Browse All Co-culture Organisms

Organism ID Organism Name Producer Organism Inducer Organism NP ID NP Name Effect of Co-culture Reference
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC490616 dechloro-5'-hydroxygriseofulvin Novel NP PMID[30837981]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490536 notoamide M Novel NP PMID[29884864]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490533 Dendrodolide N Novel NP DOI[10.3390/md18020073]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490533 dendrodolide N Novel NP PMID[31979232]
NPO41353 Aspergillus BM-05 + Aspergillus BM-05ML n.a. n.a. NPC487808 psychrophilin E Novel NP PMID[24483240]
NPO41499 Streptomyces endus S-522 + Tsukamurella pulmonis TP-B0596 /Corynebacterium glutamicum ATCC13869 Streptomyces endus S-522 Tsukamurella pulmonis TP-B0596 /Corynebacterium glutamicum ATCC13869 NPC490538 Alchivemycin A Novel NP PMID[21097597]
NPO41572 Tsukamurella pulmonis + Streptomyces endus S-522 n.a. n.a. NPC490538 alchivemycin A New found in coculture PMID[21097597]
NPO41425 Fusarium tricinctum + Fusarium begonia n.a. n.a. NPC490541 subenniatin B Novel NP PMID[31953204]
NPO40592 Saccharopolyspora erythraea + Fusarium pallidoroseum n.a. n.a. NPC490911 N-demethylophiosetin Novel NP PMID[24422636]
NPO41366 Aspergillus sulphureus KMM 4640 + Isaria felina KMM 4639 n.a. n.a. NPC490549 diorcinol J Novel NP DOI[10.1007/s10600-016-1601-z]
NPO41443 mangrove fungi strain Nos. K38 + mangrove fungi strain E33 n.a. n.a. NPC490550 ethyl 5-ethoxy-2-formyl-3-hydroxy-4-methylbenzoate Novel NP DOI[10.1007/s10600-013-0751-5]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC490555 penicitrinol L Novel NP PMID[31953204]
NPO41464 Pseudoxylaria sp. + Microtermes sp n.a. n.a. NPC490558 pseudoxylallemycin A Novel NP PMID[27341414]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490626 fusatricinones D Novel NP PMID[35518011]
NPO41464 Pseudoxylaria sp. + Microtermes sp n.a. n.a. NPC490559 pseudoxylallemycin C Novel NP PMID[27341414]
NPO41464 Pseudoxylaria sp. + Microtermes sp n.a. n.a. NPC490581 pseudoxylallemycin E Novel NP PMID[27341414]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC484454 berkeleylactone A Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC484455 berkeleylactone B Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC484456 berkeleylactone C Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC490560 berkeleylactone D Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC490561 berkeleylactone E Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC484459 berkeleylactone F Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC490562 berkeleylactone G Novel NP PMID[28326781]
NPO41451 Penicillium fuscum + Penicillium camembertii/clavigerum n.a. n.a. NPC490563 berkeleylactone H Novel NP PMID[28326781]
NPO41409 Escherichia coli + Saccharomyces cerevisiae n.a. n.a. NPC490627 functionalized sesquiterpenes New found in coculture PMID[25558867]
NPO41492 Streptomyces coelicolor + actinomycete strain n.a. n.a. NPC490971 Prodiginine Novel NP PMID[23963177]
NPO41464 Pseudoxylaria sp. + Microtermes sp n.a. n.a. NPC490570 pseudoxylallemycin F Novel NP PMID[27341414]
NPO41356 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34 n.a. n.a. NPC490571 pseurotin G Novel NP PMID[28744271]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 n.a. n.a. NPC490571 pseurotin G Novel NP PMID[28744271]
NPO41454 Penicillium sp. Ma(M3)V + Trichoderma sp. Gc(M2)1 n.a. n.a. NPC490573 (Z)-2-ethylhex-2-enedioic acid Novel NP DOI[10.1177/1934578X1300800610]
NPO41454 Penicillium sp. Ma(M3)V + Trichoderma sp. Gc(M2)1 n.a. n.a. NPC490574 (E)-4-oxo-2-propylideneoct-7-enoic acid Novel NP DOI[10.1177/1934578X1300800610]
NPO41500 Streptomyces fradiae 007 + Penicillium sp. WC-29-5 n.a. n.a. NPC490667 (9R, 14S)-epoxy-11-deoxyfunicone Novel NP PMID[24714124]
NPO41469 Rhodococcus fascians + Streptomyces padanus n.a. n.a. NPC490579 rhodostreptomycin A Novel NP PMID[18179219]
NPO41469 Rhodococcus fascians + Streptomyces padanus n.a. n.a. NPC490580 rhodostreptomycin B Novel NP PMID[18179219]
NPO41400 Emericella sp. + Salinispora arenicola n.a. n.a. NPC490582 umezawamide A Novel NP PMID[17323993]
NPO41400 Emericella sp. + Salinispora arenicola n.a. n.a. NPC490583 umezawamide B Novel NP PMID[17323993]
NPO41580 Wickerhamomyces anomalus + Saccharomyces cerevisae n.a. n.a. NPC490628 Ethyl acetate Yield-increased in coculture PMID[31175063]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490585 10-O-acetylsclerotiamide Novel NP PMID[29884864]
NPO41366 Aspergillus sulphureus KMM 4640 + Isaria felina KMM 4639 n.a. n.a. NPC490585 10-O-acetylsclerotiamide Novel NP PMID[29884864]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490586 10-O-ethylsclerotiamide Novel NP PMID[29884864]
NPO41366 Aspergillus sulphureus KMM 4640 + Isaria felina KMM 4639 n.a. n.a. NPC490586 10-O-ethylsclerotiamide Novel NP PMID[29884864]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490587 10-O-ethylnotoamide R Novel NP PMID[29884864]
NPO41366 Aspergillus sulphureus KMM 4640 + Isaria felina KMM 4639 n.a. n.a. NPC490587 10-O-ethylnotoamide R Novel NP PMID[29884864]
NPO41433 Gordonia sp. KMC005 + Streptomyces tendae KMC006 n.a. n.a. NPC484727 gordonic acid Novel NP PMID[28845982]
NPO41549 Streptomyces tendae KMC006 + Gordonia sp. KMC005 Streptomyces tendae KMC006 Gordonia sp. KMC005 NPC484727 Gordonic acid Novel NP PMID[28845982]
NPO41455 Penicillium variabile + Talaromyces aculeatus n.a. n.a. NPC486914 nafuredin B Novel NP PMID[29144133]
NPO41574 two fungal morphs of the marine algal-derived Aspergillus alliaceus n.a. n.a. NPC490588 allianthrone A Novel NP PMID[29517220]
NPO41375 Catenuloplanes sp. RD067331 + Tsukamurella pulmonis n.a. n.a. NPC481033 catenulobactin A Novel NP PMID[30130105]
NPO41375 Catenuloplanes sp. RD067331 + Tsukamurella pulmonis n.a. n.a. NPC481034 catenulobactin B Novel NP PMID[30130105]
NPO41569 Trichoderma sp. (Strain 307) + Acinetobacter johnsonii (Strain B2) n.a. n.a. NPC490589 microsphaeropsisin B Novel NP PMID[28208607]
NPO41569 Trichoderma sp. (Strain 307) + Acinetobacter johnsonii (Strain B2) n.a. n.a. NPC490590 microsphaeropsisin C Novel NP PMID[28208607]
NPO41569 Trichoderma sp. (Strain 307) + Acinetobacter johnsonii (Strain B2) n.a. n.a. NPC490591 (3R, 7R)-7-hydroxy-de-O-methyllasiodiplodin Novel NP PMID[28208607]
NPO41569 Trichoderma sp. (Strain 307) + Acinetobacter johnsonii (Strain B2) n.a. n.a. NPC490592 (3R)-5-oxo-de-O-methyllasiodiplodin Novel NP PMID[28208607]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 n.a. n.a. NPC490758 borrelidin J Novel NP PMID[31134000]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 n.a. n.a. NPC490759 borrelidin K Novel NP PMID[31134000]
NPO41447 Nigrospora oryzae + Irpex lacteus n.a. n.a. NPC490597 nigrosirpexin A Novel NP PMID[30076888]
NPO41447 Nigrospora oryzae + Irpex lacteus n.a. n.a. NPC490599 nigirpexin A Novel NP PMID[30076888]
NPO41447 Nigrospora oryzae + Irpex lacteus n.a. n.a. NPC490600 nigirpexin B Novel NP PMID[30076888]
NPO41447 Nigrospora oryzae + Irpex lacteus n.a. n.a. NPC490601 nigirpexin C Novel NP PMID[30076888]
NPO41447 Nigrospora oryzae + Irpex lacteus n.a. n.a. NPC490602 nigirpexin D Novel NP PMID[30076888]
NPO41342 Aspergillus sclerotiorum SCSGAF 0053 + Penicillium citrinum SCSGAF 0052 n.a. n.a. NPC490607 sclerotiorumin C Novel NP PMID[27936301]
NPO41363 Aspergillus sclerotiorum + Penicillium citrinum n.a. n.a. NPC490607 sclerotiorumin C Novel NP PMID[27936301]
NPO41576 unidentified fungi n.a. n.a. NPC490608 (-)-byssochlamic acid imide Novel NP PMID[31953204]
NPO41442 mangrove fungi strain No. K38 + mangrove fungi strain No. E33 n.a. n.a. NPC490608 (-)-byssochlamic acid imide Novel NP DOI[10.1007/s10600-017-2092-2]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC490609 penicitrinone F Novel NP PMID[31953204]
NPO41470 Rhodococcus sp. + Micromonospora sp. n.a. n.a. NPC490610 Keyicin Novel NP PMID[29121465]
NPO41356 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34 n.a. n.a. NPC490611 luteoride D Novel NP PMID[28744271]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 n.a. n.a. NPC490611 luteoride D Novel NP PMID[28744271]
NPO41542 Streptomyces sp. JB5 + Bacillus sp n.a. n.a. NPC490612 dentigerumycin E Novel NP PMID[30406080]
NPO41543 Streptomyces sp. JB5 + Bacillus sp. GN1 Streptomyces sp. JB5 Bacillus sp. GN1 NPC490612 Dentigerumycin E Novel NP PMID[30406080]
NPO41548 Streptomyces sp. strain JB5 + Bacillus sp. (GN1) n.a. n.a. NPC490612 dentigerumycin E Novel NP PMID[30406080]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490613 8a-hydroxy-spiciferinone Novel NP DOI[10.3390/md18020073]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490613 8a-hydroxy-spiciferinone Novel NP PMID[31979232]
NPO41546 Streptomyces sp. NZ-6 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. NZ-6 Tsukamurella pulmonis TP-B0596 NPC490921 Niizalactams C Yield-increased in coculture PMID[26624939]
NPO41546 Streptomyces sp. NZ-6 + Tsukamurella pulmonis TP-B0596 n.a. n.a. NPC490921 niizalactam C Novel NP PMID[26624939]
NPO41362 Aspergillus nidulans + Escherichia coli n.a. n.a. NPC490631 F-9775B New found in coculture PMID[19666480]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 n.a. n.a. NPC490763 brevianamide X Novel NP PMID[28744271]
NPO41563 transgenic Escherichia coli + Saccharomyces cerevisiae strains n.a. n.a. NPC490659 corytuberine Novel NP PMID[18492807]
NPO41446 n α-proteobacterium (strain CNJ-328) + Libertella sp n.a. n.a. NPC490660 libertellenone C Novel NP PMID[15993608]
NPO41563 transgenic Escherichia coli + Saccharomyces cerevisiae strains n.a. n.a. NPC490988 scoulerine Novel NP PMID[18492807]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490661 notoamide F Novel NP PMID[29884864]
NPO41363 Aspergillus sclerotiorum + Penicillium citrinum n.a. n.a. NPC490671 1-(4-benzyl-1H-pyrrol-3-yl)ethanone Novel NP PMID[27936301]
NPO41567 Trichoderma harzianum M10 + Talaromyces pinophilus F36CF n.a. n.a. NPC490632 Ferrirubin Yield-increased in coculture PMID[29085019]
NPO41356 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34 n.a. n.a. NPC185404 11-O-methylpseurotin A New found in coculture PMID[28744271]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 n.a. n.a. NPC185404 11-O-methylpseurotin A New found in coculture PMID[28744271]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC185404 11-O-methylpseurotin A Novel NP PMID[29884864]
NPO41431 Gluconobacter oxydans, Ketogulonicigenium vulgare n.a. n.a. NPC34952 2-keto-L-gulonic acid Yield-increased in coculture PMID[26809519]
NPO41432 Gluconobacter oxydans + Ketogulonicigenium vulgare + Bacillus endophyticus n.a. n.a. NPC34952 2-keto-L-gulonic acid Yield-increased in coculture PMID[30368638]
NPO41430 Gluconobacter oxydans + Ketogulolicigenium vulgare n.a. n.a. NPC34952 2-keto-L-gulonic acid (2-KGA) Yield-increased in coculture PMID[26809519]
NPO41348 Alternaria tenuissima + Fusarium culmorum n.a. n.a. NPC490633 DON Yield-increased in coculture PMID[22776416]
NPO41349 Alternaria tenuissima + Fusarium graminearum n.a. n.a. NPC490633 DON Yield-increased in coculture PMID[22776416]
NPO41351 Amycolatopsis sp. AA4 + Streptomyces coelicolor M145 Amycolatopsis sp. AA4 Streptomyces coelicolor M145 NPC490603 amycomicin (AMY) Novel NP PMID[30228116]
NPO41369 Aureobasidium pullulans + Saccharomyces cerevisiae n.a. n.a. NPC490821 Fructo-oligosaccharide (FOS) Yield-increased in coculture PMID[30708187]
NPO41557 Talaromyces pinophilus + Trichoderma harzianum n.a. n.a. NPC142967 Dimerumic acid Yield-increased in coculture PMID[29085019]
NPO41440 Janthinobacterium spp. ZZ145 + Janthinobacterium spp. ZZ148 n.a. n.a. NPC490594 Janthinopolyenemycin A Novel NP DOI[10.1016/j.tetlet.2018.08.022]
NPO41439 Janthinobacterium spp. strain ZZ145 + Janthinobacterium spp. strain ZZ148 n.a. n.a. NPC490594 janthinopolyenemycins A Novel NP DOI[10.1016/j.tetlet.2018.08.022]
NPO41440 Janthinobacterium spp. ZZ145 + Janthinobacterium spp. ZZ148 n.a. n.a. NPC490594 janthinopolyenemycin A Novel NP PMID[31953204]
NPO41440 Janthinobacterium spp. ZZ145 + Janthinobacterium spp. ZZ148 n.a. n.a. NPC490596 janthinopolyenemycin B Novel NP DOI[10.1016/j.tetlet.2018.08.022]
NPO41439 Janthinobacterium spp. strain ZZ145 + Janthinobacterium spp. strain ZZ148 n.a. n.a. NPC490596 janthinopolyenemycins B Novel NP DOI[10.1016/j.tetlet.2018.08.022]
NPO41440 Janthinobacterium spp. ZZ145 + Janthinobacterium spp. ZZ148 n.a. n.a. NPC490596 janthinopolyenemycin B Novel NP PMID[31953204]
NPO41569 Trichoderma sp. (Strain 307) + Acinetobacter johnsonii (Strain B2) n.a. n.a. NPC490617 de-O-methyllasiodiplodins Novel NP PMID[28208607]
NPO41396 Cordyceps cicadae + its endophytic bacteria n.a. n.a. NPC490907 N6-(2-hydroxyethyl)-adenosine (HEA) Yield-increased in coculture PMID[31463998]
NPO41546 Streptomyces sp. NZ-6 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. NZ-6 Tsukamurella pulmonis TP-B0596 NPC487118 Niizalactams A Novel NP PMID[26624939]
NPO41546 Streptomyces sp. NZ-6 + Tsukamurella pulmonis TP-B0596 n.a. n.a. NPC487118 niizalactam A Novel NP PMID[26624939]
NPO41546 Streptomyces sp. NZ-6 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. NZ-6 Tsukamurella pulmonis TP-B0596 NPC490557 Niizalactams B Novel NP PMID[26624939]
NPO41546 Streptomyces sp. NZ-6 + Tsukamurella pulmonis TP-B0596 n.a. n.a. NPC490557 niizalactam B Novel NP PMID[26624939]
NPO41467 Ralstonia eutropha MTCC 2487 + Pseudomonas putida MTCC 2475 + Azotobacter vinelandii MTCC 2459 n.a. n.a. NPC490959 Poly-(3-hydroxybutyrate) (PHB) Yield-increased in coculture DOI[10.1016/j.bej.2019.107334]
NPO41555 Synechococcus elongatus PCC 7942 + Halomonas boliviensis n.a. n.a. NPC490959 Poly-(3-hydroxybutyrate) (PHB) Yield-increased in coculture PMID[29061492]
NPO41461 Pseudomonas malodorous NBRC 14164 + Saccharomyces cerevisiae BY4741 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture DOI[10.1016/j.cjche.2018.11.013]
NPO41476 Saccharophagus degradans 2–40 + Bacillus cereus n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture DOI[10.3390/app7030225]
NPO41553 Synechococcus elongatus PCC 7942 + Azotobacter vinelandii AV3 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture PMID[27232890]
NPO41554 Synechococcus elongatus PCC 7942 + Escherichia coli n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture PMID[28127397]
NPO41552 Synechococcus elongatus cscB + Pseudomonas putida cscAB n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture PMID[28814973]
NPO41466 Ralstonia eutropha H16 + Bacillus subtilis 5119 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) New found in coculture PMID[29486411]
NPO41346 Aeromonas hydrophila ATCC7966 + Acinetobacter junii BP25 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture PMID[31494436]
NPO41463 Pseudomonas putida KT2440 + Escherichia coli MG1655 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture PMID[32140930]
NPO41398 Cupriavidus necator DSM 428 + Pseudomonas citronellolis NRRL B-2504 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) New found in coculture PMID[32260526]
NPO41399 Cupriavidus necator IPT 026 + Xanthomonas campestris IBSBF 1867 n.a. n.a. NPC490960 Polyhydroxyalkanoates (PHAs) Yield-increased in coculture PMID[30925313]
NPO41561 Trametes robiniophila Murr. + Pleurotus ostreatus n.a. n.a. NPC490967 postrediene A (Sesterterpene compound 1) Novel NP PMID[31053589]
NPO41561 Trametes robiniophila Murr. + Pleurotus ostreatus n.a. n.a. NPC490968 postrediene B (Sesterterpene compound 2) Novel NP PMID[31053589]
NPO41561 Trametes robiniophila Murr. + Pleurotus ostreatus n.a. n.a. NPC490969 postrediene C (Sesterterpene compound 3) Novel NP PMID[31053589]
NPO41456 Phomopsis sp. K38 + Alternaria sp. E33 n.a. n.a. NPC16122 8-hydroxy-3-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ether Novel NP DOI[10.1007/s10600-011-9939-8]
NPO41577 Unidentified fungi E33 + Unidentified fungi K38 n.a. n.a. NPC16122 8-Hydroxy-3-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ether Novel NP PMID[20839130]
NPO41522 Streptomyces sp. FXJ1.4038 + Mycobacterium sp. HX09-1 n.a. n.a. NPC490668 1 putative novel compound Novel NP PMID[34835313]
NPO41523 Streptomyces sp. FXJ1.4059 + Mycobacterium sp. HX10-42 n.a. n.a. NPC490668 1 putative novel compound Novel NP PMID[34835313]
NPO41526 Streptomyces sp. FXJ1.4087 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490668 1 putative novel compound Novel NP PMID[34835313]
NPO41532 Streptomyces sp. FXJ1.4102 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490668 1 putative novel compound Novel NP PMID[34835313]
NPO41536 Streptomyces sp. FXJ1.4110 + Mycobacterium sp. HX14-21 n.a. n.a. NPC490668 1 putative novel compound Novel NP PMID[34835313]
NPO41541 Streptomyces sp. FXJ1.4122 + Mycobacterium sp. HX14-21 n.a. n.a. NPC490668 1 putative novel compound Novel NP PMID[34835313]
NPO41518 Streptomyces sp. FXJ1.172 + Mycobacterium sp. HX14-21 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41519 Streptomyces sp. FXJ1.235 + Mycobacterium sp. HX10-42 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41520 Streptomyces sp. FXJ1.235 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41525 Streptomyces sp. FXJ1.4075 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41527 Streptomyces sp. FXJ1.4094 + Mycobacterium sp. HX09-1 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41528 Streptomyces sp. FXJ1.4097 + Mycobacterium sp. HX09-1 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41535 Streptomyces sp. FXJ1.4106 + Mycobacterium sp. HX10-42 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41538 Streptomyces sp. FXJ1.4112 + Mycobacterium sp. HX09-1 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41540 Streptomyces sp. FXJ1.4112 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490678 2 putative novel compounds Novel NP PMID[34835313]
NPO41524 Streptomyces sp. FXJ1.4064 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490691 3 putative novel compounds Novel NP PMID[34835313]
NPO41529 Streptomyces sp. FXJ1.4097 + Mycobacterium sp. HX10-42 n.a. n.a. NPC490691 3 putative novel compounds Novel NP PMID[34835313]
NPO41434 Haematococcus pluvialis, Phaffia rhodozyma AS2-1557 n.a. n.a. NPC490657 Biomass Yield-increased in coculture DOI[10.1016/j.cattod.2004.09.052]
NPO41384 Chlorella sp. KKUS2 Toluraspore Y30 n.a. n.a. NPC490657 Biomass Yield-increased in coculture DOI[10.5281/zenodo.1332532]
NPO41385 Chlorella sp. KKUS2 Toluraspore YU5/2 n.a. n.a. NPC490657 Biomass Yield-increased in coculture DOI[10.5281/zenodo.1332532]
NPO41483 Spirulina platensis UTEX 1926 Rhodotorula glutinis 2.541 n.a. n.a. NPC490657 Biomass Yield-increased in coculture PMID[18931954]
NPO41386 Chlorella vulgaris TISTR 8261 Trichosporonoides spathulata n.a. n.a. NPC490657 Biomass Yield-increased in coculture PMID[24676571]
NPO28977 Tetradesmus obliquus n.a. n.a. NPC490657 Biomass Yield-increased in coculture PMID[34175768]
NPO41438 Isochrysis galbana 8701 Ambrosiozyma cicatricosa n.a. n.a. NPC490657 Biomass Yield-increased in coculture PMID[18086439]
NPO41411 Escherichia coli K12 + Acinetobacter bayily n.a. n.a. NPC490657 biomass Yield-increased in coculture PMID[25470793]
NPO41556 Synechocystis sp. PCC 6803 + Paenibacillus camelliae/Curtobacterium ammoniigenes Synechocystis sp. PCC 6803 Paenibacillus camelliae / Curtobacterium ammoniigenes NPC490658 biomass yield Yield-increased in coculture PMID[34940910]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490912 new natural products 1 New found in coculture PMID[24175613]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490916 new natural products 3 New found in coculture PMID[24175613]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490917 new natural products 4 New found in coculture PMID[24175613]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC243701 lateropyrone Yield-increased in coculture PMID[24175613]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC243701 lateropyrone Yield-increased in coculture PMID[35518011]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC243701 lateropyrone Yield-increased in coculture PMID[24175613]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC490662 (-)-citreoisocoumarin New found in coculture PMID[24175613]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490662 (-)-citreoisocoumarin New found in coculture PMID[35518011]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490662 (-)-citreoisocoumarin New found in coculture PMID[24175613]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC490663 (-)-citreoisocoumarinol Novel NP PMID[24175613]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC205926 (-)-notoamide B Novel NP PMID[29884864]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC207179 (+)-Afzelechin Yield-increased in coculture PMID[26860871]
NPO41560 Three-strain Escherichia coli polyculture n.a. n.a. NPC207179 (+)-Afzelechin Yield-increased in coculture PMID[28588129]
NPO41459 Pleosporales sp. + Bacillus wiedmannii n.a. n.a. NPC205917 (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one New found in coculture PMID[30738076]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490576 (E)-5,9-dihydroxydodec-6-enoic acid New found in coculture PMID[30785282]
NPO41485 Stereum hirsutum + Coprinus micaceus/Coprinus disseminatus n.a. n.a. NPC294226 1,2-dihydroxyanthraquinone Yield-increased in coculture DOI[10.1007/s11306-007-0100-4]
NPO41584 Xylaria sp. + Penicillium crustosum n.a. n.a. NPC490672 1,3-dihydroxy-5-(12-hydroxyheptadecyl)benzene Yield-increased in coculture PMID[31265288]
NPO41584 Xylaria sp. + Penicillium crustosum n.a. n.a. NPC490673 1,3-dihydroxy-5-(12-sulfoxyheptadecyl)benzene Yield-increased in coculture PMID[31265288]
NPO41345 Actinokineospora sp. EG49 + Nocardiopsis sp. RV163 n.a. n.a. NPC79911 1,6-dihydroxyphenazine New found in coculture PMID[24857962]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC490675 12,13-dihydroxy-fumitremorgin C New found in coculture PMID[31953204]
NPO41457 Phytopathogenic Fungi Fusarium oxysporum + endophytic fungus Paraconiothyrium n.a. n.a. NPC490500 13-hydroperoxy-9,11-octadecadienoic acid Novel NP PMID[23077591]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490676 17-hydroxynotoamide D Novel NP PMID[29884864]
NPO41366 Aspergillus sulphureus KMM 4640 + Isaria felina KMM 4639 n.a. n.a. NPC490676 17-hydroxynotoamide D Novel NP PMID[29884864]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC490584 17-O-ethylnotoamide M Novel NP PMID[29884864]
NPO41366 Aspergillus sulphureus KMM 4640 + Isaria felina KMM 4639 n.a. n.a. NPC490584 17-O-ethylnotoamide M Novel NP PMID[29884864]
NPO41355 Aspergillus flavipes + Streptomyces sp. n.a. n.a. NPC490677 19,20-dihydro-aspochalasin D Yield-increased in coculture PMID[26783945]
NPO41460 Pseudomonas aeruginosa + Aspergillus fumigatus n.a. n.a. NPC120798 1-hydroxyphenazine New found in coculture PMID[22869730]
NPO41460 Pseudomonas aeruginosa + Aspergillus fumigatus n.a. n.a. NPC1527 1-methoxyphenazine New found in coculture PMID[22869730]
NPO41389 Clostridium acetobutylicum + Clostridium ljungdahlii n.a. n.a. NPC140389 2,3-butanediol New found in coculture PMID[30391511]
NPO41562 Trametes versicolor + Ganoderma applanatum n.a. n.a. NPC490683 2,5,6-trihydroxy-4,6-diphenylcyclohex-4-ene-1,3-dione Novel NP PMID[29375514]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490686 21,24-cyclopentalanosta-3 Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490687 21,25-triol-8-en Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490688 22,25-triol Yield-increased in coculture PMID[20830471]
NPO41459 Pleosporales sp. + Bacillus wiedmannii n.a. n.a. NPC490689 23R-hydroxy-(20Z,24R)-ergosta-4,6,8(14),20(22)-tetraen-3-one Novel NP PMID[30738076]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490694 3-hydroxybenzoic acid methyl esters Yield-increased in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41562 Trametes versicolor + Ganoderma applanatum n.a. n.a. NPC317645 3-phenyllactic acid New found in coculture PMID[27616058]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC490641 cytochalasin Q Yield-increased in coculture PMID[30837981]
NPO41531 Streptomyces sp. FXJ1.4099 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490697 4 putative novel compounds Novel NP PMID[34835313]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490699 4-hydroxybenzoic acid methyl esters Yield-increased in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490545 4-O-demethylisobutyrolactone II New found in coculture DOI[]
NPO41345 Actinokineospora sp. EG49 + Nocardiopsis sp. RV163 n.a. n.a. NPC490516 5a,6,11a,12-tetrahydro-5a,11a-dimethyl[1,4]benzoxazino[3,2-b][1,4]benzoxazine New found in coculture PMID[24857962]
NPO41508 Streptomyces nigrescens HEK616 + Tsukamurella pulmonis TP-B0596/Corynebacterium glutamicum Streptomyces nigrescens HEK616 Tsukamurella pulmonis TP-B0596 or Corynebacterium glutamicum NPC490702 5-Alkyl-1,2,3,4-tetrahydroquinolines Novel NP PMID[25826296]
NPO41435 Heterobasidion abietinum + Streptomyces n.a. n.a. NPC490703 5-formylsalicic acid5-FSA Yield-increased in coculture PMID[29350358]
NPO41460 Pseudomonas aeruginosa + Aspergillus fumigatus n.a. n.a. NPC490704 5-N-methylated phenazine-1-carboxylic acid New found in coculture PMID[22869730]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC490707 6-methoxy spirotryprostatin B New found in coculture PMID[31953204]
NPO41577 Unidentified fungi E33 + Unidentified fungi K38 n.a. n.a. NPC490708 7-(,-dimethylallyloxy) -6-hydroxy-4-methylcoumarin Novel NP DOI[10.1007/s10600-015-1252-5]
NPO41442 mangrove fungi strain No. K38 + mangrove fungi strain No. E33 n.a. n.a. NPC490709 7-(,-dimethylallyloxy)-6-hydroxy-4-methylcoumarin Novel NP DOI[10.1007/s10600-015-1252-5]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC100784 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone New found in coculture PMID[35518011]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC490710 7-O-acetylcytochalasin B Yield-increased in coculture PMID[30837981]
NPO41579 Weissella confusa 11GU1 P. freudenreichii JS15 n.a. n.a. NPC68874 Acetate Yield-increased in coculture PMID[26256717]
NPO41505 Streptomyces lividans TK23 + One of mycolic acid-containing bacteria Streptomyces lividans TK23 One of mycolic acid-containing bacteria NPC490494 Actinorhodin New found in coculture PMID[21097597]
NPO41495 Streptomyces coelicolor + Myxococcus xanthus Streptomyces coelicolor Myxococcus xanthus NPC490494 Actinorhodin Yield-increased in coculture PMID[21342463]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC2724 alcohols Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41395 Clostridium ljungdahlii + Clostridium kluyveri n.a. n.a. NPC2724 alcohols New found in coculture PMID[27877166]
NPO41350 Alternaria tenuissima + Nigrospora sphaerica n.a. n.a. NPC32470 alternariol Yield-increased in coculture PMID[24114180]
NPO41500 Streptomyces fradiae 007 + Penicillium sp. WC-29-5 n.a. n.a. NPC32470 alternariol New found in coculture PMID[24714124]
NPO41350 Alternaria tenuissima + Nigrospora sphaerica n.a. n.a. NPC267509 alternariol monomethyl ether Yield-increased in coculture PMID[24114180]
NPO41350 Alternaria tenuissima + Nigrospora sphaerica n.a. n.a. NPC5062 alterperylenol Yield-increased in coculture PMID[24114180]
NPO41350 Alternaria tenuissima + Nigrospora sphaerica n.a. n.a. NPC85310 altertoxin I Yield-increased in coculture PMID[24114180]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC490714 analogs 5-hydroxygriseofulvin Novel NP PMID[30837981]
NPO41578 Vibrio coralliilyticus + Photobacterium galatheae n.a. n.a. NPC247089 andrimid Yield-increased in coculture PMID[33693627]
NPO41361 Aspergillus nidulans + Aspergillus fumigatus n.a. n.a. NPC490717 antibacterial diphenyl ethers Yield-increased in coculture PMID[35595930]
NPO41575 two species of Streptomyces n.a. n.a. NPC490718 antibiotic metabolite(s) New found in coculture PMID[11099234]
NPO41487 Streptomyces cinnabarinus + Alteromonas sp. n.a. n.a. NPC490719 antifouling diterpene lobocompactol Yield-increased in coculture PMID[23047094]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC210003 Apigetrin Yield-increased in coculture PMID[29362971]
NPO41490 Streptomyces cinnamoneus NBRC 13823 + Tsukamurella pulmonis TP-B0596 Streptomyces cinnamoneus NBRC 13823 Tsukamurella pulmonis TP-B0596 NPC490720 arcyriaflavin E Novel NP PMID[25335694]
NPO41489 Streptomyces cinnamoneus NBRC 13823 + Tsukamurella pulmonis n.a. n.a. NPC490720 arcyriaflavin E Novel NP PMID[25335694]
NPO41565 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB2) n.a. n.a. NPC490729 aspartic Yield-increased in coculture PMID[31665025]
NPO41355 Aspergillus flavipes + Streptomyces sp. n.a. n.a. NPC475800 aspochalasin E Yield-increased in coculture PMID[26783945]
NPO41355 Aspergillus flavipes + Streptomyces sp. n.a. n.a. NPC490534 aspochalasin H Yield-increased in coculture PMID[26783945]
NPO41355 Aspergillus flavipes + Streptomyces sp. n.a. n.a. NPC490572 aspochalasin M Yield-increased in coculture PMID[26783945]
NPO41355 Aspergillus flavipes + Streptomyces sp. n.a. n.a. NPC79155 aspochalasin P Yield-increased in coculture PMID[26783945]
NPO41434 Haematococcus pluvialis, Phaffia rhodozyma AS2-1557 n.a. n.a. NPC74086 Astaxanthin Yield-increased in coculture DOI[10.1016/j.cattod.2004.09.052]
NPO41477 Serpula lacrymans + different kinds of bacteria(Bacillus subtilis; Pseudomonas putida; Streptomyces iranensis.) n.a. n.a. NPC490730 atromentic acid Yield-increased in coculture PMID[27699944]
NPO41559 Talaromyces purpurogenus H4 + Phanerochaete sp. H2 n.a. n.a. NPC118402 austin New found in coculture PMID[31250361]
NPO41352 Aspergillus austroafricanus + Bacillus subtilis/Streptomyces lividans n.a. n.a. NPC490731 austramide Novel NP PMID[27070198]
NPO41514 Streptomyces sp. + Bacillus mycoides n.a. n.a. NPC75907 bacillamide A Yield-increased in coculture PMID[25643750]
NPO41515 Streptomyces sp. CGMCC4.7185 + Bacillus mycoides n.a. n.a. NPC75907 bacillamide A Yield-increased in coculture PMID[25643750]
NPO41514 Streptomyces sp. + Bacillus mycoides n.a. n.a. NPC26409 bacillamide B Yield-increased in coculture PMID[25643750]
NPO41515 Streptomyces sp. CGMCC4.7185 + Bacillus mycoides n.a. n.a. NPC26409 bacillamide B Yield-increased in coculture PMID[25643750]
NPO41514 Streptomyces sp. + Bacillus mycoides n.a. n.a. NPC277920 bacillamide C Yield-increased in coculture PMID[25643750]
NPO41515 Streptomyces sp. CGMCC4.7185 + Bacillus mycoides n.a. n.a. NPC277920 bacillamide C Yield-increased in coculture PMID[25643750]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490648 davallialactone Yield-increased in coculture PMID[20830471]
NPO41513 Streptomyces sp. + Aspergillus sp n.a. n.a. NPC490748 bacteriostatic cyclo-(L-phenylalanine-trans-4-hydroxy-L-proline) New found in coculture PMID[30116041]
NPO41490 Streptomyces cinnamoneus NBRC 13823 + Tsukamurella pulmonis TP-B0596 Streptomyces cinnamoneus NBRC 13823 Tsukamurella pulmonis TP-B0596 NPC184905 BE-13793C Yield-increased in coculture PMID[25335694]
NPO41545 Streptomyces sp. MA37 + Pseudomonas sp. Streptomyces sp. MA37 Pseudomonas sp. NPC184905 BE-13793C New found in coculture PMID[31936318]
NPO41545 Streptomyces sp. MA37 + Pseudomonas sp. n.a. n.a. NPC184905 BE-13793C New found in coculture PMID[31936318]
NPO41367 Aspergillus sydowii + Bacillus subtilis Aspergillus sydowii Bacillus subtilis NPC490749 benzoic acid derivatives N1 Novel NP PMID[35522265]
NPO41367 Aspergillus sydowii + Bacillus subtilis Aspergillus sydowii Bacillus subtilis NPC490750 benzoic acid derivatives N2 Novel NP PMID[35522265]
NPO41367 Aspergillus sydowii + Bacillus subtilis Aspergillus sydowii Bacillus subtilis NPC490751 benzoic acid derivatives N3 Novel NP PMID[35522265]
NPO41367 Aspergillus sydowii + Bacillus subtilis Aspergillus sydowii Bacillus subtilis NPC490752 benzoic acid derivatives N4 Novel NP PMID[35522265]
NPO41367 Aspergillus sydowii + Bacillus subtilis Aspergillus sydowii Bacillus subtilis NPC490753 benzoic acid derivatives N7 Novel NP PMID[35522265]
NPO41563 transgenic Escherichia coli + Saccharomyces cerevisiae strains n.a. n.a. NPC490754 benzylisoquinoline alkaloids magnoflorine Novel NP PMID[18492807]
NPO41420 Fusarium fujikuroi + Ralstonia solanacearum n.a. n.a. NPC179654 bikaverin New found in coculture PMID[29789359]
NPO41501 Streptomyces griseorubiginosus 43708 + Pseudomonas maltophilia 1928 Streptomyces griseorubiginosus 43708 Pseudomonas maltophilia 1928 NPC490508 Biphenomycin A Yield-increased in coculture PMID[1476432]
NPO41378 Chaetomium sp. + bacteria n.a. n.a. NPC490551 bipherin A New found in coculture DOI[]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 Streptomyces rochei MB037 Rhinocladiella similis 35 NPC490760 Borrelidins J Novel NP PMID[31134000]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 n.a. n.a. NPC490760 borrelidins J Novel NP PMID[31134000]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 n.a. n.a. NPC490761 borrelidins K Novel NP PMID[31134000]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 Streptomyces rochei MB037 Rhinocladiella similis 35 NPC490761 Borrelidins K Novel NP PMID[31134000]
NPO41412 Escherichia coli RQ5.1 + Escherichia coli CB1.1 n.a. n.a. NPC490762 branched-chain alcohols Yield-increased in coculture PMID[35033081]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC17059 brevianamide F New found in coculture PMID[31953204]
NPO41391 Clostridium acetobutylicum + Nesterenkonia sp. strain F n.a. n.a. NPC294703 butanol Yield-increased in coculture PMID[31709516]
NPO41388 Clostridium acetobutylicum + Clostridium cellulolyticum n.a. n.a. NPC294703 butanol Yield-increased in coculture PMID[24188120]
NPO41416 Faecalibacterium prausnitzii + Bifidobacterium catenulatum Faecalibacterium prausnitzii Bifidobacterium catenulatum NPC149209 butyrate Yield-increased in coculture PMID[32466189]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC149209 butyrate Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41428 Geobacter Sulfurreducens + Clostridium pasteurianum n.a. n.a. NPC149209 butyrate Yield-increased in coculture PMID[28287150]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490764 butyrolactones isobutyrolactone II New found in coculture DOI[]
NPO41583 Xylaria flabelliformis + Aspergillus fischeri n.a. n.a. NPC257240 C25H34O6 Novel NP PMID[32096649]
NPO41568 Trichoderma reesei + Lactobacillus pentosus + Clostridium tyrobutyricum, Veilonella criceti, Megasphaera elsdenii n.a. n.a. NPC490765 C3 fatty acid New found in coculture PMID[32855308]
NPO41568 Trichoderma reesei + Lactobacillus pentosus + Clostridium tyrobutyricum, Veilonella criceti, Megasphaera elsdenii n.a. n.a. NPC490766 C4 fatty acid New found in coculture PMID[32855308]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC490767 C4 fatty-acid Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41395 Clostridium ljungdahlii + Clostridium kluyveri n.a. n.a. NPC490767 C4 fatty-acid New found in coculture PMID[27877166]
NPO41568 Trichoderma reesei + Lactobacillus pentosus + Clostridium tyrobutyricum, Veilonella criceti, Megasphaera elsdenii n.a. n.a. NPC490768 C5 fatty acid New found in coculture PMID[32855308]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC490769 C5 fatty-acid Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41395 Clostridium ljungdahlii + Clostridium kluyveri n.a. n.a. NPC490769 C5 fatty-acid New found in coculture PMID[27877166]
NPO41568 Trichoderma reesei + Lactobacillus pentosus + Clostridium tyrobutyricum, Veilonella criceti, Megasphaera elsdenii n.a. n.a. NPC490770 C6 fatty acid New found in coculture PMID[32855308]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC490771 C6 fatty-acid Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41395 Clostridium ljungdahlii + Clostridium kluyveri n.a. n.a. NPC490771 C6 fatty-acid New found in coculture PMID[27877166]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC490772 C7 fatty-acid Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41395 Clostridium ljungdahlii + Clostridium kluyveri n.a. n.a. NPC490772 C7 fatty-acid New found in coculture PMID[27877166]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC490773 C8 fatty-acid Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41395 Clostridium ljungdahlii + Clostridium kluyveri n.a. n.a. NPC490773 C8 fatty-acid New found in coculture PMID[27877166]
NPO41392 Clostridium autoethanogenum + Clostridium kluyveri n.a. n.a. NPC332988 caproate Yield-increased in coculture PMID[27042211]
PMID[31792266]
NPO41394 Clostridium kluyveri. + Methanogen 166 n.a. n.a. NPC332988 caproate Yield-increased in coculture PMID[30361817]
NPO41471 Rhodotorula glutinis + Chlorella vulgaris n.a. n.a. NPC490775 Carotenoid New found in coculture PMID[30969398]
NPO41383 Chlorella sp. + Beijerinckia n.a. n.a. NPC490776 Carotenoids Yield-increased in coculture DOI[10.1016/j.algal.2019.101744]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490489 cephalochromin Yield-increased in coculture DOI[10.3390/md18020073]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490489 cephalochromin Yield-increased in coculture PMID[31979232]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC490489 cephalochromin n.a. PMID[35054969]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490619 depsipeptides enniatins B1 Yield-increased in coculture PMID[35518011]
NPO41379 Chaetomium sp. + Pseudomonas aeruginosa n.a. n.a. NPC490778 chaetobutenolides A Yield-increased in coculture DOI[]
NPO41379 Chaetomium sp. + Pseudomonas aeruginosa n.a. n.a. NPC490779 chaetobutenolides B Yield-increased in coculture DOI[]
NPO41379 Chaetomium sp. + Pseudomonas aeruginosa n.a. n.a. NPC490780 chaetobutenolides C Yield-increased in coculture DOI[]
NPO41380 Chaunopycnis sp. CMB-MF028 + Trichoderma hamatum CMB-MF030 n.a. n.a. NPC490564 chaunopyran A New found in coculture PMID[28383912]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 Streptomyces leeuwenhoekii strain strain C58 Aspergillus fumigatus MR2012 NPC490781 chaxapeptin New found in coculture PMID[28744271]
NPO41358 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C58 n.a. n.a. NPC490781 chaxapeptin Yield-increased in coculture PMID[28744271]
NPO41502 Streptomyces leeuwenhoekii C34 + Aspergillus fumigatus MR2012 Streptomyces leeuwenhoekii C34 Aspergillus fumigatus MR2012 NPC490781 Chaxapeptin Novel NP PMID[28744271]
NPO41503 Streptomyces leeuwenhoekii C58 + Aspergillus fumigatus MR2012 Streptomyces leeuwenhoekii C58 Aspergillus fumigatus MR2012 NPC490781 chaxapeptin Yield-increased in coculture PMID[28744271]
NPO41383 Chlorella sp. + Beijerinckia n.a. n.a. NPC246026 Chlorophyll a Yield-increased in coculture DOI[10.1016/j.algal.2019.101744]
NPO41383 Chlorella sp. + Beijerinckia n.a. n.a. NPC102266 Chlorophyll b Yield-increased in coculture DOI[10.1016/j.algal.2019.101744]
NPO41516 Streptomyces sp. CJ-5 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. CJ-5 Tsukamurella pulmonis TP-B0596 NPC490546 Chojalactones A Novel NP PMID[25742189]
NPO41516 Streptomyces sp. CJ-5 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. CJ-5 Tsukamurella pulmonis TP-B0596 NPC490547 Chojalactones B Novel NP PMID[25742189]
NPO41516 Streptomyces sp. CJ-5 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. CJ-5 Tsukamurella pulmonis TP-B0596 NPC490548 Chojalactones C Novel NP PMID[25742189]
NPO41378 Chaetomium sp. + bacteria n.a. n.a. NPC490552 chorismeron New found in coculture DOI[]
NPO41418 fungi Penicillium citrinum + Beauveria felina n.a. n.a. NPC473107 Citrifelin A New found in coculture PMID[26295595 ]
NPO41418 fungi Penicillium citrinum + Beauveria felina n.a. n.a. NPC473108 Citrifelin B New found in coculture PMID[26295595]
NPO41354 Aspergillus clavatonanicus + Pytium ultimum n.a. n.a. NPC29084 Clavatol New found in coculture PMID[18317751]
NPO41415 Eutypa lata + Botryosphaeria obtusa n.a. n.a. NPC490794 compound Novel NP PMID[29459851]
NPO41557 Talaromyces pinophilus + Trichoderma harzianum n.a. n.a. NPC490542 Coprogen B Yield-increased in coculture PMID[29085019]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC490796 cyclic depsipeptides of the enniatin type Yield-increased in coculture PMID[24175613]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490797 cyclic depsipeptides of the enniatin type 6 Yield-increased in coculture PMID[24175613]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490798 cyclic depsipeptides of the enniatin type 7 Yield-increased in coculture PMID[24175613]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC490799 cyclic depsipeptides of the enniatin type 8 Yield-increased in coculture PMID[24175613]
NPO41456 Phomopsis sp. K38 + Alternaria sp. E33 n.a. n.a. NPC490800 cyclo-(D-proline-L-tyrosine-L-proline-L-tyrosine) Novel NP PMID[25422539]
PMID[24571709]
NPO41456 Phomopsis sp. K38 + Alternaria sp. E33 n.a. n.a. NPC490801 cyclo-(glycine-L-phenylalanine-L-proline-L-tyrosine) Novel NP PMID[25422539]
PMID[24571709]
NPO41410 Escherichia coli + Saccharomyces cerevisiae coculture n.a. n.a. NPC490656 Genistein New found in coculture PMID[16960736]
NPO41456 Phomopsis sp. K38 + Alternaria sp. E33 n.a. n.a. NPC490578 Cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline) Novel NP PMID[25422539]
PMID[24571709]
NPO41422 Fusarium oxysporum + Serratia sp. + Achromobacter sp n.a. n.a. NPC490802 cyclocaryophyllan-4-ol New found in coculture PMID[19396945]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC490485 cytochalasin C Yield-increased in coculture PMID[30837981]
NPO41370 Bacillus amyloliquefaciens ACCC11060 + Trichoderma asperellum GDFS1009 n.a. n.a. NPC285322 D-aspartic acid Yield-increased in coculture PMID[30285749]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC490804 dec arboxydihydrocitrinone Novel NP PMID[31953204]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC30545 dendrodolide E New found in coculture PMID[31979232]
NPO41500 Streptomyces fradiae 007 + Penicillium sp. WC-29-5 n.a. n.a. NPC138508 deoxyfunicone New found in coculture PMID[24714124]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490806 depsipeptides enniatins A1 Yield-increased in coculture PMID[35518011]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490807 depsipeptides enniatins B Yield-increased in coculture PMID[35518011]
NPO41547 Streptomyces sp. PTY087I2 + Selected human pathogens Streptomyces sp. PTY087I2 Selected human pathogens NPC490569 dihydrogranaticin B Yield-increased in coculture PMID[28800088]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490809 dihydrolateropyrone New found in coculture PMID[35518011]
NPO41480 Shewanella oneidensis + Klebsiella pneumoniae (GMO) n.a. n.a. NPC490811 electricity Yield-increased in coculture PMID[30936852]
NPO41482 Shiraia sp. S9 + Pseudomonas fulva SB1 n.a. n.a. NPC490492 elsinochrome A Yield-increased in coculture PMID[31277643]
NPO41482 Shiraia sp. S9 + Pseudomonas fulva SB1 n.a. n.a. NPC490497 elsinochrome B Yield-increased in coculture PMID[31277643]
NPO41482 Shiraia sp. S9 + Pseudomonas fulva SB1 n.a. n.a. NPC490498 elsinochrome C Yield-increased in coculture PMID[31277643]
NPO41374 Burkholderia gladioli + Rhizopus microsporus n.a. n.a. NPC490503 enacyloxin IIa New found in coculture PMID[25250879]
NPO41473 Saccharomyces cerevisae MK 175 + Candida tropicalis MK-118 n.a. n.a. NPC490812 Endoglucanase Yield-increased in coculture DOI[10.1016/j.indcrop.2018.07.021]
NPO41427 Fusarium tricinctum + Streptomyces lividans/Bacillus subtilis n.a. n.a. NPC32492 enniatin A1 Yield-increased in coculture PMID[35518011]
NPO41427 Fusarium tricinctum + Streptomyces lividans/Bacillus subtilis n.a. n.a. NPC212866 enniatin B Yield-increased in coculture PMID[35518011]
NPO41427 Fusarium tricinctum + Streptomyces lividans/Bacillus subtilis n.a. n.a. NPC178919 enniatin B1 Yield-increased in coculture PMID[35518011]
NPO41347 Agaricus blazei LPB03 + Chlorella vulgaris LEB106 n.a. n.a. NPC490813 EPS Yield-increased in coculture PMID[22415788]
NPO41579 Weissella confusa 11GU1 P. freudenreichii JS15 n.a. n.a. NPC490813 EPS Yield-increased in coculture PMID[26256717]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC18603 ergosterol n.a. PMID[35054969]
NPO41436 ichia kudriazevii YS201 + Bacillus subtilis BS38 n.a. n.a. NPC2724 ethanol Yield-increased in coculture PMID[31993527]
NPO41457 Phytopathogenic Fungi Fusarium oxysporum + endophytic fungus Paraconiothyrium n.a. n.a. NPC490814 f oxylipins 13- oxo-9,11-octadecadienoic acid Novel NP PMID[23077591]
NPO41557 Talaromyces pinophilus + Trichoderma harzianum n.a. n.a. NPC490817 Ferricrocin Yield-increased in coculture PMID[29085019]
NPO41509 Streptomyces rapamycinicus + Aspergillus fumigatus n.a. n.a. NPC490822 fumicycline B Novel NP PMID[23649940]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC70192 fumitremorgin B New found in coculture PMID[31953204]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC70192 fumitremorgin B Yield-increased in coculture PMID[30837981]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC305984 fumitremorgin C New found in coculture PMID[31953204]
NPO41421 Fusarium oxysporum + Sarocladium strictum n.a. n.a. NPC41717 Fusaric acid Yield-increased in coculture PMID[26999098]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490824 fusatricinones A Novel NP PMID[35518011]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490825 fusatricinones B Novel NP PMID[35518011]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490826 fusatricinones C Novel NP PMID[35518011]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490620 foscoparianol D Yield-increased in coculture PMID[20830471]
NPO41484 Staphylococcus lentus SZ2 + Vibrio harveyi n.a. n.a. NPC490757 biosurfactant (BS-SLSZ2 with antibiofilm properties) Yield-increased in coculture PMID[29685351]
NPO41565 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB2) n.a. n.a. NPC197087 glutamine Yield-increased in coculture PMID[31665025]
NPO41562 Trametes versicolor + Ganoderma applanatum n.a. n.a. NPC490925 novel xyloside (compound 3) Novel NP PMID[27616058]
NPO41547 Streptomyces sp. PTY087I2 + Selected human pathogens Streptomyces sp. PTY087I2 Selected human pathogens NPC490832 Granaticin Yield-increased in coculture PMID[28800088]
NPO41547 Streptomyces sp. PTY087I2 + Selected human pathogens Streptomyces sp. PTY087I2 Selected human pathogens NPC490526 granatomycin D Yield-increased in coculture PMID[28800088]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC490543 H28 New found in coculture PMID[8216897]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC490537 H31 New found in coculture PMID[8216897]
NPO41557 Talaromyces pinophilus + Trichoderma harzianum n.a. n.a. NPC490833 harziaphilic acid Novel NP PMID[29085019]
NPO41567 Trichoderma harzianum M10 + Talaromyces pinophilus F36CF n.a. n.a. NPC490833 harziaphilic acid Novel NP PMID[29085019]
NPO41517 Streptomyces sp. CMB-StM0423 + Aspergillus sp. CMB-AsM0423 Streptomyces sp. CMB-StM0423 Aspergillus sp. CMB-AsM0423 NPC314889 Heronapyrrole B New found in coculture PMID[30116041]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC490509 H35b (fomannoxinalcohol) Novel NP PMID[8216897]
NPO41564 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB1) n.a. n.a. NPC237812 histidine Yield-increased in coculture PMID[31665025]
NPO41578 Vibrio coralliilyticus + Photobacterium galatheae n.a. n.a. NPC314800 holomycin Yield-increased in coculture PMID[33693627]
NPO41570 Trichophyton rubrum + Bionectria ochroleuca n.a. n.a. NPC490836 Hydroxysulfoxy-2,2-dimethylthielavin P Novel NP PMID[23734767]
NPO41410 Escherichia coli + Saccharomyces cerevisiae coculture n.a. n.a. NPC273538 Icaritin New found in coculture DOI[10.1016/j.scib.2021.03.002]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC477300 inoscavin B Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC300680 inoscavin C Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490841 inotodisaccharide and melanins Yield-increased in coculture PMID[20830471]
NPO41374 Burkholderia gladioli + Rhizopus microsporus n.a. n.a. NPC490842 iso enacyloxin IIIa New found in coculture PMID[25250879]
NPO41422 Fusarium oxysporum + Serratia sp. + Achromobacter sp n.a. n.a. NPC60556 isocaryophyllene New found in coculture PMID[19396945]
NPO41389 Clostridium acetobutylicum + Clostridium ljungdahlii n.a. n.a. NPC163707 isopropanol New found in coculture PMID[30391511]
NPO41378 Chaetomium sp. + bacteria n.a. n.a. NPC176408 isosulochrin New found in coculture DOI[]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC176408 isosulochrin New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41477 Serpula lacrymans + different kinds of bacteria(Bacillus subtilis; Pseudomonas putida; Streptomyces iranensis.) n.a. n.a. NPC490843 isoxerocomic Yield-increased in coculture PMID[27699944]
NPO41550 Streptomyces tenjimariensis SS-939 + One of 53 marine bacterial isolates Streptomyces tenjimariensis SS-939 One of 53 marine bacterial isolates NPC48960 Istamycin A Yield-increased in coculture PMID[12032613]
NPO41550 Streptomyces tenjimariensis SS-939 + One of 53 marine bacterial isolates Streptomyces tenjimariensis SS-939 One of 53 marine bacterial isolates NPC50650 Istamycin B Yield-increased in coculture PMID[12032613]
NPO41401 engineered Pseudomonas putida KT2440 + Bacillus coagulans NL01 Bacillus coagulans NL01 engineered Pseudomonas putida KT2440 NPC76217 lactic acid Yield-increased in coculture PMID[34838093]
NPO41462 Pseudomonas putida KT2440 + Bacillus coagulans NL01 n.a. n.a. NPC76217 lactic acid Yield-increased in coculture PMID[34838093]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC265910 G42 (oospolactone) New found in coculture PMID[8216897]
NPO41371 Bacillus amyloliquefaciens ACCC11060 + Trichoderma asperellum GDFS1010 n.a. n.a. NPC270805 L-allothreonine Yield-increased in coculture PMID[30285749]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490844 lanosta-7,9(11),23-triene-3 Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490845 lanostane-type triterpenoids Yield-increased in coculture PMID[20830471]
NPO41362 Aspergillus nidulans + Escherichia coli n.a. n.a. NPC105648 lecanoric acid New found in coculture PMID[19666480]
NPO41372 Bacillus amyloliquefaciens ACCC11060 + Trichoderma asperellum GDFS1011 n.a. n.a. NPC137958 L-glutamic acid Yield-increased in coculture PMID[30285749]
NPO41446 n α-proteobacterium (strain CNJ-328) + Libertella sp n.a. n.a. NPC490848 libertellenone B Novel NP PMID[15993608]
NPO41534 Streptomyces sp. FXJ1.4106 + Mycobacterium sp. HX09-1 n.a. n.a. NPC490669 1 putative novel compound related to tetrodecamycin (Polyketide) Novel NP PMID[34835313]
NPO41571 Triple coculture of Trichoderma viride + Aspergillus terreus + Leptosphaerulina sp. n.a. n.a. NPC490850 ligninolytic enzymes Yield-increased in coculture PMID[30235638]
NPO41359 Aspergillus fumigatus + microalgae n.a. n.a. NPC85813 linoleic acid Yield-increased in coculture PMID[25419574]
NPO41539 Streptomyces sp. FXJ1.4112 + Mycobacterium sp. HX10-42 n.a. n.a. NPC490680 2 putative novel compounds related to collinomycin (Polyketide) Novel NP PMID[34835313]
NPO41384 Chlorella sp. KKUS2 Toluraspore Y30 n.a. n.a. NPC490853 Lipids Yield-increased in coculture DOI[10.5281/zenodo.1332532]
NPO41385 Chlorella sp. KKUS2 Toluraspore YU5/2 n.a. n.a. NPC490853 Lipids Yield-increased in coculture DOI[10.5281/zenodo.1332532]
NPO41483 Spirulina platensis UTEX 1926 Rhodotorula glutinis 2.541 n.a. n.a. NPC490853 Lipids Yield-increased in coculture PMID[18931954]
NPO41387 Chlorella vulgaris TISTR 8261 Trichosporonoides spathulata JU4-57 n.a. n.a. NPC490853 Lipids Yield-increased in coculture PMID[24676571]
NPO41381 Chlorella pyrenoidosa FACHB-9 Rhodospiridium toruloides AS2.1389 n.a. n.a. NPC490853 Lipids Yield-increased in coculture PMID[25299489]
NPO41465 R. kratochvilovae CCY 20-2-26 + Desmodesmus sp. R. kratochvilovae CCY 20-2-26 Desmodesmus sp. NPC490853 Lipids Yield-increased in coculture PMID[34071194]
NPO41566 Trichoderma harzianum IHEM5437 + Bacillus velezensis GA1 Bacillus velezensis GA1 Trichoderma harzianum IHEM5437 NPC490854 lipopeptide Yield-increased in coculture PMID[35630500]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490855 lipopeptide fusaristatin A Yield-increased in coculture PMID[35518011]
NPO41488 Streptomyces cinnabarinus PK209 + Alteromonas sp. KNS-16 Streptomyces cinnabarinus PK209 Alteromonas sp. KNS-16 NPC490539 Lobocompactol Yield-increased in coculture PMID[23047094]
NPO41488 Streptomyces cinnabarinus PK209 + Alteromonas sp. KNS-16 n.a. n.a. NPC490539 lobocompactol Yield-increased in coculture PMID[23047094]
NPO41544 Streptomyces sp. KUSC_F0 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. KUSC_F0 Tsukamurella pulmonis TP-B0596 NPC490858 Longicatenamides A Novel NP PMID[33483628]
NPO41544 Streptomyces sp. KUSC_F0 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. KUSC_F0 Tsukamurella pulmonis TP-B0596 NPC490859 Longicatenamides B Novel NP PMID[33483628]
NPO41544 Streptomyces sp. KUSC_F0 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. KUSC_F0 Tsukamurella pulmonis TP-B0596 NPC490860 Longicatenamides C Novel NP PMID[33483628]
NPO41537 Streptomyces sp. FXJ1.4111 + Mycobacterium sp. HX10-55 n.a. n.a. NPC490692 3 putative novel compounds related to actinoperylone (Polyketide) Novel NP PMID[34835313]
NPO41544 Streptomyces sp. KUSC_F0 + Tsukamurella pulmonis TP-B0596 Streptomyces sp. KUSC_F0 Tsukamurella pulmonis TP-B0596 NPC490861 Longicatenamides D Novel NP PMID[33483628]
NPO41564 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB1) n.a. n.a. NPC112890 lysine Yield-increased in coculture PMID[31665025]
NPO41530 Streptomyces sp. FXJ1.4099 + Mycobacterium sp. HX10-42 n.a. n.a. NPC490693 3 putative novel compounds related to fogacin (Polyketide) Novel NP PMID[34835313]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC490863 macrocarpon C Novel NP PMID[24175613]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC490863 macrocarpon C New found in coculture PMID[35518011]
NPO41441 mangrove endophytic fungi strain Nos.3893 + mangrove endophytic fungi strain Nos.1924 n.a. n.a. NPC490864 marinamide Novel NP DOI[10.1007/s11434-006-1426-4]
NPO41441 mangrove endophytic fungi strain Nos.3893 + mangrove endophytic fungi strain Nos.1924 n.a. n.a. NPC490865 marinamide methyl ester Novel NP DOI[10.1007/s11434-006-1426-4]
NPO41452 Penicillium pinophilum + Trichoderma harzianum n.a. n.a. NPC167264 MC-141 Yield-increased in coculture PMID[22008698]
NPO41463 Pseudomonas putida KT2440 + Escherichia coli MG1655 n.a. n.a. NPC490869 medium-chain-length polyhydroxyalkanoates Yield-increased in coculture PMID[32140930]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490870 melanins Yield-increased in coculture PMID[20830471]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC268948 melledonal A Yield-increased in coculture PMID[8003259]
NPO41521 Streptomyces sp. FXJ1.264 + Mycobacterium sp. HX09-1 n.a. n.a. NPC490705 6 putative novel compounds (Polyketide) Novel NP PMID[34835313]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC108744 melledonal C Yield-increased in coculture PMID[8003259]
NPO41558 Talaromyces purpurogenus H4 + Phanerochaete sp n.a. n.a. NPC490871 meroterpenoid austin Novel NP PMID[31250361]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490872 methyl davallialactone Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490873 methyl inoscavin A Yield-increased in coculture PMID[20830471]
NPO41510 Streptomyces rimosus + Aspergillus terreus n.a. n.a. NPC490875 milbemycin New found in coculture PMID[34660550]
NPO41533 Streptomyces sp. FXJ1.4102 + Mycobacterium sp. HX14-21 n.a. n.a. NPC490679 2 putative novel compounds (Unknown; Unknown) Novel NP PMID[34835313]
NPO41405 Escherichia coli + Escherichia coli (GMO) n.a. n.a. NPC107877 muconic acid Yield-increased in coculture PMID[26369810]
NPO41345 Actinokineospora sp. EG49 + Nocardiopsis sp. RV163 n.a. n.a. NPC490883 N-(2-hydroxyphenyl)-acetamide New found in coculture PMID[24857962]
NPO41562 Trametes versicolor + Ganoderma applanatum n.a. n.a. NPC490884 N-(4-methoxyphenyl)formamide 2-O--D-xyloside Novel NP PMID[27616058]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490885 N1 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490886 N10 New found in coculture PMID[33579268]
NPO41472 Rhodutola glutinis DBVPG 3853, Debaryomyces castellii DBVPG 3503 n.a. n.a. NPC490777 Carotenoids (-carotene, torulene, torularhodin) Yield-increased in coculture PMID[11348447]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490887 N11 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490888 N12 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490889 N13 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490890 N14 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490891 N15 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490892 N16 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490893 N17 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490894 N18 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490895 N19 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490896 N2 New found in coculture PMID[33579268]
NPO41491 Streptomyces coelicolor + actinomycete n.a. n.a. NPC262615 desferrioxamine B Novel NP PMID[23963177]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490897 N20 Novel NP PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490898 N21 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490899 N22 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490900 N23 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490901 N24 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490902 N25 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490903 N3 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490904 N4 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490905 N5 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490906 N6 Novel NP PMID[33579268]
NPO41402 Enterobacter sp. Pup14A + Pseudomonas aeruginosa n.a. n.a. NPC186750 pyocyanin Novel NP PMID[17185230]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490908 N7 Novel NP PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490909 N8 New found in coculture PMID[33579268]
NPO41367 Aspergillus sydowii + Bacillus subtilis n.a. n.a. NPC490910 N9 Novel NP PMID[33579268]
NPO41514 Streptomyces sp. + Bacillus mycoides n.a. n.a. NPC190296 N-acetyltryptamine Yield-increased in coculture PMID[25643750]
NPO41515 Streptomyces sp. CGMCC4.7185 + Bacillus mycoides n.a. n.a. NPC190296 N-acetyltryptamine Yield-increased in coculture PMID[25643750]
NPO41574 two fungal morphs of the marine algal-derived Aspergillus alliaceus n.a. n.a. NPC490514 nalgiolaxin Yield-increased in coculture PMID[29517220]
NPO41474 Saccharomyces cerevisiae + Escherichia coli n.a. n.a. NPC79943 naringenin Yield-increased in coculture PMID[32624852]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC79943 Naringenin Yield-increased in coculture PMID[29318204]
NPO41410 Escherichia coli + Saccharomyces cerevisiae coculture n.a. n.a. NPC79943 Naringenin Yield-increased in coculture PMID[32624852]
NPO41475 Saccharomyces cerevisiae + Saccharomyces cerevisiae coculture n.a. n.a. NPC79943 Naringenin Yield-increased in coculture PMID[33453581]
NPO40704 Streptomyces sp. RKND-216 + Alteromonas sp. RKMC-009 Streptomyces sp. RKND-216 Alteromonas sp. RKMC-009 NPC486910 N-Carbamoyl-2-hydroxy-3-methoxybenzamide Novel NP PMID[32869646]
NPO40704 Streptomyces sp. RKND-216 + Alteromonas sp. RKMC-009 n.a. n.a. NPC486910 N-carbamoyl-2-hydroxy-3-methoxybenzamide Novel NP PMID[32869646]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490913 new natural products 10 New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490914 new natural products 11 New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490915 new natural products 12 New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490918 new natural products 8 New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490919 new natural products 9 New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41364 Aspergillus sclerotiorum + Streptomyces n.a. n.a. NPC490924 notoamides Yield-increased in coculture PMID[34564188]
NPO41514 Streptomyces sp. + Bacillus mycoides n.a. n.a. NPC490926 N-propanoyltryptamine Yield-increased in coculture PMID[25643750]
NPO41515 Streptomyces sp. CGMCC4.7185 + Bacillus mycoides n.a. n.a. NPC490926 N-propanoyltryptamine Yield-increased in coculture PMID[25643750]
NPO41445 Moniliophthora roreri + Trichoderma harzianum n.a. n.a. NPC490927 NPs harzianolide New found in coculture PMID[26637047]
NPO41359 Aspergillus fumigatus + microalgae n.a. n.a. NPC261831 oleic acid Yield-increased in coculture PMID[25419574]
NPO41415 Eutypa lata + Botryosphaeria obtusa n.a. n.a. NPC490929 O-methylmellein New found in coculture PMID[29459851]
NPO41569 Trichoderma sp. (Strain 307) + Acinetobacter johnsonii (Strain B2) n.a. n.a. NPC490930 one new natural product Novel NP PMID[28208607]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC117418 orientin Yield-increased in coculture PMID[33930665]
NPO41362 Aspergillus nidulans + Escherichia coli n.a. n.a. NPC262671 Orsellinic acid New found in coculture PMID[19666480]
NPO41562 Trametes versicolor + Ganoderma applanatum n.a. n.a. NPC262671 orsellinic acid New found in coculture PMID[27616058]
NPO41570 Trichophyton rubrum + Bionectria ochroleuca n.a. n.a. NPC490931 orsellinic acid derivatives(characterized as hydroxysulfoxy-2,2-dimethylthielavin P) Novel NP PMID[23734767]
NPO41502 Streptomyces leeuwenhoekii C34 + Aspergillus fumigatus MR2012 Streptomyces leeuwenhoekii C34 Aspergillus fumigatus MR2012 NPC34838 nocardamine Yield-increased in coculture PMID[28744271]
NPO41503 Streptomyces leeuwenhoekii C58 + Aspergillus fumigatus MR2012 Streptomyces leeuwenhoekii C58 Aspergillus fumigatus MR2012 NPC34838 Nocardamine Novel NP PMID[28744271]
NPO41403 Escherichia coli (GMO) + Saccharomyces cerevisiae (GMO) n.a. n.a. NPC490934 oxygenated taxanes New found in coculture PMID[25558867]
NPO41409 Escherichia coli + Saccharomyces cerevisiae n.a. n.a. NPC490934 oxygenated taxanes New found in coculture PMID[25558867]
NPO40592 Saccharopolyspora erythraea + Fusarium pallidoroseum n.a. n.a. NPC490936 pallidor osetin A Novel NP PMID[24422636]
NPO40592 Saccharopolyspora erythraea + Fusarium pallidoroseum n.a. n.a. NPC490937 pallidor osetin B Novel NP PMID[24422636]
NPO41359 Aspergillus fumigatus + microalgae n.a. n.a. NPC216630 palmitic acid Yield-increased in coculture PMID[25419574]
NPO41354 Aspergillus clavatonanicus + Pytium ultimum n.a. n.a. NPC471611 patulin New found in coculture PMID[18317751]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC245058 dihydrocitrinone Novel NP PMID[31953204]
NPO41417 Four strain Escherichia coli polyculture n.a. n.a. NPC115216 Pelargonidin 3-O-glucoside Yield-increased in coculture PMID[28588129]
NPO41452 Penicillium pinophilum + Trichoderma harzianum n.a. n.a. NPC103201 penicillide Yield-increased in coculture PMID[22008698]
NPO41455 Penicillium variabile + Talaromyces aculeatus n.a. n.a. NPC490939 penitalarins A Novel NP PMID[29144133]
NPO41455 Penicillium variabile + Talaromyces aculeatus n.a. n.a. NPC490940 penitalarins B Novel NP PMID[29144133]
NPO41455 Penicillium variabile + Talaromyces aculeatus n.a. n.a. NPC490941 penitalarins C Novel NP PMID[29144133]
NPO41584 Xylaria sp. + Penicillium crustosum n.a. n.a. NPC490942 penixylarins A New found in coculture PMID[31265288]
NPO41584 Xylaria sp. + Penicillium crustosum n.a. n.a. NPC490943 penixylarins B New found in coculture PMID[31265288]
NPO41584 Xylaria sp. + Penicillium crustosum n.a. n.a. NPC490944 penixylarins C Yield-increased in coculture PMID[31265288]
NPO41584 Xylaria sp. + Penicillium crustosum n.a. n.a. NPC490945 penixylarins D Yield-increased in coculture PMID[31265288]
NPO41482 Shiraia sp. S9 + Pseudomonas fulva SB1 n.a. n.a. NPC490524 perylenequinone New found in coculture PMID[31277643]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC290664 phelligridin C Yield-increased in coculture PMID[20830471]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC47386 phelligridin H Yield-increased in coculture PMID[20830471]
NPO41460 Pseudomonas aeruginosa + Aspergillus fumigatus n.a. n.a. NPC490946 phenazine-1- carboxamide New found in coculture PMID[22869730]
NPO41460 Pseudomonas aeruginosa + Aspergillus fumigatus n.a. n.a. NPC219848 phenazine-1-carboxylic acid New found in coculture PMID[22869730]
NPO41460 Pseudomonas aeruginosa + Aspergillus fumigatus n.a. n.a. NPC490947 phenazine-1-sulfate New found in coculture PMID[22869730]
NPO41437 Inonotus obliquus + Phellinus punctatus n.a. n.a. NPC490948 phenolic compounds Yield-increased in coculture PMID[20830471]
NPO41564 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB1) n.a. n.a. NPC490949 phenyl alanine Yield-increased in coculture PMID[31665025]
NPO41562 Trametes versicolor + Ganoderma applanatum n.a. n.a. NPC490950 phenyl polyketide, 2,5,6-trihydroxy-4, 6-diphenylcyclohex-4-ene-1,3-dione Yield-increased in coculture PMID[29375514]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC484638 phexandiol A New found in coculture PMID[30785282]
NPO41491 Streptomyces coelicolor + actinomycete n.a. n.a. NPC315725 coelichelin Novel NP PMID[23963177]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC484639 phexandiol B New found in coculture PMID[30785282]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490951 phexandiol C New found in coculture PMID[30785282]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490952 phomesters A New found in coculture PMID[30785282]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490953 phomesters B New found in coculture PMID[30785282]
NPO41368 Aspergillus terreus + Bacillus sp. Strains n.a. n.a. NPC490954 phomesters C New found in coculture PMID[30785282]
NPO41482 Shiraia sp. S9 + Pseudomonas fulva SB1 n.a. n.a. NPC490955 pigments hypocrellin A Yield-increased in coculture PMID[31277643]
NPO41482 Shiraia sp. S9 + Pseudomonas fulva SB1 n.a. n.a. NPC490956 pigments hypocrellin C Yield-increased in coculture PMID[31277643]
NPO41404 Escherichia coli + Escherichia coli n.a. n.a. NPC490957 Pinene Yield-increased in coculture PMID[30108554]
NPO41490 Streptomyces cinnamoneus NBRC 13823 + Tsukamurella pulmonis TP-B0596 Streptomyces cinnamoneus NBRC 13823 Tsukamurella pulmonis TP-B0596 NPC31700 Arcyriaflavin A Novel NP PMID[25335694]
NPO41551 Synechococcus elongatus (GMO) + Bacillus Subtilis, Escherichia coli, Saccharomyces cerevisiae, Halomonas boliviensis n.a. n.a. NPC490532 Polyhydroxybutyrate Yield-increased in coculture PMID[29061492]
PMID[28127397]
NPO41373 Bacillus sp. SM01 + Cupriavidus necator NCIMB 11599 n.a. n.a. NPC490532 Polyhydroxybutyrate (PHB) Yield-increased in coculture PMID[33775761]
NPO41479 Setophoma terrestris + Bacillus amyloliqui n.a. n.a. NPC490961 polyketide blennolide K Novel NP PMID[29288594]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC490962 polyketides acremonisol A Yield-increased in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41362 Aspergillus nidulans + Escherichia coli n.a. n.a. NPC490963 polyketides F-9775A New found in coculture PMID[19666480]
NPO41376 Chaetomium globosum CGMCC 6882 + UV-irradiated G. pentaphyllum n.a. n.a. NPC490964 polysaccharide Yield-increased in coculture PMID[31321528]
NPO41478 Serratia marcescens BMJ816 + Serratia marcescens AMJ817 n.a. n.a. NPC490567 prodigiosin (PG) New found in coculture PMID[30401454]
NPO41564 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB1) n.a. n.a. NPC11433 proline Yield-increased in coculture PMID[31665025]
NPO41428 Geobacter Sulfurreducens + Clostridium pasteurianum n.a. n.a. NPC490488 propanediol Yield-increased in coculture PMID[28287150]
NPO41579 Weissella confusa 11GU1 P. freudenreichii JS15 n.a. n.a. NPC238637 Propionate Yield-increased in coculture PMID[26256717]
NPO41378 Chaetomium sp. + bacteria n.a. n.a. NPC158654 protocatechuic acid methyl ester New found in coculture DOI[]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC158654 protocatechuic acid methyl ester New found in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC282255 pseudoanguillosporin A n.a. PMID[35054969]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC107378 pseudoanguillosporin B n.a. PMID[35054969]
NPO41464 Pseudoxylaria sp. + Microtermes sp n.a. n.a. NPC490972 pseudoxylallemycin B Novel NP PMID[27341414]
NPO41464 Pseudoxylaria sp. + Microtermes sp n.a. n.a. NPC490973 pseudoxylallemycin D Novel NP PMID[27341414]
NPO41374 Burkholderia gladioli + Rhizopus microsporus n.a. n.a. NPC491006 the tricarboxylic fatty acid bongkrekic acid Novel NP PMID[25250879]
NPO41413 Escherichia coli strains n.a. n.a. NPC490977 pyranoanthocyanins Yield-increased in coculture PMID[31125607]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC490978 Pyranocyanidin-3-O-glucoside-catechol Yield-increased in coculture PMID[31125607]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC490979 Pyranocyanidin-3-O-glucoside-phenol Yield-increased in coculture PMID[31125607]
NPO41565 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB2) n.a. n.a. NPC19576 pyroglutamic acid Yield-increased in coculture PMID[31665025]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC490506 G27 Novel NP PMID[8216897]
NPO41506 Streptomyces lividans TK23 + Tsukamurella pulmonis TP-B0596 n.a. n.a. NPC490980 red pigment New found in coculture PMID[21097597]
NPO41512 Streptomyces sp. (strain B033) + Selected Proteobacteria Streptomyces sp. (strain B033) Selected Proteobacteria NPC490565 Resistomycin New found in coculture PMID[25537064]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC153923 sclerotiamide Novel NP PMID[29884864]
NPO41581 wild-type Lactobacillus plantarum + engineered Saccharomyces cerevisiae strain n.a. n.a. NPC94167 riboflavin Yield-increased in coculture PMID[34370382]
NPO41510 Streptomyces rimosus + Aspergillus terreus n.a. n.a. NPC490987 rimocidin New found in coculture PMID[31321600]
NPO41355 Aspergillus flavipes + Streptomyces sp. n.a. n.a. NPC490502 rosellichalasin Yield-increased in coculture PMID[26783945]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC222342 Sakuranetin Yield-increased in coculture PMID[32285175]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 n.a. n.a. NPC63399 pentalenic acid New found in coculture PMID[28744271]
NPO41358 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C58 n.a. n.a. NPC63399 pentalenic acid New found in coculture PMID[28744271]
NPO41503 Streptomyces leeuwenhoekii C58 + Aspergillus fumigatus MR2012 Streptomyces leeuwenhoekii C58 Aspergillus fumigatus MR2012 NPC63399 pentalenic acid Novel NP PMID[28744271]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC317183 SB236050 Yield-increased in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41377 Chaetomium sp. + Bacillus subtilis n.a. n.a. NPC327809 SB238569 Yield-increased in coculture DOI[10.1016/j.tet.2016.08.022]
NPO41342 Aspergillus sclerotiorum SCSGAF 0053 + Penicillium citrinum SCSGAF 0052 n.a. n.a. NPC490605 sclerotiorumins A Novel NP PMID[27936301]
NPO41342 Aspergillus sclerotiorum SCSGAF 0053 + Penicillium citrinum SCSGAF 0052 n.a. n.a. NPC490606 sclerotiorumins B Novel NP PMID[27936301]
NPO41452 Penicillium pinophilum + Trichoderma harzianum n.a. n.a. NPC490989 Secopenicillide C Novel NP PMID[22008698]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC490598 seco-penicitrinol A Novel NP PMID[31953204]
NPO41378 Chaetomium sp. + bacteria n.a. n.a. NPC490554 serkydayn New found in coculture DOI[]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC261502 penicitrinone A Novel NP PMID[31953204]
NPO41481 Shewanella sp. + Serratia sp. n.a. n.a. NPC490990 Serratiochelin A Yield-increased in coculture PMID[32674317]
NPO41403 Escherichia coli (GMO) + Saccharomyces cerevisiae (GMO) n.a. n.a. NPC331737 sesquiterpenes New found in coculture PMID[25558867]
NPO41378 Chaetomium sp. + bacteria n.a. n.a. NPC490553 shikimeran A New found in coculture DOI[]
NPO41416 Faecalibacterium prausnitzii + Bifidobacterium catenulatum Faecalibacterium prausnitzii Bifidobacterium catenulatum NPC490994 short-chain fatty acid Yield-increased in coculture PMID[32466189]
NPO41445 Moniliophthora roreri + Trichoderma harzianum n.a. n.a. NPC263668 sorbicillinol New found in coculture PMID[26637047]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC472600 soudanone A New found in coculture PMID[35054969]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC472603 soudanone D New found in coculture PMID[35054969]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC490515 phenol A Novel NP PMID[31953204]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC472604 soudanone E New found in coculture PMID[35054969]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC490997 soudanone H Novel NP PMID[35054969]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC490998 soudanone I Novel NP PMID[35054969]
NPO41458 Plenodomus influorescens + Pyrenochaeta nobilis n.a. n.a. NPC490519 spiciferinone New found in coculture PMID[31979232]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC204970 spirotryprostatin A New found in coculture PMID[31953204]
NPO41359 Aspergillus fumigatus + microalgae n.a. n.a. NPC209970 stearic acid Yield-increased in coculture PMID[25419574]
NPO41468 Rhizobium strain 10II + Ankistrodesmus sp. strain SP2-15 n.a. n.a. NPC149821 stearidonic acid Yield-increased in coculture PMID[23948276]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 Streptomyces rochei MB037 Rhinocladiella similis 35 NPC490518 7-methoxy-2,3-dimethylchromone-4-one Yield-increased in coculture PMID[31134000]
NPO41511 Streptomyces rochei MB037 + Rhinocladiella similis 35 n.a. n.a. NPC490518 7-methoxy-2,3-dimethylchromone-4-one Novel NP PMID[31134000]
NPO41350 Alternaria tenuissima + Nigrospora sphaerica n.a. n.a. NPC490490 Stemphyperylenol Yield-increased in coculture PMID[24114180]
NPO41507 Streptomyces nigrescens HEK616 + Tsukamurella pulmonis TP-B0596 Streptomyces nigrescens HEK616 Tsukamurella pulmonis TP-B0596 NPC491000 Streptoaminals Yield-increased in coculture PMID[27459894]
NPO41504 Streptomyces lividans 66 + Verticillium dahliae Streptomyces lividans 66 Verticillium dahliae NPC6797 Streptorubin B Yield-increased in coculture PMID[22151498]
NPO41452 Penicillium pinophilum + Trichoderma harzianum n.a. n.a. NPC491001 Stromemycin Yield-increased in coculture PMID[22008698]
NPO41453 Penicillium pinophilum FKI-5653 + Trichoderma Harzianum FKI-5655 n.a. n.a. NPC491001 stromemycin Yield-increased in coculture PMID[22008698]
NPO41408 Escherichia coli + Pichia pastoris n.a. n.a. NPC234392 stylopine Yield-increased in coculture PMID[34663314]
NPO41407 Escherichia coli + Methanobacterium formicicum n.a. n.a. NPC169697 succinate Yield-increased in coculture PMID[24785787]
PMID[29230577]
NPO41344 Actinobacillus succinogenes + Saccharomyces cerevisiae n.a. n.a. NPC236709 succinic acid Yield-increased in coculture PMID[33937964]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC474394 phenol A acid Novel NP PMID[31953204]
NPO41445 Moniliophthora roreri + Trichoderma harzianum n.a. n.a. NPC491002 T39 butenolide New found in coculture PMID[26637047]
NPO41409 Escherichia coli + Saccharomyces cerevisiae n.a. n.a. NPC491004 tanshinone precursors New found in coculture PMID[25558867]
NPO41448 Paraconiothyrium SSM001 + Alternaria alternata Paraconiothyrium SSM001 Alternaria alternata NPC208553 Taxol Yield-increased in coculture DOI[10.3389/fmicb.2013.00003]
NPO41419 Fusarium + Taxus suspension cells n.a. n.a. NPC208553 Taxol Yield-increased in coculture PMID[29605937]
NPO41449 Paraconiothyrium SSM001 + other fungal strains n.a. n.a. NPC208553 taxol Yield-increased in coculture PMID[23346084]
NPO41356 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34 n.a. n.a. NPC194640 terezine D New found in coculture PMID[28744271]
NPO41357 Aspergillus fumigatus MR2012 + Streptomyces leeuwenhoekii strain C34/strain C58 n.a. n.a. NPC194640 terezine D New found in coculture PMID[28744271]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC187648 notoamide D Novel NP PMID[29884864]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC471645 the lipopeptide fusaristatin A Yield-increased in coculture PMID[24175613]
NPO41424 Fusarium tricinctum + Bacillus subtilis 168 trpC2 n.a. n.a. NPC471645 fusaristatin A Yield-increased in coculture PMID[24175613]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC239770 The mycotoxins cytochalasin D Yield-increased in coculture PMID[30837981]
NPO41382 Chlorella sorokiniana L3 + Chryseobacterium scophthalmus n.a. n.a. NPC491007 Total chlorophyll Yield-increased in coculture DOI[10.1016/j.algal.2018.01.012]
NPO41557 Talaromyces pinophilus + Trichoderma harzianum n.a. n.a. NPC197367 Trichoharzin Yield-increased in coculture PMID[29085019]
NPO41573 two Aspergillus sp. strains n.a. n.a. NPC491013 triterpene ergosterol Novel NP PMID[31953204]
NPO41446 n α-proteobacterium (strain CNJ-328) + Libertella sp n.a. n.a. NPC6804 libertellenone A Novel NP PMID[15993608]
NPO41564 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB1) n.a. n.a. NPC203468 tryptophan Yield-increased in coculture PMID[31665025]
NPO41564 Trichoderma asperellum GDFS1009 + Bacillus amyloliquefaciens 1841(TB1) n.a. n.a. NPC106551 tyrosine Yield-increased in coculture PMID[31665025]
NPO41497 Streptomyces coelicolor A3 (2) + Escherichia coli C600 Streptomyces coelicolor A3 (2) Escherichia coli C600 NPC220647 Undecylprodigiosin Yield-increased in coculture DOI[10.1016/j.bej.2010.11.008]
NPO41496 Streptomyces coelicolor A3 (2) + Bacillus subtilis ATCC 6633 Streptomyces coelicolor A3 (2) Bacillus subtilis ATCC 6633 NPC220647 Undecylprodigiosin Yield-increased in coculture PMID[20878541]
NPO41505 Streptomyces lividans TK23 + One of mycolic acid-containing bacteria Streptomyces lividans TK23 One of mycolic acid-containing bacteria NPC220647 undecylprodigiosin New found in coculture PMID[21097597]
NPO41504 Streptomyces lividans 66 + Verticillium dahliae Streptomyces lividans 66 Verticillium dahliae NPC220647 undecylprodigiosin Yield-increased in coculture PMID[22151498]
NPO41498 Streptomyces coelicolor M145 + Corallococcus coralloides B035 Streptomyces coelicolor M145 Corallococcus coralloides B035 NPC220647 Undecylprodigiosin Yield-increased in coculture PMID[24249103]
NPO41493 Streptomyces coelicolor + Corallococcus coralloides n.a. n.a. NPC220647 undecylprodigiosin (Red) Yield-increased in coculture PMID[24249103]
NPO41494 Streptomyces Coelicolor + Escherichia coli n.a. n.a. NPC220647 undecylprodigiosin Yield-increased in coculture PMID[27241291]
NPO41497 Streptomyces coelicolor A3 (2) + Escherichia coli C600 Streptomyces coelicolor A3 (2) Escherichia coli C600 NPC220647 Undecylprodigiosin Yield-increased in coculture PMID[27241291]
NPO41397 Cosmospora sp. + Magnaporthe oryzae n.a. n.a. NPC490568 ustilaginoidin G n.a. PMID[35054969]
NPO41446 n α-proteobacterium (strain CNJ-328) + Libertella sp n.a. n.a. NPC490523 libertellenone D Novel NP PMID[15993608]
NPO41477 Serpula lacrymans + different kinds of bacteria(Bacillus subtilis; Pseudomonas putida; Streptomyces iranensis.) n.a. n.a. NPC491015 variegatic Yield-increased in coculture PMID[27699944]
NPO41500 Streptomyces fradiae 007 + Penicillium sp. WC-29-5 n.a. n.a. NPC184702 vermistatin New found in coculture PMID[24714124]
NPO41486 Streptomyces bullii + Aspergillus fumigatus n.a. n.a. NPC60844 verruculogen New found in coculture PMID[31953204]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC60844 verruculogen Yield-increased in coculture PMID[30837981]
NPO41406 Escherichia coli + Escherichia coli coculture n.a. n.a. NPC209846 Vitexin Yield-increased in coculture PMID[33930665]
NPO41423 Fusarium tricinctum + Bacillus subtilis n.a. n.a. NPC490681 2-(carboxymethylamino) benzoic acid Novel NP PMID[24175613]
NPO41393 Clostridium butyricum + Acinetobacter bayily (GMO) n.a. n.a. NPC491018 wax esters Yield-increased in coculture PMID[29988745]
NPO41379 Chaetomium sp. + Pseudomonas aeruginosa n.a. n.a. NPC491019 WF-3681 methyl ester Yield-increased in coculture DOI[]
NPO41477 Serpula lacrymans + different kinds of bacteria(Bacillus subtilis; Pseudomonas putida; Streptomyces iranensis.) n.a. n.a. NPC491021 xerocomic Yield-increased in coculture PMID[27699944]
NPO41473 Saccharomyces cerevisae MK 175 + Candida tropicalis MK-118 n.a. n.a. NPC491022 Xylanase Yield-increased in coculture DOI[10.1016/j.indcrop.2018.07.021]
NPO41348 Alternaria tenuissima + Fusarium culmorum n.a. n.a. NPC33144 Zearalenone(ZON) Yield-increased in coculture PMID[22776416]
NPO41349 Alternaria tenuissima + Fusarium graminearum n.a. n.a. NPC33144 Zearalenone(ZON) Yield-increased in coculture PMID[22776416]
NPO41426 Fusarium tricinctum + Streptomyces lividans n.a. n.a. NPC33144 zearalenone New found in coculture PMID[35518011]
NPO41582 Xylaria cubensis + Aspergillus fischeri n.a. n.a. NPC490535 zygosporin E Yield-increased in coculture PMID[30837981]
NPO41414 Escherichia coli(M3B_M3E) + Escherichia coli (M2E) + Escherichia coli (M1D) n.a. n.a. NPC491023 ,-dicarboxylic acids Yield-increased in coculture PMID[33028823]
NPO41551 Synechococcus elongatus (GMO) + Bacillus Subtilis, Escherichia coli, Saccharomyces cerevisiae, Halomonas boliviensis n.a. n.a. NPC490712 -amylase Yield-increased in coculture PMID[29061492]
PMID[28127397]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC71934 notoamide C Novel NP PMID[29884864]
NPO41473 Saccharomyces cerevisae MK 175 + Candida tropicalis MK-118 n.a. n.a. NPC490756 -glucosidase Yield-increased in coculture DOI[10.1016/j.indcrop.2018.07.021]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC65825 dehydronotoamide C Novel NP PMID[29884864]
NPO41360 Aspergillus fumigatus + Sphingomonas sp. n.a. n.a. NPC134648 glionitrin A Novel NP PMID[19159274]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC246877 penicitrinol A Novel NP PMID[31953204]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC40592 notoamide Q Novel NP PMID[29884864]
NPO41456 Phomopsis sp. K38 + Alternaria sp. E33 n.a. n.a. NPC490525 (-)-byssochlamic acid bisdiimide Novel NP PMID[20839130]
NPO41450 Penicillium citrinum + Aspergillus sydowii n.a. n.a. NPC314796 citrinin Novel NP PMID[31953204]
NPO41573 two Aspergillus sp. strains n.a. n.a. NPC490528 aspergicin Novel NP PMID[31953204]
NPO41343 Two marine-derived mangrove epiphytic Aspergillus sp. Fungi n.a. n.a. NPC490528 aspergicin Novel NP DOI[10.1007/s10600-011-0053-8]
NPO41429 Gloeophyllum abietinum + Heterobasidion annosum n.a. n.a. NPC490530 G29 Novel NP PMID[8216897]
NPO40704 Streptomyces sp. RKND-216 + Alteromonas sp. RKMC-009 Streptomyces sp. RKND-216 Alteromonas sp. RKMC-009 NPC490604 carbazoquinocin G Yield-increased in coculture PMID[32869646]
NPO40705 Streptomyces sp. RKND-216 + Mycobacterium smegmatis ATCC 120515 n.a. n.a. NPC490604 carbazoquinocin G Novel NP PMID[32869646]
NPO41509 Streptomyces rapamycinicus + Aspergillus fumigatus n.a. n.a. NPC314811 fumicycline A Novel NP PMID[23649940]
NPO41365 Aspergillus sulphureus + Isaria felina n.a. n.a. NPC129277 17-epi-notoamide Q Novel NP PMID[29884864]
NPO41425 Fusarium tricinctum + Fusarium begonia n.a. n.a. NPC490540 subenniatin A Novel NP PMID[31953204]

  Browse All Engineered Organisms

Organism ID Organism Name Parent Organism Name Engineered Gene in Organism Purpose of Engineering Engineering Category Engineering Description NP ID NP Name NP Yeild of Parent Organism NP Yeild of Engineered Organism Yeild Change Reference
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490625 Fisetin n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490628 ethyl acetate n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490630 GABA n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC236761 1,3-propanediol n.a. 32 mg/L and 500 mg/L (in flask and bioreactor) >80-fold higher PMID[29077207]
NPO41730 Myxococcus xanthus DK1622 Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC490637 diterpenes n.a. n.a. n.a. PMID[30995838]
NPO42001 A new engineered strain of Streptomyces venezuelae Streptomyces venezuelae n.a. Increase NP yield n.a. n.a. NPC490664 (-)-α-bisabolol n.a. n.a. 5-fold PMID[25006988]
NPO41657 Corynebacterium glutamicum Sorn11 Corynebacterium glutamicum lysE Increase NP yield n.a. the overexpression of lysE gene NPC490665 (+)-ambrein n.a. 18.4 g/L 21.8% increase PMID[28938890]
NPO41792 Streptomyces albus ADE Streptomyces albus J1074 spnA B C D E Increase NP yield n.a. The PKS operon spnABC was overexpressed under the control of the rpsLp-cf promoter in S. albus J1074 (C416-M)-OE3 and the PKS gene spnD was overexpressed under the control of the rpsLp-tp promoter in AE NPC127582 (+)-nootkatone n.a. n.a. ~12-fold PMID[34584996]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC86683 (+)-valencene n.a. 1 gram per liter ~15,000-fold PMID[20929806]
NPO42007 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica PAI Increase NP yield n.a. Multi-copy amplification of PAI gene NPC490666 (1R)-6β-hydroxy-1,8-cineole(55h) n.a. n.a. ~30-fold PMID[22545818]
NPO41590 Aspergillus oryzae SaMF2103a-68 Aspergillus oryzae NRRL 3488 C4T318 mdh3 and pyc Increase NP yield n.a. overexpressing all three genes NPC32441 (2S)-naringenin n.a. 154 g/L >3-fold PMID[23925533]
NPO41948 A new engineered strain of Nicotiana benthamiana Nicotiana benthamiana TS gene Heterologous expression n.a. n.a. NPC490674 11-oxo-β-amyrin n.a. 11-27 μg taxadiene/g of dry weight 1.4- or 1.9-fold increase PMID[24463610]
NPO41604 Candida famata riboflavin-overproducing strains Candida famata BCRP; RIB1; RIB6;DhRFE; CfRFE Increase NP yield n.a. n.a. NPC284039 2,3,5,6-Tetramethylpyrazine n.a. n.a. 1.4- to 6-fold more riboflavin PMID[33751427]
NPO41670 Emericella foeniculicola NU152 Emericella foeniculicola TR21 TR21 Increase NP yield n.a. n.a. NPC490682 2,3-BDO n.a. 51.44 ± 0.22 μg per g 1.46-fold DOI[10.1016/j.procbio.2011.07.012]
NPO41836 A new engineered strain of Bacillus subtilis 168 Bacillus subtilis 168 PhrQ-RapQ-ComA QS system Increase NP yield n.a. developed a PhrQ-RapQ-ComA based QS system to dynamically fine-tune complicated metabolic pathways in B. subtilis 168 for MK-4 production NPC490684 20S-O-Glc-DM 120.1 ± 0.6 mg/L 178.9 ± 2.8 mg/L 1.49- fold PMID[33992404]
NPO41819 VTC2-Ketogulonigenium vulgare Ketogulonigenium vulgare vtc2 Increase NP yield n.a. the key gene vtc2 was overexpressed to obtain the strain VTC2; Taking advantage of VTC2, we constructed a synthetic microbial consortium system containing the K. vulgare and VTC2 NPC36168 2-hydroxyphenazine n.a. 13.2 ± 0.52 g/L 1.49-fold PMID[34977392]
NPO41949 A new engineered strain of Nicotiana benthamiana Nicotiana benthamiana n.a. Increase NP yield n.a. redirecting germacrene A synthase (GAS) from the cytosol to mitochondria NPC286485 3-hydroxypropionic acid n.a. n.a. 15-fold increase in production PMID[21858047]
NPO41768 Saccharomyces cerevisiae strain BJM-45 Saccharomyces cerevisiae BJ5464 FPP;erg9; rox1; bts1; dpp1; lpp1 Increase NP yield n.a. Overexpression of erg10, erg13, tHMG1, erg12, erg8, erg19, erg20 and idi1; Δrox1, down-regulated erg9, Δbts1, Δdpp1, Δlpp1 NPC490695 3β- O-Glc-DM n.a. 539.3 mg/L 160-fold improvement PMID[31699116]
NPO41770 Saccharomyces cerevisiae strain pah1 Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490696 3β,12β-Di-O-Glc-PPD n.a. n.a. 16-fold PMID[28216107]
NPO41785 Shimwellia blattae (p424IbPSO, pIZpntAB) Shimwellia blattae (p424IbPSO) AdhA; pntAB Increase NP yield n.a. we have overexpressed the NAD-dependent alcohol dehydrogenase (AdhA) from L. lactis to offer a new enzyme to finish the pathway. Second, we have modulated the cell redox balance of the host by cloning the pntAB transhydrogenase encoding gene from E. coli to increase the NADPH levels required by IlvC and YqhD reductases. NPC490700 4ʹ-O-methyl-daidzein total yield 11.9% total yield 16.4%; 5.98 g/L; 0.19 ± 0.010 gIbOH/L h; 2.32 ± 0,12gIbOH g/X 19.3% higher isobutanol production; 39.0% more isobutanol than the original strain PMID[33407735]
NPO41927 A new engineered strain of Bacillus subtilis Bacillus subtilis yyzE ypqE ptsG Incerase NP yield Metabolic engineering > Transporter engineering strategies Knock-out yyzE, ypqE, and ptsG genes NPC490701 4ʹ-O-methyl-genistein n.a. n.a. 2.03-fold DOI[10.1002/biot.201700020]
NPO41591 Trichoderma sp. AYA 20-1 Trichoderma sp. Gen 9 n.a. Increase NP yield n.a. n.a. NPC101249 5-ALA n.a. n.a. 2.11-fold DOI[10.1007/s12010-017-2429-0]
NPO41591 Trichoderma sp. AYA 20-1 Cladosporium sp. Gen 20 n.a. Increase NP yield n.a. n.a. NPC101249 5-ALA n.a. n.a. 2.11-fold DOI[10.1007/s12010-017-2429-0]
NPO41776 Saccharomyces cerevisiae β-carotenogenic strain SM14-ΔURA3 Saccharomyces cerevisiae YAH1; ARH1 Increase NP yield n.a. Employing gene screening and enzyme truncation analyses, we first constructed basal violaxanthin-producing strains NPC101249 5-ALA n.a. 3.2 mg/Gdcw; final production of 7.3 mg/gDCW (increase gene copy number of carotenogenic genes) 2.2-fold increase PMID[32001334]
NPO41878 A new engineered strain of Pichia pastoris Pichia pastoris n.a. Increase NP yield n.a. being modified by interacting proteins, the two enzymes were successfully co-localized(dammarenediol-II synthase and squalene epoxidase) NPC101249 5-ALA n.a. n.a. 2.1-fold enhancement PMID[27074597]
NPO41799 Streptomyces hygrospinosus OaniF Streptomyces hygrospinosus var. beijingensis aniF Increase NP yield n.a. overexpressing aniF NPC101249 5-ALA n.a. n.a. 2.1 times higher PMID[30656223]
NPO41784 Serratia marcescens SK68 Serratia marcescens JNB5-1 rcsB Increase NP yield n.a. rcsB-disrupted; a Tn5G transposon insertion library was constructed using Escherichia coli/pRK2013 Tn5G as the donor strain and S. marcescens JNB5-1 as the recipient strain, and a prodigiosin-hyperproducing mutant, SK68, was isolated NPC101249 5-ALA 51.01 mg/liter 116.48 mg/liter 2.28-fold PMID[33158890]
NPO41684 Escherichia coli HH 31-LFT Escherichia coli HH 31-LT fdhCbopt Increase NP yield n.a. fdhCbopt was codon optimized and inserted into either plasmid containing the leuDHBcopt-tyrBEc operon or hmaS3-hmo1 operon and resulted in plasmid LFT and F31 NPC101249 5-ALA n.a. 2.38 mM 2.1 times higher PMID[35024478]
NPO41777 Saccharomyces cerevisiae: AY-SB1 (ΔBDH1:loxP/ΔBDH1:loxP) and AY-SD1B2 (ΔBDH1:loxP-PGK1p-BDH2-PGK1t/ΔBDH1:loxP-PGK1p-BDH2-PGK1t) Saccharomyces cerevisiae AY15 BDH1 BDH2 ALS ILV2 Increase NP yield Metabolic Engineering disrupting BDH1, overexpressing BDH2, he α-acetolactate synthase (ALS) and replacing the promoter of the ILV2 gene with a strong promoter (PGK1p) NPC490706 6-dEB n.a. AY-SBI: 7.58 mg/L; AY-SD1B2: 9.47 mg/L 2.3- and 2.87-fold increase PMID[33324376]
NPO41811 Streptomyces piomogeues OpieR Streptomyces piomogeues var. Hangzhouwanensis pieR Increase NP yield n.a. overexpressing pieR NPC314350 acarbose n.a. n.a. 2.3-fold PMID[30560207]
NPO41972 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae TAL Increase NP yield n.a. n.a. NPC270334 acetoin n.a. n.a. 2.44-fold higher than control cells PMID[21570474]
NPO41841 A new engineered strain of Daldinia eschscholzii Daldinia eschscholzii n.a. Novel NP construction n.a. Compounds 1 and 2 were constructed, which exhibitingsignificant antiviral activity against H1N1 with IC50 values of 45.2 and 31.4 μM, respectively. NPC490643 costunolide-glutathione n.a. n.a. n.a. PMID[35387230]
NPO41926 A new engineered strain of Bacillus subtilis Bacillus subtilis YerP Incerase NP yield Metabolic engineering > Transporter engineering strategies overexpression of lipopetide transporters YerP NPC490494 actinorhodin n.a. 1.58 g/L 2.45-fold PMID[25366377]
NPO41834 A new engineered strain of Bacillus cereus Bacillus cereus n.a. Increase NP yield n.a. n.a. NPC60764 aloesaponarin II n.a. n.a. 2.49-fold increase PMID[33356788]
NPO41812 Streptomyces pristinaespiralis ΔPIIΔpapR3/PI Streptomyces pristinaespiralis HCCB10218 snaE1 snaE2 papR3 PI BGC Increase NP yield n.a. deleting the PII biosynthetic genes (snaE1 and snaE2), deleting the repressor gene papR3 and chromosomal integration of an extra copy of the PI biosynthetic gene cluster (BGC) NPC220498 alphitolic acid n.a. 132 mg/L 2.4-fold PMID[29062970]
NPO41591 Trichoderma sp. AYA 20-1 Trichoderma sp. Gen 9 n.a. Increase NP yield n.a. n.a. NPC215313 amorpha-4,11-diene n.a. n.a. 2.58-fold increase DOI[10.1007/s12010-017-2429-0]
NPO41591 Trichoderma sp. AYA 20-1 Cladosporium sp. Gen 20 n.a. Increase NP yield n.a. n.a. NPC215313 amorpha-4,11-diene n.a. n.a. 2.58-fold increase DOI[10.1007/s12010-017-2429-0]
NPO41947 A new engineered strain of Nicotiana benthamiana Nicotiana benthamiana SQS; EAS Heterologous expression n.a. n.a. NPC215313 amorpha-4,11-diene n.a. n.a. 2.8-fold increase PMID[25159317]
NPO41970 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae ERG9 Increase NP yield n.a. n.a. NPC215313 Amorphadiene n.a. 350 mg/L(after 96 h cultivation) 2~5-fold increase PMID[25889168]
NPO41799 Streptomyces hygrospinosus OaniF Streptomyces hygrospinosus var. beijingensis aniF Increase NP yield n.a. overexpressing aniF NPC215313 Amorphadiene n.a. n.a. 2.9 times higher PMID[30656223]
NPO41750 Rhodopseudomonas palustris [Δshc, ΔcrtB] Rhodopseudomonas palustris TIE-1 CrtB shc DXS DPS UbiA Increase NP yield n.a. crtB gene was deleted to block the carotenoid pathway; hopanoid pathway was blocked by deleting shc gene; co-expression of rate-limiting enzymes (DXS, DPS and UbiA) was combined with the pathway blocking method NPC215313 amorphadiene n.a. 8·2 mg/g DCW 2.9 times higher PMID[33783839]
NPO41750 Rhodopseudomonas palustris [Δshc, ΔcrtB] Rhodopseudomonas palustris [Δshc] CrtB shc DXS DPS UbiA Increase NP yield n.a. crtB gene was deleted to block the carotenoid pathway; hopanoid pathway was blocked by deleting shc gene; co-expression of rate-limiting enzymes (DXS, DPS and UbiA) was combined with the pathway blocking method NPC215313 amorphadiene n.a. 8·2 mg/g DCW 2.9 times higher PMID[33783839]
NPO41732 Ogataea polymorpha OP043 Ogataea polymorpha n.a. Increase NP yield n.a. Using the CMGE-MC method, ∼ 10 copies of the fusion expression cassette P ScTEF1 -TAL-P ScTPI1 -4CL-P ScTEF2 -STS were integrated into the genome. NPC490713 Anaerobic n.a. 97.23 ± 4.84 mg/L 20.73-fold PMID[30337956]
NPO41730 Myxococcus xanthus DK1622 Myxococcus xanthus n.a. Increase NP yield Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC204546 anisomycin n.a. 160 mg/L 20-fold PMID[30995838]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield Metabolic engineering > Modular pathway engineering In module 1, we employed a modified GAL system to overexpress the genes of the naringenin biosynthesis pathway and investigated their synergistic action. In module 2, we simultaneously up-regulated acetyl-CoA production and down-regulated fatty acid biosynthesis in order to increase the precursor supply, malonyl-CoA. In module 3, we engineered the tyrosine biosynthetic pathway to eliminate the feedback inhibition of tyrosine and also down-regulated competing pathways. NPC490716 Anthocyanins n.a. 90 mg/L 20-fold PMID[28707470]
NPO41767 Saccharomyces cerevisiae SPO810 Saccharomyces cerevisiae S288c aro8 aro10 Increase NP yield Metabolic engineering overexpressing aro8 aro10 NPC50898 Apigenin n.a. titer: 2.61 g/L; yield: 0.37 g/g 218% increase PMID[25681107]
NPO41935 A new engineered strain of Escherichia coli Escherichia coli MetJ Increase NP yield n.a. modulation of plasmid copy number and optimization of VvAOMT1 and CkmOMT2 expression conditions; CRISPRi was utilized to silence the transcriptional repressor MetJ NPC50898 Apigenin n.a. 51 mg/L (56 mg/L upon scale-up to shake flask) 21-fold improvement overall PMID[28095853]
NPO41592 Bacillus licheniformis DW2△lrp::BrnQ Bacillus licheniformis DW2 BrnQ Lrp Increase NP yield n.a. deletion of lrp; overexpression of BrnQ NPC282169 Apigenin-7-O-glucuronide 788.48 U/mL 965.34 U/mL 22.42% increase PMID[30417137]
NPO41817 Synechococcus elongatus PCC 7942 Synechococcus elongatus n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. 19.8 mg/L 23-fold PMID[27688805]
NPO41598 Bacillus subtilis RH33/pMX45 Bacillus subtilis DB104 n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 2-fold PMID[29605937]
NPO41598 Bacillus subtilis RH33/pMX45 Bacillus subtilis 24/pMX45 n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 2-fold PMID[29605937]
NPO41654 Corynebacterium glutamicum SO26 Corynebacterium glutamicum S9114 mscCG2, gdh2 Increase NP yield n.a. mscCG2 deletion, CgS9114_12202 (gdh2) overexpression and rational modulation in tricarboxylic acid cycle was firstly demonstrated to increase l-ornithine production NPC226453 Arginine 30.8 g/L 38.5 g/L (in shake flask) ; 43.6 g/L (in shake flask and fed-batch fermentation) 25% increase PMID[30939382]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 283% increase PMID[34824227]
NPO41675 Enterobacter sp. CGMCC Enterobacter sp. CGMCC 5087 pheAfbrDAHP Increase NP yield Metabolic engineering overexpressing pheAfbrDAHP NPC226453 Arginine n.a. titer: 0.34g/L; yield: 0.02 g/g 226% increase PMID[24766677]
NPO41589 Ashbya gossypii I4 Ashbya gossypii A4 (ATCC10895) ADE4 ADE12 PNP1 Increase NP yield n.a. GPD:ADE4 des , ΔADE12, ΔPNP1 NPC226453 Arginine 11.1 ± 2.4mg/L 268.8 ± 8.1mg/L 27-fold. PMID[25889888]
NPO41965 A new engineered strain of Rhodopseudomonas palustris TIE-1 Rhodopseudomonas palustris TIE-1 shc Increase NP yield n.a. Disabling shc NPC226453 Arginine n.a. 3.8 mg/g DCW 27-fold PMID[26886756]
NPO41735 Phomopsis sp. Strain G2-119 Phomopsis sp. strain A123 n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 243-fold PMID[27067587]
NPO41736 Phomopsis sp. Strain G2-448 Phomopsis sp. strain A123 n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 241-fold PMID[27067587]
NPO41737 Phomopsis sp. Strain G2-866 Phomopsis sp. strain A123 n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 225-fold PMID[27067587]
NPO41738 Phomopsis sp. Strain G2-919 Phomopsis sp. strain A123 n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 275-fold PMID[27067587]
NPO41754 Saccharomyces cerevisiae CEN.PK2 Saccharomyces cerevisiae CrtE; CrtB; CrtI Increase NP yield n.a. n.a. NPC226453 Arginine 2.43 mg/g DCW 54.63 mg/g DCW 22-fold PMID[27329233]
NPO41914 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica NDPS1; LS Increase NP yield n.a. n.a. NPC226453 Arginine 0.006 mg/g DCW 23.56 mg/L; 1.36 mg/g DCW 226-fold increase PMID[27777617]
NPO41770 Saccharomyces cerevisiae strain pah1 Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 2-fold PMID[28216107]
NPO41977 A new engineered strain of Saccharomyces cerevisiae BY4741 Saccharomyces cerevisiae BY4741 tHMG1, POS5 Increase NP yield n.a. Overexpression of tHMG1 and POS5 with mitochondrial presequence NPC226453 Arginine n.a. 58.6 ± 1.43mg/g DCW; 28.4 ± 1.08 mg/L 27.5-fold PMID[28845666]
NPO41779 Saccharopolyspora erythraea WBΔ3446 Saccharopolyspora erythraea WB SACE_3446 Increase NP yield n.a. inactivating SACE_3446 NPC226453 Arginine n.a. 4095mg/L 23% increase PMID[29062926]
NPO41908 A new engineered strain of Salinispora tropica M1152 Salinispora tropica M1152 salA-C Increase NP yield Microbial chassis engineering Operating genetic engineering in a marine actinomycetes Salinispora tropica via replacing three biosynthetic genes salA-C of salinosporamide BGC with an attB site NPC226453 Arginine n.a. n.a. 3 folds PMID[30105571]
NPO41778 Saccharopolyspora erythraea E3::F1F0ATPase Saccharopolyspora erythraea E3 α β and γ (atpAGD SACE_6282–6280) Increase NP yield Metabolic engineering > Cofactor engineering-guided metabolic optimization overexpressing the entire F1F0-ATPase (with α, β, and γ subunits) complex resulted in increased intracellular [ATP]/[ADP] ratio NPC226453 Arginine n.a. n.a. 28% increase PMID[32078772]
NPO41809 Streptomyces lincolnensis Δ6156 Streptomyces lincolnensis NRRL 2936 slinc6156 Increase NP yield n.a. NRRL 2936 with in-frame deletion of slinc6156 NPC226453 Arginine n.a. n.a. 22.4-fold PMID[32322696]
NPO41699 Escherichia coli slig-2 Escherichia coli HH31-LRT rocGBs Increase NP yield n.a. By altering the number of slig, two rocGBs conjoined with one leuDHBcopt to adequately supply NADH and NH4+ NPC226453 Arginine n.a. 3.72mM 2-fold PMID[35024478]
NPO41644 Corynebacterium glutamicum PAS-15ΔaccD3 Corynebacterium glutamicum PAS-15 accD3 Increase NP yield n.a. accD3 gene deletion NPC490721 argyrin A2 n.a. 378.92 ± 16.14 mg/L 3.2-fold PMID[30276713]
NPO41762 Saccharomyces cerevisiae JHY43D24 Saccharomyces cerevisiae ILV5ΔN48 ILV3ΔN19 Increase NP yield n.a. the ILV5ΔN48 and ILV3ΔN19 genes were integrated into the rDNA sites of the alsS-integrated strain, and the strains with multi-copy integration were screened based on the growth recovery. NPC490722 argyrin F3 n.a. 263.2 mg/L 3.3-fold PMID[30850698]
NPO41799 Streptomyces hygrospinosus OaniF Streptomyces hygrospinosus var. beijingensis aniF Increase NP yield n.a. overexpressing aniF NPC490723 argyrin G3 n.a. n.a. 3.4 times higher PMID[30656223]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. an efficient 2,3- BDO producing yeast strain was rapidly constructed with up to 25-copy genome integration of 2,3-BDO biosynthesis pathway. Further strain engineering was conducted by multiplex disruption of ADH1, PDC1, PDC5 and MTH1 using a 2μ-based replicative CRISPR Cas9 plasmid containing donor DNAs. NPC490725 argyrin J n.a. 50.5g/L 3.9-fold PMID[32006629]
NPO41985 A new engineered strain of Saccharomyces cerevisiae H1246 Saccharomyces cerevisiae H1246 n.a. Increase NP yield n.a. 1) expressed CpFAH12 in S. cerevisiae H1246 under the GAL1 promoter ; 2) co-expressed CpFAH12 and fungal diacylglycerol O-acyltransferase CpDGAT2 NPC490726 argyrin K n.a. n.a. 30% increase PMID[20023082]
NPO41930 A new engineered strain of Candida tropicalis H5343 Candida tropicalis H5343 n.a. Increase NP yield n.a. overexpressed cytochrome P450 monooxygenase and reductase genes NPC490727 argyrin L n.a. n.a. 30% increase DOI[10.1038/nbt0892-894]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Novel NPs activation Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC490646 DAM n.a. n.a. n.a. PMID[34301933]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Novel NPs activation Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC490646 DAM n.a. n.a. n.a. PMID[29666226]
NPO41802 Streptomyces lincolnensis B48 Streptomyces lincolnensis NRRL 2936 n.a. Increase NP yield n.a. the high-yield strain B48 produces 2.5 g/L lincomycin, approximately 30-fold as the wild-type strain NRRL 2936. NPC490728 argyrins n.a. 2.5 g/L 30-fold PMID[32322696]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. Then the Lightning GTR-CRISPR was applied to simplify yeast lipid metabolism through two-round ORF deletions for these eight genes. After the first-round deletion of FAA1, FAA4, POX1, and ARE2, the plasmid was anti-selected by growing the cells on 5-FOA medium, and the second-round deletions of PAH1, LPP1, DPP1, and ARE1 were carried out. NPC35656 artemisinic acid 19.93 mg/L 559.52 mg/L 30-fold PMID[30837474]
NPO41794 Streptomyces aureofaciens 3ctcPΔctcK Streptomyces aureofaciens F3 ctcK ctcP Biosynthesize NP n.a. Deleting ctcK and overexpressing ctcP of three extra copies simultaneously NPC35656 artemisinic acid n.a. 21.6 mg/L 31% increase PMID[32637665]
NPO41731 Nodulisporium sylviform rearrangement strain Nodulisporium sylviform NCEU-1 n.a. Increase NP yield n.a. n.a. NPC30443 artemisinin n.a. 516.37 μg/L 31.52–44.72% more DOI[10.1007/s11427-008-0037-5]
NPO41734 Penicillium expansum FS8486 Aspergillus tamarii FS-132 n.a. Increase NP yield n.a. n.a. NPC30443 artemisinin n.a. n.a. 317% more DOI[10.1016/S1872-2075(07)60044-2]
NPO41695 Escherichia coli PLH-5 Escherichia coli PLH-1 n.a. Increase NP yield n.a. the PLS was introduced into strain B0032, a PLH-producing strain reconstructed in a previous study29, resulting in the engineered strain B0033 and the population PLH-5 consisting of B0033 NPC30443 artemisinin n.a. 2.26 g/L 335% increase PMID[34824227]
NPO41704 Escherichia coli strain B-MP6 Escherichia coli EHT1; MP Increase NP yield n.a. we cloned several genes, namely, ubiC, pobA, hbad, and/or EHT1, into E. coli. NPC68088 asperfuranone n.a. n.a. 347.7 mg/L PMID[32786833]
NPO41928 A new engineered strain of Bacillus subtilis Bacillus subtilis PbdhA Incerase NP yield; Shorten fermentation time Metabolic engineering > Cofactor engineering-guided metabolic optimization PbdhA is the promoter gene of YodC. Moderating expression of YodC via the promoter PbdhA weakened the synthesis of NADH-dependent byproduct 2,3-butanediol, lactate, and ethanol. NPC74086 astaxanthin n.a. 56.7 g/L 35.3%; reduced fermentation duration of 1.7-fold; improved acetoin productivity to 0.639 gL/h.improved acetoin productivity to 0.639 gL/h. PMID[24525333]
NPO41863 A new engineered strain of Escherichia coli BL21(DE3) Escherichia coli BL21(DE3) aroAT gdh YDR380w YGL157w Increase NP yield Metabolic engineering overexpressing aroAT gdh YDR380w YGL157w NPC74086 astaxanthin n.a. titer: 4.7g/L; yield: 0.29 g/g 3-fold PMID[19016485]
NPO41586 Actinoplanes sp. QQ-1 Actinoplanes sp. SE50 acb cluster treY Increase NP yield; reduce by-product component n.a. introducing an extra copy of the acb cluster; deleting the treY gene NPC74086 astaxanthin 2.35g/L 3.18g/L 35% increase PMID[29552655]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490615 atolypene A n.a. 30 mg per L per OD600 of TAL 4.2-fold improvement PMID[29096626]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490614 atolypene B n.a. 30 mg per L per OD600 of TAL 4.2-fold improvement PMID[29096626]
NPO41765 Saccharomyces cerevisiae ScLCZ11 Saccharomyces cerevisiae LCZ11 MtOAS, AtCPR1 Increase NP yield n.a. n.a. NPC170880 avermectin B1a n.a. 123.27 mg/L 4.77-fold DOI[10.1002/aic.16370]
NPO41771 Saccharomyces cerevisiae strain ScLCZ11 Saccharomyces cerevisiae strain ScLCZ08 n.a. Increase NP yield n.a. n.a. NPC170880 avermectin B1a n.a. 123.27mg/L 4.77-fold DOI[10.1002/aic.16370]
NPO41764 Saccharomyces cerevisiae ScLCZ08 Saccharomyces cerevisiae LCZ08 MtOAS, AtCPR1 Increase NP yield n.a. n.a. NPC490732 axadiene n.a. 155.58 mg/L 4.95-fold DOI[10.1002/aic.16370]
NPO41771 Saccharomyces cerevisiae strain ScLCZ11 Saccharomyces cerevisiae strain ScLCZ08 n.a. Increase NP yield n.a. n.a. NPC490499 bacillomycin n.a. 155.58 mg/L 4.95-fold DOI[10.1002/aic.16370]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490733 bacillothiazol 1 n.a. 8.7+/-0.85mg/l 40-fold increase PMID[18485776]
NPO41758 Saccharomyces cerevisiae EG60 derived haploid strain Saccharomyces cerevisiae six deletions (rox1, dos2, yer134c, vba5, ynr063w and ygr259c) Increase NP yield n.a. n.a. NPC490734 bacillothiazol 10 n.a. n.a. 40-fold increase PMID[25903744]
NPO41780 Saccharopolyspora erythraea WBΔ3446Δ3986 Saccharopolyspora erythraea WB SACE_3446 SACE_3986 Increase NP yield n.a. inactivating SACE_3446 and SACE_3986 NPC490735 bacillothiazol 11 n.a. 4670mg/L 41% increase PMID[29062926]
NPO41781 Saccharopolyspora spinosa 4-7 Saccharopolyspora spinosa y-2 n.a. Increase NP yield n.a. n.a. NPC490736 bacillothiazol 12 n.a. 428 mg/L 436.27% more PMID[19132553]
NPO41766 Saccharomyces cerevisiae SGibSdCg Saccharomyces cerevisiae SgibS n.a. Increase NP yield Genetic engineering SGibSdC:: pRS42K:: gRNA(E)- gRNA(C) - gRNA(M) - gRNA(A1) - gRNA(A4) - gRNA(A5) - gRNA(A6) NPC490737 bacillothiazol 13 n.a. 156.7 mg/L 44.3% increase PMID[30949594]
NPO41596 Bacillus subtilis RF1-aPaGaTgV Bacillus subtilis RF1 purR tnrA glnR vgb Increase NP yield Metabolic engineering Knockout of the purR and knockdown of the tnrA and glnR genes; Dynamically control the expression of the vgb gene NPC490738 bacillothiazol 14 n.a. 10.71 g/l 45.51% increases PMID[33957462]
NPO41674 Ensifer adhaerens hmm (genotype: PmetH-CobSV-PibpA-CobQ-Pmdh-CobW) Ensifer adhaerens HY-1 CobSV CobQ CobW Increase NP yield n.a. CobSV was expreesed by strong promoter, CobQ was expressed by medium-strong promoter, CobW was expressed by medium-strong promoter. (Table S1) NPC490739 bacillothiazol 2 n.a. 143.8 mg/L in shaking flasks; 171.2 mg/L using fed-batch fermentation 48% increase (in shaking flasks) PMID[35664931]
NPO41593 Bacillus licheniformis WX/pPvgb-YwbN-Vgb Bacillus licheniformis WX-02 YwbN Pvgb Increase NP yield n.a. introducing twin-arginine translocation (Tat) signal peptides (SPYwbN with the best performance) into VHB expression cassette; four promoters were screened, and Pvgb was proven as the more suitable promoter for VHB expression and γ-PGA synthesis NPC490740 bacillothiazol 3 31.01g/L 46.39 g/L 49.26% increase PMID[35155838]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield Metabolic engineering combination of a metabolic engineering strategy with fermentation technology optimization can be used to obtain significant amounts of the high-value sesquiterpene α-santalene NPC490741 bacillothiazol 4 n.a. 0.0052 Cmmol (Cmmol glucose)(-1); final 0.036 Cmmol (g biomass)(-1) h(-1) 4-fold improvement over the reference strain PMID[22938570]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Novel NPs activation Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC490649 dammarenediol-II n.a. n.a. n.a. PMID[34301933]
NPO41923 A new engineered strain of Bacillus amyloliquefaciens Bacillus amyloliquefaciens n.a. Incerase NP yield n.a. n.a. NPC490742 bacillothiazol 5 n.a. 20.3 g/L 5.34-fold PMID[26410449]
NPO41605 Clostridium cellulovorans adhE2-fnrCA-thlACA-hbdCT Clostridium cellulovorans adhE2 thlACA hbdCT fnr Increase NP yield n.a. thiolase(thlACA) from C. acetobutylicum and 3‐hydroxybutyryl‐CoA dehydrogenase (hbdCT) from C. tyrobutyricum were overexpressed in C. cellulovorans adhE2 to increase the flux from acetyl‐CoA to butyryl‐CoA. In addiction, fnr was also overexpressed. NPC490743 bacillothiazol 6 n.a. 0.34g/g 50% increase PMID[33844271]
NPO41751 Rhodopseudomonas palustris R. palustris [Δshc, ΔcrtB] Rhodopseudomonas palustris DXS (Gene ID: 6408677); fused CrtE (Gene ID: 6409364); HpnD (Gene ID:6411947) Increase NP yield n.a. n.a. NPC490744 bacillothiazol 7 n.a. 23.3 mg/g DCW 50-fold increase; increased by 57% (blocking the carotenoid pathway); 178-fold increase(blocking branched pathways + expressing rate-limiting enzymes) PMID[34278608]
NPO41701 Escherichia coli strain (tyrR- and csrA-repressed S17-1) Escherichia coli murE Increase NP yield n.a. n.a. NPC490745 bacillothiazol 8 n.a. 2 g per liter of tyrosine 55% increase(compared to the reported engineered strain (XQ56 harboring the plasmid p15CadA)) PMID[23334451]
NPO41601 Burkholderia thailandensis ΔtstP Burkholderia thailandensis MSMB43 tstP Increase NP yield Metabolic engineering Deletion of tstP NPC490746 bacillothiazol 9 n.a. 144.7 ± 2.3 mg/L 58% increase PMID[29062925]
NPO41887 A new engineered strain of Saccharomyces cerevisiae BA21 Saccharomyces cerevisiae BA21 UGTPg1 Increase NP yield n.a. n.a. NPC490747 bacitracin n.a. 1.4 mg/L 5-fold PMID[24603359]
NPO41727 Mutant strains of Streptomyces sp. U121 Streptomyces sp. U121 genome shuffling of Streptomyces sp. U121 Increase NP yield n.a. n.a. NPC239312 Baicalein n.a. n.a. 5-fold PMID[17043823]
NPO41877 A new engineered strain of Myxococcus xanthus Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC490650 Dicarboxylic acids n.a. n.a. n.a. PMID[31340171]
NPO41906 A new engineered strain of Saccharomyces cerevisiae YS58 Saccharomyces cerevisiae YS58 gap1 aro8 aro10 adh2 gdh2 Increase NP yield Metabolic engineering overexpressing gap1 aro8 aro10 adh2 gdh2 NPC53069 Berberine n.a. titer: 6.3 g/L; yield: 0.70g/g 5-fold PMID[29642888]
NPO41747 Recombinant Saccharomyces cerevisiae(overexpressed strain MO3) Saccharomyces cerevisiae ACE1 Increase NP yield n.a. CRISPR/Cpf1 system was applied for ADY2 and ACE1 deletion, and overexpression of HES1, ACE1, CUP1, and SOD1 by genomic integration. NPC264317 Betulinic acid n.a. n.a. 6.4-fold (YPD media) and increase accounts for over 60%(YPM media) PMID[33498600]
NPO41685 Escherichia coli HH 31-LT Escherichia coli SC-LT hmaSAmopt hmoScopt Increase NP yield n.a. hmaS from Actinosynnema mirum and hmo from S. coelicolor were expressed in E.coli for phenylglycine synthesis NPC264317 Betulinic acid n.a. 1.13 mM (172.9 mg/L) L-phg 5-fold increase PMID[35024478]
NPO41877 A new engineered strain of Myxococcus xanthus Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC490651 D-glucaric acid n.a. n.a. n.a. PMID[29694699]
NPO42008 A new engineered strain of Yarrowia lipolytica G3-3.21 Yarrowia lipolytica G3-3.21 n.a. Increase NP yield n.a. UV irradiation and genome shuffling NPC26111 bisabolene n.a. 3.75 g/L 6.5-fold PMID[26091898]
NPO41904 A new engineered strain of Saccharomyces cerevisiae YPH499 Saccharomyces cerevisiae YPH499 adh, aro10 Increase NP yield Metabolic engineering adh was coexpressed with aro10 in S. cerevisiae YPH499 NPC490512 botryococcene n.a. n.a. 6.5-fold PMID[26975754]
NPO41587 Actinoplanes teichomyceticus mutant strains Actinoplanes teichomyceticus n.a. Increase NP yield n.a. n.a. NPC315208 bottromycin n.a. n.a. 65.3% more PMID[29605937]
NPO41600 Burkholderia sp. FERM BP-3421 Escherichia coli n.a. Increase NP yield Microbial chassis engineering Cultivation conditions optimization of Burkholderia sp. FERM BP3421 and deletion of one autologous BGC to alleviate metabolic and gene expression resources competition NPC315208 bottromycin n.a. n.a. 65-580 folds PMID[31913601]
NPO42007 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica PAI Increase NP yield n.a. Expression of the codon-optimized PAI gene in Y. lipolytica NPC69128 bottromycin A2 n.a. n.a. 6-fold PMID[22545818]
NPO41603 C-1027 overproducing recombinant strains Streptomyces globisporus SgcR; SgcR1 Incerase NP yield BGC engineering inactivating the negative regulator SgcR and overproducing the positive regulator SgcR1 NPC149209 butyrate 74 mg/liter a titer of 466 mg/liter 6-fold increase PMID[20551990, PMID]
NPO41770 Saccharomyces cerevisiae strain pah1 Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC149209 butyrate n.a. n.a. 6-fold PMID[28216107]
NPO41956 A new engineered strain of Nicotiana tabacum Nicotiana tabacum PTS-FPS; ADS; LMS; GPS Heterologous expression n.a. n.a. NPC490652 costunolide n.a. n.a. more than 1,000-fold PMID[17057703]
NPO41961 A new engineered strain of Nicotiana benthamiana Nicotiana benthamiana PTS-FPS; ADS; LMS; GPS Heterologous expression n.a. n.a. NPC490652 costunolide n.a. n.a. more than 1,000-fold PMID[17057703]
NPO41899 A new engineered strain of Saccharomyces cerevisiae JDY52 Saccharomyces cerevisiae JDY52 GgbAS, MtCPR, CYP716A12, AtCPR, LjCPR Increase NP yield n.a. 1) improving the pairing efficiency between cytochrome P450 monooxygenase and reductase; 2) the cellular galactose regulatory network was reconstructed by knocking out galactose metabolic genes GAL80 and GAL1; 3) the 3-hydroxy-3-methylglutaryl-CoA reductase, squalene synthase and 2,3-oxidosqualene synthase were further overexpressed NPC313627 C-1027 n.a. 606.9 ± 9.1 mg/L 7.6-fold PMID[29526355]
NPO41797 Streptomyces davaonensis strain RML7 Streptomyces davaonensis rosB, rosA Increase NP yield n.a. n.a. NPC490653 corallopyronin D 20 µM roseoflavin (maximum) 34.9 ± 5.2 µM (ca. 14 mg/l) increased by 78%; productivities almost doubled PMID[31451111]
NPO41669 Deinococcus radiodurans R1, ΔcrtLm/crtB+ dxs+ Deinococcus radiodurans R1 Strain crtLm crtB dxs Increase NP yield Metabolic engineering the crtLm gene-encoding lycopene cyclase was deleted; he crtB gene-encoding phytoene synthase and the dxs gene-encoding 1-deoxy-d-xylulose 5-phosphate synthase were overexpressed NPC306277 cadaverine n.a. n.a. 722.2 ± 26.6 mg/L and 203.5 ± 4.5 mg/g DCW of lycopene titer and content PMID[32275417]
NPO41810 Streptomyces lincolnensis ΔBGC33 Streptomyces lincolnensis NRRL 2936 BGC33 Increase NP yield; n.a. NRRL 2936 with deletion of BGC33 NPC306277 cadaverine n.a. n.a. 7.7-fold PMID[32322696]
NPO41702 Escherichia coli strain B-4-HBA3 Escherichia coli ubiC Increase NP yield n.a. we cloned several genes, namely, ubiC, pobA, hbad, and/or EHT1, into E. coli. NPC4638 canthaxanthin n.a. n.a. 723.5 mg/L PMID[32786833]
NPO41881 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae BTS1, the carotenogenic crtYB, crtI genes and the plant PhCCD1 gene Increase NP yield n.a. n.a. NPC490774 capistruin n.a. 0.63 ± 0.02 mg/g DCW; 1 mg/g DCW at 50 h 8.5-fold; a 15-fold increase PMID[26063466]
NPO41717 Fusarium maire strain K178 Fusarium maire strain Y1117 n.a. Increase NP yield n.a. n.a. NPC490775 carotenoid n.a. n.a. 8.6-fold DOI[10.1360/yc-006-1627]
NPO41880 A new engineered strain of Rhodobacter sphaeroides Rhodobacter sphaeroides crtI4; crtC; crtI3 Increase NP yield n.a. n.a. NPC490775 Carotenoid n.a. 10.32 mg/g dry cell weight 88% increase PMID[29806774]
NPO41782 Schizochytrium sp. OaldH-gpo-trxR Schizochytrium sp. ATCC20888 ALDH GPO TRXR Increase NP yield Genetic engineering co-overexpression of the enzymes thioredoxin reductase (TRXR), aldehyde dehydrogenase (ALDH), glutathione peroxidase (GPO) NPC490775 Carotenoid lipid yield: 18.3g/L; DHA production: 6.2 g/L lipid yield: 33.1 g/L; DHA production: 13.3 g/L 80.9%, and 114.5% increases PMID[33726826]
NPO41770 Saccharomyces cerevisiae strain pah1 Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC219876 Catechin n.a. n.a. 8-fold PMID[28216107]
NPO41951 A new engineered strain of Nicotiana tabacum Nicotiana tabacum ADS; FPS Increase NP yield n.a. Redirecting amorpha-4,11-diene synthase (ADS) and farnesyl diphosphate synthase (FPS) from the cytosol to plastids in Nicotiana tabacum NPC490654 costunolide-cysteine conjugates n.a. over 25 μg/g fresh weight (FW) more than 40 000-fold PMID[20723135]
NPO41716 Fusarium asiaticum RR108 ΔFaFlbA Fusarium asiaticum RR108 FaFlbA Increase NP yield n.a. Targeted deletion of the FaFlbA gene, encoding a regulator of G protein signalling protein NPC490782 chitinimide A n.a. 2847 mg/kg 9.07-fold PMID[34865297]
NPO41716 Fusarium asiaticum RR108 ΔFaFlbA Fusarium asiaticum RR108 FaFlbA Increase NP yield n.a. Targeted deletion of the FaFlbA gene, encoding a regulator of G protein signalling protein NPC490783 chitinimide B n.a. 2073.12 mg/kg 9.43-fold PMID[34865297]
NPO41703 Escherichia coli strain B-DHB6 Escherichia coli pobA Increase NP yield n.a. we cloned several genes, namely, ubiC, pobA, hbad, and/or EHT1, into E. coli. NPC490784 chitinimide C n.a. n.a. 942.0 mg/L PMID[32786833]
NPO41897 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 CYP88D6, CYP72A154, CYP72A63 Increase NP yield n.a. we developed a novel and highly efficient pathway for the synthesis of GA and 11-oxo-β-amyrin in Saccharomyces cerevisiae by introducing efficient cytochrome P450s (CYP450s: Uni25647 and CYP72A63) and pairing their reduction systems from legume plants through transcriptome and genome-wide screening and identification. Increase the copy number of Uni25647 and pairing cytochrome P450 reductases (CPRs) from various plant sources. NPC490785 chitinimide D n.a. 18.9 mg/L 945.6-fold PMID[29196123]
NPO41798 Streptomyces fradiae strain GS1 and GS2 Streptomyces fradiae strain 1 n.a. Increase NP yield n.a. n.a. NPC490786 chitinimide E n.a. n.a. 9-fold PMID[11832946]
NPO41913 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica 4HPPD Increase NP yield n.a. gene 4HPPD was characterized and overexpressed in the chassis strain with up to three copies NPC490655 corosolic acid n.a. 4.5 g/L Minimum yields of 4.5 g/L PMID[33920006]
NPO41829 Yarrowia lipolytica strain po1fk7P(po1fk4–2 ΔylDGA2 ΔylDGA1::loxP harbor pYLXP′-citB-ylIDP2-ylODC) Yarrowia lipolytica gene YALI0E20977g; gene YALI0C05258g; gene YALI0D06930g; ylARO10-ylARO8-GapY3-PAR3 to the pBR docking site of the triple knockout strain (po1fk2, ALD2, ALD3, and PHA2 were knocked out) Increase NP yield n.a. n.a. NPC490787 chitinimide F n.a. 2669.54 mg/L a 4.16-fold increase;0.702 g/g (carbon conversion yiel from l-phenylalanine, 95.0% of the theoretical maximal) PMID[32134637]
NPO41991 A new engineered strain of Saccharomyces cerevisiae strain Saccharomyces cerevisiae strain low pH-responsive promoters Increase NP yield n.a. n.a. NPC490788 chitinimide G n.a. n.a. a tenfold enhancement of the production(control strain with the TEF1 promoter) PMID[27325743]
NPO41950 A new engineered strain of Nicotiana tabacum Nicotiana tabacum n.a. Heterologous expression n.a. a 12-enzyme pathway was introduced into Nicotiana tabacum chloroplasts NPC490789 chitinimide H n.a. 0.1 mg per gram of fresh plant matter comparable to the levels seen in the native producer Artemisia annua PMID[24499788]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490790 chitosanase n.a. 252 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC314309 cinnamycin n.a. 548 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490791 cis-N-methylstylopine n.a. 676 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
NPO41722 Methanosarcina acetivorans ispS+ Methanosarcina Species Archaea ispS Increase NP yield n.a. n.a. NPC118429 Citrulline n.a. 4% total C flux direct up to 4% of total carbon flux to isoprene PMID[33452028]
NPO41705 Escherichia coli strain T5(P)-dxs, T5(P)-idi, rrnB(P)-yjiD-ycgW, delta gdh delta aceE delta fdhF, pACLYC Escherichia coli single (rpoS, appY, yjiD, ycgW, and yhbL), double (yjiD-ycgW) and triple (yjiD-ycgW-yhbL) overexpressions with four gene deletion backgrounds, including single (delta gdhA, or delta aceE), double (delta gdhA delta aceE), and triple (delta gdhA delta aceE delta fdhF) knockouts Increase NP yield n.a. n.a. NPC118429 Citrulline n.a. over 16 000 ppm; 5 g/L of glucose(24h) double the levels (from a control strain) PMID[17509919]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC118429 Citrulline n.a. 80 μg/L critical intermediates by 32-fold; additional 45-fold through culture optimization PMID[25981946]
NPO41763 Saccharomyces cerevisiae reEngineered CEN.PK2 amorpha-4,11-diene strain Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC314184 cobalamin n.a. n.a. doubled PMID[22247290]
NPO41936 A new engineered strain of Escherichia coli Escherichia coli tolC Increase NP yield n.a. n.a. NPC299369 coenzyme Q10 n.a. n.a. fivefold increase PMID[19633652]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. The regulatory protein AraC in Escherichia coli was engineered to respond to the inducer mevalonate NPC490792 component III n.a. n.a. fourfold increase PMID[21268200]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490793 component IV n.a. 9.1 g/L high yield recovery (>98%) PMID[27825357]
NPO41789 Starmerella bombicola EG1 Starmerella bombicola eg1 NP activation n.a. a series of recombinant strains of S. bombicola in which several main cellulase genes from P. oxalicum were heterologously expressed were constructed NPC75179 Compound K n.a. 1.879 g/L increased by 39.5% than that of control strain; increased by 68.8% than that in the medium with only 2% glucose PMID[33006017]
NPO41841 A new engineered strain of Daldinia eschscholzii Daldinia eschscholzii n.a. Novel NP construction n.a. Compounds 1 and 2 were constructed, which exhibitingsignificant antiviral activity against H1N1 with IC50 values of 45.2 and 31.4 μM, respectively. NPC43053 crocetin n.a. n.a. n.a. PMID[35387230]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Novel NPs activation Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC490803 deactylanisomycin n.a. n.a. n.a. PMID[34301933]
NPO41877 A new engineered strain of Myxococcus xanthus Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC37793 Delphinidin 3-O-glucoside n.a. n.a. n.a. PMID[29694699]
NPO41877 A new engineered strain of Myxococcus xanthus Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC490805 deoxycinnamycin n.a. n.a. n.a. PMID[29694699]
NPO41877 A new engineered strain of Myxococcus xanthus Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC490808 didesmethylmensacarcin n.a. n.a. n.a. PMID[31340171]
NPO41730 Myxococcus xanthus DK1622 Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC490810 DKxanthene n.a. n.a. n.a. PMID[30995838]
NPO41730 Myxococcus xanthus DK1622 Myxococcus xanthus n.a. Novel NPs activation Microbial chassis engineering Modification of heterologous production platform by simplifying native metabolic background and combinatorial engineering of complex synthetic BGCs NPC44155 echinenone n.a. n.a. n.a. PMID[30995838]
NPO41895 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 bAS, CPR, CYP72A63, CYP93E2 or CYP716A12 Increase NP yield n.a. n.a. NPC254847 emodin n.a. n.a. n.a. PMID[23378447]
NPO41895 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 bAS, CPR, CYP72A63, CYP93E2 or CYP716A12 Increase NP yield n.a. n.a. NPC166885 endocrocin n.a. n.a. n.a. PMID[23378447]
NPO41882 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae CYP716A12, UGT73F3 Increase NP yield n.a. n.a. NPC124732 ent-Kaurene n.a. n.a. n.a. PMID[28216107]
NPO41859 A new engineered strain of Escherichia coli Escherichia coli AcrAB-TolC, MdtEF-TolC, mexAB-OprM Heterologous biosynthesis; Increase NP yield Transporter engineering Overexpression of native efflux pumps AcrAB-TolC, MdtEF-TolC; Overexpression of exogenous pumps mexAB-OprM; and Modulating the copy number of pump NPC490991 sesquiterpene (+)-valencene n.a. 404 mg/L n.a. PMID[23864262]
NPO41934 A new engineered strain of Escherichia coli Escherichia coli hpnC, hpnD, hpnE Biosynthesize NP n.a. Expression of hpnC, hpnD, and hpnE from Zymomonas mobilis NPC212214 epothilones n.a. n.a. n.a. PMID[26258173]
NPO41974 A new engineered strain of Saccharomyces cerevisiae AH22 Saccharomyces cerevisiae AH22 tHMG1 Increase NP yield n.a. Overexpression of tHMG1 under constitutive promoter NPC212214 epothilones n.a. n.a. n.a. PMID[9487712]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490815 fatty acid n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490818 flavonoids n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490819 fralnimycin n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41843 A new engineered strain of Escherichia coli Escherichia coli acrE Increase NP yield Metabolic engineering > Transporter engineering strategies Overexpressing resistance nodulation cell division family transporter acrE, mdtE and mdtC NPC490839 Indolpolyketone B (2R, 4R) n.a. n.a. titer: 46.4% increase PMID[30309591]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490823 functionalized terpenoids n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41835 A new engineered strain of Bacillus subtilis Bacillus subtilis n.a. Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490827 gardenia blue n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Novel NPs activation Microbial chassis engineering Genome reduction of S. albus by deleting 15 dispensable endogenous BGCs and increase copy number of exogenous BGCs via introducing phiC31 attB sites to generate cluster-free strains NPC14552 geosmin n.a. n.a. n.a. PMID[30196100]
NPO41683 Escherichia coli G05 Escherichia coli YJM25 pntAB ptsG galP glk Increase NP yield Metabolic engineering > Cofactor engineering-guided metabolic optimization both metabolic engineering through the introduction of dual pathway genes and deletion of competing pathway genes and coenzyme engineering through the overexpression of transhydrogenase PntAB were implemented in engineered E. coli strains. We also modified phosphotransferase system (PTS) by deleting the ptsG gene and modulating galP and glk genes expression to improve the co-utilization of glucose and glycerol. NPC490840 Indolpolyketone B (2S, 4S) n.a. 665.2 mg/L titer: 5.5-fold, yield: 2.1-fold PMID[30719552]
NPO41973 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae 10-gene cluster Novel NPs activation n.a. n.a. NPC304079 geranic acid n.a. 2.2 mg/L over 18,000-fold improvement PMID[29610307]
NPO41844 A new engineered strain of Escherichia coli Escherichia coli acrE mdtE mdtC cmr Increase NP yield Metabolic engineering > Transporter engineering strategies Overexpressing acrE, mdtE and mdtC together with deleting cmr NPC269823 geranylgeraniol n.a. n.a. production: >2 folds PMID[30309591]
NPO41661 Corynebacterium glutamicum strain RML5; Corynebacterium glutamicum strain RML6 Corynebacterium glutamicum rosB, rosA, RFK Heterologous expression; Increase NP yield n.a. n.a. NPC66654 Ginsenoside CK n.a. (maximum) 1.6 ± 0.2 µM (ca. 0.7 mg/l) reach maximum contents of roseoflavin faster than S. davaonensis PMID[31451111]
NPO41952 A new engineered strain of Nicotiana tabacum Nicotiana tabacum LMS Increase NP yield n.a. targeting the expression of limonene synthase (LMS) from the cytosol to plastids in Nicotiana tabacum NPC66654 Ginsenoside CK n.a. n.a. tenfold PMID[17057703]
NPO41950 A new engineered strain of Nicotiana tabacum Nicotiana tabacum n.a. Increase NP yield n.a. targeted expression of amorphadiene synthase (ADS) in the mitochondria of Nicotiana tabacum NPC66654 Ginsenoside CK n.a. n.a. six-fold enhancement compared to expression of ADS in the cytosol PMID[22158354]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Increase NP yield Microbial chassis engineering Genome reduction of S. albus by deleting 15 dispensable endogenous BGCs and increase copy number of exogenous BGCs via introducing phiC31 attB sites to generate cluster-free strains NPC120123 Ginsenoside Rg3 n.a. n.a. Titer increase PMID[30196100]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Increase NP yield Microbial chassis engineering Genome reduction of S. albus by deleting 15 dispensable endogenous BGCs and increase copy number of exogenous BGCs via introducing phiC31 attB sites to generate cluster-free strains NPC47566 Ginsenoside Rh1 n.a. n.a. Titer increase PMID[30196100]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield Microbial chassis engineering Pathway engineering via separating the biosynthetic pathway into two parts and facilitating the accumulation of multiple metabolic precursors NPC88000 ginsenoside Rh2 n.a. n.a. Titer increase PMID[20929806]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Increase NP yield Microbial chassis engineering Genome reduction of S. albus by deleting 15 dispensable endogenous BGCs and increase copy number of exogenous BGCs via introducing phiC31 attB sites to generate cluster-free strains NPC88000 Ginsenoside Rh2 n.a. n.a. Titer increase PMID[30196100]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Increase NP yield Microbial chassis engineering Genome reduction of S. albus by deleting 15 dispensable endogenous BGCs and increase copy number of exogenous BGCs via introducing phiC31 attB sites to generate cluster-free strains NPC160734 Ginsenoside F1 n.a. n.a. Titer increase PMID[30196100]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Increase NP yield Microbial chassis engineering Metabolic and morphological engineering of Streptomyces hosts via adding microparticles to submerged cultures NPC490501 glidobactin A n.a. n.a. Titer increase PMID[32808679]
NPO41816 Streptomyces spp. Streptomyces spp. n.a. Increase NP yield Microbial chassis engineering Metabolic and morphological engineering of Streptomyces hosts via adding microparticles to submerged cultures NPC490829 glidopeptin A n.a. n.a. Titer increase PMID[33974270]
NPO41879 A new engineered strain of Pseudomonas spp. Pseudomonas spp. n.a. Increase NP yield Microbial chassis engineering Culture condition optimization, regulation of transcriptional level by genetic engineering, and development of integration vectors of exogenous BGCs into the chromosome of P. putida NPC289758 glucose n.a. n.a. Titer increase PMID[34175462]
NPO41879 A new engineered strain of Pseudomonas spp. Pseudomonas spp. n.a. Increase NP yield Microbial chassis engineering Culture condition optimization, regulation of transcriptional level by genetic engineering, and development of integration vectors of exogenous BGCs into the chromosome of P. putida NPC490830 glucosinolates n.a. n.a. Titer increase PMID[34175462]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Increase NP yield Microbial chassis engineering Screening of native constitutive strong promoters and metabolic pathway engineering of S. brevitalea DSM 7029 NPC490831 glucosylated version medicagenic-28-O-glucoside n.a. n.a. Titer increase PMID[31999442]
PMID[32603592]
PMID[34301933]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Increase NP yield Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC137958 Glutamate n.a. n.a. Titer increase PMID[29666226]
PMID[34301933]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Increase NP yield Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC165122 glycolic acid n.a. n.a. Titer increase PMID[29666226]
PMID[34301933]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Increase NP yield Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC233455 Glycyrrhetinic acid n.a. n.a. Titer increase PMID[29666226]
PMID[34301933]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Increase NP yield Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC61198 guanosine n.a. n.a. Titer increase PMID[29666226]
PMID[34301933]
NPO41783 Schlegelella brevitalea DSM 7029 Schlegelella brevitalea n.a. Increase NP yield Microbial chassis engineering Establishment of highly efficient genetic manipulation system and rational genome reduction of S. brevitalea DSM 7029 via deleting transposase, genomic islands and other dispensable genes NPC282616 Gypsogenic acid n.a. n.a. Titer increase PMID[29666226]
PMID[34301933]
NPO41730 Myxococcus xanthus DK1622 Myxococcus xanthus n.a. Increase NP yield Microbial chassis engineering Screening of native constitutive strong promoters and metabolic pathway engineering of M. xanthus DK 1622 NPC490834 heterologous FS n.a. n.a. Titer increase PMID[34757714]
NPO41730 Myxococcus xanthus DK1622 Myxococcus xanthus n.a. Increase NP yield Microbial chassis engineering Screening of native constitutive strong promoters and metabolic pathway engineering of M. xanthus DK 1622 NPC484372 holrhizin A n.a. n.a. Titer increase PMID[34757714]
NPO41833 A new engineered strain of Aspergillus spp. Aspergillus spp. n.a. Increase NP yield Microbial chassis engineering Genome reduction of A. nidulans via deleting 6 endogenous BGCs to eliminate undesired toxins and substrates competition, combined with establishment of an efficient heterologous expression procedure NPC236637 Homoeriodictyol n.a. n.a. Titer increase PMID[23621425]
NPO41833 A new engineered strain of Aspergillus spp. Aspergillus spp. n.a. Increase NP yield Microbial chassis engineering Establishment of precursors biosynthesis and metabolic engineering of A. oryzae for heterologous production of polyketides NPC115906 hydrocodone n.a. n.a. Titer increase PMID[34947068]
NPO41803 Streptomyces lincolnensis O191 Streptomyces lincolnensis NRRL 2936 slinc191 Increase NP yield n.a. NRRL 2936 ɸC31 attB::pIB191 NPC315623 Hydroxycitric acid n.a. n.a. titer: 114% PMID[32322696]
NPO41807 Streptomyces lincolnensis Δ377 Streptomyces lincolnensis NRRL 2936 slinc377 Increase NP yield n.a. NRRL 2936 with in-frame deletion of slinc377 NPC273538 Icaritin n.a. n.a. titer: 244% increase PMID[32322696]
NPO41678 Escherichia coli AS226 Escherichia coli n.a. Increase NP yield n.a. ΔldhAΔpflBΔfrdΔackA-pta, ΔpflB::pck*-kivD-ilvD, ΔpflB::M1-93-kivD-ilvD, ΔadhE, ΔtdcDE, ΔtdcDE::M1-93-alsS, ΔldhA::M1-64-alsS, ΔmgsA::M1-46-ilvC, M1-46-pntAB, M1-30-yfjB NPC490520 icosalide A1 n.a. titer: 10.8g/L; yield:0.255 g/g titer: 28% increase; yield: 22% increase PMID[23246519]
NPO41744 Pseudomonas putida KT2440 strain Pseudomonas putida n.a. Increase NP yield n.a. n.a. NPC490958 poly (lactate-co-3-hydroxybutyrate) 51 mg/l; 7 mg zeaxanthin per gram cell dry weight; 51 mg/l 239 mg/l n.a. PMID[21038098]
NPO41911 A new engineered strain of Streptomyces lincolnensis NRRL 2936 Streptomyces lincolnensis NRRL 2936 the whole 24.7 kb LDII Increase NP yield n.a. deleting the whole 24.7 kb LDII NPC490837 Indolpolyketone A(2R, 4R) n.a. n.a. titer: 284% increase PMID[32322696]
NPO41910 A new engineered strain of Streptomyces bingchenggensis Streptomyces bingchenggensis TP2 TP5 Increase NP yield n.a. the appropriate native temporal promoters were selected and used to tune the expression of TP2 and TP5 NPC490838 Indolpolyketone A(2S, 4S) n.a. 3321 mg/L titer: 36.9% increase PMID[32695892]
NPO41791 Streptomyces A56-DT Streptomyces sco6196 Increase NP yield n.a. expressing sco6196 NPC54320 inosine n.a. 9.31g/L titer: 50% increase PMID[31819261]
NPO42010 A new engineered strain of Yarrowia Lipolytica Po1g Yarrowia Lipolytica Po1g n.a. Increase NP yield n.a. 1) Y. lipolytica Po1g was transformed with Δ6, Δ12-desaturases genes from M. alpina, under the hybrid hp4d promoter; 2) the simultaneous expression of both desaturases using one plasmid NPC88839 isobutanol n.a. 0.6 n.a. PMID[20188875]
NPO41715 Escherichia coli XL1-Blue Escherichia coli dxs Increase NP yield n.a. n.a. NPC88839 isobutanol n.a. n.a. twofold higher than when dxs was expressed from the IPTG-inducible trc and lac promoters (P(trc) and P(lac) PMID[11180061]
NPO41589 Ashbya gossypii I4 Ashbya gossypii A4 (ATCC10895) ADE4 ADE12 PNP1 Increase NP yield n.a. GPD:ADE4 des , ΔADE12, ΔPNP1 NPC88839 isobutanol 75.3 ± 4.2mg/L 138.0 ± 6.9mg/L n.a. PMID[25889888]
NPO41861 A new engineered strain of Escherichia coli BL21(DE3) Escherichia coli BL21(DE3) cscB cscA cscK ino1 miox udh suhB zwf pgi ptsG uxaC gudD glk Increase NP yield Microbial chassis engineering we co-expressed cscB, cscA, cscK, ino1, miox, udh, and suhB in E. coli BL21 (DE3), functionally constructing an unreported route from sucrose to D-glucaric acid. Further deletion of chromosomal zwf, pgi, ptsG, uxaC, gudD, over-expression of glk NPC88839 isobutanol n.a. ~1.42g/L n.a. PMID[29715517]
NPO41845 A new engineered strain of Escherichia coli Escherichia coli mdtC Increase NP yield Metabolic engineering > Transporter engineering strategies Overexpressing resistance nodulation cell division family transporter acrE, mdtE and mdtC NPC88839 isobutanol n.a. n.a. titer:33.8% increase PMID[30309591]
NPO41846 A new engineered strain of Escherichia coli Escherichia coli mdtE Increase NP yield Metabolic engineering > Transporter engineering strategies Overexpressing resistance nodulation cell division family transporter acrE, mdtE and mdtC NPC88839 isobutanol n.a. n.a. titer:65.2% increase PMID[30309591]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. Increase NP yield Microbial chassis engineering Culture condition optimization of Y. lipolytica via nutrient screening and coexpression of a myxo-ppt with the artificial PUFA gene cluster from myxobacteria NPC88839 isobutanol n.a. 0.168 n.a. PMID[31492836]
NPO41804 Streptomyces lincolnensis O348 Streptomyces lincolnensis NRRL 2936 slinc348 Increase NP yield n.a. NRRL 2936 ɸC31 attB::pIB348 NPC88839 isobutanol n.a. n.a. titer: 702% PMID[32322696]
NPO41805 Streptomyces lincolnensis OlmbB2 Streptomyces lincolnensis NRRL 2936 lmbB2 Increase NP yield n.a. NRRL 2936 ɸC31 attB::pIBlmbB2 NPC88839 isobutanol n.a. n.a. titer: 77% PMID[32322696]
NPO41806 Streptomyces lincolnensis OlmbU Streptomyces lincolnensis NRRL 2936 lmbU Increase NP yield n.a. NRRL 2936 ɸC31 attB::pIBlmbU NPC88839 isobutanol n.a. n.a. titer: 75% PMID[32322696]
NPO41796 Streptomyces cyaneogriseus ssp. ScyTP2P2 Streptomyces cyaneogriseus ssp. NMWT1 TP2 Increase NP yield n.a. Integrated a copy of TP2 driven by the promoter P2 (Psbi_07857) NPC88839 isobutanol 327mg/L 499mg/L titer: 52.6% increase PMID[32695892]
NPO41706 Escherichia coli strains TSW008 and TSW009 Escherichia coli strains TSW001 ProP ProVWX Increase NP yield Metabolic engineering > Transporter engineering strategies elimination of transporters ProP and ProVWX NPC88839 isobutanol n.a. TSW008: 24.9g/l; TSW009: 26 g/l TSW009: 116% increases PMID[33653345]
NPO41773 Saccharomyces cerevisiae WPK3 Saccharomyces cerevisiae ZW04BY-RS n.a. Increase NP yield n.a. WPK3--WPK2 TRP1:: TEF1p-synUGTPg1-FBA1t (WPK1--ZW04BY-RS rDNA:: TDH3p-synUGTPg1-PRM9t) NPC88839 isobutanol n.a. 1.75g/L n.a. PMID[33869813]
NPO41773 Saccharomyces cerevisiae WPK3 Saccharomyces cerevisiae ZW04BY-RS n.a. Increase NP yield n.a. WPK3--WPK2 TRP1:: TEF1p-synUGTPg1-FBA1t (WPK1--ZW04BY-RS rDNA:: TDH3p-synUGTPg1-PRM9t) NPC88839 isobutanol n.a. 1.9g/L n.a. PMID[33869813]
NPO41793 Streptomyces albus ADE-AP Streptomyces albus ADE ACC PCC and AcsA Increase NP yield n.a. Extra acsA and pccBE were overexpressed under the control of kasOp*, additional accA2 and accBE were overexpressed under the control of rpsLp-cf in ADE, PKS of candicidin BGC in ADE was replaced by acsA and pccBE to interrupt the expression of the candicidin PKS gene NPC88839 isobutanol n.a. ~70 mg/L n.a. PMID[34584996]
NPO41719 Gluconobacter oxydans MD-16 Gluconobacter oxydans WSH-003 upp and l-sorbosone DH. Glucose DH2 NAD-dependent xylitol DH NAD-dependent xylitol DH 2 gluconate 5-DH sldSLC PTS glucose DH Mannitol DH PQQ-dependent DH 3 alcohol DH aldehyde DH 3 aldehyde DH (NAD(+)) gluconate2-DH aldehyde DH vhb Increase NP yield Systematic engineering 16 different types of dehydrogenases were inactivated consecutively and the gene vhb encoding hemoglobin was introduced and overexpressed NPC53545 Isoorientin n.a. 298.61 g/L n.a. PMID[35356389]
NPO41795 Streptomyces avermitilis NEAU12TP5P4 Streptomyces avermitilis NEAU12 TP5 Increase NP yield n.a. Integrated a copy of TP5 driven by the promoter P4 (Psbi_06929) NPC96619 Isoprene 3533mg/L 5092mg/L n.a. PMID[32695892]
NPO41772 Saccharomyces cerevisiae WPK12 Saccharomyces cerevisiae ZW04BY-RS n.a. Increase NP yield n.a. WPK12--WPK8 ΔALG5 (WPK8--WPK6 YORWδ22:: TEF1p-URA6-ENO2t, TDH3p-YNK1-FBA1t; WPK6-- WPK3 YPRCt3:: GPD1p-UGP1-FBA1t, PGK1p-PGM2-PRM9t) NPC96619 isoprene n.a. 5.74 g/ L n.a. PMID[33869813]
NPO41753 Saccharomyces cerevisiae BJ5464-NpgA Saccharomyces cerevisiae n.a. Increase NP yield Metabolic engineering Construction of a library of orthologous biosynthetic bricks for optimization of the biosynthesis of endocrocin and emodin. NPC289774 Isovitexin n.a. 528.4 ± 62.7 mg/L n.a. PMID[31028901]
NPO41692 Escherichia coli NT1005/CadA-lysA-dapA-cadB Escherichia coli NT1003 CadA lysA dapA cadB Increase NP yield Metabolic engineering n.a. NPC116775 Kaempferol n.a. 58.7 g/L; yield: 0.396g/g n.a. PMID[34584992]
NPO41773 Saccharomyces cerevisiae WPK3 Saccharomyces cerevisiae ZW04BY-RS n.a. Increase NP yield n.a. WPK3--WPK2 TRP1:: TEF1p-synUGTPg1-FBA1t (WPK1--ZW04BY-RS rDNA:: TDH3p-synUGTPg1-PRM9t) NPC76217 lactic acid n.a. 6.19g/L n.a. PMID[33869813]
NPO41630 Corynebacterium glutamicum CGGN2-GNA1-CgglmS Corynebacterium glutamicum S9114 GNA1 nagA gamA ldh glmS Increase NP yield Metabolic engineering exogenously expressing the GNA1 gene, deleting nagA and gamA genes, knockout of ldh and adding glms into the expression vector pJYW-4-ceN NPC490487 L-alanyl-L-glutamine n.a. 6.9 g/L n.a. PMID[31198861]
NPO41753 Saccharomyces cerevisiae BJ5464-NpgA Saccharomyces cerevisiae n.a. Increase NP yield Metabolic engineering Construction of a library of orthologous biosynthetic bricks for optimization of the biosynthesis of endocrocin and emodin. NPC490846 L-asparaginase activity n.a. 661.2 ± 50.5 mg/L n.a. PMID[31028901]
NPO41848 A new engineered strain of Escherichia coli Escherichia coli lgtA wbgO Increase NP yield n.a. The strain was constructed by chromosomally integrating the genes lgtA and wbgO, encoding β-1,3-N-acetylglucosaminyltransferase and β-1,3-galactosyltransferase. NPC161593 L-DOPA n.a. 219.1±3.5 mg/L n.a. PMID[25044565]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs activation n.a. n.a. NPC490847 L-glutaminase activities n.a. ~1.5 g/L n.a. PMID[23113661]
NPO41907 A new engineered strain of Saccharomyces cerevisiae ZD-PPD-016(URA3-) Saccharomyces cerevisiae ZD-PPD-016(URA3-) UGT51 Increase NP yield n.a. we have demonstrated high-level production of ginsenoside Rh2 in Saccharomyces cerevisiae via repurposing an inherently promiscuous glycosyltransferase, UGT51. NPC490849 lignan sesamin n.a. ~300 mg/L n.a. PMID[28479190]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC226168 lignans n.a. ~570 ± 45 mg/L n.a. PMID[26951651]
NPO41909 A new engineered strain of Staphylococcus albus Staphylococcus albus n.a. increae NP yield; NP de novo biosynthesis n.a. n.a. NPC34764 limonene n.a. 0.002 mg/L n.a. PMID[28611737]
NPO41964 A new engineered strain of Physcomitrella patens Physcomitrella patens Taxadiene synthase gene Heterologous expression n.a. n.a. NPC34764 limonene n.a. 0.05% fresh weight of tissue n.a. PMID[19241134]
NPO41963 A new engineered strain of Physcomitrella patens Physcomitrella patens HMGR Heterologous expression n.a. n.a. NPC34764 limonene n.a. 0.039 mg/g dry weight of α/β santalene n.a. PMID[25477891]
NPO41909 A new engineered strain of Staphylococcus albus Staphylococcus albus n.a. Increase NP yield n.a. n.a. NPC180871 linalool n.a. 0.089 mg/L n.a. PMID[28611737]
NPO41941 A new engineered strain of Escherichia coli MG1655 Escherichia coli MG1655 ro8 kdc yigB Increase NP yield n.a. coexpression of aro8, kdc, and yigB NPC313821 lincomycin n.a. 0.28g/L n.a. PMID[28436122]
NPO41909 A new engineered strain of Staphylococcus albus Staphylococcus albus n.a. Increase NP yield n.a. n.a. NPC313821 lincomycin n.a. 0.09 mg/L n.a. PMID[28611737]
NPO41909 A new engineered strain of Staphylococcus albus Staphylococcus albus n.a. Increase NP yield n.a. n.a. NPC313821 lincomycin n.a. 0.384 mg/L n.a. PMID[28611737]
NPO41969 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae crtI; crtE; crtYB Increase NP yield n.a. introducing the expression of a carotenoid-cleavage dioxygenase from raspberry (Rubus ideaus RiCCD1) NPC313821 lincomycin n.a. 0.22 mg g−1 dry weight n.a. PMID[24486029]
NPO41666 Corynebacterium glutamicum ΔAPE6937R42 Corynebacterium glutamicum argR Increase NP yield n.a. Removal of feedback repression of ArgR by deletion of argR NPC313821 lincomycin n.a. 0.32 g/L n.a. PMID[25163446]
NPO41649 Corynebacterium glutamicum SJ8074 (pEK-Ptrc::1469) Corynebacterium glutamicum ncgl1469 Increase NP yield n.a. Insertion of a strong Ptrc promoter in the upstream region of ncgl1469 gene NPC313821 lincomycin n.a. 0.32 g/L n.a. PMID[25720798]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield Transporter engineering; and regulatory factor modulating. n.a. NPC313821 lincomycin n.a. 0.5 g/L n.a. PMID[25769286]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. Yeast chromosomes integration; Cell factories establishment. NPC313821 lincomycin n.a. 0.17 g/L n.a. PMID[25769286]
NPO41852 A new engineered strain of Escherichia coli Escherichia coli cep94A Increase NP yield Metabolic engineering cep94A gene (locus tag Sde_1318) was amplified from genomic DNA of Saccharophagus degradans 2–40; all other genes were amplified from genomic DNA of E. coli W3110 using primers listed in SI Table S1; Cep94A and lacY genes were individually assembled into pETM6 (Addgene plasmid # 49795) using Gibson assembly technique. NPC313821 lincomycin n.a. 0.51 g GA g/L xylose n.a. PMID[33527231]
NPO41697 Escherichia coli SC-LT Escherichia coli BW25113 tryrBEc hmaSSc hmoSc leuDHBcopt Heterologous expression; Increase NP yield n.a. A heterologous L-phg pathway was constructed by co-overexpressing the aromatic transaminase (tyrBEc) from E.coli, hydroxymandelate synthase (hmaSSc) and hydroxymandelate oxidase (hmoSc) from S. coelicolor, and a codon-optimized leucine dehydrogenase (leuDHBcopt) from Bacillus clausii NPC313821 lincomycin n.a. 0.23 mM (35.3 mg/L) L-phg n.a. PMID[35024478]
NPO41909 A new engineered strain of Staphylococcus albus Staphylococcus albus n.a. NP de novo biosynthesis n.a. n.a. NPC328590 lipase n.a. 0.599 mg/L n.a. PMID[30440014]
NPO41648 Corynebacterium glutamicum SA9 Corynebacterium glutamicum n.a. Increase NP yield n.a. n.a. NPC490851 lipid n.a. 0.616 g/L n.a. PMID[29744279]
NPO42004 A new engineered strain of Synechocystis sp. PCC 6803 Synechocystis sp. PCC 6803 shc Increase NP yield n.a. Disabling shc (squalene hopene cyclase) NPC490852 lipid and docosahexaenoic acid(DHA) n.a. 0.67 /OD750 n.a. PMID[24625633]
NPO41646 Corynebacterium glutamicum SA13 Corynebacterium glutamicum lysE, putP Increase NP yield n.a. the deletion of lysE and putP genes NPC147686 Liquiritigenin n.a. 0.734 g/L n.a. PMID[29744279]
NPO41707 Escherichia coli TS-1 Escherichia coli KW001 BSglnA Increase NP yield n.a. Derived from KW001, BSglnA replacing the native glnA NPC3357 L-malic acid n.a. 0.810 g/L n.a. PMID[32671235]
NPO41647 Corynebacterium glutamicum SA15 Corynebacterium glutamicum rhtA Increase NP yield n.a. heterologous expression of rhtA gene from E. coli NPC490856 long-chain Dicarboxylic acids n.a. 0.872 g/L n.a. PMID[29744279]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC490856 long-chain Dicarboxylic acids n.a. 0.85 mg/L n.a. PMID[29771352]
NPO41975 A new engineered strain of Saccharomyces cerevisiae BY4741 Saccharomyces cerevisiae BY4741 ERG1 Increase NP yield n.a. Point mutations in ERG1, the gene responsible for conversion of squalene to squalene epoxide, thereby promoting hypersensitivity to terbinafine NPC93081 l-ornithine n.a. 1 mg/10(9) cells n.a. PMID[24119181]
NPO41892 A new engineered strain of Saccharomyces cerevisiae CEN. PK 2-1D Saccharomyces cerevisiae CEN. PK 2-1D PgDS, PgPPDS, PgUGT74AE2, PgUGT94Q2 Increase NP yield n.a. n.a. NPC490493 l-sorbose n.a. 1.3 mg/L n.a. PMID[25320211]
NPO41963 A new engineered strain of Physcomitrella patens Physcomitrella patens HMGR Heterologous expression n.a. n.a. NPC93888 L-threonine n.a. 1.34 mg/g dry weight n.a. PMID[25477891]
NPO41742 Pseudomonas putida DSM 12264 Pseudomonas putida n.a. Novel NPs activation n.a. n.a. NPC490862 luminmide A, B n.a. 1.35 mg/L n.a. PMID[25471523]
NPO41711 Escherichia coli TS-8 Escherichia coli KW001 thrA Increase NP yield n.a. Derived from TS-7 (Derived from TS-6, serAmut), serAmut -thrAmut NPC484676 luminmycin A n.a. 1.380 g/L n.a. PMID[32671235]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. UGTPgs characterization; Structural modeling; Protein chimeric. NPC313179 lutein n.a. 1.4 mg/L n.a. PMID[24603359]
NPO41886 A new engineered strain of Saccharomyces cerevisiae AM109 Saccharomyces cerevisiae AM109 CYP712K1, CYP712K2, CYP712K3, UBC7 Increase NP yield n.a. n.a. NPC279121 Luteolin n.a. 1.4 mg/L n.a. PMID[31992268]
NPO41757 Saccharomyces cerevisiae D20RH18 Saccharomyces cerevisiae ZW-PPD-B UGTPg29, UGTPg45 Increase NP yield n.a. Based on the two UGTs and a yeast chassis to produce PPD, yeast cell factories were built to produce Rh2 and/or Rg3 from glucose. NPC99088 lycopene n.a. 1.45 μmol/g DCW n.a. PMID[25769286]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. Novel NPs activation n.a. n.a. NPC99088 lycopene n.a. 1.5 g/L; 0.048 g/g n.a. PMID[28986998]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC99088 lycopene n.a. 1.55 mg/L n.a. PMID[29771352]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC99088 lycopene n.a. 1.86 mg/L n.a. PMID[29771352]
NPO41874 A new engineered strain of Lactococcus lactis Lactococcus lactis n.a. Increase NP yield n.a. n.a. NPC99088 lycopene n.a. 1.5 mg/L n.a. PMID[30978503]
NPO41748 Rhodobacter sphaeroides HY01 under phosphate- limited conditions Rhodobacter sphaeroides HY01 n.a. Increase NP yield n.a. under phosphate- limited conditions (decreased phosphate or in the absence of inorganic phosphate addition) NPC99088 lycopene n.a. 1.95 g/L n.a. PMID[31890925]
NPO41903 A new engineered strain of Saccharomyces cerevisiae WLT-MVA5 Saccharomyces cerevisiae WLT-MVA5 PGM2, UGP1, UGT1 Increase NP yield n.a. We induced overexpression of PGM2, UGP1, and UGT1 genes in WLT-MVA5, and obtained a strain that produces ginsenoside CK. NPC99088 lycopene n.a. 1.70 ± 0.16 g/L n.a. PMID[32075645]
NPO41709 Escherichia coli TS-5 Escherichia coli KW001 icd gdhA Increase NP yield n.a. Derived from TS-1,::icd-::gdhA with J23119 promoter NPC99088 lycopene n.a. 1.492 g/L n.a. PMID[32671235]
NPO41712 Escherichia coli TS-9 Escherichia coli KW001 pntAB sthA Increase NP yield n.a. Derived from TS-8,::sthA-pntAB with J23119 promoter NPC99088 lycopene n.a. 1.510 g/L n.a. PMID[32671235]
NPO42005 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica acs, ylACL1, ylHGM1 Increase NP yield n.a. Overexpression of acs (from Salmonella enterica), ylACL1 (encodes acetyl-CoA synthase), and ylHMG1, addition of 10 mM citrate NPC112890 Lysine n.a. 10 mg/g DCW n.a. PMID[29986837]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Heterologous biosynthesis; Increase NP yield n.a. EST database mining; Enzymatic UGT characterization; and Prompter replacement. NPC112890 Lysine n.a. 10 mg/L n.a. PMID[26358188]
NPO41826 Yarrowia lipolytica ST6075 Yarrowia lipolytica 5999 crtW crtZ Increase NP yield n.a. introduced b-carotene ketolase (crtW) from Paracoccus sp. N81106 and hydroxylase (crtZ) from Pantoea ananatis to convert b-carotene into astaxanthin; XdcrtI↑-XdcrtYB↑, PscrtW↑-PacrtZ↑ & XdcrtI↑-XdcrtYB↑, loop-out hphMX (parent strain: ST5204) NPC84319 Maslinic acid n.a. 10.4 ± 0.5 mg/L n.a. PMID[29552653]
NPO41988 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 n.a. Increase NP yield n.a. Overexpression of squalene biosynthetic pathway using a library of 13 new constitutive promoters NPC490866 Medicagenic-28-O-glucoside n.a. 100 mg/L n.a. DOI[10.1016/j.ces.2016.06.004]
NPO41858 A new engineered strain of Escherichia coli Escherichia coli metK Increase NP yield n.a. harboring E. coli K12-derived metK encoding S-adenosine-l-methionine (SAM) synthase (accession number: K02129) for enhancement of SAM as a precursor and Streptomyces avermitilis originated SaOMT2 (O-methyltransferase, accession number: NP_823558) for methylation of daidzein and genistein as preferred substrates. NPC490867 medium chain fatty acid(C6-C10, MCFAs) n.a. 102.88 mg/L n.a. PMID[26498482]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490867 medium chain fatty acid(C6-C10, MCFAs) n.a. 108 mg/L n.a. PMID[29386648]
NPO41990 A new engineered strain of Saccharomyces cerevisiae SR7 Saccharomyces cerevisiae SR7 tHMGR1, ERG10 Increase NP yield n.a. Overexpression of tHMG1, expression of ispA NPC490867 medium chain fatty acid(C6-C10, MCFAs) n.a. 1026 ± 37 mg/L n.a. PMID[29396745]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490867 medium chain fatty acid(C6-C10, MCFAs) n.a. 106.5 mg/L n.a. PMID[30496827]
NPO41986 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 tHMG1, IDI1, ERG20, ERG9 Increase NP yield n.a. Overexpression of tHMG1, IDI1, ERG20, and ERG9 NPC490874 methylparaben [MP] n.a. 119.08 mg/L n.a. DOI[10.1016/j.ces.2016.06.014]
NPO41639 Corynebacterium glutamicum ORN1 Corynebacterium glutamicum ArgB Increase NP yield n.a. Removal of feedback inhibition through site-directed mutagenesis of ArgB NPC319951 mevalonate n.a. 12.1 g/L n.a. PMID[26393954]
NPO41981 A new engineered strain of Saccharomyces cerevisiae CEN.PK 113-5D Saccharomyces cerevisiae CEN.PK 113-5D FAR, WS, ELO2 Increase NP yield n.a. heterologous expression of FAR from Marinobacter aquaeolei together with the WS from S. chinensis and native elongase (ELO2) NPC319951 mevalonate n.a. 12.24 ± 3.35 mg/g n.a. PMID[27858995]
NPO41616 Corynebacterium crenatum MT-M4 Corynebacterium crenatum n.a. Increase NP yield n.a. Removal of feedback inhibition through site-directed mutagenesis of ArgB NPC490876 milbemycin A3/A4 n.a. 12.3 g/L n.a. PMID[26777906]
NPO41828 Yarrowia lipolytica ST9671 Yarrowia lipolytica FjTAL At4CL1 VvVST1 Increase NP yield n.a. n.a. NPC490877 mixture of C5 and C15 alcohols and their derivatives(MAIN: C10) n.a. 12.4 ± 0.3 g/L n.a. PMID[32818629]
NPO41650 Corynebacterium glutamicum SJC8514 (pEK-CJBDmut) Corynebacterium glutamicum ncgl0462 and argCJBD Increase NP yield n.a. Co-expression of ncgl0462 and argCJBD NPC490878 monoterpene limonene n.a. 12.48 g/L n.a. PMID[29898721]
NPO41966 A new engineered strain of Rhodopseudomonas palustris TIE-1 Rhodopseudomonas palustris TIE-1 shc, crtE, hpnD Increase NP yield n.a. Disabling shc gene, co-expression of crtE and hpnD NPC490879 monoterpenes n.a. 12.6 mg/g DCW n.a. PMID[26886756]
NPO41664 Corynebacterium glutamicum ZQJY-7 Corynebacterium glutamicum odhA Increase NP yield n.a. the attenuation of odhA gene by mutation of RBS NPC490880 myxochelins n.a. 12.8 g/L n.a. PMID[32627539]
NPO41922 A new engineered strain of Artemisia annua L. Artemisia annua L. TXS (taxadiene synthase) gene Heterologous expression n.a. n.a. NPC490881 myxochromides n.a. 129.7 μg/g dry mass n.a. PMID[25705665]
NPO41611 Corynebacterium crenatum CCM04 Corynebacterium crenatum cgl2310 Increase NP yield n.a. the deletion of cgl2310 gene NPC490882 n-butanol n.a. 15.34 g/L n.a. PMID[32140378]
NPO41668 Corynebacterium glutamicumΔAPE6937 Corynebacterium glutamicum n.a. Increase NP yield n.a. Two stages of adaptive evolution based on the growth selection NPC223174 N-acetylglucosamine n.a. 13.6 g/L n.a. PMID[23725060]
NPO41612 Corynebacterium crenatum CCM05 Corynebacterium crenatum n.a. Increase NP yield n.a. n.a. NPC223174 N-acetylglucosamine n.a. 13.29 g/L n.a. PMID[32140378]
NPO41996 A new engineered strain of Schizosaccharomyces pombe ARC010-1 Schizosaccharomyces pombe ARC010-1 CpFAH12 Increase NP yield n.a. Holic and coworkers to introduce CpFAH12 controlled by the NMT1 inducible promoter into S. pombe ARC010-1 NPC79943 Naringenin n.a. 137.4 µg/ml n.a. PMID[22370951]
NPO41971 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae GFP; EcCFS Increase NP yield n.a. n.a. NPC79943 Naringenin n.a. 131 mg/l n.a. PMID[25151135]
NPO41631 Corynebacterium glutamicum CgS1/pEC-SB-rhtA Corynebacterium glutamicum hemA, RhtA Increase NP yield n.a. the co-expression of hemA and RhtA genes NPC79943 Naringenin n.a. 14.7 g/L n.a. PMID[26921424]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC79943 Naringenin n.a. 14.54 mg/L n.a. PMID[28634125]
NPO41656 Corynebacterium glutamicum Sorn10 Corynebacterium glutamicum argR, argF, argCJBD Increase NP yield n.a. Removal of feedback repression of ArgR by deletion of argR; the deletion of argF; the heterologous expression of argCJBD NPC79943 naringenin n.a. 15.1 g/L n.a. PMID[28938890]
NPO41739 Pichia pastoris GSA-Aor-OCH1 Pichia pastoris GS115 OCH1 β-galactosidase gene Increase NP yield n.a. OCH1 disrupted strain integrated with inducible vector β-galactosidase gene from A. oryzae borne vector NPC79943 Naringenin n.a. 1434.75 U/mL n.a. PMID[29062968]
NPO41891 A new engineered strain of Saccharomyces cerevisiae BY-OA Saccharomyces cerevisiae BY-OA CaCYP716C49 Increase NP yield n.a. n.a. NPC79943 Naringenin n.a. 141 mg/L n.a. PMID[30339834]
NPO41884 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae SmFPS, AtSQS2, AtSQE2 Increase NP yield n.a. n.a. NPC79943 Naringenin n.a. 15 g/L n.a. PMID[30361526]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. NP biosynthesis n.a. n.a. NPC79943 Naringenin n.a. 134.2 mg/L n.a. PMID[31622552]
NPO41610 Corynebacterium crenatum CCM02 Corynebacterium crenatum putP Increase NP yield n.a. the deletion of putP gene NPC79943 Naringenin n.a. 14.2 g/L n.a. PMID[32140378]
NPO41759 Saccharomyces cerevisiae GY-1 Saccharomyces cerevisiae BY4742 bAS, OAS, CPRs genes, PPDS, PPTS Increase NP yield n.a. n.a. NPC216401 nemadectin n.a. 15.9 mg/L n.a. PMID[24424342]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs identification Microbial chassis engineering Introduction of exogenous phosphopantetheinyl transferases from Stigmatella aurantiaca for CP domain activation in standard recombineering host, E. coli GB2006 NPC227622 erythromycin n.a. n.a. n.a. PMID[22544021]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC490923 N-Methylanthranilate Production n.a. 152 mg/L n.a. PMID[29771352]
NPO41888 A new engineered strain of Saccharomyces cerevisiae BY4724 Saccharomyces cerevisiae BY4724 PgDDS, PgPPDS, AtCPR1 Increase NP yield n.a. 1) dammarenediol-II synthase and protopanaxadiol synthase genes of Panax ginseng, together with a NADPH-cytochrome P450 reductase gene of Arabidopsis thaliana, were introduced into Saccharomyces cerevisiae; 2) overexpressing truncated 3-hydroxyl-3-methylglutaryl-CoA reductase, farnesyl diphosphate synthase, squalene synthase and 2,3-oxidosqualene synthase genes, together with increasing protopanaxadiol synthase activity through codon optimization NPC202771 noscapine n.a. 1548 mg/L n.a. PMID[24126082]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC227622 erythromycin A n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs identification Microbial chassis engineering Introduction of exogenous phosphopantetheinyl transferases from Stigmatella aurantiaca for CP domain activation in standard recombineering host, E. coli GB2007 NPC227622 erythromycin A n.a. n.a. n.a. PMID[22851214]
NPO41660 Corynebacterium glutamicum Sorn7 Corynebacterium glutamicum odhA Increase NP yield n.a. replacing the start codon ATG of odhA gene; replacing the natural RBS of odhA with the sequence of synthetic RBS with strengths of 837 au NPC490928 oleanane-type sapogenin β-amyri n.a. 16 g/L n.a. PMID[28938890]
NPO41997 A new engineered strain of Solanum lycopersicum (tomato) Solanum lycopersicum (tomato) n.a. Heterologous expression n.a. n.a. NPC142415 Oleanolic acid n.a. 160 mg of highly pure taxadiene from 1 kg of freeze dried fruit n.a. PMID[17106766]
NPO41769 Saccharomyces cerevisiae strain BY-2OA Saccharomyces cerevisiae BY-OA GgβAS, MtOAS, AtCPR1 Increase NP yield n.a. Using the DNA assembler method, one copy of Glycyrrhiza glabra beta-amyrin synthase (GgbAS), Medicago truncatula oleanolic acid synthase (MtOAS) and Arabidopsis thaliana cytochrome P450 reductase 1 (AtCPR1) genes were introduced into Saccharomyces cerevisiae strain BY-OA, resulting in strain BY-20A NPC142415 Oleanolic acid n.a. 165.7 mg/L n.a. PMID[25272488]
NPO41840 A new engineered strain of Cupriavidus necator Cupriavidus necator n.a. Novel NPs activation n.a. n.a. NPC142415 oleanolic acid n.a. 17 mg per gram CDW n.a. PMID[29232490]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC142415 Oleanolic acid n.a. 1652 mg/L n.a. PMID[30061932]
NPO41831 Yarrowia Lipolytica YL-MVA-CK Yarrowia Lipolytica ATCC 201249 n.a. Increase NP yield n.a. overexpression of key genes in the MVA pathway and fusion of cytochrome P450 monooxygenase (PPDS) and NADPH-P450 reductase. NPC142415 oleanolic acid n.a. 161.8 mg/L n.a. PMID[30757901]
NPO41771 Saccharomyces cerevisiae strain ScLCZ11 Saccharomyces cerevisiae strain ScLCZ08 n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 175.15 mg/L n.a. DOI[10.1002/aic.16370]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. Firstly, we synthesized or cloned the genes encoding dammarenediol-II synthase (DS), PgUGT74AE2 and UGTPg1 from P. ginseng. Furthermore, the anti-colon cancer activities of both 3β-O-Glc-DM and 20S-O-Glc-DM were demonstrated by in vitro and in vivo assays. we engineered S. cerevisiae by introducing the codon-optimized genes encoding DS together with PgUGT74AE2 or UGTPg1. The engineered strains were optimized to increase the production of DM glucosides by integrating multi-copy DS and UGT genes into yeast via the CRISPR/Cas9 system, overexpressing several key enzymes of the upstream biosynthetic pathway, down-regulating the competitive branch pathway and overexpressing the transcriptional activator HAC1. NPC93081 Ornithine n.a. 2.4 g/L n.a. DOI[10.1039/C8GC04066D]
NPO41759 Saccharomyces cerevisiae GY-1 Saccharomyces cerevisiae BY4742 bAS, OAS, CPRs genes, PPDS, PPTS Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 17.2 mg/L n.a. PMID[24424342]
NPO41624 Corynebacterium glutamicum ALA6 Corynebacterium glutamicum ppc, pyk Increase NP yield n.a. the insertion of a strong Psod promoter in the upstream region of ppc gene; the deletion of pyk gene NPC93081 Ornithine n.a. 2.07 g/L n.a. PMID[26616115]
NPO41993 A new engineered strain of Saccharomyces cerevisiae YPH499 Saccharomyces cerevisiae YPH499 HMG1 Increase NP yield n.a. Overexpression of HMG1 (encodes HMGR) NPC93081 Ornithine n.a. 191.9mg/L n.a. PMID[19592534]
NPO41983 A new engineered strain of Saccharomyces cerevisiae EGY48 Saccharomyces cerevisiae EGY48 HMG2 Increase NP yield n.a. Overexpression of HMG2 with a K6R stabilizing mutation in Hmg2p, an HMGR isoenzyme NPC93081 Ornithine n.a. 18.3 mg/g DCW n.a. PMID[20550581]
NPO41662 Corynebacterium glutamicum YW03 Corynebacterium glutamicum argR Increase NP yield n.a. Removal of feedback repression of ArgR by deletion of argR NPC93081 Ornithine n.a. 17.3 g/L n.a. PMID[23725060]
NPO41942 A new engineered strain of Escherichia coli XL1-Blue Escherichia coli XL1-Blue hSQS Increase NP yield n.a. Expression of hSQS NPC93081 Ornithine n.a. 2.7mg/L n.a. PMID[24333579]
NPO41980 A new engineered strain of Saccharomyces cerevisiae BY4742-TRP Saccharomyces cerevisiae BY4742-TRP tHMG1, LYS2, ERG9, ERG1, bAS Increase NP yield n.a. Overexpression of tHMG1, LYS2, ERG9, ERG1, expression of bAS (b-amyrin synthase) from Glycyrrhiza glabra NPC93081 Ornithine n.a. 183.4mg/L n.a. PMID[24424342]
NPO41609 Corynebacterium crenatum CCM02 Corynebacterium crenatum ncgl1221 Increase NP yield n.a. the deletion of ncgl1221 gene NPC93081 Ornithine 17.73 g/L 19.56 g/L n.a. PMID[26264811]
NPO41667 Corynebacterium glutamicum ΔAPE6937R42 Corynebacterium glutamicum strain ΔAPE6937 argF, argBfbr Increase NP yield n.a. Co-expression of argF and argBfbr NPC93081 Ornithine n.a. 17.3 ± 0.4 g/L n.a. PMID[26267114]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 2.3 mg/L n.a. PMID[28634125]
NPO41642 Corynebacterium glutamicum orn8 Corynebacterium glutamicum lysE Increase NP yield n.a. the insertion of a strong mutant Ptac promoter in the upstream region of lysE gene NPC93081 Ornithine n.a. 19 g/L n.a. PMID[29153651]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 185 mg/L n.a. PMID[29386648]
NPO41885 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae UGTPg45 Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 179.3 mg/L(in shake flasks); 2.25 g/L (in 10 L fed-batch fermentation) n.a. PMID[30652026]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 191.9 mg/L n.a. PMID[30684358]
NPO41723 Mucor circinelloides M65-TE-01 Mucor circinelloides M65 TE-01 Increase NP yield n.a. TE-01 over-expressing NPC93081 Ornithine 0.11 ± 0.04g/L 2.25 ± 0.05g/L n.a. PMID[30759801]
NPO41725 Mucor circinelloides M65-TE-03 Mucor circinelloides M65 TE-03 Increase NP yield n.a. TE-03 over-expressing NPC93081 Ornithine 0.11 ± 0.04g/L 2.58 ± 0.04g/L n.a. PMID[30759801]
NPO41726 Mucor circinelloides M65-TE-04 Mucor circinelloides M65 TE-04 Increase NP yield n.a. TE-04 over-expressing NPC93081 Ornithine 0.11 ± 0.04g/L 2.77 ± 0.02g/L n.a. PMID[30759801]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC93081 Ornithine n.a. 17 mg/L n.a. PMID[33195815]
NPO41597 Bacillus subtilis RF1-L3 Bacillus subtilis RF1 mCherry egfp zwf ribBA and ywlf Increase NP yield n.a. First, we tuned the expression of mCherry and egfp genes within operons by generating libraries of tunable intergenic regions (TIGRs) and confirmed the relative expression of the two reporter genes. Next, we used this strategy to tune the expression of zwf, ribBA, and ywlf genes within operons through the TIGR library. NPC93081 Ornithine n.a. 2.7 g/L in the shake flask and 11.77 g/L in fed-batch fermentation n.a. PMID[35467340]
NPO41718 Gluconobacter japonicus-Δga5dh-1-ga2dh-A Gluconobacter japonicus CGMCC 1.49 ga5dh-1 ga2dh-A Increase NP yield;reduce by-product component n.a. Knocking out the ga5dh-1 gene from a competitive pathway and overexpressing the ga2dh-A gene from the 2-KGA synthesis pathway via homologous recombination NPC38065 Orobol n.a. 2.99 g/L/h in a 15 L fermenter n.a. PMID[31384676]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC490932 oxidized derivative medicagenic acid n.a. 20.38 mg/L n.a. PMID[28634125]
NPO41643 Corynebacterium glutamicum orn9 Corynebacterium glutamicum ncgl2228 Increase NP yield n.a. the insertion of a transcription terminator upstream of ncgl2228 gene NPC490933 oxyCOR A n.a. 20.6 g/L n.a. PMID[29153651]
NPO41640 Corynebacterium glutamicum Orn10 Corynebacterium glutamicum proB Increase NP yield n.a. Insertion of a terminator in the upstream region proB NPC490934 oxygenated taxanes n.a. 20.8 g/L n.a. PMID[29153651]
NPO41995 A new engineered strain of Schizosaccharomyces pombe Schizosaccharomyces pombe TGL3, TGL4, TGL5 Increase NP yield n.a. Increased copy number of the overexpressed phospholipase NPC490935 P(3HB) n.a. 200.1 μg/ml of intracellular RA and 184.5 μg/ml of extracellular RA n.a. PMID[25109267]
NPO41992 A new engineered strain of Saccharomyces cerevisiae Y2805 Saccharomyces cerevisiae Y2805 tHMGR1, ispA Increase NP yield n.a. Overexpression of tHMG1, expression of ispA NPC490938 pamamycins n.a. 2011 ± 75 mg/L n.a. PMID[29396745]
NPO41740 Pichia pastoris strain co-expressing HPO and CPR Pichia pastoris n.a. Increase NP yield n.a. n.a. NPC20306 patchoulol n.a. 208 mg L−1 cell culture n.a. PMID[24747046]
NPO41920 A new engineered strain of Yarrowia Lipolytica ATCC 201249 Yarrowia Lipolytica ATCC 201249 n.a. Increase NP yield n.a. Then, we engineered the redox cofactor supply module by introducing NADPH- or NADH-generating enzymes and the acetyl-CoA generation module by directly overexpressing acetyl-CoA synthases or reinforcing the β-oxidation pathway NPC20306 patchoulol n.a. 204.89 ± 11.56 mg/L n.a. PMID[31053076]
NPO41945 A new engineered strain of Forsythia koreana Forsythia koreana PLR; CYP81Q1 Heterologous expression n.a. generated a transgenic cell line overexpressing an RNA interference (RNAi) construct of PLR (PLR-RNAi). down-regulation of PLR expression NPC115216 Pelargonidin 3-O-glucoside n.a. 20-fold pinoresinol n.a. PMID[19887541]
NPO41759 Saccharomyces cerevisiae GY-1 Saccharomyces cerevisiae BY4742 bAS, OAS, CPRs genes, PPDS, PPTS Increase NP yield n.a. n.a. NPC490517 Peonidin 3-O-glucoside n.a. 21.4 mg/L n.a. PMID[24424342]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs identification Microbial chassis engineering Introduction of exogenous phosphopantetheinyl transferases from Stigmatella aurantiaca for CP domain activation in standard recombineering host, E. coli GB2005 NPC294852 Eriodictyol n.a. n.a. n.a. PMID[22909174]
NPO41934 A new engineered strain of Escherichia coli Escherichia coli hpnC, hpnD, hpnE Biosynthesize NP n.a. Expression of hpnC, hpnD, and hpnE from Rhodopseudomonas palustris NPC294852 Eriodictyol n.a. n.a. n.a. PMID[26258173]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC294852 Eriodictyol n.a. n.a. n.a. PMID[27687863]
NPO41800 Streptomyces lavendulaeΔorfVI Streptomyces lavendulae CGMCC 4.1386 orfVI NP activation Metabolic engineering > reporter-guided strategies replacing orfVI gene with xylE NPC294852 Eriodictyol n.a. n.a. n.a. PMID[30417141]
NPO41801 Streptomyces lavendulaeΔstnN Streptomyces lavendulae CGMCC 4.1386 StnNE NP activation Metabolic engineering > reporter-guided strategies replacing StnN gene with xylE NPC294852 Eriodictyol n.a. n.a. n.a. PMID[30417141]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC219848 phenazine-1-carboxylic acid n.a. 214 mg/L n.a. PMID[33195815]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490622 final ursolic acid n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]
NPO41878 A new engineered strain of Pichia pastoris Pichia pastoris n.a. Increase NP yield n.a. n.a. NPC194724 piericidin A1 n.a. 23 mg/L n.a. PMID[30978503]
NPO41891 A new engineered strain of Saccharomyces cerevisiae BY-OA Saccharomyces cerevisiae BY-OA CaCYP716C49 Increase NP yield n.a. n.a. NPC243083 Pinocembrin n.a. 23 mg/L n.a. PMID[30339834]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. By first reconstructing the plant flavonoid biosynthetic pathway genes from five different species: phenylalanine ammonia lyase from Rhodotorula toruloides (PAL), 4-coumarate-coenzyme A ligase from Petroselinum crispum (4CL), chalcone synthase from Petunia hybrida (CHS), chalcone isomerase from Medicago sativa (CHI) and an oxidoreductase flavone synthase I from P. crispum (FNSI), production of the intermediates chrysin and apigenin was achieved by feeding phenylalanine and tyrosine as precursors NPC490491 PLH n.a. 23.6 mg/L n.a. PMID[30496827]
NPO41860 A new engineered strain of Escherichia coli Escherichia coli dxs, ispD, ispF, idi Heterologous biosynthesis; Increase NP yield n.a. Exploiting exogenous MEP pathway genes dxs, ispD, ispF, and idi from four bacteria Erwinia taxi, Streptomyces, avermitilis, Saccharopolyspora erythraea, and Bacillus subtilis to improve isoprenoid production. NPC31187 Polpunonic acid n.a. 232 mg/L n.a. DOI[10.1016/j.procbio.2014.10.022]
NPO41608 Corynebacterium crenatum Cc5 lysC30 Corynebacterium crenatum lysC Increase NP yield n.a. the attenuation of lysC gene by replacing the natural RBS with the sequence of synthetic RBS with strengths of 30 au NPC490966 poly-γ-glutamic acid n.a. 25.8 g/L n.a. PMID[27338253]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Efficient biotransformation n.a. n.a. NPC490567 prodigiosin n.a. 2580 mg/L n.a. DOI[10.1039/C8GC03728K]
NPO41679 Escherichia coli BL21 with introduced bglA Escherichia coli BL21 bglA Increase NP yield n.a. introduce a constructed plasmid harboring bglA obtained from Thermotoga maritima to Escherichia coli NPC490567 prodigiosin n.a. 26.2857 μg/mL n.a. PMID[34504963]
NPO41976 A new engineered strain of Saccharomyces cerevisiae BY4741 Saccharomyces cerevisiae BY4741 ERG9, POS5 Increase NP yield n.a. Overexpression of ERG9and tHMGR, insertion mutation in ERG1 NPC11433 Proline n.a. 270mg/L n.a. PMID[25788404]
NPO41655 Corynebacterium glutamicum SO4 Corynebacterium glutamicum cg3035 Increase NP yield n.a. Insertion of a strong Ptac promoter in the upstream region of cg3035 NPC11433 Proline n.a. 26.8 g/L n.a. PMID[26521658]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC11433 Proline n.a. 26.57 mg/L n.a. PMID[28634125]
NPO41623 Corynebacterium glutamicum 1006ΔargR Corynebacterium glutamicum argR Increase NP yield n.a. Removal of feedback repression of ArgR by deletion of argR NPC80530 Protopanaxadiol n.a. 28.3 g/L n.a. PMID[23725060]
NPO41752 Saccharomyces cerevisiae BD02 Saccharomyces cerevisiae n.a. Increase NP yield n.a. With our newly developed Di-CRISPR platform, we were able to attain highly efficient and markerless integration of large biochemical pathways and achieve an unprecedented 18-copy genomic integration of a 24 kb combined xylose utilization NPC80530 Protopanaxadiol n.a. 3.02 g/L n.a. PMID[26546089]
NPO41625 Corynebacterium glutamicum ALA7 Corynebacterium glutamicum rhtA Increase NP yield n.a. heterologous expression of rhtA gene from E. coli NPC80530 Protopanaxadiol n.a. 3.14 g/L n.a. PMID[26616115]
NPO41698 Escherichia coli slig-1 Escherichia coli rocGBs Increase NP yield n.a. By altering the number of slig, one rocGB conjoined with one leuDHBcopt to adequately supply NADH and NH4+ NPC80530 Protopanaxadiol n.a. 3.28mM n.a. PMID[35024478]
NPO41700 Escherichia coli slig-3 Escherichia coli rocGBs Increase NP yield n.a. By altering the number of slig, three rocGBs conjoined with one leuDHBcopt to adequately supply NADH and NH4+ NPC80530 Protopanaxadiol n.a. 3.01mM n.a. PMID[35024478]
NPO41756 Saccharomyces cerevisiae D20RG1 Saccharomyces cerevisiae ZW-PPD-B UGTPg29, UGTPg45 Increase NP yield n.a. Based on the two UGTs and a yeast chassis to produce PPD, yeast cell factories were built to produce Rh2 and/or Rg3 from glucose. NPC102253 protopanaxatriol n.a. 3.49 μmol/g DCW n.a. PMID[25769286]
NPO41827 Yarrowia lipolytica ST7403 Yarrowia lipolytica ST7023 crtW crtZ Increase NP yield n.a. optimizing the copy numbers of crtZ and crtW NPC308267 protopine n.a. 3.5 mg/g DCW (54.6 mg/L) n.a. PMID[29552653]
NPO41724 Mucor circinelloides M65-TE-02 Mucor circinelloides M65 TE-02 Increase NP yield n.a. TE-02 over-expressing NPC490974 Puromycin B 5.07 ± 0.11g/L 3.96 ± 0.07g/L n.a. PMID[30759801]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490975 Puromycin C 0.5 mg/L 30 mg/L;480 mg/L(in fed-batch fermentation) n.a. PMID[29077207]
NPO41919 A new engineered strain of Yarrowia Lipolytica ATCC 201249 Yarrowia Lipolytica ATCC 201249 XR, XDH, yIXKS Increase NP yield n.a. introducing xylose reductase (XR) and xylitol dehydrogenase (XDH) from Scheffersomyces stipitis, overexpressing endogenous xylulose kinase (ylXKS) and heterologous PPD synthetic modules NPC490976 pyomelanin n.a. 300.63 mg/L n.a. PMID[31103047]
NPO41820 Yarrowia Lipolytica JMY3479 Yarrowia Lipolytica W29 pox1–6, dga1, dga2, are1, lro1, YlFAD2, coPAI Increase NP yield n.a. the elimination of β-oxidation genes (pox1–6Δ), the inability to store lipids as triglycerides (dga1Δ, dga2Δ, are1Δ, lro1Δ) and the overexpression of the native Δ12-desaturase gene (YlFAD2). Additionally, coPAI gene was expressed. NPC242399 pyridinopyrone A n.a. 302mg/L n.a. PMID[28357546]
NPO41988 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 n.a. Increase NP yield n.a. Overexpression of squalene biosynthetic pathway using a library of 13 new constitutive promoters, supplementation of terbinafine NPC89025 Pyruvate n.a. 304.16 mg/L n.a. DOI[10.1016/j.ces.2016.06.004]
NPO41987 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 tHMG1, IDI1, ERG20, ERG9, ERG10, ERG13, ERG12, ERG8, MVD1 Increase NP yield n.a. Overexpression of tHMG1, IDI1, ERG20, ERG9, ERG10 (encoding acetyl-CoA C-acetyltransferase), ERG13 (HMG-CoA synthase), ERG12 (mevalonate kinase), ERG8 (phosphomevalonate kinase), and MVD1 (diphosphomevalonate decarboxylase) NPC20791 Quercetin n.a. 304.49 mg/L n.a. DOI[10.1016/j.ces.2016.06.014]
NPO41823 Yarrowia lipolytica ST5204 Yarrowia lipolytica ST3683 crtYB crtI Increase NP yield n.a. introducing crtYB and crtI genes to Y. lipolytica for b-carotene biosynthesis; ST3683 - XdcrtI↑-XdcrtYB↑ NPC20791 Quercetin n.a. 31.1 ± 0.5 mg/L n.a. PMID[29552653]
NPO41621 Corynebacterium glutamicum 1006△argR-argJ Corynebacterium glutamicum argJ Increase NP yield n.a. Overexpression of argJ NPC162791 Rebaudioside A n.a. 31.6 g/L n.a. PMID[26521658]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Heterologous biosynthesis; Increase NP yield Transporter engineering. Modules standardization; Codon optimization; N terminus truncation and substitation; and KAH replacement. NPC104170 Resokaempferol n.a. 32 mg/L n.a. PMID[23864262]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC161571 resveratrol n.a. 33.1+/-5.6mg/l n.a. PMID[18485776]
NPO41977 A new engineered strain of Saccharomyces cerevisiae BY4741 Saccharomyces cerevisiae BY4741 tHMG1, POS5 Increase NP yield n.a. Overexpression of tHMG1 and POS5 without mitochondrial presequence NPC161571 Resveratrol n.a. 33.0 ± 2.96mg/g DCW; 46.0 ± 4.08mg/L n.a. PMID[28845666]
NPO41651 Corynebacterium glutamicum SO17 Corynebacterium glutamicum mscCG2 Increase NP yield n.a. the deletion of mscCG2 gene NPC161571 resveratrol n.a. 32.7 g/L n.a. PMID[30939382]
NPO41652 Corynebacterium glutamicum SO18 Corynebacterium glutamicum gdh2 Increase NP yield n.a. the insertion of a strong Peftu promoter in the upstream region of gdh2 gene NPC490981 retinoids n.a. 33.7 g/L n.a. PMID[30939382]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Green production n.a. overexpressing seven heterologous enzymes and five native enzymes and the strain YC1053 overexpressing seven heterologous enzymes and four native enzymes NPC490983 rhizomide A n.a. 336.8 mg/L n.a. PMID[32004707]
NPO41641 Corynebacterium glutamicum ORN11 Corynebacterium glutamicum gdh Increase NP yield n.a. the insertion of a strong Peftu promoter in the upstream region of gdh gene; NPC490986 rhizoxins n.a. 34.1 g/L n.a. PMID[29153651]
NPO41620 Corynebacterium crenatum SYPA-lysE Corynebacterium crenatum lysE Increase NP yield n.a. the overexpression of lysE gene NPC94167 riboflavin n.a. 35.9 g/L n.a. PMID[23559017]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC94167 Riboflavin n.a. 34.7 mg/L n.a. PMID[26488898]
NPO41838 A new engineered strain of Corynebacterium glutamicum Corynebacterium glutamicum n.a. Construct NP producting platform strain n.a. four gene clusters comprising 21 genes involved in the catabolism of aromatic compounds were deleted; Expression of plant-derived and codon-optimized genes coding for a chalcone synthase (CHS) and a chalcone isomerase (CHI) NPC94167 riboflavin n.a. 35 mg/L n.a. PMID[27288926]
NPO41645 Corynebacterium glutamicum PHE243 Corynebacterium glutamicum R aroG aroCKB ubiC hdpA pyk Increase NP yield Metabolic engineering > Transporter engineering strategies Multiple chromosomal integrations of a mutated aroG gene from Escherichia coli, encoding a 3-deoxy-d-arabinoheptulosonic acid 7-phosphate (DAHP) synthase, and wild-type aroCKB from C. glutamicum, encoding chorismate synthase, shikimate kinase, and 3-dehydroquinate synthase, were effective in increasing product titers. The last step of the 4-HBA biosynthesis pathway was recreated in C. glutamicum by expressing a highly 4-HBA-resistant chorismate pyruvate-lyase (UbiC) from the intestinal bacterium Providencia rustigianii. To enhance the yield of 4-HBA, we reduced the formation of by-products, such as 1,3-dihydroxyacetone and pyruvate, by deleting hdpA, a gene coding for a haloacid dehalogenase superfamily phosphatase, and pyk, a gene coding for a pyruvate kinase, from the bacterial chromosome. NPC94167 Riboflavin n.a. 36.6 g/liter n.a. PMID[29305513]
NPO41826 Yarrowia lipolytica ST6075 Yarrowia lipolytica 5999 crtW crtZ Increase NP yield n.a. introduced b-carotene ketolase (crtW) from Paracoccus sp. N81106 and hydroxylase (crtZ) from Pantoea ananatis to convert b-carotene into astaxanthin; XdcrtI↑-XdcrtYB↑, PscrtW↑-PacrtZ↑ & XdcrtI↑-XdcrtYB↑, loop-out hphMX (parent strain: ST5204) NPC94167 riboflavin n.a. 35.3 ± 1.8 mg/L n.a. PMID[29552653]
NPO41940 A new engineered strain of Escherichia coli BL21(DE3) Escherichia coli BL21(DE3) hopA, hopB, hopD Increase NP yield n.a. Expression of hopA and hopB (squalene/phytoene synthases) together with hopD (farnesyl diphosphate synthase) from Streptomyces peucetius NPC94060 Roseoflavin n.a. 4.1mg/L n.a. PMID[19767465]
NPO41942 A new engineered strain of Escherichia coli XL1-Blue Escherichia coli XL1-Blue hSQS Increase NP yield n.a. Expression of human SQS (hSQS) NPC94060 Roseoflavin n.a. 4.2 mg/L n.a. PMID[25282635]
NPO41896 A new engineered strain of Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae INVSc1 CbβAS Increase NP yield n.a. Cloned and characterized CbβAS, a β‐amyrin synthase that catalyzes the cyclization of oxidosqualene in the biosynthesis of conyzasaponins. Ectopic expression of CbβAS in INVSc1 yeast successfully yielded β‐amyrin. NPC246165 sabinene n.a. 4.432 mg/L n.a. PMID[28979844]
NPO41760 Saccharomyces cerevisiae INVSc1 Saccharomyces cerevisiae n.a. Increase NP yield n.a. Domergue et al., constructed a S. cerevisiae INVSc1 strain carrying Δ5-desaturase from P. tricornutum, Δ6-elongase from Physcomitrella patens and Δ6-desaturase from Ostreococcus tauri NPC46451 sanguinarine n.a. 4.5% of TFA n.a. PMID[15769252]
NPO41817 Synechococcus elongatus PCC 7942 Synechococcus elongatus n.a. Increase NP yield n.a. n.a. NPC490522 sapogenins n.a. 4.6 ± 0.4 mg/L in 7 days n.a. PMID[29068210]
NPO41817 Synechococcus elongatus PCC 7942 Synechococcus elongatus n.a. Increase NP yield n.a. n.a. NPC490504 saponins n.a. 4.6 ± 0.4 mg/L in 7 days n.a. PMID[29068210]
NPO42003 A new engineered strain of Synechococcuselongatus PCC 7942 Synechococcuselongatus PCC 7942 dxs, idi Increase NP yield n.a. Overexpression of dxs and idi, expression of ispA from E. coli NPC88454 sclareol n.a. 4.98 ± 0.90 /OD730 n.a. PMID[27688805]
NPO41614 Corynebacterium crenatum Cc-QF-4 Corynebacterium crenatum argF, argA, argE Increase NP yield n.a. Deletion of argF; the heterologous expression of argA from E. coli and argE from Serratia marcescens NPC88454 sclareol n.a. 40.4 g/L n.a. PMID[29728854]
NPO41839 A new engineered strain of Corynebacterium glutamicum Corynebacterium glutamicum ANS, 3GT Increase NP yield n.a. Anthocyanidin synthase (ANS) from Petunia hybrida and 3-O-glucosyltransferase (3GT) from Arabidopsis thaliana were coexpressed in C. glutamicum ATCC 13032; Optimized expression of ANS and 3GT NPC88454 sclareol n.a. 40 mg/L n.a. PMID[30217197]
NPO41990 A new engineered strain of Saccharomyces cerevisiae SR7 Saccharomyces cerevisiae SR7 tHMGR1, ERG10 Increase NP yield n.a. Overexpression of tHMG1, expression of ispA NPC130230 Scutellarein n.a. 400 ± 45 mg/L n.a. PMID[29396745]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC43211 Scutellarin n.a. 400mg/L n.a. PMID[23727191]
NPO41696 Escherichia coli POP8(BUT003&BUT004) Escherichia coli 8739 n.a. Increase NP yield n.a. but003: 8739 harboring pT-DEBA, pPLS; BUT004: F0602 harboring pATTCH(zu), pTCH NPC490992 sesquiterpene germacrene A n.a. 41.61 g/L n.a. PMID[34824227]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. UGTPgs characterization; Structural modeling; Protein chimeric. NPC331737 sesquiterpenes n.a. 42 mg/L n.a. PMID[26032089]
NPO41774 Saccharomyces cerevisiae ZW-F1-17 Saccharomyces cerevisiae ZW-PPD-B UGTPg1, UGTPg100, UGTPg101 Increase NP yield n.a. we constructed yeast recombinants to biosynthesize F1 and Rh1 by introducing the genetically engineered PPT-producing pathway and UGTPg1 or UGTPg100. NPC490993 sesquiterpenoid artemisinic acid n.a. 42.1 mg/L n.a. PMID[26032089]
NPO41617 Corynebacterium crenatum pJCtac-argJ Corynebacterium crenatum argJ Increase NP yield n.a. Insertion of a strong Ptac promoter in the upstream region of argJ NPC490995 Silybin and isosilybin n.a. 42.4 g/L n.a. PMID[21785983]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. Increase NP yield n.a. n.a. NPC98386 soyasapogenol B n.a. 48.1 mg/L n.a. PMID[30695641]
NPO41856 A new engineered strain of Escherichia coli Escherichia coli Scpr Increase NP yield n.a. harbors a fusion gene composed of CYP57B3 from Aspergillus oryzae and a cytochrome P450 oxidoreductase gene (sCPR) from Saccharomyces cerevisiae NPC490999 spinosad n.a. 48.61 mg/L n.a. PMID[26699751]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP de novo biosynthesis n.a. n.a. NPC490999 spinosad n.a. 5.31 mg/L n.a. PMID[28634125]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo biosynthesis n.a. n.a. NPC490999 spinosad n.a. 484 mg/L n.a. PMID[33195815]
NPO41989 A new engineered strain of Saccharomyces cerevisiae SHY3 Saccharomyces cerevisiae SHY3 n.a. Increase NP yield n.a. Disruption of a gene involved in the conversion of squalene to ergosterol by homologous recombination NPC490999 Spinosad n.a. 5 mg/g DCW n.a. PMID[7765777]
NPO41821 Yarrowia lipolytica MTLY40-2P Yarrowia lipolytica POX2-5, POX2 Increase NP yield n.a. disrupting some and upregulating other POX genes (POX2-5 gene disruption and POX2 overexpression). NPC123965 Squalene n.a. 7 g/L n.a. DOI[10.1016/j.procbio.2015.05.019]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. NP biosynthesis n.a. We next introduced 11 heterologous genes and modified 12 native yeast genes to construct a yeast strain capable of producing 8-prenylkaempferol with high efficiency; relocating GmOMT2 into mitochondria (higher pH than cytoplasm) of the 8-prenylkaempferol–producing yeast strain NPC123965 Squalene n.a. 7.2 mg/L n.a. DOI[10.1016/j.scib.2021.03.002]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. Firstly, we synthesized or cloned the genes encoding dammarenediol-II synthase (DS), PgUGT74AE2 and UGTPg1 from P. ginseng. Furthermore, the anti-colon cancer activities of both 3β-O-Glc-DM and 20S-O-Glc-DM were demonstrated by in vitro and in vivo assays. we engineered S. cerevisiae by introducing the codon-optimized genes encoding DS together with PgUGT74AE2 or UGTPg1. The engineered strains were optimized to increase the production of DM glucosides by integrating multi-copy DS and UGT genes into yeast via the CRISPR/Cas9 system, overexpressing several key enzymes of the upstream biosynthetic pathway, down-regulating the competitive branch pathway and overexpressing the transcriptional activator HAC1. NPC123965 Squalene n.a. 5.6 g/L n.a. DOI[10.1039/C8GC04066D]
NPO41933 A new engineered strain of Corynebacterium glutamicum Corynebacterium glutamicum PcPS Novel NPs activation n.a. (i) construction of a farnesyl pyrophosphate-producing platform strain by combining genomic deletions with heterologous expression of ispA from Escherichia coli; (ii) prevention of carotenoid-like byproduct formation; (iii) overproduction of limiting enzymes from the 2-c-methyl-d-erythritol 4-phosphate (MEP)-pathway to increase precursor supply; and (iv) heterologous expression of the plant patchoulol synthase gene PcPS from Pogostemon cablin. NPC123965 Squalene n.a. 60 mg/L; 18 mg L-1 d-1 n.a. DOI[10.3390/genes9040219]
NPO42005 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica acs, ylACL1, ylHGM1 Increase NP yield n.a. Overexpression of acs (from Salmonella enterica), ylACL1 (encodes acetyl-CoA synthase), and ylHMG1, addition of 20 mM sodium acetate NPC123965 Squalene n.a. 7 mg/g DCW n.a. PMID[29986837]
NPO41720 Lactococcus lactis FS1076 (MG1363 Δ3 ldh Δpta ΔadhE Δals) Lactococcus lactis als Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 54.6 g/L n.a. PMID[33490054]
NPO41984 A new engineered strain of Saccharomyces cerevisiae H1246 Saccharomyces cerevisiae H1246 coPAI Increase NP yield n.a. expressed the codon-optimized coPAI gene in S. cerevisiae NPC123965 Squalene n.a. 5.7% of 10,12-CLA of total FFA n.a. PMID[16324883]
NPO41949 A new engineered strain of Nicotiana benthamiana Nicotiana benthamiana n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 60 ng.g(-1) FW n.a. PMID[21858047]
NPO41672 Engineered Escherichia coli strain YJM28 Escherichia coli n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 5.44 mg/L; 0.97 g/L n.a. PMID[23631625]
NPO42009 A new engineered strain of Yarrowia Lipolytica JMY2556 Yarrowia Lipolytica JMY2556 POX1-6, Δ12-desaturase,RcFAH12, CpFAH12, LRO1 Increase NP yield n.a. 1) deleting POX1-6 genes; 2)native Δ12- desaturase was removed; 3) introducing the Δ12- hydroxylase gene (RcFAH12) from R. communis; 4) Expressing the hydroxylase gene (CpFAH12) from C. purpurea and co-expressing an additional copy of CpFAH12; 5) overexpressing the native Y. lipolytica PDAT acyltransferase (LRO1) NPC123965 Squalene n.a. 63 mg/g of DCW n.a. PMID[24136468]
NPO41943 A new engineered strain of Escherichia coli XL1-Blue Escherichia coli XL1-Blue hSQS, tHMGR, EGR13, EGR12, EGR8, MVD1, atoB, ispA Increase NP yield n.a. Co-expression of hSQS, chimeric mevalonate pathway containing tHMGR, ERG13 (hydroxymethylglutaryl-CoA synthase), ERG12 (mevalonate kinase), ERG8 (phosphomevalonate kinase) and MVD1 (mevalonate diphosphate decarboxylase) from S. cerevisiae, overexpression of atoB (acetyl-CoA acetyltransferase), idi (isoprenyl diphosphate isomerise) and ispA (farnesyl diphosphate synthase) NPC123965 Squalene n.a. 54mg/g DCW; 230mg/L n.a. PMID[25282635]
NPO41944 A new engineered strain of Escherichia coli XL1-Blue Escherichia coli XL1-Blue tSQS, tHMGR, tHMGR, ERG13, ERG12, ERG8, MVD1, atoB, idi, ispA Increase NP yield n.a. Co-expression of Thermosynechococcus elongatus SQS (tSQS), chimeric mevalonate pathway containing tHMGR, ERG13, ERG12, ERG8, and MVD1 from S. cerevisiae, overexpression of atoB, idi, and ispA NPC123965 Squalene n.a. 55 mg/g DCW; 150mg/L n.a. PMID[25282635]
NPO41632 Corynebacterium glutamicum CIT2 Corynebacterium glutamicum argR, argG Increase NP yield n.a. Deletion of argR and argG NPC123965 Squalene n.a. 5.43 g/L n.a. PMID[25492493]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. Heterologous biosynthesis; Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 59 mg/L n.a. PMID[26062534]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC123965 Squalene n.a. 62.7 mg/L n.a. PMID[26488898]
NPO41615 Corynebacterium crenatum H-7 GH Corynebacterium crenatum argGH Increase NP yield n.a. Overexpression of argGH operon NPC123965 Squalene n.a. 67.92 g/L n.a. PMID[26521658]
NPO41606 Corynebacterium crenatum Cc1 Corynebacterium crenatum argGH, argCJBDFR, argR Increase NP yield n.a. Insertion of a strong Peftu promoter in the upstream region of argGH and argCJBDFR operons; the inactivation of argR NPC123965 Squalene n.a. 53.2 g/L n.a. PMID[27338253]
NPO41607 Corynebacterium crenatum Cc4 Corynebacterium crenatum pyc, gltA Increase NP yield n.a. replacing the start codon GTG of pyc gene with ATG; implementing an additional copy of gltA gene on chromosome NPC123965 Squalene n.a. 68.6 g/L n.a. PMID[27338253]
NPO41635 Corynebacterium glutamicum GABA6C Corynebacterium glutamicum yggB, cgmA Increase NP yield n.a. the deletion of yggB and cgmA genes NPC123965 Squalene n.a. 63.2 g/L n.a. PMID[27800627]
NPO41619 Corynebacterium crenatum SYPA-argBEH3 Corynebacterium crenatum n.a. Increase NP yield n.a. Removal of feedback inhibition through site-directed mutagenesis of ArgB NPC123965 Squalene n.a. 61.2 g/L n.a. PMID[28005186]
NPO41855 A new engineered strain of Escherichia coli Escherichia coli PhANS, At3GT Increase NP yield n.a. Anthocyanin O-methyltransferase (AOMT) orthologs from various plant sources were co-expressed in Escherichia coli with Petunia hybrida anthocyanidin synthase (PhANS) and Arabidopsis thaliana anthocyanidin 3-O-glucosyltransferase (At3GT) NPC123965 Squalene n.a. 56.3 mg/L n.a. PMID[28095853]
NPO41627 Corynebacterium glutamicum ARG (glnA–aspA–gdh) Corynebacterium glutamicum glnA, aspA, gdh Increase NP yield n.a. the co-expression of glnA, aspA and gdh genes NPC123965 Squalene n.a. 53.2 g/L n.a. PMID[28120129]
NPO42002 A new engineered strain of Synechococcus elongatus PCC 7942 Synechococcus elongatus PCC 7942 CpcB1-SQS Increase NP yield n.a. Expression of CpcB1-SQS protein NPC123965 Squalene n.a. 7.16 ± 0.05/OD730 n.a. PMID[28365988]
NPO41990 A new engineered strain of Saccharomyces cerevisiae SR7 Saccharomyces cerevisiae SR7 tHMGR1, ERG10 Increase NP yield n.a. Co-expression oftHMG1 and ERG10 gene in xylose-rich medium NPC123965 Squalene n.a. 532mg/L n.a. PMID[28667762]
NPO42006 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica codon-optimized linalool synthase gene Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 6.96±0.29mg/L n.a. PMID[28684180]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. Novel NPs activation n.a. n.a. NPC123965 Squalene n.a. 6.5 g/L; 90 mg/g DCW n.a. PMID[28986998]
NPO41633 Corynebacterium glutamicum CO9 Corynebacterium glutamicum argF Increase NP yield n.a. Insertion of a T4 terminator in the upstream region argF NPC123965 Squalene n.a. 6.1 g/L n.a. PMID[29478233]
NPO41826 Yarrowia lipolytica ST6075 Yarrowia lipolytica 5999 crtW crtZ Increase NP yield n.a. introduced b-carotene ketolase (crtW) from Paracoccus sp. N81106 and hydroxylase (crtZ) from Pantoea ananatis to convert b-carotene into astaxanthin; XdcrtI↑-XdcrtYB↑, PscrtW↑-PacrtZ↑ & XdcrtI↑-XdcrtYB↑, loop-out hphMX (parent strain: ST5204) NPC123965 Squalene n.a. 5.7 ± 0.5 mg/L n.a. PMID[29552653]
NPO41637 Corynebacterium glutamicum JML05 Corynebacterium glutamicum n.a. Increase NP yield n.a. Removal of feedback repression of ArgR and FarR NPC123965 Squalene n.a. 51.96 g/L n.a. PMID[30446890]
NPO41638 Corynebacterium glutamicum JML06 Corynebacterium glutamicum n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 52.7 g/L n.a. PMID[30446890]
NPO41885 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae UGTPg45 Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 529.0 mg/L(in shake flasks); 11.02 g/L(in 10 L fed-batch fermentation) n.a. PMID[30652026]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 54.2 mg/L n.a. PMID[30695641]
NPO41723 Mucor circinelloides M65-TE-01 Mucor circinelloides M65 TE-01 Increase NP yield n.a. TE-01 over-expressing NPC123965 Squalene 5.07 ± 0.11g/L 7.40 ± 0.09g/L n.a. PMID[30759801]
NPO41725 Mucor circinelloides M65-TE-03 Mucor circinelloides M65 TE-03 Increase NP yield n.a. TE-03 over-expressing NPC123965 Squalene 5.07 ± 0.11g/L 6.57 ± 0.04g/L n.a. PMID[30759801]
NPO41726 Mucor circinelloides M65-TE-04 Mucor circinelloides M65 TE-04 Increase NP yield n.a. TE-04 over-expressing NPC123965 Squalene 5.07 ± 0.11g/L 5.96 ± 0.73g/L n.a. PMID[30759801]
NPO41755 Saccharomyces cerevisiae CLy12a-ATF1-ACS2-CAB2 Saccharomyces cerevisiae CLy12a ATF1 ACS2 CAB2 Increase NP yield Genetic engineering The genes encoding phosphopantothenate-cysteine ligase, acetyl-CoA synthetase, and alcohol acetyltransferase were overexpressed by inserting the strong promoter PGK1p and the terminator PGK1t before and after the relevant metabolic genes, respectively, and then combine them NPC123965 Squalene n.a. 610.26 (± 14.28) mg/L n.a. PMID[30810845]
NPO41918 A new engineered strain of Yarrowia Lipolytica ATCC 201249 Yarrowia Lipolytica ATCC 201249 CYPs, CPRs, ERG1, ERG9, and HMG1 Increase NP yield n.a. First, by screening 25 combinations of cytochrome P450 monooxygenases (CYPs) and NADPH-cytochrome P450 reductases (CPRs), each of which originated from 5 different sources, we selected two optimal betulinic acid-producing strains. Then, ERG1, ERG9, and HMG1 in the MVA module were overexpressed in the two strains NPC123965 Squalene n.a. 51.87 ± 2.77 mg/L n.a. PMID[31053076]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 648.63 mg/L n.a. PMID[31690080]
NPO41665 Corynebacterium glutamicum ZQJY-7 Corynebacterium glutamicum n.a. Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 6.59 g/L n.a. PMID[32627539]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo biosynthesis n.a. n.a. NPC123965 Squalene n.a. 588 mg/L n.a. PMID[32830192]
NPO41857 A new engineered strain of Escherichia coli Escherichia coli aroGfbr, tyrAfbr, tyrR Increase NP yield n.a. The tyrosine synthesis pathway was enhanced by overexpressing feedback inhibition-resistant genes (aroGfbr and tyrAfbr) and knocking out a repressor gene (tyrR). NPC123965 Squalene n.a. 523.7 mg/L n.a. PMID[34052445]
NPO41921 A new engineered strain of Zymomonas mobilis Zymomonas mobilis XDH gene xylose reductase gene Increase NP yield n.a. The expression of XDH gene from Paraburkholderia xenovorans; deletion of the xylose reductase gene NPC123965 Squalene n.a. 56.44 ± 1.93 g/L(from 54.27 ± 0.26 g /Lxylose) in a bioreactor; 11.13g/L(from 10 g /Lxylose) with sugarcane bagasse hydrolysate as a cheap feedstock n.a. PMID[34202822]
NPO41915 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica CLA4 MHY1 Increase NP yield Microbial chassis engineering the strains were morphologically engineered by deleting CLA4 and MHY1 genes to convert the mycelium back to the yeast form, which further increased the β-carotene production by 139%. NPC123965 squalene n.a. 7.6 g/L and 159 mg/g DCW n.a. PMID[34762415]
NPO41994 A new engineered strain of Saccharomyces cerevisiae YUG37 Saccharomyces cerevisiae YUG37 ERG1 Increase NP yield n.a. Regulation of ERG1 expression by promoter tet0 7 -CYC1 NPC239720 streptothricin F n.a. 7.85 ± 0.25 mg/g DCW n.a. PMID[25298782]
NPO41713 Escherichia coli UR6 Escherichia coli W3110 genes in the pyrimidine operon(Ptrc-pyrB pyrC pyrAA pyrAB pyrK pyrD pyrF pyrE); genes involved in uridine catabolism (udk udp rihA rihB rihC) Increase NP yield Metabolic Engineering Eight genes of B. subtilis pyr operon was introduced into chromosome of W3110; ive genes involved in uridine catabolism were knocked out NPC234392 stylopine n.a. 70.3 g/L n.a. PMID[30189293]
NPO41636 Corynebacterium glutamicum GDK-9△ldhA Corynebacterium glutamicum ldhA Increase NP yield n.a. the deletion of ldhA gene NPC236709 succinic acid n.a. 70.4 g/L n.a. PMID[25763057]
NPO41916 A new engineered strain of Yarrowia lipolytica Yarrowia lipolytica n.a. Increase NP yield n.a. n.a. NPC236709 Succinic Acid n.a. 71.2 mg/L n.a. PMID[30695641]
NPO41694 Escherichia coli p15/AQ10 Escherichia coli BaCD Increase NP yield Metabolic engineering > Modular pathway engineering over-expressing l-amino acid α-ligase (BacD) from Bacillus subtilis, and inactivating the peptidases PepA, PepB, PepD, and PepN, as well as the dipeptide transport system Dpp. NPC227051 surfactin n.a. 71.7 mM AQ with a productivity of 3.98 mM/h n.a. PMID[32527330]
NPO41745 Ralstonia eutropha NCIMB11599 Ralstonia eutropha sacC Increase NP yield n.a. constructed a sucrose utilization pathway in Ralstonia eutropha NCIMB11599 and R. eutropha 437–540 by introducing the Mannheimia succiniciproducens MBEL55E sacC gene that encodes β-fructofuranosidase NPC490577 syringolin G n.a. 73.2 wt% n.a. PMID[25258020]
NPO41745 Ralstonia eutropha NCIMB11599 Ralstonia eutropha sacC Increase NP yield n.a. constructed a sucrose utilization pathway in Ralstonia eutropha NCIMB11599 and R. eutropha 437–540 by introducing the Mannheimia succiniciproducens MBEL55E sacC gene that encodes β-fructofuranosidase NPC490575 syringolin H n.a. 73.2 wt% n.a. PMID[25258020]
NPO41758 Saccharomyces cerevisiae EG60 derived haploid strain Saccharomyces cerevisiae six deletions (rox1, dos2, yer134c, vba5, ynr063w and ygr259c) Increase NP yield n.a. n.a. NPC491003 TAL(as well as its precursor) n.a. 750 mg/L n.a. PMID[25903744]
NPO41629 Corynebacterium glutamicum Cc5-800 Corynebacterium glutamicum icd, gdh, odhA Increase NP yield n.a. the overexpression of icd and gdh genes; the attenuation of odhA by replacing the natural RBS of odhA gene with the sequence of synthetic RBS with strengths of 800 au NPC281398 Tanshinone IIA n.a. 76.8 g/L n.a. PMID[27338253]
NPO41978 A new engineered strain of Saccharomyces cerevisiae BY4742 Saccharomyces cerevisiae BY4742 tHMGRr, upc2.1 Increase NP yield n.a. Overexpression of tHMGR and upc2.1 (a mutated regulatory factor that induces sterol biosynthetic gene) NPC490496 taxa-4(5),11(12)-diene n.a. 78mg/L n.a. PMID[22566191]
NPO41901 A new engineered strain of Saccharomyces cerevisiae W303-1a Saccharomyces cerevisiae W303-1a ERG1, ERG7, ERG9, ERG20 Increase NP yield n.a. 1) Combinatorially overexpressing every gene in MVA pathway and optimizing metabolic balance in triterpene biosynthesis module; 2) In sterol biosynthesis module, fine-tuning lanosterol synthase gene (ERG7) expression using TetR–TetO gene regulation system; 3) increasing cytoplasmic acetyl-CoA supply by overexpressing a Salmonella ACS (acetyl-CoA synthetase gene) mutant ACSseL641P NPC490496 taxadiene n.a. 8.09 g/L n.a. DOI[10.1002/aic.16502]
NPO41622 Corynebacterium glutamicum 1006ΔargR Corynebacterium glutamicum argJ Increase NP yield n.a. Overexpression of argJ NPC490496 taxadiene n.a. 8.51 g/L n.a. PMID[25492493]
NPO41851 A new engineered strain of Escherichia coli Escherichia coli gene encoding dammarenediol-II synthase Novel NPs activation n.a. n.a. NPC490496 taxadiene n.a. 8.63 mg l(-1) n.a. PMID[26739962]
NPO41862 A new engineered strain of Escherichia coli BL21(DE3) Escherichia coli BL21(DE3) SS, SE, CPR, McSE, AtCPR, Increase NP yield n.a. dammarenediol-II biosynthetic pathway was reconstituted in E. coli by co-expression of squalene synthase (SS), squalene epoxidase (SE), NADPH-cytochrome P450 reductase (CPR) from Saccharomyces cerevisiae, and SE from Methylococcus capsulatus (McSE), NADPH-cytochrome P450 reductase (CPR) from Arabidopsis thaliana. NPC490496 taxadiene n.a. 8.63 mg/L n.a. PMID[26739962]
NPO41825 Yarrowia lipolytica ST6057 Yarrowia lipolytica ST5404 SQS1 Increase NP yield n.a. tHMG1↑-GGS1↑, XdcrtI↑-XdcrtYB↑, URA3-PSQS1_50bp:SQS1 NPC490496 taxadiene n.a. 797.1 ± 57.2 n.a. PMID[29552653]
NPO41663 Corynebacterium glutamicum ZQJY-6 Corynebacterium glutamicum avtA Increase NP yield n.a. the deletion of avtA gene NPC490496 taxadiene n.a. 8.01 g/L n.a. PMID[32627539]
NPO41837 A new engineered strain of Corynebacterium glutamicum Corynebacterium glutamicum hom, lysC, pys Increase NP yield n.a. Genomic introduction of three point mutations in the relevant genes encoding the homoserine dehydrogenase gene (hom), aspartokinase gene (lysC), and pyruvate carboxylase (pyc) NPC246162 Taxifolin n.a. 80 g/L n.a. PMID[11876415]
NPO41671 Engineered Escherichia coli strain Escherichia coli GPP; sabinene synthase genes Increase NP yield n.a. n.a. NPC246162 Taxifolin n.a. 82.18 mg/L n.a. PMID[24512040]
NPO41588 Another Engineered Escherichia coli strain Engineered Escherichia coli strain n.a. Increase NP yield n.a. n.a. NPC246162 Taxifolin n.a. 8.74g/L n.a. PMID[28672185]
NPO41976 A new engineered strain of Saccharomyces cerevisiae BY4741 Saccharomyces cerevisiae BY4741 ERG9, POS5 Increase NP yield n.a. Overexpression of ERG9 and POS5 without mitochondrial presequence NPC208553 Taxol n.a. 85mg/L n.a. PMID[25788404]
NPO41850 A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC208553 Taxol n.a. 88 mg/L n.a. PMID[33195815]
NPO41898 A new engineered strain of Saccharomyces cerevisiae INVSx1 Saccharomyces cerevisiae INVSx1 UGT109A1, DS, PDDS, ATR1 Increase NP yield n.a. 1) we constructed metabolically engineered yeasts to produce 3β,12β-Di-O-Glc-PPD by introducing the genes encoding B. subtilis UGT109A1, Panax ginseng dammarenediol-II synthase (DS), P. ginseng cytochrome P450-type protopanaxadiol synthase (PPDS) together with Arabidopsis thaliana NADPH-cytochrome P450 reductase (ATR1) into Saccharomyces cerevisiae INVSc1; 2) overexpressing tHMG1 NPC491005 Teicoplanin n.a. 9.05 mg/L n.a. PMID[28778764]
NPO41658 Corynebacterium glutamicum Sorn2 Corynebacterium glutamicum n.a. Increase NP yield n.a. n.a. NPC180756 thebaine n.a. 9.8 g/L n.a. PMID[28938890]
NPO41883 A new engineered strain of Saccharomyces cerevisiae Saccharomyces cerevisiae n.a. Heterologous biosynthesis; Increase NP yield n.a. Yeast chromosomes integration; Cell factories establishment. NPC233950 thiolactomycin n.a. 92 mg/L n.a. PMID[26032089]
NPO41628 Corynebacterium glutamicum C1* strain Corynebacterium glutamicum anmt Heterologous expression n.a. n.a. NPC491008 total lipids n.a. final titer of 0.5 g/L; volumetric productivity of 0.01 g·L-1·h-1; yield of 4.8 mg·g-1 glucose n.a. PMID[32521697]
NPO41775 Saccharomyces cerevisiae ZW-Rh1-20 Saccharomyces cerevisiae ZW-PPD-B UGTPg1, UGTPg100, UGTPg101 Increase NP yield n.a. we constructed yeast recombinants to biosynthesize F1 and Rh1 by introducing the genetically engineered PPT-producing pathway and UGTPg1 or UGTPg100. NPC491008 total lipids n.a. 92.8 mg/L n.a. PMID[26032089]
NPO41721 Mannheimia succiniciproducens PALK (pMS3-pelB-cti) Mannheimia succiniciproducens PALK CTI PelB Increase NP yield n.a. PALK harboring pMS3-pelB-cti NPC491008 total lipids n.a. 97.10g/L n.a. PMID[29380151]
NPO41872 A new engineered strain of Escherichia coli Escherichia coli the PHA synthetase PhaCHb Increase NP yield; reduce production cost n.a. The PHA synthetase PhaCHb in the genome of H. bluephagenesis was knocked out by CRISPR/Cas 9 and complementarily expressed as the TyrVs-PhaCHb fusion protein to facilitate the synthesis of TyrVs-decorated PHA nanogranules in vivo NPC491008 total lipids 446.10 mg/L 974.36 mg/L n.a. PMID[34206459]
NPO41673 Engineered Pichia pastoris Pichia pastoris n.a. Increase NP yield n.a. n.a. NPC491009 total opioid n.a. more than 100 mg L-1 n.a. PMID[30197866]
NPO41842 A new engineered strain of Escherichia coli Escherichia coli kivD adh2 Increase NP yield Metabolic engineering overexpressing kivD adh2 NPC203468 tryptophan n.a. titer: 0.88g/L; yield: 0.11 g/g n.a. PMID[18172501]
NPO41868 A new engineered strain of Escherichia coli BW25113(DE3) Escherichia coli BW25113(DE3) ipdC yahK aroFfbrpheAfbr; ∆feaB Increase NP yield Metabolic engineering overexpressing ipdC yahK aroFfbrpheAfbr; ∆feaB NPC203468 tryptophan n.a. titer: 0.94g/L; yield: 0.09 g/g n.a. PMID[22752168]
NPO41865 A new engineered strain of Escherichia coli BL21(DE3) Escherichia coli BL21(DE3) PAAS Increase NP yield Metabolic engineering overexpressing PAAS NPC203468 tryptophan n.a. titer: 0.34g/L; yield: 0.43 g/g n.a. PMID[24081322]
NPO41866 A new engineered strain of Escherichia coli BP-24 Escherichia coli BP-24 kdc adh1 aroF pheAfbr Increase NP yield Metabolic engineering overexpressing kdc adh1 aroF pheAfbr NPC203468 tryptophan n.a. titer: 0.29g/L; yield: 0.01 g/g n.a. PMID[24318591]
NPO41890 A new engineered strain of Saccharomyces cerevisiae BY4741 Saccharomyces cerevisiae BY4741 aro4fbraro7fbr; aro8∆ tyr1∆ aro3∆ Increase NP yield Metabolic engineering overexpressing aro4fbraro7fbr; aro8∆ tyr1∆ aro3∆ NPC203468 tryptophan n.a. titer: 0.41 g/L; yield: 0.02 g/g n.a. PMID[24733517]
NPO41869 A new engineered strain of Escherichia coli DG02 Escherichia coli DG02 aroGfbr pheAfbrkdc yjgB aro8 Increase NP yield Metabolic engineering overexpressing aroGfbr pheAfbrkdc yjgB aro8 NPC203468 tryptophan n.a. titer: 1.02 g/L; yield: 0.05 g/g n.a. PMID[29808680]
NPO41873 A new engineered strain of Kluyveromyces marxianus BY25569 Kluyveromyces marxianus BY25569 aro10 adh2 aroGfbr Increase NP yield Metabolic engineering overexpressing aro10 adh2 aroGfbr NPC490513 tunicamycin B2 n.a. titer: 1.3 g/L; yield: 0.07 g/g n.a. PMID[24910335]
NPO41838 A new engineered strain of Corynebacterium glutamicum Corynebacterium glutamicum n.a. Increase NP yield n.a. n.a. NPC316205 Tylosin n.a. titer: 120 g/L; yield: 0.55 g lysine/g glucose n.a. PMID[21241816]
NPO41875 A new engineered strain of Mannheimia succiniciproducens Mannheimia succiniciproducens n.a. Increase NP yield n.a. n.a. NPC43246 uridine n.a. titer: 134.25 g/L; yield: 1.25 mol/mol glucose n.a. PMID[32327663]
NPO41847 A new engineered strain of Escherichia coli Escherichia coli DAR1, GPP2, dhaB1, dhaB2, dhaB3, dhaBX, yqhD, glpK, gldA, gap, gaIP, glk Increase NP yield n.a. A metabolic pathway was designed that diverted from dihydroxyacetone phosphate (DHAP), a central metabolite in the glycolytic pathway (Figure 8), by introducing genes encoding glycerol-3-phosphate dehydrogenase (DAR1), glycerol-3-posphate-phosphatase (GPP2), both from S. cerevisiae, glycerol dehydratase (dhaB1, dhaB2, dhaB3), and the reactivation enzyme for glycerol dehydratase (dhaBX) from Klebsiella pneumoniae, and finally the native E. coli oxidoreductase (yqhD). In addition, carbon flux to competing pathways was reduced by deleting the genes for glycerol kinase (glpK) and glycerol dehydrogenase (gldA) as well as downregulation of glycerol aldehyde dehydrogenase activity (gap). Furthermore, the phosphoenolpyruvate transferase system (PTS) for glucose uptake was replaced by a galactose permease (galP) to prevent the loss of phosphorenol pyruvate for glucose uptake and an ATP-dependent phosphorylation of glucose by glucokinase (glk). NPC51700 ursolic acid n.a. titer: 135g/L; yield: 0.51g 1,3-propanediol/g glucose n.a. PMID[14580573]
NPO41714 Escherichia coli WΔ4IB4 Escherichia coli budB ilvCFBR ilvD kdcA adhAFBR ldhA adhE pta frdA Increase NP yield n.a. overexpressing budB, ilvCFBR, ilvD, kdcA, adhAFBR; ΔldhAΔadhEΔptaΔfrdA NPC491014 ursolic acid precursor α-amyrin n.a. titer: 15.6g/L; yield: 0.22 g/g (carbon sources: glucose) n.a. PMID[33068182]
NPO41680 Escherichia coli CFTi91zpee Escherichia coli alsS, kivD, ilvC, ilvD, pgl, zwf, edd, eda pgi gntR gnd pflB ldhA Increase NP yield n.a. overexpressing alsS, kivD, ilvC, ilvD, pgl, zwf, edd, eda; ΔpgiΔgntRΔgndΔpflBΔldhA NPC490507 ustiloxin B n.a. titer: 15g/L; yield: 0.37 g/g n.a. PMID[31319852]
NPO41690 Escherichia coli LAFCmlcPU Escherichia coli alsS, kivD, ilvC, ilvD, adhA ldhA adhE pflB pta-ackA mlc Increase NP yield n.a. overexpressing alsS, kivD, ilvC, ilvD, adhA; ΔldhA ΔadhEΔpflBΔpta-ackA mlc* NPC86683 valencene n.a. titer: 19.0g/L; yield: 0.24 g/g n.a. PMID[22561880]
NPO41714 Escherichia coli WΔ4IB4 Escherichia coli budB ilvCFBR ilvD kdcA adhAFBR ldhA adhE pta frdA Increase NP yield n.a. overexpressing budB, ilvCFBR, ilvD, kdcA, adhAFBR; ΔldhAΔadhEΔptaΔfrdA NPC86683 valencene n.a. titer: 19.6g/L; yield: 0.107 g/g (carbon sources: cheese whey) n.a. PMID[33068182]
NPO41864 A new engineered strain of Escherichia coli BL21(DE3) Escherichia coli BL21(DE3) laad pdc adh gdh Increase NP yield Metabolic engineering overexpressing laad pdc adh gdh NPC10559 violaxanthin n.a. titer: 2.88g/L; yield: 0.72 g/g n.a. PMID[29560727]
NPO41693 Escherichia coli NV3r1 Escherichia coli alsS, kivD, ilvC, ilvD, adhA Increase NP yield n.a. overexpressing alsS, kivD, ilvC, ilvD, adhA; NTG-created mutant based on BW25113, with wild type rpoS NPC490529 vioprolide A n.a. titer: 21.2g/L; yield:0.31 g/g n.a. PMID[21911074]
NPO41687 Escherichia coli JCL260 Escherichia coli alsS, kivD, ilvC, ilvD adhE ldhA frdBC fnr pta pflB Increase NP yield n.a. overexpressing alsS, kivD, ilvC, ilvD; ΔadhEΔldhAΔfrdBCΔfnrΔptaΔpflB NPC490511 vioprolide B n.a. titer: 22g/L; yield: 0.35 g/g n.a. PMID[18172501]
NPO41900 A new engineered strain of Saccharomyces cerevisiae MT2 Saccharomyces cerevisiae MT2 gln3 Increase NP yield Metabolic engineering overexpressing gln3 NPC491016 vioprolide C n.a. titer: 3.59 g/L; yield: 0.72 g/g n.a. PMID[27908775]
NPO41905 A new engineered strain of Saccharomyces cerevisiae YS58 Saccharomyces cerevisiae YS58 cat8 Increase NP yield Metabolic engineering overexpressing cat8 NPC490510 vioprolide D n.a. titer: 3.73 g/L; yield: 0.68 g/g n.a. PMID[27770224]
NPO41902 A new engineered strain of Saccharomyces cerevisiae W303-1B Saccharomyces cerevisiae W303-1B aro9 aro10 aro80; ald3∆ Increase NP yield Metabolic engineering overexpressing aro9 aro10 aro80; ald3∆ NPC491017 VvAOMT1 n.a. titer: 4.8g/L; yield: 0.48 g/g n.a. PMID[23836015]
NPO41676 Escherichia coli AL17 Escherichia coli alsS kivD ilvC ilvD adhA adhE frdBC fnr-ldhA pta pflB Increase NP yield n.a. overexpressing alsS, kivD, ilvC, ilvD, adhA; ∆adhE∆frdBC∆fnr-ldhA∆pta∆pflB NPC491018 Wax esters n.a. titer: 5.1g/L (carbon sources: cellobionic acid and glucose) n.a. PMID[25889729]
NPO41688 Escherichia coli JCL260 Escherichia coli alsS, kivD, ilvC, ilvD, adhA adhE frdBC fnr ldhA pta pflB Increase NP yield n.a. overexpressing alsS, kivD, ilvC, ilvD, adhA; ΔadhEΔfrdBCΔfnrΔldhAΔptaΔpflB NPC491020 xanthophyll zeaxanthin n.a. titer: 50.8g/L; yield: 0.29 g/g n.a. PMID[21547458]
NPO41691 Escherichia coli mlcXT7-LAFC-AAKCD Escherichia coli alsS adhA kivd ilvC ilvD Increase NP yield n.a. Genomic knock-in of alsS, adhA, kivd, ilvC and ilvD NPC490505 Xylonic Acid n.a. titer: 8.4g/L; yield: 0.23 g/g n.a. PMID[25359477]
NPO41594 Bacillus subtilis 1A751-Sfp-nrs Bacillus subtilis 1A751-Sfp nrs Novel NPs activation Microbial chassis engineering The expression constructs were introduced into Bacillus subtilis 1A751-Sfp by natural competence transformation, inserting at the amyE locus of Bacillus subtilis 1A751-Sfp. NPC490624 flavonoid compounds n.a. n.a. n.a. DOI[10.1021/acscatal.1c05131]