
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.73872
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, FABP3, GLRA1, KDR, SLC6A2, SLC6A3, SRC 5.7248
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 5.67577
[BP] GO:0051940 None DRD1, DRD2, DRD3, DRD4 5.67577
[BP] GO:0051584 None DRD1, DRD2, DRD3, DRD4 5.67577
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.67577
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.56761
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.53245
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.53245
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.48461
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.46802
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.44425
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, GRIK5, IGF1R, KDR, MMP9, PIM1, PPARD, PRKCA, PTPN1, SRC, TOP2A, XDH 5.39574
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, HSD17B1, HSD17B2, MET, PPARA, PPARD 5.34684
[BP] GO:0032879 regulation of localization ACHE, ADORA3, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, GRIK5, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, SRC 5.27033
[BP] GO:0030817 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 5.2029
[BP] GO:0042417 None DRD1, DRD2, DRD3, DRD4, SLC6A3 5.18699
[BP] GO:0007188 None DRD1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 5.1323
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 5.1303
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.95299
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3, PRKCA 4.92304
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PRKCA, SRC, XDH 4.8883
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, GLRA1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PPARD, RORC, SRC 4.85632
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC 4.85361
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PRKCA 4.85284
[BP] GO:0060134 None DRD1, DRD2, DRD3, SLC6A3 4.85108
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARD 4.84859
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GLRA1, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PPARD, RORC, SRC 4.84654
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3, PRKCA 4.83796
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, PPARD, PRKCA, SRC 4.83796
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, SLC6A3 4.83042
[BP] GO:0030814 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 4.80574
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARD, PRKCA, SRC 4.76955
[BP] GO:0007626 None DRD1, DRD2, DRD3, DRD4, GLRA1, GRM1, GRM5, SLC6A3 4.76069
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.75526
[BP] GO:0051580 None DRD1, DRD2, DRD3, DRD4 4.75526
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, MET, MMP12, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 4.75526
[BP] GO:0030802 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 4.75526
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.75175
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3, PRKCA 4.75175
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 4.72906
[BP] GO:0007187 None DRD1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.72031
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.6959
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, GLRA1, GRIK5, GRM5, IGF1R, KDR, MMP2, PPARD, RORC, SRC 4.68657
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, GLO1, PIM1, PPARA, PPARD, TYR, XDH 4.66143
[BP] GO:0019220 regulation of phosphate metabolic process CDC25B, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 4.58011
[BP] GO:0060078 None DRD4, GLRA1, GRIA2, GRIA4, GRIK5, GRM5 4.58011
[BP] GO:1900371 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 4.56588
[BP] GO:0032225 None DRD1, DRD2, DRD3, DRD4 4.55844
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, SRC 4.55844
[BP] GO:0030808 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 4.55397
[BP] GO:0051174 regulation of phosphorus metabolic process CDC25B, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 4.54378
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARD, PRKCA, SRC 4.52431
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD2, DRD4, F3, FLT3, GRM1, KDR, MET, PPARD, PRKCA, PTPN1, SRC, XDH 4.43138
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, PPARA, RORC, SRC, TOP2A 4.4225
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 4.40564
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, GLO1, GLRA1, GRM3, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, TOP2A, XDH 4.35382
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3, PRKCA 4.33977
[BP] GO:0030799 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PRKCA 4.33037
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 4.32032
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PRKCA, PTPN1, SRC 4.27525
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TOP2A, XDH 4.25684
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GLRA1, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PPARD, PTPN1, RORC, SRC, TOP2A 4.20194
[BP] GO:0048148 None DRD1, DRD2, DRD3, DRD4 4.20165
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HSD17B1, HSD17B2, PPARD, PRKCA 4.18869
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARD, PRKCA, SRC 4.14292
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, PPARD, TYR, XDH 4.1344
[BP] GO:0042752 None DRD2, DRD3, DRD4, PPARA, RORC, TOP2A 4.04316
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PPARA, PRKCA 4.02749
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, DRD3, F3, FABP4, KDR, MET, MMP12, PPARA, PPARD, PRKCA, SLC6A3 4.00192
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC 3.98491
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD4, GRM3, GRM8, PPARA, PRKCA 3.94292
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, GLO1, GLRA1, GRM3, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, XDH 3.92483
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.90132
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 3.88827
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PPARD 3.84466
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.82377
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, MET, PPARA, PPARD 3.78902
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F3, FABP4, FLT3, GRM1, KDR, MET, MMP12, MMP2, MMP9, PPARD, PRKCA, PTPN1, SRC, XDH 3.78592
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD4 3.77233
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.75133
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3, PRKCA 3.75133
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3, PRKCA 3.72412
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, GLRA1, GRM5, IGF1R, MMP2, PPARA, SRC 3.71124
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PPARD, SLC6A3, SRC, XDH 3.67343
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PPARD, PRKCA, PTPN1, SRC 3.62946
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, PPARD 3.6234
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PTPN1, XDH 3.6202
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PPARD, RORC, SRC, TYR 3.6202
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PTPN1, XDH 3.61752
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KDR 3.60182
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.5061
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PPARD 3.5061
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, GLRA1, KDR, SRC 3.50359
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, TOP2A, XDH 3.45393
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 3.45063
[BP] GO:0007267 None DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.41632
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARD 3.39253
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.39253
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.39253
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.39253
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, TYR, XDH 3.38919
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 3.36653
[BP] GO:0042391 None DRD1, DRD4, GLRA1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.35625
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 3.33022
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.27397
[BP] GO:0030534 None DRD1, DRD2, DRD3, DRD4, GLRA1, PPARA 3.26643
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD4 3.23624
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.23624
[BP] GO:0010562 positive regulation of phosphorus metabolic process CDC25B, DRD1, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 3.21959
[BP] GO:0045937 positive regulation of phosphate metabolic process CDC25B, DRD1, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 3.21959
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, CDC25B, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, TOP2A, XDH 3.2123
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD4 3.19785
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, TOP2A, XDH 3.17652
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A3 3.17652
[BP] GO:0009893 positive regulation of metabolic process AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, TOP2A, XDH 3.17652
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, FABP4, GLRA1, MMP9, SLC6A3 3.17652
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, SLC6A3, SRC, TOP2A, TYR, XDH 3.16324
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, TYR, XDH 3.15284
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TOP2A, TYR, XDH 3.13268
[BP] GO:0032502 developmental process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, RORC, SLC6A3, SRC, TOP2A, TYR 3.09066
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD4, SLC6A3 3.08133
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.07652
[BP] GO:2001023 None DRD1, DRD2, DRD3, DRD4, MET 3.06144
[BP] GO:0051049 regulation of transport ACHE, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, DRD4, GRIK5, GRM5, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, SRC 3.05941
[BP] GO:0051588 None DRD1, DRD2, DRD3, DRD4, GRIK5 3.0477
[BP] GO:0023052 None DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.0477
[BP] GO:0042325 regulation of phosphorylation CDC25B, DRD1, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 3.00494
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, GRM1, MMP2, PPARA, PPARD, SRC, TYR 2.99004
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MMP9, PRKCA, PTPN1, SRC, XDH 2.94562
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD4 2.94187
[BP] GO:0007154 None AXL, DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.90645
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, PPARD, SRC, TYR 2.90522
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.90522
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A3 2.90522
[BP] GO:0001932 regulation of protein phosphorylation CDC25B, DRD1, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.8273
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.79941
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARD, PRKCA, PTPN1, SRC, XDH 2.7744
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, PRKCA, SRC 2.75745
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.74998
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, PPARA, PPARD 2.74139
[BP] GO:0046942 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARD, SLC1A1 2.74139
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.70313
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.69109
[BP] GO:0015849 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARD, SLC1A1 2.66709
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.65822
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, DRD3, PPARA, PPARD, SLC6A3 2.65074
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.63421
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.62729
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.62729
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, DRD4, FLT3, GRM1, KDR, PRKCA, PTPN1, SRC, XDH 2.62729
[BP] GO:0042069 None DRD1, DRD4, SLC6A3 2.62729
[BP] GO:0042053 None DRD1, DRD4, SLC6A3 2.62729
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.61514
[BP] GO:0099566 None GRM1, GRM5 2.61514
[BP] GO:0051944 None DRD2, DRD4 2.61514
[BP] GO:0060160 None DRD2, DRD3 2.61514
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61514
[BP] GO:0051586 None DRD2, DRD4 2.61514
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, GLRA1, GRM5, IGF1R, MMP2, SRC 2.61116
[BP] GO:0001934 positive regulation of protein phosphorylation CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.61002
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.59557
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, XDH 2.58962
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARD, PRKCA, PTPN1, SRC, XDH 2.56525
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.55449
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD 2.5351
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A3 2.52889
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.52889
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD1, DRD2, DRD4 2.5258
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, GRM1, GRM5 2.52424
[BP] GO:0080090 regulation of primary metabolic process ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, XDH 2.5187
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.51329
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP4, FLT3, GRM1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PPARD, PRKCA, PTPN1, SLC6A3, SRC, XDH 2.51204
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.5049
[BP] GO:0006810 None ACHE, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, GLRA1, GRIA2, GRIA4, GRIK5, MMP12, MMP9, PPARA, PPARD, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.50444
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, XDH 2.49828
[BP] GO:0007610 None DRD1, DRD2, DRD3, DRD4, GLRA1, GRM1, GRM5, PPARA, SLC6A3 2.49828
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC 2.47396
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, DRD3, DRD4, GRIK5, MMP12, PPARD, PRKCA, SRC 2.47073
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, XDH 2.47073
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.46217
[BP] GO:0042327 positive regulation of phosphorylation CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.46217
[BP] GO:0050708 None ACHE, DRD2, DRD3, DRD4, MMP12, PPARD, PRKCA, SRC 2.43831
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.43619
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.43619
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43619
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, PPARD 2.43354
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.42898
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, GLRA1, GRM5, IGF1R, MMP2, SRC 2.41868
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, DRD2, DRD3, F3, KDR, MET, MMP12, MMP9, PIM1, PRKCA, SLC1A1, SLC6A3, SRC 2.4033
[BP] GO:0051234 None ACHE, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, GLRA1, GRIA2, GRIA4, GRIK5, MMP12, MMP9, PPARA, PPARD, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.38845
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.38814
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.38411
[BP] GO:0051582 None DRD2, DRD4 2.38411
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.38411
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.368
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, GLRA1, HSD17B2, KDR, MMP2, SRC 2.35894
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.34882
[BP] GO:0060079 None GLRA1, GRIA2, GRIA4, GRIK5 2.34882
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, XDH 2.34536
[BP] GO:0030335 positive regulation of cell migration DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, SRC 2.34392
[BP] GO:0043408 regulation of MAPK cascade DRD2, DRD4, FLT3, GRM1, IGF1R, KDR, PRKCA, PTPN1, SRC, XDH 2.32389
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.30719
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.30719
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.30719
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3 2.30537
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PRKCA, SRC, TOP2A 2.29497
[BP] GO:0002791 None ACHE, DRD2, DRD3, DRD4, MMP12, PPARD, PRKCA, SRC 2.28725
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.26831
[BP] GO:0043086 negative regulation of catalytic activity CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, IGF1R, MMP9, PRKCA, PTPN1, SRC 2.26831
[BP] GO:0007628 None DRD1, DRD2, GLRA1 2.26666
[BP] GO:0051046 None ACHE, CYP19A1, DRD2, DRD3, DRD4, GRIK5, MMP12, PPARD, PRKCA, SRC 2.25962
[BP] GO:2000147 positive regulation of cell motility DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, SRC 2.25558
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, PRKCA 2.24245
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.23321
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA 2.22786
[BP] GO:0090659 None DRD1, DRD2, GLRA1 2.22786
[BP] GO:0071702 None CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, MMP12, PPARA, PPARD, SLC1A1, SLC6A2, SLC6A3 2.22468
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD4, SLC6A3 2.22218
[BP] GO:0051952 None DRD1, DRD2, DRD3, DRD4 2.21741
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, XDH 2.21621
[BP] GO:0021853 None DRD1, DRD2 2.21121
[BP] GO:0010641 None F3, SRC 2.21121
[BP] GO:1904936 None DRD1, DRD2 2.21121
[BP] GO:0090325 None DRD2, DRD3 2.21121
[BP] GO:0015893 None CA2, DRD1, SLC1A1, SLC6A2, SLC6A3 2.207
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, GLRA1, MMP9 2.207
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1 2.207
[BP] GO:0045934 None APEX1, AURKB, DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, MMP12, PPARA, PPARD, PRKCA, RORC, SRC 2.20099
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.20099
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.20099
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TOP2A, XDH 2.20096
[BP] GO:0051272 positive regulation of cellular component movement DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, SRC 2.20008
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, PPARA, SRC 2.19546
[BP] GO:0008344 None DRD1, DRD2, DRD4, GLRA1 2.19407
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 2.18255
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 2.17972
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.17628
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PPARD 2.1583
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.13775
[BP] GO:0051179 None ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, DRD3, DRD4, FABP3, GLRA1, GRIA2, GRIA4, GRIK5, MMP12, MMP9, PPARA, PPARD, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.13292
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.13292
[BP] GO:0045744 None DRD2, DRD3, MET 2.13292
[BP] GO:0010039 response to iron ion CYP1A1, DRD2, SLC6A3 2.13292
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC6A3, SRC, TOP2A, XDH 2.12537
[BP] GO:0080134 regulation of response to stress CYP19A1, DRD2, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PRKCA, PTPN1, SRC, XDH 2.12159
[BP] GO:0040017 positive regulation of locomotion DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, SRC 2.11485
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, XDH 2.11243
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, DRD3, FABP3, FLT3, PPARA, RORC, SRC 2.11243
[BP] GO:0032410 None DRD2, DRD3, DRD4, MMP9 2.11243
[BP] GO:1904063 None DRD2, DRD3, DRD4, MMP9 2.11243
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.10078
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3 2.09463
[BP] GO:0021843 None DRD1, DRD2 2.09202
[BP] GO:0021830 None DRD1, DRD2 2.09202
[BP] GO:0032415 None DRD3, DRD4 2.09202
[BP] GO:0051934 None SLC6A2, SLC6A3 2.09202
[BP] GO:0021984 None DRD2, SLC6A3 2.09202
[BP] GO:0090494 None SLC6A2, SLC6A3 2.09202
[BP] GO:0090493 None SLC6A2, SLC6A3 2.09202
[BP] GO:0051583 None SLC6A2, SLC6A3 2.09202
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.09202
[BP] GO:0021826 None DRD1, DRD2 2.09202
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.09202
[BP] GO:0019725 cellular homeostasis APEX1, CA2, CA7, DRD1, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM5 2.08782
[BP] GO:0006775 fat-soluble vitamin metabolic process CYP1A1, CYP3A4, PPARD 2.08131
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, SLC6A3, TYR 2.07932
[BP] GO:0045859 regulation of protein kinase activity CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC 2.07932
[BP] GO:0048585 negative regulation of response to stimulus CYP19A1, DRD1, DRD2, DRD3, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, SLC6A3, SRC, XDH 2.07932
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.07932
[BP] GO:0001666 response to hypoxia CYP1A1, DRD2, MMP2, PPARA, PPARD, SRC 2.07437
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, GRM1, GRM5 2.06371
[BP] GO:0051050 positive regulation of transport ACHE, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, DRD4, MMP12, PPARD, SRC 2.03234
[BP] GO:0009892 negative regulation of metabolic process APEX1, AURKB, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC, SRC, XDH 2.03234
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, PPARD, RORC, SLC6A3, SRC, TYR 2.02751
[BP] GO:0030336 None ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, PPARD 2.02704
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2 2.01763
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM5 2.01677
[BP] GO:0051047 None ACHE, CYP19A1, DRD2, DRD3, MMP12, PPARD, SRC 2.01677
[BP] GO:0001523 None AKR1B10, CYP1A1, CYP1B1, PPARD 2.01677
[BP] GO:0006869 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARD 2.01677
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, DRD2, MMP2, PPARA, PPARD, SRC 2.01677
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, FLT3, MET, PIM1, PPARD, SRC, TYR 2.01677
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC 2.00851
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 6.05079
[CC] GO:0005886 plasma membrane ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CSNK2A1, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLO1, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 5.34684
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, FLT3, GLRA1, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 5.15338
[CC] GO:0044459 plasma membrane part ADORA3, AXL, CA2, CA4, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC 4.65521
[CC] GO:0044456 None ACHE, DRD2, DRD4, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 4.52431
[CC] GO:0098590 plasma membrane region CA2, CA4, DRD1, DRD2, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 4.42348
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.72412
[CC] GO:0097060 None GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.45393
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLO1, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 3.32659
[CC] GO:0043005 None CA2, DRD2, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.25013
[CC] GO:0042995 cell projection AKR1B1, CA2, DRD1, DRD2, DRD3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.81062
[CC] GO:0014069 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.55413
[CC] GO:0099572 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.55413
[CC] GO:0120025 None AKR1B1, CA2, DRD1, DRD2, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.52206
[CC] GO:0044425 membrane part ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 2.36371
[CC] GO:0098794 None DRD2, DRD4, GRIA2, GRIA4, GRM3 2.16673
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.09202
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, TYR, XDH 11.2792
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, F3, FABP3, FABP4, FLT3, GLO1, GLRA1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TOP2A, TYR, XDH 9.86958
[MF] GO:0030594 None DRD1, DRD2, DRD3, DRD4, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM5 8.39993
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.34929
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.08457
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, FLT3, GLRA1, IGF1R, KDR, MET, PIM1, PPARA, PPARD, PRKCA, SLC6A3, SRC, TOP2A 7.56557
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TOP2A, TYR, XDH 7.21577
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, RORC 7.03748
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD4, SLC6A3 6.4958
[MF] GO:0004872 receptor activity ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, RORC 6.32456
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, RORC 6.13116
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD, PRKCA, PTPN1, RORC 5.91884
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.80665
[MF] GO:0004871 signal transducer activity ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GLRA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, RORC 5.80665
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD4, SLC6A3 5.78118
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.56585
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.33581
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.27249
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 5.15338
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 5.15338
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD4 4.96455
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PRKCA, PTPN1, SRC, TOP2A, TYR, XDH 4.88592
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PRKCA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TOP2A, TYR, XDH 4.88592
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.70608
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD4, SLC6A3 4.69656
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.33977
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.32032
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.12014
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.02032
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.72412
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.67343
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.51667
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.45393
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.29562
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.27397
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.05667
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SRC 3.05667
[MF] GO:0005231 None GLRA1, GRIA2, GRIA4, GRIK5 2.83885
[MF] GO:0022824 None GLRA1, GRIA2, GRIA4, GRIK5 2.77734
[MF] GO:0022835 None GLRA1, GRIA2, GRIA4, GRIK5 2.77734
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.71762
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.62729
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.62729
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.61514
[MF] GO:0005330 None SLC6A2, SLC6A3 2.61514
[MF] GO:0099583 None GRM1, GRM5 2.61514
[MF] GO:0032403 protein complex binding ACHE, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SRC 2.61002
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.59557
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.38411
[MF] GO:0004971 None GRIA2, GRIA4 2.38411
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.38411
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.34079
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.26666
[MF] GO:0005230 None GLRA1, GRIA2, GRIA4, GRIK5 2.23321
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.21121
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.13587
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.13292
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.09202
[MF] GO:0005329 None SLC6A2, SLC6A3 2.09202
[MF] GO:0004064 arylesterase activity CA1, CA2 2.09202
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.05004


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, GRM1, GRM3, GLRA1, GRM5, ADORA3, GRM8, DRD1, DRD2, DRD3, DRD4, GRIA4 9.6548
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.582
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2961
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.3012
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.9226
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, PRKCA, DRD1, DRD2, DRD3, SLC6A3, DRD4, GRIA4 6.9435
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, PRKCA, DRD1, DRD2, GRM1 5.2753
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2, SLC6A3 5.1877
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, PRKCA, DRD1, SLC6A3, GRIA4 4.5522
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, IGF1R 4.4848
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4619
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.5342
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, PRKCA, MMP9, MET, IGF1R, PPARD 3.6411
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PRKCA, GRM1, GRIA4 3.8639
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, PRKCA, DRD2, MET, IGF1R 3.4612
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1128
Long-term depression_Homo sapiens_hsa04730 GRIA2, PRKCA, GRM1, IGF1R 3.5388
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, PRKCA, GRM1 3.2783
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, PRKCA, GRM1 3.4262
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.2783
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, PRKCA, F3 2.8496
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.8496
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PRKCA, MMP9, MET, CDC25B 2.8321
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, DRD1, DRD2, PPARA, GRIA4 2.7523
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, PRKCA, MET, IGF1R 2.7383
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.1438
Metabolic pathways_Homo sapiens_hsa01100 AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1B1, TYR, CYP3A4, CYP19A1, XDH 2.329
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PRKCA, DRD1, GRM1 2.0443
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.4694
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.3979
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0443
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8496
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.9763
Ras signaling pathway_Homo sapiens_hsa04014 KDR, PRKCA, MET, IGF1R 1.7647
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, PRKCA, GRIA4 1.9355
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.3318
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6054
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.7366
Hepatitis B_Homo sapiens_hsa05161 SRC, PRKCA, MMP9 1.5482
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA, PPARD 1.5722
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2, SLC6A3 1.5722
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.5794
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2, SLC6A3 1.3365
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, PRKCA, MET, IGF1R 1.3188
Glioma_Homo sapiens_hsa05214 PRKCA, IGF1R 1.3365
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0399
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 1.1147
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA 1.1759
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1147
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3278
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PRKCA 1.0419
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.1052
Morphine addiction_Homo sapiens_hsa05032 PRKCA, DRD1 1.1538
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0499
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCA, IGF1R 1.0882
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.2924
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.1737
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3188
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA 0.8133
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.1179
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3237
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.9318
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PRKCA 1.041
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 1.0122
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2569
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, PRKCA 1.005
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3195
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4077
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3188
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.569
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3223
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3345
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3328
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3638
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.346
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3537
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3632
Influenza A_Homo sapiens_hsa05164 PRKCA 0.3638
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3532
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3906
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3 0.3751
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.4067
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.403
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4178
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4264
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.422
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4264
Platelet activation_Homo sapiens_hsa04611 SRC 0.446
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4277
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.446
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.446
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4686
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.446
Axon guidance_Homo sapiens_hsa04360 MET 0.4408
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.446
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4466
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5103
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.5056
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA 0.4966
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4966
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5134
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4966
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5103
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5794
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5053
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.497
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.505
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.5103
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5103
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5103
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5056
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5144
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5103
Peroxisome_Homo sapiens_hsa04146 XDH 0.5134
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5103
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5198
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5516
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.669
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.561
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5539
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.569
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5683
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5528
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5786
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.569
Shigellosis_Homo sapiens_hsa05131 SRC 0.569
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6012
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA 0.6012
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8617
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5702
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6012
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6242
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6242
Malaria_Homo sapiens_hsa05144 MET 0.6302
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8798
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.738
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.6421
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8173
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCA 0.7077
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0443
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7469
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7025
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7469
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7605
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7945
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8274
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2105


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)