Prescription Description
| Prescription ID | TCMF1342 |
| Pinyin Name | Jiu Wei Qiang Huo Wan |
| Chinese Name | 九味羌活丸 |
| English Name | Jiuwei Qianghuo Pills |
| Function Description | 发热 |
| Indications | Fever |
| Disease ICD-11 Category |
MG26 [Fever of other or unknown origin, 其他或不明原因的发热
]; |
| Human Tissues Associated with Indication | Lung, blood |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1665 | Notopterygium incisum | 羌活 | TCMH1665 | JF755946 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH211 | Atractylodes lancea | 苍术 | TCMH211 | ITSAN4439-14 |
| TCMH2239 | Asarum sieboldii | 细辛 | TCMH2239 | ITSAI1576-14 |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH118 | Angelica dahurica | 白芷 | TCMH118 | ITSAK3312-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
Showing 1 to 10 of 81 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1191 | Bacillus megaterium |
| TCMT1209 | Staphylococcus haemolyticus |
Showing 1 to 10 of 75 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9 | 3.47289 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.01088 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.08362 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA | 10.9916 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 4.08261 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.92948 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.26659 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.81032 |
| [BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.22339 |
| [BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.51237 |
Showing 1 to 10 of 140 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6623 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3 | 0.5959 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, ERBB2, EGFR | 3.2606 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5544 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, ADRB1, CACNA1C | 1.5283 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, F3 | 1.8576 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.529 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7001 |
| Alzheimer's disease_Homo sapiens_hsa05010 | CACNA1C | 0.3935 |
| Amphetamine addiction_Homo sapiens_hsa05031 | CACNA1C | 0.5566 |
Showing 1 to 10 of 140 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples