NPASS Compound

Natural Product: NPC80230

Natural Product ID	NPC80230
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	Desoxypodophyllotoxin
IUPAC Name	(5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
Synonyms	(-)-Deoxypodophyllotoxin; 4-Deoxypodophyllotoxin; Beta-Apopicropodophyllin; Deoxypodophyllotoxin; Desoxypodophyllotoxin
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL63970
PubChem CID	345501
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0001392] Lignans, neolignans and related compounds [CHEMONTID:0001510] Lignan lactones

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 51 55 0 0 0 0 0 0 0 0999 V2000 -1.0745 1.9995 -3.4170 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.2081 1.7200 -2.6186 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.0870 0.8291 -1.5646 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8754 0.2234 -1.2986 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6697 -0.6709 -0.2742 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7745 -0.9483 0.5101 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.0079 -0.3785 0.2973 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.1456 0.5085 -0.7453 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3896 1.1085 -0.9913 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.7855 2.3217 -0.4112 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.1211 -0.6641 1.0949 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.0461 -1.5611 2.1747 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5982 -1.3334 0.0513 C 0 0 1 0 0 0 0 0 0 0 0 0 1.2367 -1.9730 -1.1080 C 0 0 1 0 0 0 0 0 0 0 0 0 0.5292 -2.0265 -2.3791 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6941 -2.0979 -2.6860 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4948 -1.9854 -3.3774 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8050 -1.8972 -2.7885 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4554 -1.1683 -1.5242 C 0 0 2 0 0 0 0 0 0 0 0 0 3.4315 -1.3487 -0.3918 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8387 -0.5257 0.6982 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4921 -0.5190 0.8983 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9789 0.2561 1.9081 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8042 1.0152 2.7080 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6121 1.8818 3.7827 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7632 2.6596 3.9815 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7923 1.8373 3.4190 O 0 0 0 0 0 0 0 0 0 0 0 0 3.1679 1.0075 2.5048 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6781 0.2277 1.4896 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.2553 2.4806 -2.8595 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.3395 2.6887 -4.2451 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.6554 1.0730 -3.8680 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0553 0.4668 -1.9291 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.7092 -1.6506 1.3534 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.8842 2.3324 -0.2137 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.2763 2.5115 0.5594 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.5694 3.1957 -1.0515 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5211 -2.4796 1.7995 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.0814 -1.8266 2.4734 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5036 -1.1573 3.0369 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3219 -2.2036 0.7482 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5902 -3.0320 -0.8763 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1802 -2.9075 -2.5521 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4939 -1.3241 -3.4165 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1963 -0.1333 -1.7180 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4574 -1.0636 -0.6365 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3779 -2.4155 -0.0633 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1012 0.2997 2.1143 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7570 3.5844 3.3619 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0305 2.8239 5.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7477 0.2391 1.3512 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 2 0 4 5 1 0 5 6 2 0 6 7 1 0 7 8 2 0 8 9 1 0 9 10 1 0 7 11 1 0 11 12 1 0 5 13 1 0 13 14 1 0 14 15 1 0 15 16 2 0 15 17 1 0 17 18 1 0 18 19 1 0 19 20 1 0 20 21 1 0 21 22 2 0 22 23 1 0 23 24 2 0 24 25 1 0 25 26 1 0 26 27 1 0 27 28 1 0 28 29 2 0 8 3 1 0 22 13 1 0 28 24 1 0 19 14 1 0 29 21 1 0 1 30 1 0 1 31 1 0 1 32 1 0 4 33 1 0 6 34 1 0 10 35 1 0 10 36 1 0 10 37 1 0 12 38 1 0 12 39 1 0 12 40 1 0 13 41 1 1 14 42 1 1 18 43 1 0 18 44 1 0 19 45 1 6 20 46 1 0 20 47 1 0 23 48 1 0 26 49 1 0 26 50 1 0 29 51 1 0 M END

Standard InCHIKey	ZGLXUQQMLLIKAN-SVIJTADQSA-N
Standard InCHI	InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1
SMILES	COc1cc(cc(c1OC)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2Cc2c1cc1OCOc1c2

Calculated Properties

Physi-Chem Properties

MedChem Properties

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

ADMET: Distribution

ADMET: Metabolism

ADMET: Excretion

ADMET: Toxicity

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO17839	Machaerium mucronulatum	Species	Dolichopodidae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/S0031-9422(00)94598-9]
NPO14144	Hernandia peltata	Species	Hernandiaceae	Eukaryota	n.a.	stem	n.a.	DOI[10.1021/np960034d]
NPO25454	Plumbago europaea	Species	Plumbaginaceae	Eukaryota	n.a.	root	n.a.	DOI[10.2225/vol5-issue3-fulltext-4]
NPO14144	Hernandia peltata	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.3987/R-1980-04-0397]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	root	n.a.	PMID[10230514]
NPO13539	Thuja occidentalis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11000026]
NPO21302	Cladosporium herbarum	Species	Cladosporiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11325242]
NPO7174	Callyspongia truncata	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[12088440]
NPO7174	Callyspongia truncata	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[12713420]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12956064]
NPO14144	Hernandia peltata	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[14987061]
NPO7090	Ammi majus	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15009205]
NPO21302	Cladosporium herbarum	Species	Cladosporiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16038560]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	Roots	Panan, Zhejiang Province, China	2004-MAY	PMID[17256902]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	n.a.	root	n.a.	PMID[17256902]
NPO28528	Bridelia ferruginea	Species	Phyllanthaceae	Eukaryota	roots	Gabon	1987	PMID[18327911]
NPO28528	Bridelia ferruginea	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18327911]
NPO27983	Penicillium paneum	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21495659]
NPO1338	Arcangelisia gusanlung	Species	Menispermaceae	Eukaryota	n.a.	stem	n.a.	PMID[21500777]
NPO14752	Sinopodophyllum emodi	Species	Berberidaceae	Eukaryota	roots and rhizomes	n.a.	n.a.	PMID[21570846]
NPO26380	Tacca plantaginea	Species	Taccaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23031596]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24913660]
NPO9604	Amycolatopsis lurida	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[25323720]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25608854]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25712646]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota	rhizomes	Liaoning province, China	2011-SEP	PMID[25927664]
NPO3925	Bursera microphylla	Species	Burseraceae	Eukaryota	Resin	Baha de Kino	2013-JAN	PMID[25966052]
NPO11163	Methylobacterium organophilum	Species	Methylobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26032177]
NPO10903	Sinopodophyllum hexandrum	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26359402]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26731565]
NPO28528	Bridelia ferruginea	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26938998]
NPO8247	Austrobaileya scandens	Species	Austrobaileyaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27214307]
NPO18983	Cleidion brevipetiolatum	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31419126]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32078653]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32223924]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34203980]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35481430]
NPO17802	Simmondsia chinensis	Species	Simmondsiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35889256]
NPO18707	Allium ursinum	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37241721]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37241749]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37298924]
NPO25454	Plumbago europaea	Species	Plumbaginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37800169]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37894884]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38370080]
NPO11163	Methylobacterium organophilum	Species	Methylobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[3928379]
NPO18707	Allium ursinum	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39684509]
NPO40480	Hyptis tomentosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[521819]
NPO17947	Hyptis verticillata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8277312]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2504	Gersemia rubiformis	Species	Nephtheidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12785	Bursera fagaroides	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14752	Sinopodophyllum emodi	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7090	Ammi majus	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO22727	Avena fatua	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO27244	Dysosma pleiantha	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21569	Helichrysum fulvum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16798	Piper sylvaticum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12801	Aglaia meridionalis	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18707	Allium ursinum	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9604	Amycolatopsis lurida	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18061	Anacystis cyanea	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1338	Arcangelisia gusanlung	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17718	Artemisia schmidtiana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16293	Babylonia japonica	Species	Buccinidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19189	Brickellia pendula	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7174	Callyspongia truncata	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18377	Chaetomium retardatum	Species	Chaetomiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17275	Chamaemelum scariosum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19127	Citrus tankan	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3050	Cladonia pseudodidyma	Species	Cladoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21302	Cladosporium herbarum	Species	Cladosporiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18983	Cleidion brevipetiolatum	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21938	Coleus carnosus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18847	Copaifera paupera	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9535	Cortinarius basirubescens	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18792	Crotalaria lechnaultii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16829	Dunaliella acidophila	Species	Dunaliellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15358	Entandrophragma cylindricum	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12072	Escallonia philippiana	Species	Escalloniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17596	Ficus maxima	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18242	Gleichenia glauca	Species	Gleicheniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18520	Helipterum strictum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3746	Hesperocyparis nevadensis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13594	Hippocratea indica	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18306	Juniperus thurifera	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11677	Lactobacillus acidophilus	Species	Lactobacillaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11603	Lathyrus macrorrhizus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13963	Laurencia elata	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19057	Lentinellus omphalodes	Species	Auriscalpiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17839	Machaerium mucronulatum	Species	Dolichopodidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17385	Magnolia acuminata	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17831	Millettia racemosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18575	Ochtodes crockeri	Species	Rhizophyllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5764	Ophioglossum vulgatum	Species	Ophioglossaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12282	Parmelia conspersa	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25454	Plumbago europaea	Species	Plumbaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7807	Polyporus sulphureus	Species	Polyporaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18173	Pyrocystis lunula	Species	Pyrocystaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17190	Senecio erraticus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17802	Simmondsia chinensis	Species	Simmondsiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10712	Tabebuia rosea	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17068	Talaromyces wortmanni	Species	Trichocomaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15608	Tanacetum santolina	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17709	Timonius kaniensis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6893	Dimorphotheca sinuata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14144	Hernandia peltata	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17947	Hyptis verticillata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10903	Sinopodophyllum hexandrum	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8247	Austrobaileya scandens	Species	Austrobaileyaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3025	Schefflera capitata	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18997	Hernandia sonora	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7609	Thujopsis dolabrata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25340	Galega officinalis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO404	Aconitum barbatum	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26179	Chrysosplenium tetrandrum	Species	Saxifragaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26473	Garcinia eugeniifolia	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4464	Senecio mexicanus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO27316	Paepalanthus bromelioides	Species	Eriocaulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO23382	Podophyllum emodii	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO28528	Bridelia ferruginea	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25651	Tecoma grandiflora	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13539	Thuja occidentalis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26380	Tacca plantaginea	Species	Taccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO27983	Penicillium paneum	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO27244	Dysosma pleiantha	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3925	Bursera microphylla	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19127	Citrus tankan	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16293	Babylonia japonica	Species	Buccinidae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO22354	Mallotus anomalus	Species	Salangidae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17385	Magnolia acuminata	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13539	Thuja occidentalis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7090	Ammi majus	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO31302	Thujopsis dolobrata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25454	Plumbago europaea	Species	Plumbaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18306	Juniperus thurifera	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO23382	Podophyllum emodii	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3403	Juniperus silicicola	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17947	Hyptis verticillata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13963	Laurencia elata	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26380	Tacca plantaginea	Species	Taccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25340	Galega officinalis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO27316	Paepalanthus bromelioides	Species	Eriocaulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20275.1	Juniperus sabina var. tamariscifolia	Varieties	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18997	Hernandia sonora	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29945	Libocedrus sp	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7609	Thujopsis dolabrata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25340	Galega officinalis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5764	Ophioglossum vulgatum	Species	Ophioglossaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23382	Podophyllum emodii	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3925	Bursera microphylla	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15358	Entandrophragma cylindricum	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19127	Citrus tankan	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13539	Thuja occidentalis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26380	Tacca plantaginea	Species	Taccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17947	Hyptis verticillata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14144	Hernandia peltata	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18997	Hernandia sonora	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO20275.1	Juniperus sabina var. tamariscifolia	Varieties	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO27890	Russula cyanoxantha	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO27244	Dysosma pleiantha	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7090	Ammi majus	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17385	Magnolia acuminata	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26473	Garcinia eugeniifolia	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22354	Mallotus anomalus	Species	Salangidae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO27121	Libocedrus sp.	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25454	Plumbago europaea	Species	Plumbaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17831	Millettia racemosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18306	Juniperus thurifera	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3403	Juniperus silicicola	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13963	Laurencia elata	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO27316	Paepalanthus bromelioides	Species	Eriocaulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO16293	Babylonia japonica	Species	Buccinidae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26380	Tacca plantaginea	Species	Taccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17385	Magnolia acuminata	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19127	Citrus tankan	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO7090	Ammi majus	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO10903	Sinopodophyllum hexandrum	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO11677	Lactobacillus acidophilus	Species	Lactobacillaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO17839	Machaerium mucronulatum	Species	Dolichopodidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18173	Pyrocystis lunula	Species	Pyrocystaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3050	Cladonia pseudodidyma	Species	Cladoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9535	Cortinarius basirubescens	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21302	Cladosporium herbarum	Species	Cladosporiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7807	Polyporus sulphureus	Species	Polyporaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17709	Timonius kaniensis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17802	Simmondsia chinensis	Species	Simmondsiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4464	Senecio mexicanus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3746	Hesperocyparis nevadensis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27244	Dysosma pleiantha	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18847	Copaifera paupera	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19127	Citrus tankan	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13594	Hippocratea indica	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5764	Ophioglossum vulgatum	Species	Ophioglossaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7090	Ammi majus	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21938	Coleus carnosus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17718	Artemisia schmidtiana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18575	Ochtodes crockeri	Species	Rhizophyllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1338	Arcangelisia gusanlung	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18983	Cleidion brevipetiolatum	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28528	Bridelia ferruginea	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18306	Juniperus thurifera	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17385	Magnolia acuminata	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13963	Laurencia elata	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16653	Matteuccia struthiopteris	Species	Onocleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12282	Parmelia conspersa	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18707	Allium ursinum	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12072	Escallonia philippiana	Species	Escalloniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17068	Talaromyces wortmanni	Species	Trichocomaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21569	Helichrysum fulvum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11603	Lathyrus macrorrhizus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10712	Tabebuia rosea	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15358	Entandrophragma cylindricum	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16293	Babylonia japonica	Species	Buccinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6893	Dimorphotheca sinuata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19189	Brickellia pendula	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17831	Millettia racemosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25454	Plumbago europaea	Species	Plumbaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1576	Anthriscus sylvestris	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15608	Tanacetum santolina	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18520	Helipterum strictum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17275	Chamaemelum scariosum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14752	Sinopodophyllum emodi	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7174	Callyspongia truncata	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18061	Anacystis cyanea	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO3025	Schefflera capitata	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9604	Amycolatopsis lurida	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO17190	Senecio erraticus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18242	Gleichenia glauca	Species	Gleicheniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17596	Ficus maxima	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18377	Chaetomium retardatum	Species	Chaetomiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16829	Dunaliella acidophila	Species	Dunaliellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11163	Methylobacterium organophilum	Species	Methylobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO19057	Lentinellus omphalodes	Species	Auriscalpiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11417	Gesneria cardinalis	Species	Crambidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13539	Thuja occidentalis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12801	Aglaia meridionalis	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18792	Crotalaria lechnaultii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27316	Paepalanthus bromelioides	Species	Eriocaulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8247	Austrobaileya scandens	Species	Austrobaileyaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26380	Tacca plantaginea	Species	Taccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10903	Sinopodophyllum hexandrum	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3403	Juniperus silicicola	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22727	Avena fatua	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16081	Peltophorum dasyrhachis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27890	Russula cyanoxantha	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16798	Piper sylvaticum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26710	Hypotrachyna rachista	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25651	Tecoma grandiflora	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12785	Bursera fagaroides	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17947	Hyptis verticillata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22354	Mallotus anomalus	Species	Salangidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20275	Juniperus sabina	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5213	Sidastrum multiflorum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23767	Aspropaxillus candidus	Species	Tricholomataceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18997	Hernandia sonora	Species	Hernandiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25340	Galega officinalis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6959	Perymenium klattianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26179	Chrysosplenium tetrandrum	Species	Saxifragaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10219	Juniperus communis	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26473	Garcinia eugeniifolia	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8161	Argemone hispida	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7609	Thujopsis dolabrata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27983	Penicillium paneum	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO404	Aconitum barbatum	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17807	Dysosma versipellis	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2504	Gersemia rubiformis	Species	Nephtheidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27185	Phora sylvatica	Species	Phoridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3925	Bursera microphylla	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Activity	53
Vmax/Km	1
IC50	42
ED50	28
AC	1
MIC	1
T/C	1
GI50	77
GI	2
Inhibition	6
EC50	1
ID50	1
Inhibition rate	1
mortality	3

Activity Type	# Activity
Individual protein	2
Cell line	171
Protein complex	1
Organism	12
Others	15
Non-molecular	17

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1856	Individual protein	Ornithine decarboxylase	Mus musculus	Activity	<	0.08	uM	PMID[11000026]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	Vmax/Km	=	0.77	/nM.min	PMID[17998150]
NPT518	Protein complex	Tubulin	Homo sapiens	IC50	=	2400.0	nM	PMID[24331756]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT81	Cell line	A549	Homo sapiens	ED50	=	0.012	ug ml-1	PMID[12873481]
NPT147	Cell line	SK-MEL-2	Homo sapiens	ED50	=	0.009	ug ml-1	PMID[12873481]
NPT81	Cell line	A549	Homo sapiens	ED50	=	15.5	nM	PMID[11844709]
NPT147	Cell line	SK-MEL-2	Homo sapiens	ED50	=	8.4	nM	PMID[11844709]
NPT83	Cell line	MCF7	Homo sapiens	ED50	=	11.7	nM	PMID[11844709]
NPT3950	Cell line	GLC4 cell line	n.a.	IC50	=	8.0	nM	PMID[7783142]
NPT3950	Cell line	GLC4 cell line	n.a.	IC50	=	120.0	nM	PMID[7783142]
NPT81	Cell line	A549	Homo sapiens	ED50	=	23.0	nM	PMID[12419378]
NPT147	Cell line	SK-MEL-2	Homo sapiens	ED50	=	14.0	nM	PMID[12419378]
NPT83	Cell line	MCF7	Homo sapiens	ED50	=	11.0	nM	PMID[12419378]
NPT168	Cell line	P388	Mus musculus	IC50	=	10.0	nM	DOI[10.1016/0960-894X(95)00432-S]
NPT81	Cell line	A549	Homo sapiens	IC50	<	6.0	nM	DOI[10.1016/0960-894X(95)00432-S]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	6.0	nM	DOI[10.1016/0960-894X(95)00432-S]
NPT3885	Cell line	CV-1	Chlorocebus aethiops	IC50	=	6.0	nM	DOI[10.1016/0960-894X(95)00432-S]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	32.0	nM	PMID[17256902]
NPT858	Cell line	LNCaP	Homo sapiens	IC50	=	30.0	nM	PMID[17256902]
NPT90	Cell line	DU-145	Homo sapiens	Activity	=	0.0017	ug ml-1	PMID[18327911]
NPT168	Cell line	P388	Mus musculus	Activity	=	0.029	ug ml-1	PMID[18327911]
NPT377	Cell line	OVCAR-3	Homo sapiens	Activity	=	0.0027	ug ml-1	PMID[18327911]
NPT397	Cell line	NCI-H460	Homo sapiens	Activity	=	0.0018	ug ml-1	PMID[18327911]
NPT575	Cell line	KM-20L2	Homo sapiens	Activity	=	0.0014	ug ml-1	PMID[18327911]
NPT1081	Cell line	BXPC-3	Homo sapiens	Activity	=	0.00044	ug ml-1	PMID[18327911]
NPT399	Cell line	SF-295	Homo sapiens	Activity	=	0.00056	ug ml-1	PMID[18327911]
NPT83	Cell line	MCF7	Homo sapiens	ED50	=	0.0021	ug ml-1	PMID[14987061]
NPT168	Cell line	P388	Mus musculus	ED50	=	0.0023	ug ml-1	PMID[14987061]
NPT397	Cell line	NCI-H460	Homo sapiens	ED50	=	0.0027	ug ml-1	PMID[14987061]
NPT575	Cell line	KM-20L2	Homo sapiens	ED50	=	0.0028	ug ml-1	PMID[14987061]
NPT90	Cell line	DU-145	Homo sapiens	ED50	=	0.0028	ug ml-1	PMID[14987061]
NPT1081	Cell line	BXPC-3	Homo sapiens	ED50	=	0.0029	ug ml-1	PMID[14987061]
NPT395	Cell line	SF-268	Homo sapiens	ED50	=	0.0033	ug ml-1	PMID[14987061]
NPT189	Cell line	Vero	Chlorocebus aethiops	Activity	=	30.0	%	PMID[6298369]
NPT189	Cell line	Vero	Chlorocebus aethiops	Activity	=	90.7	%	PMID[6298369]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	93.0	%	PMID[6677713]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	50.0	%	PMID[6677713]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	92.0	%	PMID[6677713]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	43.0	IU/L	PMID[6677713]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	35.0	IU/L	PMID[6677713]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	137.0	IU/L	PMID[6677713]
NPT168	Cell line	P388	Mus musculus	ED50	=	0.002	ug ml-1	PMID[8277312]
NPT762	Cell line	A-431	Homo sapiens	ED50	=	4.3	ug ml-1	PMID[8277312]
NPT1851	Cell line	Col2	Homo sapiens	ED50	=	0.01	ug ml-1	PMID[8277312]
NPT2049	Cell line	HT	Homo sapiens	ED50	=	0.003	ug ml-1	PMID[8277312]
NPT858	Cell line	LNCaP	Homo sapiens	ED50	=	0.01	ug ml-1	PMID[8277312]
NPT1034	Cell line	Lu1	Homo sapiens	ED50	=	0.002	ug ml-1	PMID[8277312]
NPT133	Cell line	ZR-75-1	Homo sapiens	ED50	=	2.0	ug ml-1	PMID[8277312]
NPT91	Cell line	KB	Homo sapiens	ED50	=	0.05	ug ml-1	PMID[8277312]
NPT168	Cell line	P388	Mus musculus	IC50	=	0.0025	ug.mL-1	PMID[15332833]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	0.0025	ug.mL-1	PMID[15332833]
NPT168	Cell line	P388	Mus musculus	T/C	=	144.0	%	DOI[10.1021/np50004a005]
NPT91	Cell line	KB	Homo sapiens	ED50	=	0.032	ug ml-1	PMID[521819]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	0.2	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	12.0	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	28.9	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	58.9	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	4.5	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	3.5	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	8.6	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	87.8	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	29.7	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	6.8	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	11.0	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	82.1	%	PMID[19501508]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	6.9	nM	PMID[21570846]
NPT91	Cell line	KB	Homo sapiens	IC50	=	8.9	nM	PMID[21570846]
NPT81	Cell line	A549	Homo sapiens	IC50	=	470.0	nM	PMID[21733601]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	36000.0	nM	PMID[21733601]
NPT2245	Cell line	SiHa	Homo sapiens	IC50	=	10200.0	nM	PMID[21733601]
NPT81	Cell line	A549	Homo sapiens	Activity	=	13.1	%	PMID[21733601]
NPT81	Cell line	A549	Homo sapiens	Activity	=	85.5	%	PMID[21733601]
NPT81	Cell line	A549	Homo sapiens	Activity	=	1.4	%	PMID[21733601]
NPT81	Cell line	A549	Homo sapiens	IC50	=	1380.0	nM	PMID[22244588]
NPT2245	Cell line	SiHa	Homo sapiens	IC50	=	6010.0	nM	PMID[22041063]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	1980.0	nM	PMID[22041063]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	470.0	nM	PMID[22244588]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	7.7	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	25.2	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	9.5	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	57.6	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	34.1	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	23.5	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	37.7	%	PMID[22257529]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	29.8	%	PMID[22257529]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	6010.0	nM	PMID[22244588]
NPT2245	Cell line	SiHa	Homo sapiens	IC50	=	1980.0	nM	PMID[22244588]
NPT367	Cell line	MDA-N	Homo sapiens	GI50	n.a.	2.223	nM	PubChem BioAssay data set
NPT370	Cell line	NCI-H23	Homo sapiens	GI50	n.a.	7.145	nM	PubChem BioAssay data set
NPT368	Cell line	SN12C	Homo sapiens	GI50	n.a.	9.954	nM	PubChem BioAssay data set
NPT369	Cell line	ACHN	Homo sapiens	GI50	n.a.	3.926	nM	PubChem BioAssay data set
NPT371	Cell line	UO-31	Homo sapiens	GI50	n.a.	98.63	nM	PubChem BioAssay data set
NPT116	Cell line	HL-60	Homo sapiens	GI50	n.a.	7.129	nM	PubChem BioAssay data set
NPT372	Cell line	HOP-92	Homo sapiens	GI50	n.a.	198.61	nM	PubChem BioAssay data set
NPT90	Cell line	DU-145	Homo sapiens	GI50	n.a.	2.729	nM	PubChem BioAssay data set
NPT374	Cell line	SF-539	Homo sapiens	GI50	n.a.	7.278	nM	PubChem BioAssay data set
NPT373	Cell line	SK-MEL-5	Homo sapiens	GI50	n.a.	7.907	nM	PubChem BioAssay data set
NPT375	Cell line	Malme-3M	Homo sapiens	GI50	n.a.	14.93	nM	PubChem BioAssay data set
NPT111	Cell line	K562	Homo sapiens	GI50	n.a.	7.396	nM	PubChem BioAssay data set
NPT376	Cell line	A498	Homo sapiens	GI50	n.a.	6.95	nM	PubChem BioAssay data set
NPT377	Cell line	OVCAR-3	Homo sapiens	GI50	n.a.	8.072	nM	PubChem BioAssay data set
NPT379	Cell line	HOP-62	Homo sapiens	GI50	n.a.	12.71	nM	PubChem BioAssay data set
NPT112	Cell line	MOLT-4	Homo sapiens	GI50	n.a.	8.933	nM	PubChem BioAssay data set
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	GI50	n.a.	7.194	nM	PubChem BioAssay data set
NPT380	Cell line	U-251	Homo sapiens	GI50	n.a.	6.339	nM	PubChem BioAssay data set
NPT381	Cell line	OVCAR-8	Homo sapiens	GI50	n.a.	7.211	nM	PubChem BioAssay data set
NPT382	Cell line	OVCAR-5	Homo sapiens	GI50	n.a.	10764.65	nM	PubChem BioAssay data set
NPT572	Cell line	DMS-273	Homo sapiens	GI50	n.a.	7.278	nM	PubChem BioAssay data set
NPT383	Cell line	SNB-19	Homo sapiens	GI50	n.a.	9.204	nM	PubChem BioAssay data set
NPT385	Cell line	SR	Homo sapiens	GI50	n.a.	3.758	nM	PubChem BioAssay data set
NPT82	Cell line	MDA-MB-231	Homo sapiens	GI50	n.a.	10.0	nM	PubChem BioAssay data set
NPT384	Cell line	TK-10	Homo sapiens	GI50	n.a.	10.0	nM	PubChem BioAssay data set
NPT573	Cell line	M19-MEL	Homo sapiens	GI50	n.a.	9.863	nM	PubChem BioAssay data set
NPT323	Cell line	SW-620	Homo sapiens	GI50	n.a.	9.099	nM	PubChem BioAssay data set
NPT455	Cell line	NCI-H522	Homo sapiens	GI50	n.a.	7.534	nM	PubChem BioAssay data set
NPT386	Cell line	KM12	Homo sapiens	GI50	n.a.	6.31	nM	PubChem BioAssay data set
NPT387	Cell line	M14	Homo sapiens	GI50	n.a.	3.999	nM	PubChem BioAssay data set
NPT574	Cell line	XF498	Homo sapiens	GI50	n.a.	8.59	nM	PubChem BioAssay data set
NPT388	Cell line	NCI-H322M	Homo sapiens	GI50	n.a.	9.441	nM	PubChem BioAssay data set
NPT456	Cell line	OVCAR-4	Homo sapiens	GI50	n.a.	576.77	nM	PubChem BioAssay data set
NPT389	Cell line	RPMI-8226	Homo sapiens	GI50	n.a.	8.71	nM	PubChem BioAssay data set
NPT457	Cell line	BT-549	Homo sapiens	GI50	n.a.	10.0	nM	PubChem BioAssay data set
NPT168	Cell line	P388	Mus musculus	GI50	n.a.	5.0	nM	PubChem BioAssay data set
NPT390	Cell line	LOX IMVI	Homo sapiens	GI50	n.a.	8.017	nM	PubChem BioAssay data set
NPT147	Cell line	SK-MEL-2	Homo sapiens	GI50	n.a.	7.396	nM	PubChem BioAssay data set
NPT575	Cell line	KM-20L2	Homo sapiens	GI50	n.a.	7.031	nM	PubChem BioAssay data set
NPT81	Cell line	A549	Homo sapiens	GI50	n.a.	8.851	nM	PubChem BioAssay data set
NPT392	Cell line	SNB-75	Homo sapiens	GI50	n.a.	65.46	nM	PubChem BioAssay data set
NPT391	Cell line	HCC 2998	Homo sapiens	GI50	n.a.	7.907	nM	PubChem BioAssay data set
NPT148	Cell line	HCT-15	Homo sapiens	GI50	n.a.	8.954	nM	PubChem BioAssay data set
NPT395	Cell line	SF-268	Homo sapiens	GI50	n.a.	8.433	nM	PubChem BioAssay data set
NPT393	Cell line	HCT-116	Homo sapiens	GI50	n.a.	7.621	nM	PubChem BioAssay data set
NPT83	Cell line	MCF7	Homo sapiens	GI50	n.a.	8.75	nM	PubChem BioAssay data set
NPT394	Cell line	EKVX	Homo sapiens	GI50	n.a.	5.0	nM	PubChem BioAssay data set
NPT306	Cell line	PC-3	Homo sapiens	GI50	n.a.	3.532	nM	PubChem BioAssay data set
NPT576	Cell line	DMS-114	Homo sapiens	GI50	n.a.	6.982	nM	PubChem BioAssay data set
NPT146	Cell line	SK-OV-3	Homo sapiens	GI50	n.a.	80.35	nM	PubChem BioAssay data set
NPT396	Cell line	T47D	Homo sapiens	GI50	n.a.	2.999	nM	PubChem BioAssay data set
NPT398	Cell line	UACC-62	Homo sapiens	GI50	n.a.	9.12	nM	PubChem BioAssay data set
NPT397	Cell line	NCI-H460	Homo sapiens	GI50	n.a.	7.727	nM	PubChem BioAssay data set
NPT308	Cell line	CAKI-1	Homo sapiens	GI50	n.a.	7.112	nM	PubChem BioAssay data set
NPT552	Cell line	P388/ADR	Mus musculus	GI50	n.a.	10.76	nM	PubChem BioAssay data set
NPT400	Cell line	MDA-MB-435	Homo sapiens	GI50	n.a.	2.606	nM	PubChem BioAssay data set
NPT399	Cell line	SF-295	Homo sapiens	GI50	n.a.	6.324	nM	PubChem BioAssay data set
NPT402	Cell line	Hs-578T	Homo sapiens	GI50	n.a.	2.042	nM	PubChem BioAssay data set
NPT458	Cell line	IGROV-1	Homo sapiens	GI50	n.a.	10.28	nM	PubChem BioAssay data set
NPT578	Cell line	SNB-78	Homo sapiens	GI50	n.a.	8.75	nM	PubChem BioAssay data set
NPT401	Cell line	786-0	Homo sapiens	GI50	n.a.	3.724	nM	PubChem BioAssay data set
NPT579	Cell line	DLD-1	Homo sapiens	GI50	n.a.	8.433	nM	PubChem BioAssay data set
NPT403	Cell line	UACC-257	Homo sapiens	GI50	n.a.	8.279	nM	PubChem BioAssay data set
NPT404	Cell line	CCRF-CEM	Homo sapiens	GI50	n.a.	8.65	nM	PubChem BioAssay data set
NPT405	Cell line	NCI-H226	Homo sapiens	GI50	n.a.	7.328	nM	PubChem BioAssay data set
NPT139	Cell line	HT-29	Homo sapiens	GI50	n.a.	7.345	nM	PubChem BioAssay data set
NPT170	Cell line	SK-MEL-28	Homo sapiens	GI50	n.a.	12.47	nM	PubChem BioAssay data set
NPT406	Cell line	RXF 393	Homo sapiens	GI50	n.a.	8.872	nM	PubChem BioAssay data set
NPT738	Cell line	SN12K1	Homo sapiens	GI50	n.a.	5.957	nM	PubChem BioAssay data set
NPT732	Cell line	HOP-18	Homo sapiens	GI50	n.a.	33573.76	nM	PubChem BioAssay data set
NPT407	Cell line	COLO 205	Homo sapiens	GI50	n.a.	10.23	nM	PubChem BioAssay data set
NPT91	Cell line	KB	Homo sapiens	GI	=	100.0	%	PMID[22429510]
NPT91	Cell line	KB	Homo sapiens	IC50	=	3.0	nM	PMID[22429510]
NPT168	Cell line	P388	Mus musculus	ED50	=	0.029	ug ml-1	PMID[26938998]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	0.0027	ug.mL-1	PMID[26938998]
NPT397	Cell line	NCI-H460	Homo sapiens	GI50	=	0.0018	ug.mL-1	PMID[26938998]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	14.5	ug.mL-1	PMID[32223924]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	0.07	ug.mL-1	PMID[32223924]
NPT81	Cell line	A549	Homo sapiens	IC50	=	0.004	ug.mL-1	PMID[32223924]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	16.6	nM	PMID[36471625]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	14.5	nM	PMID[36471625]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	6.0	nM	PMID[36471625]
NPT111	Cell line	K562	Homo sapiens	IC50	=	16.0	nM	PMID[36471625]
NPT1522	Organism	Neisseria gonorrhoeae	Neisseria gonorrhoeae	MIC	=	32.0	ug.mL-1	PMID[14987061]
NPT190	Organism	Human herpesvirus 1	Human herpesvirus 1	Activity	=	38.0	nM	PMID[9834179]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	>	25.0	uM	PMID[9834179]
NPT190	Organism	Human herpesvirus 1	Human herpesvirus 1	IC50	=	25.0	nM	PMID[9834179]
NPT190	Organism	Human herpesvirus 1	Human herpesvirus 1	Activity	=	16.2	%	PMID[6298369]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	0.001	ug ml-1	PMID[8277312]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	100.0	%	PMID[8277312]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	0.0	%	PMID[8277312]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	0.06	ug ml-1	PMID[8277312]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	1.93	nM	PMID[24617915]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	0.00044	ug.mL-1	PMID[26938998]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	0.00056	ug.mL-1	PMID[26938998]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	0.0014	ug.mL-1	PMID[26938998]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	0.0017	ug.mL-1	PMID[26938998]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	18.0	nM	PMID[27214307]
NPT28107	Cell line	cancer cell lines	n.a.	AC	=	11.9	n.a.	PMID[11844709]
NPT1049	Organism	Measles virus	Measles virus	Activity	=	50.0	%	PMID[6298369]
NPT1049	Organism	Measles virus	Measles virus	Activity	=	70.0	%	PMID[6298369]
NPT1049	Organism	Measles virus	Measles virus	Activity	=	19.8	%	PMID[6298369]
NPT2	Others	Unspecified	n.a.	IC50	=	2400.0	nM	PMID[11514171]
NPT2	Others	Unspecified	n.a.	Activity	=	0.004	uM	PMID[11000026]
NPT195	Organism	Vesicular stomatitis virus	Vesicular stomatitis virus	IC50	<	25.0	nM	PMID[9834179]
NPT2	Others	Unspecified	n.a.	Inhibition	=	100.0	%	PMID[27073050]
NPT2	Others	Unspecified	n.a.	IC50	=	3200.0	nM	PMID[22429510]
NPT2	Others	Unspecified	n.a.	IC50	=	1700.0	nM	PMID[23063401]
NPT2	Others	Unspecified	n.a.	IC50	=	1760.0	nM	PMID[25462232]
NPT2	Others	Unspecified	n.a.	IC50	=	1800.0	nM	PMID[27073050]
NPT2	Others	Unspecified	n.a.	ID50	=	0.5	uM	PMID[423203]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT32	Organism	Mus musculus	Mus musculus	Inhibition rate	=	59.0	%	PMID[12419378]
NPT1769	Organism	Mythimna separata	Mythimna separata	mortality	=	39.3	%	PMID[20346661]
NPT1769	Organism	Mythimna separata	Mythimna separata	mortality	=	20.7	%	PMID[20346661]
NPT1769	Organism	Mythimna separata	Mythimna separata	mortality	=	16.7	%	PMID[20346661]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Homo sapiens	Liver	CL	=	1435.06	mL.min-1.kg-1	PMID[36471625]
Homo sapiens	Liver	T1/2	=	0.01867	hr	PMID[36471625]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference
-	Artemia	LC50	=	0.2	ug.mL-1	PMID[8277312]

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC80230 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	28526
0.1-0.2	19671
0.2-0.3	1365
0.3-0.4	197
0.4-0.5	52
0.5-0.6	20
0.6-0.7	8
0.7-0.8	0
0.8-0.85	3
0.85-0.9	0
0.9-0.95	2
0.95-1	4

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC104024
1.0	High Similarity	NPC101755
1.0	High Similarity	NPC304687
1.0	High Similarity	NPC65574
0.9423	High Similarity	NPC262455
0.9423	High Similarity	NPC177476
0.8	Intermediate Similarity	NPC218092
0.8	Intermediate Similarity	NPC246474
0.8	Intermediate Similarity	NPC162851
0.7931	Intermediate Similarity	NPC30009
0.7931	Intermediate Similarity	NPC103197
0.7586	Intermediate Similarity	NPC149505
0.7288	Intermediate Similarity	NPC480477
0.6984	Remote Similarity	NPC115281
0.6806	Remote Similarity	NPC115624
0.65	Remote Similarity	NPC239890
0.65	Remote Similarity	NPC209411
0.619	Remote Similarity	NPC237946
0.619	Remote Similarity	NPC32373
0.6	Remote Similarity	NPC210642
0.6	Remote Similarity	NPC13985
0.5965	Remote Similarity	NPC480480
0.5882	Remote Similarity	NPC163527
0.5763	Remote Similarity	NPC23336
0.5758	Remote Similarity	NPC207584
0.5758	Remote Similarity	NPC19947
0.5588	Remote Similarity	NPC119910
0.557	Remote Similarity	NPC222531
0.55	Remote Similarity	NPC40237
0.5484	Remote Similarity	NPC477698
0.5424	Remote Similarity	NPC151423
0.5397	Remote Similarity	NPC176586
0.5397	Remote Similarity	NPC210354
0.5333	Remote Similarity	NPC92693
0.5323	Remote Similarity	NPC164082
0.5254	Remote Similarity	NPC218841
0.5082	Remote Similarity	NPC475000
0.5077	Remote Similarity	NPC191158
0.5077	Remote Similarity	NPC177644
0.507	Remote Similarity	NPC288149
0.507	Remote Similarity	NPC470637

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC80230 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	5426
0.1-0.2	3621
0.2-0.3	90
0.3-0.4	6
0.4-0.5	4
0.5-0.6	0
0.6-0.7	3
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.619	Remote Similarity	NPD4965	Approved
0.619	Remote Similarity	NPD4966	Phase 4
0.619	Remote Similarity	NPD4967	Phase 2

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data