TCM Prescription: Dysentery Prescription



Prescription Description
Prescription IDTCMF1685
Pinyin NameTong Xie Yao Fang
Chinese Name痛泻要方
English NameDysentery Prescription
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, SMAD3, SRC, TEK 7.6258
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, SMAD3, SRC, TEK 7.6258
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.57369
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK 7.17769
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 6.75133
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 6.67172
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.64531
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.33738
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TRPV1 6.31086
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.25846
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 6.13414
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, SMAD3, SRC, TEK 6.13406
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK, TRPV1 6.09603
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 6.09603
[BP] GO:0042221 response to chemical AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TRPV1 6.07314
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.02325
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK 5.95319
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, SRC, TEK 5.87335
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK 5.87335
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SMAD3, SRC, TEK 5.78579
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 5.74237
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 5.69481
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.69063
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.68571
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, SMAD3, SRC, TEK 5.5329
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.46461
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 5.43954
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.43349
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, CA12, CA2, CA7, CYP19A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, PPARA, SMAD3, SRC, TEK, TRPV1 5.40026
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, SRC, TEK 5.29099
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MCL1, MET, SMAD3, SRC, TRPV1 5.27239
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 5.09298
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TRPV1 5.09298
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIM1, SMAD3, SRC, TEK 5.05521
[BP] GO:0030335 positive regulation of cell migration EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.89056
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK 4.88778
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, CA9, CSNK2A1, CYP1B1, EGFR, FABP3, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TRPV1 4.78641
[BP] GO:2000147 positive regulation of cell motility EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.77264
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 4.73807
[BP] GO:0051272 positive regulation of cellular component movement EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.67591
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.6418
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALPL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 4.60745
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK 4.58114
[BP] GO:0040017 positive regulation of locomotion EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.56456
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALPL, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, IGF1R, INSR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 4.50839
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 4.49725
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 4.31008
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP12, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, TRPV1 4.25353
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, SMAD3, SRC, TEK, TRPV1 4.20871
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.19109
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 4.08636
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC, TRPV1 4.08636
[BP] GO:0044281 small molecule metabolic process AKR1B1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, PPARA 4.08636
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK 4.01212
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 3.84283
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 3.81316
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, CA2, CA9, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, NUAK1, SMAD3, SRC, TRPV1 3.71697
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 3.71697
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 3.68877
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.68877
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, INSR, MET, SRC, TEK 3.60883
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 3.56459
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC, TRPV1 3.53423
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.52665
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 3.45864
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK 3.37255
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 3.35216
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, INSR, KDR, MCL1, MET, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 3.35048
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 3.35048
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 3.35048
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK 3.34953
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, SMAD3, SRC 3.32897
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, SMAD3, SRC 3.31984
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK 3.31984
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.28946
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, FLT3, SRC, TEK, TRPV1 3.22175
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, CA2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, INSR, KDR, MCL1, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 3.15955
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 3.14676
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 3.11741
[BP] GO:0006468 protein phosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.11741
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC 3.11639
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.11639
[BP] GO:0051049 regulation of transport ACHE, ADORA1, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, SMAD3, SRC, TRPV1 3.05387
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1B1, CYP2A13, CYP2A6 3.04017
[BP] GO:0044092 negative regulation of molecular function ADORA3, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC 3.03275
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 3.03275
[BP] GO:0044255 cellular lipid metabolic process ACHE, CSNK2A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA 3.02732
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 3.02593
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 3.02583
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.99998
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.98246
[BP] GO:0048513 animal organ development ACHE, CA2, CSNK2A1, CYP19A1, EGFR, FLT3, INSR, KDR, PPARA, SMAD3, SRC, TEK 2.98246
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.98246
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.98246
[BP] GO:0010035 response to inorganic substance AKR1B1, CA2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 2.97233
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, F10, INSR, MET, SRC, TEK 2.96457
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALPL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK 2.95517
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.9161
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, CA2, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 2.91296
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.91296
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.91296
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.8959
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.87614
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 2.87156
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.85744
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.72623
[BP] GO:0019373 epoxygenase P450 pathway CYP1B1, CYP2A13, CYP2A6 2.71264
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC, TRPV1 2.6979
[BP] GO:0019538 protein metabolic process ACHE, ALPL, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK 2.69542
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.67677
[BP] GO:0051240 positive regulation of multicellular organismal process CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 2.67677
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.67677
[BP] GO:0018193 peptidyl-amino acid modification CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.67255
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.66701
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, CA1, CA2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 2.66701
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, MMP12, SRC, TRPV1 2.61709
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, SMAD3, TRPV1 2.59604
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.59245
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, CA2, CA9, CYP1B1, EGFR, HSPA1A, MCL1, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, TRPV1 2.59245
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.58494
[BP] GO:0051894 None KDR, SMAD3, TEK 2.57991
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.57991
[BP] GO:0001666 response to hypoxia ADORA1, MMP2, PPARA, SMAD3, SRC, TEK 2.57779
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK 2.57779
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MCL1, MET, PPARA, SMAD3 2.55751
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 2.55432
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, MCL1, MET, PPARA, SMAD3 2.55087
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.52961
[BP] GO:0036293 response to decreased oxygen levels ADORA1, MMP2, PPARA, SMAD3, SRC, TEK 2.51927
[BP] GO:1903393 None KDR, SMAD3, TEK 2.49927
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.4786
[BP] GO:0016310 phosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.4786
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.45132
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, SRC, TRPV1 2.44396
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.44396
[BP] GO:0043434 None FABP3, INSR, PPARA, SRC, TEK, TRPV1 2.44396
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.43771
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.43244
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.43244
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, MET, SMAD3, SRC 2.42155
[BP] GO:0035690 cellular response to drug AKR1B1, CYP1B1, EGFR, KDR, SRC, TRPV1 2.42155
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1 2.4172
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC, TRPV1 2.417
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 2.38715
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.37084
[BP] GO:0000302 response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.37084
[BP] GO:0070482 response to oxygen levels ADORA1, MMP2, PPARA, SMAD3, SRC, TEK 2.36666
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.36502
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, SRC 2.33064
[BP] GO:1901890 None KDR, SMAD3, TEK 2.32607
[BP] GO:0009611 response to wounding ACHE, ADORA3, EGFR, PPARA, SMAD3 2.3236
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1 2.31108
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.29303
[BP] GO:0010638 positive regulation of organelle organization HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.28906
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, CA2, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 2.27653
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.26552
[BP] GO:0010907 None INSR, PPARA, SRC 2.26552
[BP] GO:0030198 extracellular matrix organization CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.26065
[BP] GO:0043062 extracellular structure organization CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.25499
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MCL1, MMP9, SRC 2.24746
[BP] GO:0040011 locomotion CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.24733
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK 2.23597
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, TEK 2.22663
[BP] GO:0042325 regulation of phosphorylation ADORA1, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK 2.21492
[BP] GO:0031399 regulation of protein modification process ADORA1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK 2.19248
[BP] GO:0016477 cell migration CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.19248
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, SRC 2.1861
[BP] GO:0045124 None CA2, EGFR, SRC 2.1861
[BP] GO:0032844 regulation of homeostatic process ADORA1, CA2, CA7, EGFR, KDR, SRC, TRPV1 2.17809
[BP] GO:0051828 entry into other organism involved in symbiotic interaction EGFR, HSPA1A, MET, SRC 2.17809
[BP] GO:0030260 entry into host cell EGFR, HSPA1A, MET, SRC 2.17809
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction EGFR, HSPA1A, MET, SRC 2.17809
[BP] GO:0044409 entry into host EGFR, HSPA1A, MET, SRC 2.17809
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK 2.17606
[BP] GO:0043549 regulation of kinase activity ADORA1, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC, TEK 2.15667
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, SMAD3, SRC, TEK 2.15263
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALPL, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 2.13403
[BP] GO:0044089 positive regulation of cellular component biogenesis HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.13403
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, EGFR, FABP3, GPR35, SMAD3, TRPV1 2.10792
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.10792
[BP] GO:0006979 response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.06841
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.06062
[BP] GO:0009268 None CA2, SRC, TRPV1 2.06062
[BP] GO:0009698 phenylpropanoid metabolic process CYP2A13, CYP2A6 2.06062
[BP] GO:0009804 coumarin metabolic process CYP2A13, CYP2A6 2.06062
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, EGFR, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK 2.05288
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, EGFR, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK 2.05288
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.05288
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 2.04446
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1B1, EGFR, FLT3, SRC, TRPV1 2.03871
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, SRC, TEK 2.03627
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, SRC 2.02753
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, MET, SMAD3, SRC 2.02312
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.02312
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, HSPA1A, IGF1R, MCL1, MET, MMP9, SRC 2.01848
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK, TRPV1 3.39084
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 3.18761
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, CA2, CA4, CA9, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK, TRPV1 2.57779
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, INSR, MET, SRC, TEK, TRPV1 2.37084
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.28653
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALPL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, FUT7, GPR35, IGF1R, INSR, KDR, MCL1, MET, MMP2, PIM1, SMAD3, SRC, TEK, TRPV1 2.24875
[CC] GO:0031253 None ADORA1, CA4, CA9, INSR, SRC, TRPV1 2.22758
[CC] GO:0032589 None ADORA1, INSR, TRPV1 2.06062
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, IGF1R, INSR, KDR, MCL1, MET, SRC, TEK, TRPV1 2.01381
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.7265
[MF] GO:0043167 ion binding ACHE, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 7.49728
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK 7.17769
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.17769
[MF] GO:0046914 transition metal ion binding CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3 7.17769
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.8757
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.42486
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.32112
[MF] GO:0004713 protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.5329
[MF] GO:0008144 drug binding ACHE, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 5.47081
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 5.25054
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 4.52365
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3 4.4404
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.43421
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.33597
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP2A13, CYP2A6 4.05567
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.72158
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.6534
[MF] GO:0016301 kinase activity CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.40376
[MF] GO:0043169 cation binding ACHE, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, TRPV1 3.15316
[MF] GO:0140096 catalytic activity, acting on a protein CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK 3.11741
[MF] GO:0008389 None CYP2A13, CYP2A6 3.03275
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.88909
[MF] GO:0020037 heme binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, SRC 2.85922
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.83304
[MF] GO:0005524 ATP binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.83002
[MF] GO:0046872 metal ion binding ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, TRPV1 2.82036
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.77209
[MF] GO:0032559 adenyl ribonucleotide binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.72949
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, SRC 2.72623
[MF] GO:0030554 adenyl nucleotide binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.71116
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP2A13 2.61976
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 2.49576
[MF] GO:0036094 small molecule binding ADORA1, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.47899
[MF] GO:0017171 serine hydrolase activity ACHE, F10, MMP1, MMP12, MMP2, MMP9 2.4172
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR 2.38715
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK, TRPV1 2.29895
[MF] GO:0043559 insulin binding IGF1R, INSR 2.28966
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1B1, CYP2A13, CYP2A6 2.24746
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP2A13, CYP2A6 2.24281
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.24281
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.24281
[MF] GO:0004064 arylesterase activity CA1, CA2 2.17438
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR 2.12583
[MF] GO:0035639 purine ribonucleoside triphosphate binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.1241
[MF] GO:0004872 receptor activity ADORA1, ADORA3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 2.12069
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.06062
[MF] GO:0001609 None ADORA1, ADORA3 2.06062
[MF] GO:0032555 purine ribonucleotide binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.04684
[MF] GO:0043168 anion binding CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.04272
[MF] GO:0017076 purine nucleotide binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.02753
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 2.02608
[MF] GO:0032553 ribonucleotide binding CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.025
[MF] GO:0004222 metalloendopeptidase activity MMP1, MMP12, MMP2, MMP9 2.02082


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.5874
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9602
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 6.0187
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 5.1977
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 5.1807
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 4.5743
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.6607
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 4.5038
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, MCL1, IGF1R 4.0926
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, CYP1B1, CYP19A1, IGF1R 4.2934
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 4.0648
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, MCL1 3.4772
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 3.2669
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.8564
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 3.2669
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.8649
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.7825
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.6353
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.6035
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.5694
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.6035
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.5224
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 2.2328
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.3303
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1B1 2.5542
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.9872
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1B1 2.4442
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, TRPV1 1.9329
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.8228
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.6741
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.5246
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.596
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.318
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5653
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.524
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.3336
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.3336
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.2937
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4083
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.318
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.3336
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 1.2167
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.3336
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1B1, CYP19A1 1.5948
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1576
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.1403
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.162
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 1.0923
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 1.1017
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 1.0825
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 1.0825
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 1.0495
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 1.0793
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0833
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 1.029
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 1.029
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.8952
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.9
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.8706
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, ALPL, AKR1B1, CYP19A1 0.7319
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.376
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.4981
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4506
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.4861
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4799
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4866
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.4892
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.5309
Apoptosis_Homo sapiens_hsa04210 MCL1 0.5604
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4795
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.5693
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.5604
Platelet activation_Homo sapiens_hsa04611 SRC 0.5913
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.6142
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.6423
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5913
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.6142
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5986
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.5913
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.6388
Axon guidance_Homo sapiens_hsa04360 MET 0.5859
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6388
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.6315
Toxoplasmosis_Homo sapiens_hsa05145 HSPA1A 0.5986
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6544
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6463
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.6684
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6463
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.659
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.6501
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.659
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2862
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.659
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.7062
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.7069
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7053
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7086
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6885
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.7226
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.694
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7303
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7238
Bile secretion_Homo sapiens_hsa04976 CA2 0.7077
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.7238
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6 0.7095
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6 0.7238
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.7238
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.7421
Shigellosis_Homo sapiens_hsa05131 SRC 0.7238
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.7615
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7319
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.744
Malaria_Homo sapiens_hsa05144 MET 0.7802
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7828
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6 0.7945
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.8511
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8775
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1B1 0.8465
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.909
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9465
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.902
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8719
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9481
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9465
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1326
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6 1.445


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)