NPASS Compound

Natural Product: NPC74474

Natural Product ID	NPC74474
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	CUUMXRBKJIDIAY-ZDUSSCGKSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	n.a.
PubChem CID	12302243
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000012] Lipids and lipid-like molecules [CHEMONTID:0000259] Prenol lipids [CHEMONTID:0001550] Sesquiterpenoids

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 35 36 0 0 0 0 0 0 0 0999 V2000 -3.4230 0.6667 0.3616 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.9522 0.8009 0.5917 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.6038 0.4401 1.9932 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2336 -0.0808 -0.4382 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.5874 -1.4835 -0.3389 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4680 -2.4006 -0.1086 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8168 -2.1044 -0.0992 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7890 -3.1716 0.1485 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1552 -0.7116 -0.3130 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5103 -0.4123 -0.3440 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9332 0.8794 -0.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9568 1.8221 -0.7746 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3720 3.2343 -1.0331 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6242 1.5338 -0.7445 C 0 0 0 0 0 0 0 0 0 0 0 0 0.1826 0.2286 -0.5065 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.8876 -0.1275 0.9774 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.8999 1.6227 0.6721 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.6728 0.5366 -0.7242 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6683 1.8451 0.3493 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.6163 -0.0416 2.1114 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.7227 1.3254 2.6530 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3454 -0.3134 2.3907 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6818 0.3069 -1.4246 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3656 -1.5962 0.4969 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.1342 -1.8509 -1.2645 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.7349 -3.4738 0.0806 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0184 -3.2107 1.2392 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6950 -3.1328 -0.4735 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3040 -4.1406 -0.0939 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2107 -1.1898 -0.1839 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9852 1.1441 -0.6092 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2750 3.4066 -0.3796 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6916 3.4025 -2.0628 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6070 3.9571 -0.6681 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1297 2.2891 -0.9016 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 2 4 1 0 4 5 1 0 5 6 1 0 6 7 2 0 7 8 1 0 7 9 1 0 9 10 2 0 10 11 1 0 11 12 2 0 12 13 1 0 12 14 1 0 14 15 2 0 15 4 1 0 15 9 1 0 1 16 1 0 1 17 1 0 1 18 1 0 2 19 1 0 3 20 1 0 3 21 1 0 3 22 1 0 4 23 1 6 5 24 1 0 5 25 1 0 6 26 1 0 8 27 1 0 8 28 1 0 8 29 1 0 10 30 1 0 11 31 1 0 13 32 1 0 13 33 1 0 13 34 1 0 14 35 1 0 M END

Standard InCHIKey	CUUMXRBKJIDIAY-ZDUSSCGKSA-N
Standard InCHI	InChI=1S/C15H20/c1-10(2)13-8-6-12(4)14-7-5-11(3)9-15(13)14/h5-7,9-10,13H,8H2,1-4H3/t13-/m0/s1
SMILES	CC(C)[C@@H]1CC=C(C)c2ccc(C)cc12

Calculated Properties

Physi-Chem Properties

Molecular Weight:	200.16	Volume:	240.337 ? Van der Waals volume.
Dense:	0.833	LogP:	4.929 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	3.811 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-5.058 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	1.0	Rigid Bonds:	11.0
TPSA:	0.0 ? Topological Polar Surface Area.	H-Bond Acceptor:	0.0
H-Bond Donor:	0.0	Rings:	2.0
Heavy Atoms:	0.0

MedChem Properties

QED Drug-Likeness Score:	0.624	GASA:	1.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	3.121	Fsp³:	0.467
MCE-18:	38.182 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Accepted	GSK Rule:	Accepted
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.604	Fluc inhibitor:	0.373 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.528 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.071 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.687	Promiscuous compounds:	0.132

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-4.715	MDCK Permeability:	-4.426
Pgp-inhibitor:	0.983	Pgp-substrate:	0.111
PAMPA:	0.037 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.0
20% Bioavailability (F20%):	0.076	30% Bioavailability (F30%):	0.102
50% Bioavailability (F50%):	0.645

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.654	MRP1:	0.945
Plasma Protein Binding (PPB):	98.116%	Volume Distribution (VD):	0.308
Fu:	1.855% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.995
OATP1B3 inhibitor:	0.79	BCRP inhibitor:	0.033
BSEP inhibitor:	0.996

ADMET: Metabolism

CYP1A2-inhibitor:	0.576	CYP1A2-substrate:	0.998
CYP2C19-inhibitor:	1.0	CYP2C19-substrate:	0.997
CYP2C9-inhibitor:	0.022	CYP2C9-substrate:	0.462
CYP2D6-inhibitor:	0.005	CYP2D6-substrate:	0.983
CYP3A4-inhibitor:	1.0	CYP3A4-substrate:	0.999
CYP2B6-substrate:	0.387	CYP2C8-inhibitor:	1.0
HLM stability:	0.963 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

9.705

Half-life (T1/2):

0.414

ADMET: Toxicity

hERG Blockers:	0.117	hERG Blockers (10um):	0.565
Human Hepatotoxicity (H-HT):	0.699	Drug-induced Liver Injury (DILI):	0.524
AMES Toxicity:	0.632	Rat Oral Acute Toxicity:	0.26
Maximum Recommended Daily Dose:	0.397	Skin Sensitization:	0.764
Carcinogencity:	0.694	Eye Corrosion:	0.892
Eye Irritation:	0.989	Respiratory Toxicity:	0.635
Drug-induced Neurotoxicity:	0.661	Ototoxicity:	0.365
Hematotoxicity:	0.546	Drug-induced Nephrotoxicity:	0.539
Genotoxicity:	0.04	RPMI-8226 Immunitoxicity:	0.077
A549 Cytotoxicity:	0.164	Hek293 Cytotoxicity:	0.191
BCF:	3.273 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	4.385 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	5.11 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	5.409 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	leaf	n.a.	DOI[10.1016/j.foodchem.2010.03.088]
NPO17619	Myrcia multiflora	Species	Myrtaceae	Eukaryota	n.a.	leaf	n.a.	PMID[11911215]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[12088434]
NPO28942	Tetraclinis articulata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12828472]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16249088]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	stems and leaves	n.a.	n.a.	PMID[18004816]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	fruit	n.a.	PMID[18020353]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18027905]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18271558]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	roots	n.a.	n.a.	PMID[18491866]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18590312]
NPO9832	Cryptocarya rugulosa	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19093800]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	twigs	n.a.	n.a.	PMID[19555125]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	Leaves; Stems	n.a.	n.a.	PMID[19653667]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	fresh leaves and stems	n.a.	n.a.	PMID[19653667]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20476749]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[20973550]
NPO17619	Myrcia multiflora	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21472649]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	root	n.a.	PMID[21506530]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	leaf	n.a.	PMID[21506530]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	stem	n.a.	PMID[21506530]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	rhizome	n.a.	PMID[21563811]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21707257]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	rhizomes	n.a.	n.a.	PMID[22671987]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	twigs	n.a.	n.a.	PMID[22677314]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22934600]
NPO14077	Chamaecyparis lawsoniana	Species	Cupressaceae	Eukaryota	n.a.	stem	n.a.	PMID[23157017]
NPO14077	Chamaecyparis lawsoniana	Species	Cupressaceae	Eukaryota	n.a.	leaf	n.a.	PMID[23157017]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23373216]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[23678820]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	rhizome	n.a.	PMID[23713285]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24299567]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25612070]
NPO18155	Salvia argentea	Species	Lamiaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[25880372]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26214125]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	rhizomes	n.a.	n.a.	PMID[26296476]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26305406]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26731565]
NPO18732	Vetiveria zizanioides	Species	Poaceae	Eukaryota	Roots	n.a.	n.a.	PMID[27598828]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	Stems	n.a.	n.a.	PMID[27704807]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	Seeds	n.a.	n.a.	PMID[28134521]
NPO49316	Campomanesia guazumifolia	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29105503]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	Rhizomes	n.a.	n.a.	PMID[29116780]
NPO6429	Phlomis regelii	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29468889]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29726697]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[30543429]
NPO15110	Petasites albus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30600899]
NPO52646	Baccharis oreophila	Genus	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30673172]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30792999]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[30848923]
NPO31482	Pterocarya stenoptera	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30919666]
NPO18732	Vetiveria zizanioides	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31108854]
NPO56029	Vitex gardneriana	Genus	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31229603]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31401871]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31464066]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31500359]
NPO13602	Lavandula multifida	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31500359]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31738062]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31994661]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32035880]
NPO51811	Myrcia eximia	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32059439]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32078653]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32415726]
NPO9832	Cryptocarya rugulosa	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32452825]
NPO7562	Premna odorata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32521614]
NPO48247	Helichrysum araxinum Takht. ex Kirp.	Genus	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32619198]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32674448]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32807141]
NPO55242	Citrus winterianus	Genus	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32975038]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	Bark	n.a.	n.a.	PMID[33151073]
NPO59176	Teucrium Capitatum L. Subsp. Lusitanicum	Genus	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[33230534]
NPO50761	Heteromorpha arborescens	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[33343238]
NPO28942	Tetraclinis articulata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[33669825]
NPO56743	Cistus ladanifer	Species	Cistaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[33921855]
NPO61560	Ocotea quixos	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34203565]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34332066]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34443694]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34486118]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34500567]
NPO47170	Artemisia pallens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34669255]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34684838]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34684884]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34770961]
NPO54335	Blepharocalyx cruckshanksii	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34834029]
NPO17619	Myrcia multiflora	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[34885839]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35108453]
NPO49049	Calendula incana subsp. maritima	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35163853]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35264638]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35344272]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35408950]
NPO24416	Artemisia tournefortiana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35508595]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35608311]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35631245]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35872238]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35889256]
NPO59923	Myriactis nepalensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[35889501]
NPO44665	Achillea coarctata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36006860]
NPO61833	Ammi crinitum	Genus	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36047989]
NPO48225	Hyptis crenata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36113677]
NPO22456	Schinus terebinthifolia	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36206869]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36235238]
NPO56743	Cistus ladanifer	Species	Cistaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36243295]
NPO55789	Prunus ulmifolia	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36302154]
NPO48520	Rhododendron davidsonianum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36310430]
NPO59410	Rhododendron heliolepi	Genus	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36310430]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36364159]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36401242]
NPO49559	Eugenia stipitata	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36469681]
NPO45619	Myrcia sylvatica	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36558108]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36558111]
NPO61853	Tanacetum balsamita	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36559586]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36577196]
NPO61201	Vouacapoua americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36616228]
NPO60587	Hypericum revolutum subsp. keniense	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36636606]
NPO13602	Lavandula multifida	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36676052]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36677644]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36770639]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36773055]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36840093]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36840093]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36903935]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36903957]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36984777]
NPO46526	Guatteria schomburgkiana	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36985605]
NPO26268	Salvia aethiopis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36987013]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36987101]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37020229]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37047195]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37049808]
NPO48225	Hyptis crenata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37110606]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37115147]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37175125]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37179510]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37226152]
NPO50176	Ferula tingitana	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37338647]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37396469]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37446712]
NPO14077	Chamaecyparis lawsoniana	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37447036]
NPO22456	Schinus terebinthifolia	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37447058]
NPO45102	Cupressus arizonica	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37482262]
NPO9773	Sideritis raeseri	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37509192]
NPO51204	Pelargonium peltatum	Species	Geraniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37513168]
NPO8443	Uvaria microcarpa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37531297]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37533252]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37571040]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37667613]
NPO47860	Gonystylus bancanus	Species	Thymelaeaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37709800]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37801906]
NPO53087	Epaltes australis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37819841]
NPO54759	Steiractinia sodiroi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37821569]
NPO23312	Matricaria aurea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37896017]
NPO55150	Grewia bulot	Genus	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37910669]
NPO62335	Eugenia brasiliensis	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37917799]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37917799]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37917799]
NPO63537	Syzygium acuminatissimum	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38005226]
NPO55450	Syzygium vestitum	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38005226]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38005226]
NPO58210	Anthemis palestina	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38005810]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38053906]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38067590]
NPO57207	Thymus fontanesii	Genus	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38199324]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38257205]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38257290]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38263385]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38370080]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38370080]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38380569]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38381096]
NPO50815	Pistacia khinjuk	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38412297]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38474654]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38474654]
NPO55000	Cyperus articulatus	Species	Cyperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38475535]
NPO4296	Polyalthia suberosa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38609961]
NPO26268	Salvia aethiopis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38611827]
NPO18155	Salvia argentea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38611827]
NPO53768	Salvia ringens	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38611827]
NPO4424	Salvia amplexicaulis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38611827]
NPO50512	Populus Ã— berolinensis	Genus	Salicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38612781]
NPO52307	psychotria asiatica	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38613430]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38617605]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38677581]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38688144]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38695450]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38695450]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38695450]
NPO14077	Chamaecyparis lawsoniana	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38794396]
NPO19162	Tsuga heterophylla	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38794396]
NPO47860	Gonystylus bancanus	Species	Thymelaeaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38802441]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38821245]
NPO22456	Schinus terebinthifolia	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38893531]
NPO45785	Peperomia leptostachya	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38930872]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38998569]
NPO60918	Drimys granadensis	Species	Winteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38999646]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39063231]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39064968]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39088897]
NPO21821	Aeschynomene indica	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39124959]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39135848]
NPO47601	Thymus zygis subsp. gracilis	Genus	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39205636]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39407547]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39489989]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39520005]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39588261]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39592457]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39592457]
NPO1942	Piper philippinum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39771253]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[4013523]
NPO4296	Polyalthia suberosa	Species	Annonaceae	Eukaryota	n.a.	leaf	n.a.	PMID[8377018]
NPO4296	Polyalthia suberosa	Species	Annonaceae	Eukaryota	n.a.	stem	n.a.	PMID[8377018]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[8864235]
NPO17619	Myrcia multiflora	Species	Myrtaceae	Eukaryota	n.a.	leaf	n.a.	PMID[9468642]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	stem	n.a.	Database[Article]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7562	Premna odorata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4296	Polyalthia suberosa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO22456	Schinus terebinthifolia	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1942	Piper philippinum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO55000	Cyperus articulatus	Species	Cyperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO24416	Artemisia tournefortiana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13602	Lavandula multifida	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8443	Uvaria microcarpa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO45102	Cupressus arizonica	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26268	Salvia aethiopis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO23312	Matricaria aurea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17619	Myrcia multiflora	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO28942	Tetraclinis articulata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9773	Sideritis raeseri	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO47170	Artemisia pallens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18732	Vetiveria zizanioides	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19162	Tsuga heterophylla	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO61201	Vouacapoua americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18155	Salvia argentea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15110	Petasites albus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO24390	Juniperus rigida	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14077	Chamaecyparis lawsoniana	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO44665	Achillea coarctata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	Bark	n.a.	n.a.	Database[FooDB]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	Bark	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Essential Oil	n.a.	n.a.	Database[FooDB]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	Shoot Essent. Oil	n.a.	n.a.	Database[FooDB]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	Stem Bark	n.a.	n.a.	Database[FooDB]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	Tissue Culture	n.a.	n.a.	Database[FooDB]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	Tissue Culture	n.a.	n.a.	Database[FooDB]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24390	Juniperus rigida	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19162	Tsuga heterophylla	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO42012	Rosmarinus officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24390	Juniperus rigida	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18732	Vetiveria zizanioides	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22456	Schinus terebinthifolia	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19162	Tsuga heterophylla	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4296	Polyalthia suberosa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO24390	Juniperus rigida	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO31458	Cinnamomum cassia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO31482	Pterocarya stenoptera	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29169	Origanum vulgare	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6701	Cinnamomum camphora	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6429	Phlomis regelii	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24390	Juniperus rigida	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7562	Premna odorata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16966	Leptospermum scoparium	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24416	Artemisia tournefortiana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14077	Chamaecyparis lawsoniana	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4988	Lavandula stoechas	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28942	Tetraclinis articulata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9138	Syzygium cumini	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8443	Uvaria microcarpa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12878	Cupressus sempervirens	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21821	Aeschynomene indica	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9370	Piper gaudichaudianum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15388	Eucalyptus globulus	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4424	Salvia amplexicaulis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19162	Tsuga heterophylla	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13602	Lavandula multifida	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18155	Salvia argentea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4296	Polyalthia suberosa	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26268	Salvia aethiopis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9773	Sideritis raeseri	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18732	Vetiveria zizanioides	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1942	Piper philippinum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23312	Matricaria aurea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25682	Acorus calamus	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3359	Psidium guajava	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10932	Melissa officinalis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9832	Cryptocarya rugulosa	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8666	Acorus tatarinowii	Species	Acoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22456	Schinus terebinthifolia	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3689	Cinnamomum verum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15110	Petasites albus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17619	Myrcia multiflora	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO912	Kadsura coccinea	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference
NPO10932	Melissa officinalis	Oil	n.a.	0.76	n.a.	n.a.	%	PMID[35408950]
NPO12878	Cupressus sempervirens	Oil	n.a.	0.01	n.a.	n.a.	%	PMID[39592457]
NPO13602	Lavandula multifida	Oil	n.a.	0.19	n.a.	n.a.	%	PMID[36676052]
NPO14077	Chamaecyparis lawsoniana	Oil	Leaves	0.03	n.a.	n.a.	%	PMID[37447036]
NPO15110	Petasites albus	Oil	n.a.	0.13	n.a.	n.a.	%	PMID[30600899]
NPO15388	Eucalyptus globulus	Oil	n.a.	0.01	n.a.	n.a.	%	PMID[39592457]
NPO16966	Leptospermum scoparium	Oil	n.a.	8.72Â±0.66	n.a.	n.a.	Î¼g/Î¼L	PMID[38370080]
NPO17619	Myrcia multiflora	Oil	n.a.	0.07	n.a.	n.a.	%	PMID[34885839]
NPO18155	Salvia argentea	Oil	n.a.	0.5	n.a.	n.a.	%	PMID[38611827]
NPO18732	Vetiveria zizanioides	Oil	n.a.	0.59	n.a.	n.a.	%	PMID[31108854]
NPO18732	Vetiveria zizanioides	Oil	n.a.	1.31	n.a.	n.a.	%	PMID[31108854]
NPO18732	Vetiveria zizanioides	Oil	n.a.	0.45	n.a.	n.a.	%	PMID[31108854]
NPO19162	Tsuga heterophylla	Oil	Leaves	0.2	n.a.	n.a.	%	PMID[38794396]
NPO1942	Piper philippinum	Oil	Aerial parts	0.142 Â± 0.022	n.a.	n.a.	%	PMID[39771253]
NPO1942	Piper philippinum	Oil	Aerial parts	0.226 Â± 0.014	n.a.	n.a.	%	PMID[39771253]
NPO19472	Thymus vulgaris	Oil	n.a.	0.01	n.a.	n.a.	%	PMID[37226152]
NPO21821	Aeschynomene indica	Oil	Leaves	0.5	n.a.	n.a.	%	PMID[39124959]
NPO22456	Schinus terebinthifolia	Oil	n.a.	0.11	n.a.	n.a.	%	PMID[37447058]
NPO22456	Schinus terebinthifolia	Oil	n.a.	0.06	n.a.	n.a.	%	PMID[37447058]
NPO22456	Schinus terebinthifolia	Oil	n.a.	0.18	n.a.	n.a.	%	PMID[37447058]
NPO22456	Schinus terebinthifolia	Oil	n.a.	0.02	n.a.	n.a.	%	PMID[37447058]
NPO22456	Schinus terebinthifolia	Oil	n.a.	0.03	n.a.	n.a.	%	PMID[37447058]
NPO22456	Schinus terebinthifolia	Oil	n.a.	1.12	n.a.	n.a.	%	PMID[37447058]
NPO22456	Schinus terebinthifolia	Oil	n.a.	0.17	n.a.	n.a.	%	PMID[37447058]
NPO23312	Matricaria aurea	Oil	Aerial parts	0.1	n.a.	n.a.	%	PMID[37896017]
NPO24416	Artemisia tournefortiana	Oil	n.a.	0.67	n.a.	n.a.	%	PMID[35508595]
NPO26268	Salvia aethiopis	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[38611827]
NPO28942	Tetraclinis articulata	Oil	n.a.	0.3	n.a.	n.a.	%	PMID[33669825]
NPO29169	Origanum vulgare	Steam distillation	n.a.	0.173	n.a.	n.a.	mg/g	PMID[35608311]
NPO29169	Origanum vulgare	n-hexane extract	n.a.	0.081	n.a.	n.a.	mg/g	PMID[35608311]
NPO29169	Origanum vulgare	CO2 extract	n.a.	0.351	n.a.	n.a.	mg/g	PMID[35608311]
NPO31458	Cinnamomum cassia	Oil	n.a.	0.38	n.a.	n.a.	%	PMID[34332066]
NPO31458	Cinnamomum cassia	Oil	Bark	0.55	n.a.	n.a.	%	PMID[38688144]
NPO31458	Cinnamomum cassia	Oil	Bark	0.12	n.a.	n.a.	%	PMID[38688144]
NPO31482	Pterocarya stenoptera	Oil	n.a.	2.73	n.a.	n.a.	%	PMID[30919666]
NPO3359	Psidium guajava	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[31401871]
NPO3689	Cinnamomum verum	Oil	Leaves	0.03	n.a.	n.a.	%	PMID[36364159]
NPO42012	Rosmarinus officinalis	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[38474654]
NPO4296	Polyalthia suberosa	Oil	n.a.	0.34	n.a.	n.a.	%	PMID[38609961]
NPO4296	Polyalthia suberosa	Oil	n.a.	0.17	n.a.	n.a.	%	PMID[38609961]
NPO4424	Salvia amplexicaulis	Oil	n.a.	0.2	n.a.	n.a.	%	PMID[38611827]
NPO44665	Achillea coarctata	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[36006860]
NPO44665	Achillea coarctata	Oil	n.a.	0.2	n.a.	n.a.	%	PMID[36006860]
NPO44665	Achillea coarctata	Oil	n.a.	0.5	n.a.	n.a.	%	PMID[36006860]
NPO44665	Achillea coarctata	Oil	n.a.	0.4	n.a.	n.a.	%	PMID[36006860]
NPO44665	Achillea coarctata	Oil	n.a.	0.3	n.a.	n.a.	%	PMID[36006860]
NPO45102	Cupressus arizonica	Oil	n.a.	0.04	n.a.	n.a.	%	PMID[37482262]
NPO45619	Myrcia sylvatica	Oil	Leaves	1.4	n.a.	n.a.	%	PMID[36558108]
NPO45619	Myrcia sylvatica	Oil	Leaves	1.9	n.a.	n.a.	%	PMID[36558108]
NPO45619	Myrcia sylvatica	Oil	Leaves	0.6	n.a.	n.a.	%	PMID[36558108]
NPO45619	Myrcia sylvatica	Oil	Leaves	0.5	n.a.	n.a.	%	PMID[36558108]
NPO45619	Myrcia sylvatica	Oil	Leaves	0.9	n.a.	n.a.	%	PMID[36558108]
NPO45785	Peperomia leptostachya	Oil	Leaves	0.2	n.a.	n.a.	%	PMID[38930872]
NPO46526	Guatteria schomburgkiana	Oil	n.a.	0.37	n.a.	n.a.	%	PMID[36985605]
NPO47170	Artemisia pallens	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[34669255]
NPO47601	Thymus zygis subsp. gracilis	Oil	n.a.	0.01 Â± 0.00	n.a.	n.a.	%	PMID[39205636]
NPO47860	Gonystylus bancanus	Oil	n.a.	0.71	n.a.	n.a.	%	PMID[38802441]
NPO47860	Gonystylus bancanus	n-hexane extract	n.a.	0.44	n.a.	n.a.	%	PMID[37709800]
NPO47860	Gonystylus bancanus	Ethyl acetate extract	n.a.	0.15	n.a.	n.a.	%	PMID[37709800]
NPO48225	Hyptis crenata	Oil	n.a.	0.4	n.a.	n.a.	%	PMID[37110606]
NPO48247	Helichrysum araxinum Takht. ex Kirp.	Oil	n.a.	0.4Â±0.01	n.a.	n.a.	%	PMID[32619198]
NPO48520	Rhododendron davidsonianum	Oil	n.a.	0.42	n.a.	n.a.	%	PMID[36310430]
NPO49049	Calendula incana subsp. maritima	Oil	n.a.	0.80 Â± 0.007	n.a.	n.a.	%	PMID[35163853]
NPO49316	Campomanesia guazumifolia	Oil	n.a.	1550	n.a.	n.a.	%	PMID[29105503]
NPO49559	Eugenia stipitata	Oil	n.a.	0.31Â±0.00	n.a.	n.a.	%	PMID[36469681]
NPO4988	Lavandula stoechas	Oil	n.a.	1.20Â±0.14	n.a.	n.a.	%	PMID[31464066]
NPO50176	Ferula tingitana	n.a.	n.a.	0.3	n.a.	n.a.	%	PMID[37338647]
NPO50512	Populus Ã— berolinensis	Ether extract	Leaves	0.23	n.a.	n.a.	%	PMID[38612781]
NPO50761	Heteromorpha arborescens	Oil	n.a.	1.12	n.a.	n.a.	%	PMID[33343238]
NPO50815	Pistacia khinjuk	Oil	Leaves	0.43	n.a.	n.a.	%	PMID[38412297]
NPO51204	Pelargonium peltatum	Oil	Leaves	0.8	n.a.	n.a.	%	PMID[37513168]
NPO51811	Myrcia eximia	Oil	n.a.	0.23	n.a.	n.a.	%	PMID[32059439]
NPO51811	Myrcia eximia	Oil	n.a.	0.58	n.a.	n.a.	%	PMID[32059439]
NPO52307	psychotria asiatica	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[38613430]
NPO52646	Baccharis oreophila	Oil	n.a.	1.34	n.a.	n.a.	%	PMID[30673172]
NPO53087	Epaltes australis	Oil	Leaves	0.1	n.a.	n.a.	%	PMID[37819841]
NPO53768	Salvia ringens	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[38611827]
NPO54335	Blepharocalyx cruckshanksii	Oil	n.a.	0.21	n.a.	n.a.	%	PMID[34834029]
NPO54759	Steiractinia sodiroi	Oil	n.a.	0.3	n.a.	n.a.	%	PMID[37821569]
NPO55000	Cyperus articulatus	Ethanolic extract	n.a.	1.03	n.a.	n.a.	%	PMID[38475535]
NPO55150	Grewia bulot	Oil	Leaves	0.8	n.a.	n.a.	%	PMID[37910669]
NPO55242	Citrus winterianus	Oil	n.a.	0.1	n.a.	n.a.	%	PMID[32975038]
NPO55450	Syzygium vestitum	Oil	Leaves	0.8	n.a.	n.a.	%	PMID[38005226]
NPO55789	Prunus ulmifolia	Oil	Leaves	0.20	n.a.	n.a.	%	PMID[36302154]
NPO56029	Vitex gardneriana	Oil	n.a.	4.4	n.a.	n.a.	%	PMID[31229603]
NPO56743	Cistus ladanifer	Oil	n.a.	0.36	n.a.	n.a.	%	PMID[33921855]
NPO56743	Cistus ladanifer	Oil	n.a.	0.42	n.a.	n.a.	%	PMID[33921855]
NPO56743	Cistus ladanifer	Oil	n.a.	0.49	n.a.	n.a.	%	PMID[33921855]
NPO57207	Thymus fontanesii	Oil	n.a.	0.01	n.a.	n.a.	%	PMID[38199324]
NPO58210	Anthemis palestina	Oven-dried	n.a.	0.14	n.a.	n.a.	%	PMID[38005810]
NPO59176	Teucrium Capitatum L. Subsp. Lusitanicum	Oil	n.a.	0.3	n.a.	n.a.	%	PMID[33230534]
NPO59410	Rhododendron heliolepi	Oil	n.a.	0.19	n.a.	n.a.	%	PMID[36310430]
NPO59923	Myriactis nepalensis	Oil	n.a.	0.5	n.a.	n.a.	%	PMID[35889501]
NPO60587	Hypericum revolutum subsp. keniense	Oil	Leaves	0.3	n.a.	n.a.	%	PMID[36636606]
NPO60587	Hypericum revolutum subsp. keniense	Oil	Flowers	0	n.a.	n.a.	%	PMID[36636606]
NPO60918	Drimys granadensis	Oil	n.a.	0.19	n.a.	n.a.	%	PMID[38999646]
NPO61201	Vouacapoua americana	Oil	n.a.	0.91	n.a.	n.a.	%	PMID[36616228]
NPO61560	Ocotea quixos	Oil	Leaves	1.18	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	0.32	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	0.08	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	5.01	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	0.45	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	3.02	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	0.38	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	0	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	0.47	n.a.	n.a.	%	PMID[34203565]
NPO61560	Ocotea quixos	Oil	Leaves	1.73	n.a.	n.a.	%	PMID[34203565]
NPO61833	Ammi crinitum	Oil	n.a.	0.2	n.a.	n.a.	%	PMID[36047989]
NPO61853	Tanacetum balsamita	Oil	Stems	0.4	n.a.	n.a.	%	PMID[36559586]
NPO62335	Eugenia brasiliensis	Oil	n.a.	0.47Â±0.05	n.a.	n.a.	%	PMID[37917799]
NPO63537	Syzygium acuminatissimum	Oil	Leaves	1.0	n.a.	n.a.	%	PMID[38005226]
NPO63537	Syzygium acuminatissimum	Oil	Fruits	0.8	n.a.	n.a.	%	PMID[38005226]
NPO6429	Phlomis regelii	Oil	n.a.	0.2	n.a.	n.a.	%	PMID[29468889]
NPO7562	Premna odorata	Oil	n.a.	0.09	n.a.	n.a.	%	PMID[32521614]
NPO7562	Premna odorata	Oil	n.a.	0.13	n.a.	n.a.	%	PMID[32521614]
NPO8443	Uvaria microcarpa	Oil	Leaves	0.2	n.a.	n.a.	%	PMID[37531297]
NPO8666	Acorus tatarinowii	Oil	n.a.	1.79Â±0.95	n.a.	n.a.	%	PMID[32807141]
NPO8666	Acorus tatarinowii	Oil	n.a.	0.09	n.a.	n.a.	%	PMID[38821245]
NPO912	Kadsura coccinea	Oil	n.a.	0.11 Â± 0.01	n.a.	n.a.	%	PMID[34684838]
NPO9138	Syzygium cumini	Oil	n.a.	0.58	n.a.	n.a.	%	PMID[32415726]
NPO9370	Piper gaudichaudianum	Oil	n.a.	0.52	n.a.	n.a.	%	PMID[39088897]
NPO9370	Piper gaudichaudianum	Oil	Leaves	2.61	n.a.	n.a.	%	PMID[37396469]
NPO9773	Sideritis raeseri	Oil	n.a.	0.37	n.a.	n.a.	%	PMID[37509192]
NPO9832	Cryptocarya rugulosa	Oil	n.a.	0.2 Â± 0.1	n.a.	n.a.	%	PMID[32452825]

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC74474 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	35410
0.1-0.2	14310
0.2-0.3	129
0.3-0.4	6
0.4-0.5	1
0.5-0.6	3
0.6-0.7	0
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.5714	Remote Similarity	NPC21594
0.5714	Remote Similarity	NPC606162
0.5455	Remote Similarity	NPC470723

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC74474 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	6478
0.1-0.2	2659
0.2-0.3	13
0.3-0.4	0
0.4-0.5	0
0.5-0.6	0
0.6-0.7	0
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
		NPD

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data