TCM-ID Component

Component: Salvia przewalskii var. mandarinorum 紫丹参

Description of the Component

Component ID	TCMH2708
Latin Name	Salvia przewalskii var. mandarinorum
English Name	Manchurian sage
Chinese Pinyin Name	Zi Dan Shen
中文名	紫丹参
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	GBVW4816-13, GBVW4757-13
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMF6963	Dan E Fu Kang Jian Ointment	丹莪妇康煎膏

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT1	EHMT2	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Transferase	Q96KQ7
TCMT126	TERT	Telomerase reverse transcriptase	Transferase	O14746
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT171	PTPN6	Protein-tyrosine phosphatase 1C	Hydrolase	P29350
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT210	CES2	Carboxylesterase 2	Hydrolase	O00748
TCMT211	CES1	Acyl coenzyme A:cholesterol acyltransferase	Transferase	P23141
TCMT214	MGLL	Monoglyceride lipase	Unclassified	Q99685
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT233	PTPN11	Protein-tyrosine phosphatase 2C	Hydrolase	Q06124
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name

Ingredient Structrues

Ingredient ID: TCMC251
Formula: C19H20O3

Common Name	1,6,6-Trimethyl-2,7,8,9-Tetrahydro-1H-Naphtho[1,2-G][1]Benzofuran-10,11-Dione
IUPAC Name	1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione
Canonical SMILES	CC1COC2=C1C(=O)C(=O)c1c2ccc2c1CCCC2(C)C
Standard InCHI	InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3
Standard InCHIKey	GVKKJJOMQCNPGB-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL1518673]; PubChem [496348];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH409	Salvia miltiorrhiza	Dan Shen Jin Gao	丹参浸膏
TCMH863	Salvia prionitis	Hong Gen Cao	红根草
TCMH2708	Salvia przewalskii var. mandarinorum	Zi Dan Shen	紫丹参
TCMH407	Salvia miltiorrhiza	Dan Shen	丹参
TCMH408	Salvia miltiorrhiza	Dan Shen Gan Jin Gao	丹参干浸膏

Ingredient ID: TCMC2126
Formula: C18H12O3

Common Name	Tanshinone I
IUPAC Name	1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
Canonical SMILES	Cc1coc2c1C(=O)C(=O)c1c2ccc2c1cccc2C
Standard InCHI	InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
Standard InCHIKey	AIGAZQPHXLWMOJ-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL363535]; PubChem [114917];
Reference of Component-Ingredient Pair	21120586

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1939	Combretum indicum	Shi Jun Zi Ren	使君子仁
TCMH1656	Angelica decursiva	Qian Hu	前胡
TCMH2244	Prunella vulgaris	Xia Ku Cao	夏枯草
TCMH409	Salvia miltiorrhiza	Dan Shen Jin Gao	丹参浸膏
TCMH95	Aquilaria sinensis	Bai Mu Xiang	白木香
TCMH863	Salvia prionitis	Hong Gen Cao	红根草
TCMH2708	Salvia przewalskii var. mandarinorum	Zi Dan Shen	紫丹参
TCMH407	Salvia miltiorrhiza	Dan Shen	丹参
TCMH408	Salvia miltiorrhiza	Dan Shen Gan Jin Gao	丹参干浸膏

Ingredient ID: TCMC1053
Formula: C18H14O3

Common Name	Dihydrotanshinone I
IUPAC Name	(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione
Canonical SMILES	C[C@H]1COC2=C1C(=O)C(=O)c1c2ccc2c1cccc2C
Standard InCHI	InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
Standard InCHIKey	HARGZZNYNSYSGJ-JTQLQIEISA-N
External Identifiers	ChEMBL [CHEMBL227075]; PubChem [11425923];
Reference of Component-Ingredient Pair	20380878

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH409	Salvia miltiorrhiza	Dan Shen Jin Gao	丹参浸膏
TCMH863	Salvia prionitis	Hong Gen Cao	红根草
TCMH2708	Salvia przewalskii var. mandarinorum	Zi Dan Shen	紫丹参
TCMH407	Salvia miltiorrhiza	Dan Shen	丹参
TCMH408	Salvia miltiorrhiza	Dan Shen Gan Jin Gao	丹参干浸膏

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC251	C19H20O3	1,6,6-Trimethyl-2,7,8,9-Tetrahydro-1H-Naphtho[1,2-G][1]Benzofuran-10,11-Dione	296.14	0.0397	3.22	4.812	3	0	43.37	3	4	22	0
TCMC1053	C18H14O3	Dihydrotanshinone I	278.09	-0.0693	3.11	4.453	3	0	43.37	2	4	21	0
TCMC2126	C18H12O3	Tanshinone I	276.08	0.6023	3.11	4.57	2	0	47.28	2	4	21	0

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1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)