Organism Name: A new engineered strain of Escherichia coli [n.a.]

Organism ID:   NPO41850
Organism Name:   A new engineered strain of Escherichia coli [n.a.]
Native / Engineered Organism:   Engineered Organism
Matched Taxonomy Level:   Strain
Organism External ID:   NCBI_Taxonomy_ID[ n.a.]
Organism Synonyms:  
Genus:   Escherichia
Family:   Enterobacteriaceae
Kingdom:   n.a.
SuperKingdom:   Bacteria

  Individual Natural Products

Natural Product ID Prefer Name (or InChiKey) IUPAC Name Number of Targets Number of Activity Records
NPC490567 prodigiosin n.a. 0 0
NPC86683 (3R,4As,5R)-4A,5-Dimethyl-3-Prop-1-En-2-Yl-2,3,4,5,6,7-Hexahydro-1H-Naphthalene (3R,4aS,5R)-4a,5-dimethyl-3-prop-1-en-2-yl-2,3,4,5,6,7-hexahydro-1H-naphthalene 7 31
NPC88000 Ginsenoside Rh2 (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol 72 86
NPC227622 Erythromycin (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 198 3548
NPC294852 Eriodictyol (2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one 45 88
NPC43211 Scutellarin (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid 31 97
NPC104170 resokaempferol n.a. 0 0
NPC123965 Squalene (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene 9 17
NPC112890 Lysine (2S)-2,6-diaminohexanoic acid 13 37
NPC94167 Riboflavin 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione 45 211
NPC226168 YJGVMLPVUAXIQN-BCVBHCCTSA-N n.a. 0 0
NPC236761 1,3-Propanediol propane-1,3-diol 2 8
NPC490975 Puromycin C n.a. 0 0
NPC490615 atolypene a n.a. 0 0
NPC490614 atolypene b n.a. 0 0
NPC142415 Oleanolic_Acid (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid 174 689
NPC490867 Medium-chain Fatty Acid (c6-c10, Mcfas) n.a. 0 0
NPC490491 plh n.a. 0 0
NPC93081 Ornithine (2S)-2,5-diaminopentanoic acid 4 6
NPC219848 Phenazine-1-Carboxylic Acid phenazine-1-carboxylic acid 35 46
NPC490999 Spinosad (1S,2S,5R,7S,9S,10S,14R,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-4,14-dimethyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione;(1S,2R,5S,7R,9R,10S,14R,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-14-methyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione 0 0
NPC208553 Paclitaxel n.a. 742 5607
NPC226453 Arginine (2S)-2-amino-5-(diaminomethylideneazaniumyl)pentanoate 43 119

  NPs produced by Co-culture Organisms (for Co-culture organisms, the full organism list can be found HERE)

Organism Name Producer Organism Inducer Organism NP ID NP Name Effect of Co-culture Reference

  NPs produced by Engineered Organisms (for Engineered organisms, the full organism list can be found HERE)

Organism Name Parent Organism Name Engineered Gene in Organism Purpose of Engineering Engineering Category Engineering Description NP ID NP Name NP Yeild of Parent Organism NP Yeild of Engineered Organism Yeild Change Reference
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC236761 1,3-propanediol n.a. 32 mg/L and 500 mg/L (in flask and bioreactor) >80-fold higher PMID[29077207]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC86683 (+)-valencene n.a. 1 gram per liter ~15,000-fold PMID[20929806]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC226453 Arginine n.a. n.a. 283% increase PMID[34824227]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490615 atolypene A n.a. 30 mg per L per OD600 of TAL 4.2-fold improvement PMID[29096626]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490614 atolypene B n.a. 30 mg per L per OD600 of TAL 4.2-fold improvement PMID[29096626]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. The regulatory protein AraC in Escherichia coli was engineered to respond to the inducer mevalonate NPC490792 component III n.a. n.a. fourfold increase PMID[21268200]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490793 component IV n.a. 9.1 g/L high yield recovery (>98%) PMID[27825357]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield Microbial chassis engineering Pathway engineering via separating the biosynthetic pathway into two parts and facilitating the accumulation of multiple metabolic precursors NPC88000 ginsenoside Rh2 n.a. n.a. Titer increase PMID[20929806]
A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs activation n.a. n.a. NPC490847 L-glutaminase activities n.a. ~1.5 g/L n.a. PMID[23113661]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC226168 lignans n.a. ~570 ± 45 mg/L n.a. PMID[26951651]
A new engineered strain of Escherichia coli Escherichia coli n.a. Heterologous biosynthesis; Increase NP yield n.a. EST database mining; Enzymatic UGT characterization; and Prompter replacement. NPC112890 Lysine n.a. 10 mg/L n.a. PMID[26358188]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490867 medium chain fatty acid(C6-C10, MCFAs) n.a. 106.5 mg/L n.a. PMID[30496827]
A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs identification Microbial chassis engineering Introduction of exogenous phosphopantetheinyl transferases from Stigmatella aurantiaca for CP domain activation in standard recombineering host, E. coli GB2006 NPC227622 erythromycin n.a. n.a. n.a. PMID[22544021]
A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs identification Microbial chassis engineering Introduction of exogenous phosphopantetheinyl transferases from Stigmatella aurantiaca for CP domain activation in standard recombineering host, E. coli GB2007 NPC227622 erythromycin A n.a. n.a. n.a. PMID[22851214]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC142415 Oleanolic acid n.a. 1652 mg/L n.a. PMID[30061932]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC93081 Ornithine n.a. 191.9 mg/L n.a. PMID[30684358]
A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC93081 Ornithine n.a. 17 mg/L n.a. PMID[33195815]
A new engineered strain of Escherichia coli Escherichia coli n.a. Novel NPs identification Microbial chassis engineering Introduction of exogenous phosphopantetheinyl transferases from Stigmatella aurantiaca for CP domain activation in standard recombineering host, E. coli GB2005 NPC294852 Eriodictyol n.a. n.a. n.a. PMID[22909174]
A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC219848 phenazine-1-carboxylic acid n.a. 214 mg/L n.a. PMID[33195815]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. By first reconstructing the plant flavonoid biosynthetic pathway genes from five different species: phenylalanine ammonia lyase from Rhodotorula toruloides (PAL), 4-coumarate-coenzyme A ligase from Petroselinum crispum (4CL), chalcone synthase from Petunia hybrida (CHS), chalcone isomerase from Medicago sativa (CHI) and an oxidoreductase flavone synthase I from P. crispum (FNSI), production of the intermediates chrysin and apigenin was achieved by feeding phenylalanine and tyrosine as precursors NPC490491 PLH n.a. 23.6 mg/L n.a. PMID[30496827]
A new engineered strain of Escherichia coli Escherichia coli n.a. Efficient biotransformation n.a. n.a. NPC490567 prodigiosin n.a. 2580 mg/L n.a. DOI[10.1039/C8GC03728K]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC490975 Puromycin C 0.5 mg/L 30 mg/L;480 mg/L(in fed-batch fermentation) n.a. PMID[29077207]
A new engineered strain of Escherichia coli Escherichia coli n.a. Heterologous biosynthesis; Increase NP yield Transporter engineering. Modules standardization; Codon optimization; N terminus truncation and substitation; and KAH replacement. NPC104170 Resokaempferol n.a. 32 mg/L n.a. PMID[23864262]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC94167 Riboflavin n.a. 34.7 mg/L n.a. PMID[26488898]
A new engineered strain of Escherichia coli Escherichia coli n.a. Increase NP yield n.a. n.a. NPC43211 Scutellarin n.a. 400mg/L n.a. PMID[23727191]
A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo biosynthesis n.a. n.a. NPC490999 spinosad n.a. 484 mg/L n.a. PMID[33195815]
A new engineered strain of Escherichia coli Escherichia coli n.a. Heterologous biosynthesis; Increase NP yield n.a. n.a. NPC123965 Squalene n.a. 59 mg/L n.a. PMID[26062534]
A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC123965 Squalene n.a. 62.7 mg/L n.a. PMID[26488898]
A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo biosynthesis n.a. n.a. NPC123965 Squalene n.a. 588 mg/L n.a. PMID[32830192]
A new engineered strain of Escherichia coli Escherichia coli n.a. NP de novo production n.a. n.a. NPC208553 Taxol n.a. 88 mg/L n.a. PMID[33195815]

  The Quantitative Compositions of NPs in Organism

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference