Prescription Description
| Prescription ID | TCMF1649 |
| Pinyin Name | Dao Chi San |
| Chinese Name | 导赤散 |
| English Name | Promoting Diuresis Powder |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH420 | Lophatherum gracile | 淡竹叶 | TCMH420 | GBVY2724-14, GBVT2442-13 |
| TCMH1531 | Akebia quinata | 木通 | TCMH1531 | ITSAJ4440-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
Showing 1 to 10 of 50 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1214 | Enterococcus faecium |
Showing 1 to 10 of 57 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0006145 | None | AOX1, XDH | 2.16535 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, AKR1B10, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 7.29415 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.80383 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.97947 |
| [BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 6.64531 |
| [BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 | 2.28969 |
| [BP] GO:0008152 | metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH | 7.25531 |
| [BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 10.6245 |
| [BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.92003 |
| [BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.02019 |
Showing 1 to 10 of 97 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1 | 1.4272 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.5268 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, F3 | 2.1175 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7731 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4884 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.7097 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.537 |
| Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.6417 |
| Bladder cancer_Homo sapiens_hsa05219 | MMP1, MMP2, MMP9 | 3.0975 |
| Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.3071 |
Showing 1 to 10 of 92 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples