TCM Prescription: Shixiang Zhitong Pills



Prescription Description
Prescription IDTCMF1407
Pinyin NameShi Xiang Zhi Tong Wan
Chinese Name十香止痛丸
English NameShixiang Zhitong Pills
Function Description气滞胃寒, 两胁胀满, 胃脘刺痛, 肚腹隐痛
IndicationsQi stagnation pattern
Disease ICD-11 Category SE91 [Qi stagnation pattern (TM1), 气滞证 (TM1) ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2281 Citrus medica 香橼 TCMH2281 ITSAJ4663-14
TCMH1634 Typha angustata 蒲黄 TCMH1634 GBVX1726-13
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, MIF, PPARA, SLC1A1, SMAD3, SRC, TEK, XDH 14.3049
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 11.7351
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 11.7257
[BP] GO:0007187 None ADORA1, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 11.5491
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TYR 11.3872
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 11.2923
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, APEX1, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 11.163
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 11.1434
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 11.0481
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 11.0481
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, APEX1, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 10.6928
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 10.4825
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 10.4699
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A 10.266
[BP] GO:0007188 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 10.0275
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AR, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 9.89217
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.75207
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 9.72727
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 9.34473
[BP] GO:0007193 None ADORA1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.25294
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 8.96458
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 8.96458
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AR, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRIK5, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 8.58048
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AR, AXL, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK 8.48955
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AR, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 8.38337
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.38337
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 8.34159
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.31713
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AR, AXL, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.1363
[BP] GO:0014070 response to organic cyclic compound APEX1, AR, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, HTR5A, NR3C1, RORC, SRC, TEK, TYR 8.07563
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 8.07563
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3, SRC 7.8277
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 7.58064
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AR, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.55653
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 7.47642
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, GRM5, HTR5A, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK 7.47642
[BP] GO:0007267 None ADORA1, ADRA1A, AR, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PGR, SLC1A1, TEK 7.37688
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, NR3C1, SRC 7.14695
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3 6.99554
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AR, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.96825
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.95194
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, AR, DRD2, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 6.87306
[BP] GO:0099536 None CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.87306
[BP] GO:0099537 None CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.87306
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.8473
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.8444
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 6.76542
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PGR, SLC1A1, TEK 6.74805
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.74805
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.74805
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.73762
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA 6.73762
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.73491
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.71648
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.71648
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, AR, DRD2, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 6.58994
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, NR3C1, RORC, SRC, TYR 6.56655
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 6.55379
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.51408
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.47182
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.4462
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA9, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SIGMAR1, SMAD3, SRC, TEK, TOP2A, TYR 6.44085
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.34104
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, HTR5A, INSR, NR3C1, PPARA, SRC, TEK 6.33256
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.27993
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 6.27847
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 6.26484
[BP] GO:0007154 None ADORA1, ADRA1A, AR, AXL, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PGR, SLC1A1, TEK 6.17801
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A 6.13621
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.10175
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.10175
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.99885
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.80222
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 5.78115
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.76352
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.75936
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.75619
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.74965
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.7241
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.71691
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.69467
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, SLC1A1, SMAD3 5.69467
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, KDR, MIF, SRC 5.65228
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 5.65224
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, AR, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.65
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 5.639
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.586
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APEX1, AR, AURKB, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.54013
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 5.54013
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.48364
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC 5.45395
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, MIF, PTPN1, SRC, TEK 5.41654
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, AR, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.40429
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, HTR2B, MIF, PIM1, PPARA, TYR, XDH 5.39963
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, AR, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.38395
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 5.37169
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 5.36538
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.36538
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.36538
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, SMAD3, SRC, TEK, TYR 5.30356
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, HTR7, PGR, PPARA, RORC, SRC, TOP2A 5.28907
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.28907
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.28907
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC 5.27862
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.27636
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.23843
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 5.21975
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APEX1, AR, AURKB, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.20943
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, RORC, SRC, TEK 5.20609
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.18646
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A 5.18507
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.1838
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.11858
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.09756
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.09756
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AR, AXL, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, F3, HSPA1A, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK 5.06155
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 5.04332
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC, TEK 5.0085
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 5.00446
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 4.9984
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC, TEK 4.94776
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.94766
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, APEX1, AR, AURKB, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.94766
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.92712
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.92712
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.90978
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CYP1B1, DRD1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC 4.90978
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.90978
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 4.90293
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.86056
[BP] GO:0042391 None ADORA1, ADRA1A, CNR1, CNR2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.82183
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.81896
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 4.80576
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.80576
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AR, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC 4.80516
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.78428
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.78428
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, HTR2A, HTR2B, KDR, MIF, SRC, TEK 4.7269
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, AR, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.71
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC, TEK 4.69071
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HTR1A, TYR 4.68775
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC 4.68675
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC 4.67441
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC, TEK 4.62768
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, INSR, SRC, TEK, TYR 4.58593
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.58593
[BP] GO:0008217 None ADORA1, ADRA1A, AR, CNR1, DRD2, DRD3, PPARA, SMAD3 4.57979
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC 4.5593
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.52167
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, AR, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.52167
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA, SMAD3, TEK 4.49024
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.48621
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.48587
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.48022
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.42002
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.41129
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.41129
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.41129
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.39903
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.39412
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.39412
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 4.39117
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.36071
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AR, AURKB, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, FABP4, GRM3, GRM8, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 4.3299
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SRC 4.31184
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.31057
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.30084
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.28615
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA 4.28615
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, AR, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.25071
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, AR, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.21305
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 4.21305
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 4.18308
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.1707
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 4.1707
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.09508
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 4.08686
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 4.05215
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 4.05215
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 4.02877
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.02877
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.02877
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, MMP12, SRC 4.02609
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 4.02599
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.01875
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.00926
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 3.99422
[BP] GO:0015701 bicarbonate transport CA12, CA2, CA4, CA7, CA9 3.97242
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.97242
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.94788
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.9222
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, PGR, SMAD3, TEK, XDH 3.9222
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.9222
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC 3.91888
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.90891
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PGR, PIM1, PPARA, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 3.9032
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.89001
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MIF, PTPN1, SMAD3, SRC, TEK, XDH 3.8857
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.8802
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CNR1, DRD1, DRD2, DRD3, GPR35, GRM5, HTR1A, HTR2A, MIF, MMP9 3.8508
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.8508
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.835
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.82399
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 3.81233
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, GRM5, HTR2A, HTR2B 3.79932
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 3.748
[BP] GO:0050890 None ADORA1, CNR1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR 3.72103
[BP] GO:0043271 negative regulation of ion transport ADORA1, CNR1, DRD2, DRD3, GPR35, HTR2A, MMP9 3.72047
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC 3.72037
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, AR, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, NR3C1, RORC, SRC 3.72037
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.72037
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, MMP12, SRC 3.71499
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.68212
[BP] GO:0007610 None CNR1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, INSR, PPARA 3.64033
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, NR3C1 3.63108
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, AR, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.61884
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.61884
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.61884
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC 3.61219
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.57958
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.57786
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 3.55734
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.55734
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, FLT3, HTR1A, MET, MIF, PIM1, SRC, TEK, TYR 3.5532
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 3.53844
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.50614
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.50614
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.49366
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.47717
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.47585
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.47585
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.47585
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.47585
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.4736
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.46208
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.44967
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HTR2B, MIF, MMP12, SRC 3.44111
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.43384
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, AR, AXL, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, XDH 3.43263
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.42893
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR 3.41926
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.41926
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 3.41815
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.41079
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.38791
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, AR, DRD1, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC 3.38464
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.37325
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.36802
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC 3.36304
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.35562
[BP] GO:1900542 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, INSR, PPARA 3.32476
[BP] GO:0007611 None CNR1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR 3.31442
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.31442
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.31442
[BP] GO:0006140 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, INSR, PPARA 3.23809
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.22964
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22964
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.22914
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC 3.22316
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, RORC 3.21841
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.21083
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK 3.19927
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, TEK 3.19856
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, RORC, SRC 3.19856
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.19368
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.18456
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.15437
[BP] GO:0015711 organic anion transport CA12, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 3.15024
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.1443
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.14244
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.13638
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HTR2B, INSR, MIF, MMP12, SMAD3, SRC 3.11742
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, GRM1, HTR2A, SLC1A1, SMAD3 3.11644
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.11644
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.11057
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 3.09113
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 3.09095
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.06948
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 3.06492
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.04894
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 3.01116
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.01037
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.00922
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.00922
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, AR, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.00678
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.00678
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.00632
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 2.98169
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.96604
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.9617
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.9538
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.9538
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 2.94745
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.9423
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.93961
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.92323
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91715
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.91715
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.91715
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, DRD3, EGFR, HTR2B, MIF, MMP12, SRC 2.90341
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.90211
[BP] GO:0050877 None ADORA1, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, INSR, TYR 2.88685
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.8513
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.8502
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.8502
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA, RORC 2.8459
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.82893
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.82829
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.82829
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 2.82829
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TOP2A 2.79903
[BP] GO:0006811 None ADRA1A, CA12, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 2.79517
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AR, AURKB, CNR1, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HSPA1A, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.78727
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CNR1, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.78727
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.78727
[BP] GO:0051130 positive regulation of cellular component organization AR, AURKB, AXL, CNR1, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.78214
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.74116
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.7381
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.7381
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.7381
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.72973
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.72623
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, MIF, SRC 2.72623
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.70942
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.70942
[BP] GO:0090087 None ACHE, ADORA1, CA2, CNR1, DRD2, DRD3, EGFR, HTR2B, MIF, MMP12, PTPN1, SMAD3, SRC 2.70686
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA 2.70116
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 2.68489
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.68033
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.67757
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.67626
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.67626
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.66977
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TOP2A 2.65634
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.64878
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.6458
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC 2.62856
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.61066
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.57532
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 2.57287
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.56708
[BP] GO:0099566 None GRM1, GRM5 2.56708
[BP] GO:0060748 None AR, PGR 2.56708
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.56708
[BP] GO:0060160 None DRD2, DRD3 2.56708
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56708
[BP] GO:0033602 None CNR1, DRD2 2.56708
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.55608
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.55608
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.55608
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CNR1, CNR2, CYP19A1, DRD2, DUSP3, MIF, MMP12 2.55589
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, CNR1, CYP1A1, HTR2A, MIF 2.54684
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.54213
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.52527
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8 2.51993
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.51739
[BP] GO:0050714 None ACHE, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 2.50581
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.48295
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.48295
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.47867
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.44769
[BP] GO:0098900 None ADRA1A, CNR1, CNR2, GPR35 2.43595
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.43356
[BP] GO:0050708 None ACHE, CNR1, DRD2, DRD3, EGFR, HTR2B, MIF, MMP12, SRC 2.42712
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.41619
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.41161
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.41161
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.41161
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC 2.40272
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR 2.39841
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.38683
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.38683
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.38683
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, GRM1, HTR2A, HTR2B 2.3813
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.3631
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.3631
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.34879
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.33236
[BP] GO:0006820 anion transport CA12, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 2.32748
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.32061
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31523
[BP] GO:0038171 None CNR1, CNR2 2.31523
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31523
[BP] GO:0050715 None DRD2, HTR2B, MIF, MMP12, SRC 2.28468
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF 2.28468
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.28458
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.2594
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.2594
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2594
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2D6, CYP3A4 2.25474
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.25474
[BP] GO:0009895 negative regulation of catabolic process ADORA1, CNR1, EGFR, HTR2B, MET, PPARA, SMAD3 2.2473
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR2A 2.2473
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.23887
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.23864
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.23085
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 2.23085
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8 2.22744
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.21507
[BP] GO:0051894 None KDR, SMAD3, TEK 2.21507
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21507
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8 2.18313
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.16949
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.16949
[BP] GO:0050927 None F3, KDR, SMAD3 2.16949
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.15572
[BP] GO:0022414 reproductive process AKR1B1, AR, AXL, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, INSR, MMP2, MMP9, PGR, SRC, TOP2A 2.15291
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.1484
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 2.1406
[BP] GO:0021853 None DRD1, DRD2 2.13449
[BP] GO:0010641 None F3, SRC 2.13449
[BP] GO:0090325 None DRD2, DRD3 2.13449
[BP] GO:0007598 None F10, F3 2.13449
[BP] GO:1904936 None DRD1, DRD2 2.13449
[BP] GO:0042321 None ADORA1, DRD2 2.13449
[BP] GO:0010513 None HTR2A, HTR2B 2.13449
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13263
[BP] GO:0050926 None F3, KDR, SMAD3 2.13263
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.13263
[BP] GO:1903393 None KDR, SMAD3, TEK 2.13263
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.11216
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.11062
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.10408
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, MIF, PPARA 2.10048
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.09651
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.09015
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.09015
[BP] GO:0045936 None DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.08707
[BP] GO:0010563 None DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.08198
[BP] GO:0006928 movement of cell or subcellular component AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.07744
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, DRD2, EGFR, HTR2A, SLC1A1 2.07488
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.07168
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.07168
[BP] GO:0051172 None APEX1, AR, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.05656
[BP] GO:1900371 None DRD1, DRD2, DRD3, GRM3, GRM8 2.05186
[BP] GO:1903524 None ADRA1A, EGFR, HTR2A, SLC1A1 2.05186
[BP] GO:0051482 None DRD1, GPR35, GRM1 2.05186
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.05186
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.05186
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF 2.05021
[BP] GO:0030808 None DRD1, DRD2, DRD3, GRM3, GRM8 2.04157
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.0292
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.0186
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.01214
[BP] GO:0048869 cellular developmental process ACHE, AR, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, TOP2A 2.00243
[BP] GO:0001936 None F3, HTR2B, KDR, TEK, XDH 2.00181
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GRM5, IGF1R, INSR, SRC 2.0007
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 11.521
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, AXL, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, SRC, TEK 9.75413
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 9.74767
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CNR1, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, SIGMAR1, SLC1A1, SRC, TEK 8.28532
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, AR, AXL, CA12, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 7.52906
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, AR, AXL, CA12, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TYR 6.28783
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, AXL, CA12, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C2, PTPN1, SIGMAR1, SLC1A1, SRC, TEK, TYR 5.28907
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.55007
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC, TEK 4.02877
[CC] GO:0043005 None ADORA1, CA2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 3.99422
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC, TEK 3.80977
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.77894
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.77894
[CC] GO:0097060 None CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 3.55734
[CC] GO:0044456 None ACHE, ADORA1, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 3.31449
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, AXL, CA12, CA4, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK, TYR 3.23342
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 3.21912
[CC] GO:0097458 None ADORA1, CA2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, SIGMAR1, SRC 2.9423
[CC] GO:0045121 membrane raft ADRA1A, CNR1, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.72296
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, SIGMAR1, SRC 2.72296
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, SIGMAR1, SRC 2.72296
[CC] GO:0098857 membrane microdomain ADRA1A, CNR1, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.70942
[CC] GO:0031233 None CA4, F10, F3 2.41619
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, CA2, CA4, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR5A, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TOP2A, TYR, XDH 2.39877
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, GRIA2, HSD11B1, HSD17B2, NR3C2, PTPN1, SIGMAR1 2.3631
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, AXL, CA12, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, EGFR, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK, TYR 2.26895
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, GRIA2, HSD11B1, HSD17B2, NR3C2, SIGMAR1 2.2473
[CC] GO:0098589 membrane region ADRA1A, CNR1, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.24414
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.21456
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.19689
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.19185
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.16949
[CC] GO:0005783 None ADORA1, APEX1, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HSPA1A, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.15983
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, SRC 2.03166
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, TEK 17.2605
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, TEK 15.7145
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, TEK 15.5184
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, SMAD3, TEK 15.5184
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 13.2658
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 13.2658
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 13.2144
[MF] GO:0046914 transition metal ion binding ALOX5, AR, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 11.521
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 9.42617
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP2A 8.43658
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.10517
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.98752
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.37818
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.09813
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 6.83365
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.82253
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.76542
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.76542
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.74805
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.74805
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.56187
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AR, AURKB, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TYR, XDH 6.52588
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.4343
[MF] GO:0004089 carbonate dehydratase activity CA12, CA2, CA4, CA7, CA9 6.10882
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3 5.85527
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.64972
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP2A, TYR, XDH 5.45395
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 5.26805
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.06407
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 4.9984
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.98973
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.9685
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.94652
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR 4.72012
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 4.66674
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH 4.38023
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.1582
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA12, CA2, CA4, CA7, CA9 4.1172
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.99422
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 3.96222
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 3.77787
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.55734
[MF] GO:0016836 hydro-lyase activity CA12, CA2, CA4, CA7, CA9 3.55421
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR 3.48539
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 3.42431
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.36802
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.36802
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 3.09113
[MF] GO:0016829 lyase activity APEX1, CA12, CA2, CA4, CA7, CA9, GLO1 3.07619
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.00922
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.91715
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.8459
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.8357
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AR, AURKB, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TYR, XDH 2.71062
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.70942
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, SRC, XDH 2.69897
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.56708
[MF] GO:0004949 None CNR1, CNR2 2.56708
[MF] GO:0099583 None GRM1, GRM5 2.56708
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.55608
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.55608
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.50581
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.47867
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.47867
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.41619
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.39841
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.34879
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.31523
[MF] GO:0004971 None GRIA2, GRIA4 2.31523
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.31523
[MF] GO:0097159 organic cyclic compound binding ADORA1, ALDH2, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.28646
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.19185
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.18313
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13449
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13449
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.09015
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.09015
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.04157
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.01214
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.01214


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, HTR2B, HTR1A, HTR2A, NR3C1, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 21.1341
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6747
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.3094
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.5618
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, GRM1, EGFR 7.0507
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1, EGFR 7.0507
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.4087
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 6.4182
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.4804
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA, GRIA4 4.7073
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.1026
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.4257
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0377
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.6849
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.5197
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9 6.8533
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.6008
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.4831
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1834
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.6849
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, GRM1, GRIA4 3.3603
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, CYP1B1 3.6849
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, GRIA4 2.9307
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 2.5782
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.8854
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.4312
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.3714
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9307
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.1561
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.3537
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.1491
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 1.9834
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1275
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A 1.7708
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9974
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.066
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.0747
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 1.9851
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9851
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9851
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 1.9897
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6923
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.7069
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6946
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9543
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9834
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.6505
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.6505
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, CYP3A4 1.9796
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.54
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2812
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4284
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.2599
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.6068
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.247
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.4261
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7778
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7852
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1832
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7852
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7307
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.759
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7261
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.978
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9352
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7199
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.0089
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9326
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7199
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9547
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7199
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2406
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7199
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9574
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7199
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2548
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2615
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2706
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2771
Tuberculosis_Homo sapiens_hsa05152 SRC 0.27
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5957
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2706
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2611
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6964
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5474
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.2948
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.302
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6731
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5211
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3095
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0458
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3386
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0417
Axon guidance_Homo sapiens_hsa04360 MET 0.3533
Platelet activation_Homo sapiens_hsa04611 SRC 0.3637
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1723
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3691
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3869
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3663
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1663
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3869
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2108
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1141
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4033
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4105
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4105
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4105
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4196
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4191
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.424
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2527
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4334
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4334
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4334
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4412
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1723
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4334
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4326
Peroxisome_Homo sapiens_hsa04146 XDH 0.4423
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4794
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4811
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4664
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4777
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4881
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5032
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5078
Shigellosis_Homo sapiens_hsa05131 SRC 0.5054
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5011
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5163
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5163
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5442
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5616
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5474
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5616
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.5092
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5616
Malaria_Homo sapiens_hsa05144 MET 0.5693
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.5653
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.408
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5733
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.5733
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5028
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5957
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6828
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.5028
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.5847
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.6946
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6505
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6788
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7307
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7151
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6964
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.857
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7307
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7151
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7199
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7307
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7307
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.7547
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8726
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9566


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)