Prescription Description
| Prescription ID | TCMF1032 |
| Pinyin Name | Ting Bei Jiao Nang |
| Chinese Name | 葶贝胶囊 |
| English Name | Ting Bei Capsule |
| Function Description | 慢性支气管炎 |
| Indications | Chronic bronchitis |
| Disease ICD-11 Category |
CA20.1 [Chronic bronchitis, 慢性支气管炎
]; |
| Human Tissues Associated with Indication | Lung, Bronchus |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2117 | Lepidium apetalum | 葶苈子 | TCMH2117 | ITSAB3973-14 |
| TCMH1486 | Ephedra sinica | 蜜麻黄 | TCMH1486 | ITSAM882-14 |
| TCMH273 | Fritillaria cirrhosa | 川贝母 | TCMH273 | ITSAP3764-14 |
| TCMH1219 | Semen armeniacae amarum | 苦杏仁 | TCMH1219 | |
| TCMH706 | Trichosanthes kirilowii | 瓜蒌皮 | TCMH706 | ITSAO4359-14 |
| TCMH1931 | Gypsum fibrosum | 石膏 | TCMH1931 | |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH2545 | Houttuynia cordata | 鱼腥草 | TCMH2545 | ITSAJ4504-14 |
| TCMH2337 | Flos inulae | 旋覆花 | TCMH2337 | |
| TCMH2601 | Haematitum | 赭石 | TCMH2601 | |
| TCMH60 | Ginkgo biloba | 白果 | TCMH60 | ITSAJ4779-14 |
| TCMH625 | Gecko | 蛤蚧 | TCMH625 | |
| TCMH1080 | Platycodon grandiflorum | 桔梗 | TCMH1080 | ITSAJ4293-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 108 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 82 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 3.40389 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.29069 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, SRC | 3.31324 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.5182 |
| [BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.42838 |
| [BP] GO:0002683 | negative regulation of immune system process | ADORA1, ALOX15, AXL, CDK6, CYP19A1, MIF, MMP12, PTPRS | 2.13435 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PPARD, SRC | 2.38531 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARD, TYR | 3.18466 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.14114 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC | 3.00753 |
Showing 1 to 10 of 232 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6358 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1, PPARD | 2.1955 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.0947 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5519 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3816 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.553 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.6724 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4218 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6214 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.3972 |
Showing 1 to 10 of 137 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples