Organism Name: A new engineered strain of Saccharomyces cerevisiae [n.a.]

Organism ID:   NPO41883
Organism Name:   A new engineered strain of Saccharomyces cerevisiae [n.a.]
Native / Engineered Organism:   Engineered Organism
Matched Taxonomy Level:   Strain
Organism External ID:   NCBI_Taxonomy_ID[ n.a.]
Organism Synonyms:  
Genus:   Saccharomyces
Family:   Saccharomycetaceae
Kingdom:   Fungi
SuperKingdom:   Eukaryota

  Individual Natural Products

Natural Product ID Prefer Name (or InChiKey) IUPAC Name Number of Targets Number of Activity Records
NPC123965 Squalene (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene 9 17
NPC93081 Ornithine (2S)-2,5-diaminopentanoic acid 4 6
NPC161571 Resveratrol 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol 325 1743
NPC313179 Lutein (1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1R,4R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol 12 35
NPC313821 lincomycin n.a. 30 367
NPC314309 cinnamycin n.a. 0 0
NPC490791 (S)-cis-N-methylstylopine (1S,13S)-13-methyl-5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene 0 0
NPC118429 L-Citrulline (2S)-2-azaniumyl-5-(carbamoylamino)pentanoate 7 13
NPC331737 sesquiterpenes n.a. 0 0
NPC233950 SYQNUQSGEWNWKV-XUIVZRPNSA-N n.a. 25 71
NPC79943 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-2,3-Dihydrochromen-4-One 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one 35 59
NPC490932 oxidized derivative medicagenic acid n.a. 0 0
NPC11433 L-Proline (2S)-pyrrolidine-2-carboxylic acid 15 24
NPC490999 Spinosad (1S,2S,5R,7S,9S,10S,14R,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-4,14-dimethyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione;(1S,2R,5S,7R,9R,10S,14R,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-14-methyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione 0 0
NPC490716 Anthocyanins n.a. 0 0
NPC490867 Medium-chain Fatty Acid (c6-c10, Mcfas) n.a. 0 0
NPC490856 Long-chain Dicarboxylic Acids n.a. 0 0
NPC99088 Lycopene (6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene 14 43
NPC490923 N-Methylanthranilate 2-(methylamino)benzoate 0 0
NPC35656 Artemisinic Acid 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoic acid 1 3
NPC490983 rhizomide a n.a. 0 0
NPC490725 argyrin j n.a. 0 0

  NPs produced by Co-culture Organisms (for Co-culture organisms, the full organism list can be found HERE)

Organism Name Producer Organism Inducer Organism NP ID NP Name Effect of Co-culture Reference

  NPs produced by Engineered Organisms (for Engineered organisms, the full organism list can be found HERE)

Organism Name Parent Organism Name Engineered Gene in Organism Purpose of Engineering Engineering Category Engineering Description NP ID NP Name NP Yeild of Parent Organism NP Yeild of Engineered Organism Yeild Change Reference
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield Metabolic engineering > Modular pathway engineering In module 1, we employed a modified GAL system to overexpress the genes of the naringenin biosynthesis pathway and investigated their synergistic action. In module 2, we simultaneously up-regulated acetyl-CoA production and down-regulated fatty acid biosynthesis in order to increase the precursor supply, malonyl-CoA. In module 3, we engineered the tyrosine biosynthetic pathway to eliminate the feedback inhibition of tyrosine and also down-regulated competing pathways. NPC490716 Anthocyanins n.a. 90 mg/L 20-fold PMID[28707470]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. an efficient 2,3- BDO producing yeast strain was rapidly constructed with up to 25-copy genome integration of 2,3-BDO biosynthesis pathway. Further strain engineering was conducted by multiplex disruption of ADH1, PDC1, PDC5 and MTH1 using a 2μ-based replicative CRISPR Cas9 plasmid containing donor DNAs. NPC490725 argyrin J n.a. 50.5g/L 3.9-fold PMID[32006629]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. Then the Lightning GTR-CRISPR was applied to simplify yeast lipid metabolism through two-round ORF deletions for these eight genes. After the first-round deletion of FAA1, FAA4, POX1, and ARE2, the plasmid was anti-selected by growing the cells on 5-FOA medium, and the second-round deletions of PAH1, LPP1, DPP1, and ARE1 were carried out. NPC35656 artemisinic acid 19.93 mg/L 559.52 mg/L 30-fold PMID[30837474]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490733 bacillothiazol 1 n.a. 8.7+/-0.85mg/l 40-fold increase PMID[18485776]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield Metabolic engineering combination of a metabolic engineering strategy with fermentation technology optimization can be used to obtain significant amounts of the high-value sesquiterpene α-santalene NPC490741 bacillothiazol 4 n.a. 0.0052 Cmmol (Cmmol glucose)(-1); final 0.036 Cmmol (g biomass)(-1) h(-1) 4-fold improvement over the reference strain PMID[22938570]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490790 chitosanase n.a. 252 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC314309 cinnamycin n.a. 548 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490791 cis-N-methylstylopine n.a. 676 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC118429 Citrulline n.a. 80 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield Transporter engineering; and regulatory factor modulating. n.a. NPC313821 lincomycin n.a. 0.5 g/L n.a. PMID[25769286]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. Yeast chromosomes integration; Cell factories establishment. NPC313821 lincomycin n.a. 0.17 g/L n.a. PMID[25769286]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC490856 long-chain Dicarboxylic acids n.a. 0.85 mg/L n.a. PMID[29771352]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. UGTPgs characterization; Structural modeling; Protein chimeric. NPC313179 lutein n.a. 1.4 mg/L n.a. PMID[24603359]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC99088 lycopene n.a. 1.55 mg/L n.a. PMID[29771352]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC99088 lycopene n.a. 1.86 mg/L n.a. PMID[29771352]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490867 medium chain fatty acid(C6-C10, MCFAs) n.a. 108 mg/L n.a. PMID[29386648]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC79943 Naringenin n.a. 14.54 mg/L n.a. PMID[28634125]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC490923 N-Methylanthranilate Production n.a. 152 mg/L n.a. PMID[29771352]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. Firstly, we synthesized or cloned the genes encoding dammarenediol-II synthase (DS), PgUGT74AE2 and UGTPg1 from P. ginseng. Furthermore, the anti-colon cancer activities of both 3β-O-Glc-DM and 20S-O-Glc-DM were demonstrated by in vitro and in vivo assays. we engineered S. cerevisiae by introducing the codon-optimized genes encoding DS together with PgUGT74AE2 or UGTPg1. The engineered strains were optimized to increase the production of DM glucosides by integrating multi-copy DS and UGT genes into yeast via the CRISPR/Cas9 system, overexpressing several key enzymes of the upstream biosynthetic pathway, down-regulating the competitive branch pathway and overexpressing the transcriptional activator HAC1. NPC93081 Ornithine n.a. 2.4 g/L n.a. DOI[10.1039/C8GC04066D]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 2.3 mg/L n.a. PMID[28634125]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 185 mg/L n.a. PMID[29386648]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490932 oxidized derivative medicagenic acid n.a. 20.38 mg/L n.a. PMID[28634125]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC11433 Proline n.a. 26.57 mg/L n.a. PMID[28634125]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC161571 resveratrol n.a. 33.1+/-5.6mg/l n.a. PMID[18485776]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Green production n.a. overexpressing seven heterologous enzymes and five native enzymes and the strain YC1053 overexpressing seven heterologous enzymes and four native enzymes NPC490983 rhizomide A n.a. 336.8 mg/L n.a. PMID[32004707]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. UGTPgs characterization; Structural modeling; Protein chimeric. NPC331737 sesquiterpenes n.a. 42 mg/L n.a. PMID[26032089]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC490999 spinosad n.a. 5.31 mg/L n.a. PMID[28634125]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP biosynthesis n.a. We next introduced 11 heterologous genes and modified 12 native yeast genes to construct a yeast strain capable of producing 8-prenylkaempferol with high efficiency; relocating GmOMT2 into mitochondria (higher pH than cytoplasm) of the 8-prenylkaempferol–producing yeast strain NPC123965 Squalene n.a. 7.2 mg/L n.a. DOI[10.1016/j.scib.2021.03.002]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. Firstly, we synthesized or cloned the genes encoding dammarenediol-II synthase (DS), PgUGT74AE2 and UGTPg1 from P. ginseng. Furthermore, the anti-colon cancer activities of both 3β-O-Glc-DM and 20S-O-Glc-DM were demonstrated by in vitro and in vivo assays. we engineered S. cerevisiae by introducing the codon-optimized genes encoding DS together with PgUGT74AE2 or UGTPg1. The engineered strains were optimized to increase the production of DM glucosides by integrating multi-copy DS and UGT genes into yeast via the CRISPR/Cas9 system, overexpressing several key enzymes of the upstream biosynthetic pathway, down-regulating the competitive branch pathway and overexpressing the transcriptional activator HAC1. NPC123965 Squalene n.a. 5.6 g/L n.a. DOI[10.1039/C8GC04066D]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 648.63 mg/L n.a. PMID[31690080]
A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. Yeast chromosomes integration; Cell factories establishment. NPC233950 thiolactomycin n.a. 92 mg/L n.a. PMID[26032089]

  The Quantitative Compositions of NPs in Organism

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference