Prescription Description
| Prescription ID | TCMF1327 |
| Pinyin Name | Chuan Xiong Cha Tiao Wan |
| Chinese Name | 川芎茶调丸 |
| English Name | Chuanxiong Chatiao Pills |
| Function Description | 头痛 |
| Indications | Headache |
| Disease ICD-11 Category |
MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征
]; |
| Human Tissues Associated with Indication | Heart, Brain |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH118 | Angelica dahurica | 白芷 | TCMH118 | ITSAK3312-14 |
| TCMH1665 | Notopterygium incisum | 羌活 | TCMH1665 | JF755946 |
| TCMH2239 | Asarum sieboldii | 细辛 | TCMH2239 | ITSAI1576-14 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH188 | Mentha haplocalyx | 薄荷 | TCMH188 | HM595443 |
| TCMH1141 | Schizonepeta tenuifolia | 荆芥 | TCMH1141 | ITSAL858-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
Showing 1 to 10 of 77 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
Showing 1 to 10 of 67 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9 | 2.53547 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA | 2.00566 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.74006 |
| [BP] GO:0002318 | myeloid progenitor cell differentiation | FLT3, KIT | 2.02504 |
| [BP] GO:0002320 | lymphoid progenitor cell differentiation | BCL2, FLT3, KIT | 3.06587 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, KIT | 2.23274 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.17668 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.43418 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.88329 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, PPARA | 10.5767 |
Showing 1 to 10 of 184 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, KIT | 1.4564 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, ERBB2, EGFR | 3.3879 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5913 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, ADRB1, CACNA1C | 1.5776 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, F3 | 1.9122 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.569 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7515 |
| Alzheimer's disease_Homo sapiens_hsa05010 | CACNA1C | 0.4182 |
| Amphetamine addiction_Homo sapiens_hsa05031 | CACNA1C | 0.5945 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6842 |
Showing 1 to 10 of 138 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples