Prescription Description
| Prescription ID | TCMF1365 |
| Pinyin Name | Dang Gui Yang Xue Wan |
| Chinese Name | 当归养血丸 |
| English Name | Danggui Yangxue Pills |
| Function Description | 血虚气弱, 月经不调 |
| Indications | Blood deficiency pattern, Irregular menstruation |
| Disease ICD-11 Category |
SF00 [Blood deficiency pattern (TM1), 血虚证 (TM1)
]; GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ]; |
| Human Tissues Associated with Indication | Uterus |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH541 | Colla corii asini | 阿胶 | TCMH541 | |
| TCMH1513 | Paeonia moutan | 牡丹皮 | TCMH1513 | |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
Showing 1 to 10 of 93 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1218 | Staphylococcus aureus |
Showing 1 to 10 of 51 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.82932 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.38036 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, EGFR, MMP2, MMP9, TEK | 3.75493 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK | 2.87969 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.02926 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH | 2.01723 |
| [BP] GO:0002793 | None | ACHE, ADORA1, EGFR, HCAR2, MMP12, SRC | 2.08904 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TYR | 2.12704 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.49149 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA | 7.18017 |
Showing 1 to 10 of 244 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4145 |
| Adherens junction_Homo sapiens_hsa04520 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.2531 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5969 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PIM1 | 1.945 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.7622 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.9905 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5822 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15 | 1.3734 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.4845 |
| Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.2453 |
Showing 1 to 10 of 134 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples