Structure

Physi-Chem Properties

Molecular Weight:  284.07
Volume:  282.482
LogP:  4.271
LogD:  3.033
LogS:  -6.12
# Rotatable Bonds:  1
TPSA:  83.83
# H-Bond Aceptor:  5
# H-Bond Donor:  2
# Rings:  3
# Heavy Atoms:  5

MedChem Properties

QED Drug-Likeness Score:  0.715
Synthetic Accessibility Score:  2.307
Fsp3:  0.125
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Accepted
GSK Rule:  Rejected
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  0
PAINS Alert:  1

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -5.078
MDCK Permeability:  1.6211337424465455e-05
Pgp-inhibitor:  0.044
Pgp-substrate:  0.003
Human Intestinal Absorption (HIA):  0.021
20% Bioavailability (F20%):  0.027
30% Bioavailability (F30%):  0.996

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.045
Plasma Protein Binding (PPB):  99.49099731445312%
Volume Distribution (VD):  0.429
Pgp-substrate:  1.0696302652359009%

ADMET: Metabolism

CYP1A2-inhibitor:  0.947
CYP1A2-substrate:  0.835
CYP2C19-inhibitor:  0.208
CYP2C19-substrate:  0.064
CYP2C9-inhibitor:  0.597
CYP2C9-substrate:  0.579
CYP2D6-inhibitor:  0.343
CYP2D6-substrate:  0.267
CYP3A4-inhibitor:  0.624
CYP3A4-substrate:  0.15

ADMET: Excretion

Clearance (CL):  7.339
Half-life (T1/2):  0.15

ADMET: Toxicity

hERG Blockers:  0.04
Human Hepatotoxicity (H-HT):  0.058
Drug-inuced Liver Injury (DILI):  0.935
AMES Toxicity:  0.856
Rat Oral Acute Toxicity:  0.207
Maximum Recommended Daily Dose:  0.926
Skin Sensitization:  0.258
Carcinogencity:  0.536
Eye Corrosion:  0.004
Eye Irritation:  0.962
Respiratory Toxicity:  0.123

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs  

  Natural Product: NPC312929

Natural Product ID:  NPC312929
Common Name*:   Physcion
IUPAC Name:   1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Synonyms:   Physcion
Standard InCHIKey:  FFWOKTFYGVYKIR-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
SMILES:  COc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(O)cc(c1)C
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   CHEMBL42624
PubChem CID:   10639
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0002448] Benzenoids
      • [CHEMONTID:0000018] Anthracenes
        • [CHEMONTID:0000151] Anthraquinones

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO12079 Dysoxylum cumingianum Species Meliaceae Eukaryota n.a. leaf n.a. DOI[10.1021/jo00051a050]
NPO25430 Xanthoceras sorbifolium Species Sapindaceae Eukaryota n.a. xylem n.a. PMID[10691716]
NPO88 Rheum undulatum Species Polygonaceae Eukaryota rhizome n.a. n.a. PMID[10714491]
NPO21244 Delphinium nuttallianum Species Ranunculaceae Eukaryota n.a. n.a. n.a. PMID[10978210]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. PMID[11076555]
NPO27239 Maclura tinctoria Species Moraceae Eukaryota n.a. n.a. n.a. PMID[11087602]
NPO8179 Laccaria amethystea Species Tricholomataceae Eukaryota n.a. n.a. n.a. PMID[11213295]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. PMID[11374975]
NPO14520 Bassia muricata Species Chenopodiaceae Eukaryota n.a. aerial part n.a. PMID[11454355]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota Roots n.a. n.a. PMID[11459643]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota n.a. n.a. n.a. PMID[11575955]
NPO27239 Maclura tinctoria Species Moraceae Eukaryota n.a. stem n.a. PMID[12932124]
NPO27239 Maclura tinctoria Species Moraceae Eukaryota n.a. n.a. n.a. PMID[12932124]
NPO30021 Rheum emodi Species Polygonaceae Eukaryota Roots Gorkha district, Nepal 1996-OCT PMID[12932135]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[136119]
NPO16746 Lendenfeldia frondosa Species Thorectidae Eukaryota n.a. n.a. n.a. PMID[1402955]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota n.a. bulb n.a. PMID[14994197]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. PMID[1517743]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. PMID[15686910]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota n.a. n.a. n.a. PMID[15844951]
NPO25801 Harungana madagascariensis Species Hypericaceae Eukaryota stem bark n.a. n.a. PMID[16499321]
NPO29417 Fallopia multiflora Species Polygonaceae Eukaryota n.a. root n.a. PMID[16564530]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota tubers n.a. n.a. PMID[16792409]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota stems Yunnan Province, China 2004 PMID[17253844]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota Roots Panan, Zhejiang Province, China 2004-MAY PMID[17256902]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota n.a. root n.a. PMID[17256902]
NPO28260 Senna alexandrina Species Fabaceae Eukaryota n.a. seed n.a. PMID[17345316]
NPO25801 Harungana madagascariensis Species Hypericaceae Eukaryota Leaves n.a. n.a. PMID[17352491]
NPO7198 Scilla socialis Species Hyacinthaceae Eukaryota n.a. n.a. n.a. PMID[17536859]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota Stems purchased from Kyoungdong Oriental Herbal Market, Seoul, Korea 2006-APR PMID[18052323]
NPO8819 Nepeta parnassica Species Lamiaceae Eukaryota aerial parts Mt. Parnassos, Greece n.a. PMID[18393463]
NPO21244 Delphinium nuttallianum Species Ranunculaceae Eukaryota n.a. n.a. n.a. PMID[19012276]
NPO2188 Dendrobium candidum Species Orchidaceae Eukaryota n.a. stem n.a. PMID[19182417]
NPO397 Thymelaea hirsuta Species Thymelaeaceae Eukaryota n.a. n.a. n.a. PMID[19284745]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[19299148]
NPO28478 Magnolia ovata Species Magnoliaceae Eukaryota n.a. leaf n.a. PMID[19658431]
NPO12477 Dodonaea viscosa Species Sapindaceae Eukaryota n.a. n.a. n.a. PMID[19719093]
NPO26326 Ocotea macrophylla Species Lauraceae Eukaryota leaves n.a. n.a. PMID[19880317]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. PMID[20476749]
NPO30179 Cassia occidentalis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[21080643]
NPO5681 Acorus gramineus Species Acoraceae Eukaryota Rhizomes n.a. n.a. PMID[21936523]
NPO5681 Acorus gramineus Species Acoraceae Eukaryota n.a. rhizome n.a. PMID[21936523]
NPO8921 Senna obtusifolia Species Fabaceae Eukaryota Seeds n.a. n.a. PMID[2213033]
NPO12477 Dodonaea viscosa Species Sapindaceae Eukaryota n.a. n.a. n.a. PMID[22512738]
NPO5681 Acorus gramineus Species Acoraceae Eukaryota rhizomes n.a. n.a. PMID[22951040]
NPO28478 Magnolia ovata Species Magnoliaceae Eukaryota n.a. fruit n.a. PMID[23157012]
NPO17553 Pleione bulbocodioides Species Orchidaceae Eukaryota n.a. n.a. n.a. PMID[23627123]
NPO32491 rumex plants n.a. Polygonaceae Eukaryota n.a. n.a. n.a. PMID[23683594]
NPO32783 endophytic aspergillus Species n.a. n.a. n.a. n.a. n.a. PMID[23683594]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. rhizome n.a. PMID[23713285]
NPO31520 Polygonum multiflorum Species Polygonaceae Eukaryota roots n.a. n.a. PMID[24499304]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota n.a. leaf n.a. PMID[24680612]
NPO23332 Dendrobium fimbriatum Species Orchidaceae Eukaryota stems n.a. n.a. PMID[25316316]
NPO26465 Coreopsis tinctoria Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[25516207]
NPO28626 Isodon rubescens Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[25590529]
NPO19996 Caulerpa peltata Species Caulerpaceae Eukaryota n.a. n.a. n.a. PMID[25593390]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota n.a. n.a. n.a. PMID[25712646]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota Fibrous Roots n.a. n.a. PMID[25760525]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota rhizomes n.a. n.a. PMID[26296476]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. PMID[26305406]
NPO31136 Cassia tora Species Fabaceae Eukaryota seeds n.a. n.a. PMID[26483136]
NPO25801 Harungana madagascariensis Species Hypericaceae Eukaryota n.a. n.a. n.a. PMID[26727375]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota Stems n.a. n.a. PMID[27310249]
NPO13237 Teucrium yemense Species n.a. n.a. Aerial Parts n.a. n.a. PMID[28581290]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota Rhizomes n.a. n.a. PMID[29116780]
NPO29417 Fallopia multiflora Species Polygonaceae Eukaryota Roots n.a. n.a. PMID[29359942]
NPO27164 Aspergillus alliaceus Species Aspergillaceae Eukaryota n.a. n.a. n.a. PMID[29517220]
NPO28688 Aster tataricus Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[30931559]
NPO865 Dendrobium loddigesii Species Orchidaceae Eukaryota n.a. n.a. n.a. PMID[31291099]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. PMID[31415170]
NPO29417 Fallopia multiflora Species Polygonaceae Eukaryota Roots n.a. n.a. PMID[31944695]
NPO27164 Aspergillus alliaceus Species Aspergillaceae Eukaryota n.a. n.a. n.a. PMID[3417561]
NPO19935 Evodia rutaecarpa Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[7463094]
NPO29417 Fallopia multiflora Species Polygonaceae Eukaryota Roots; Tubers n.a. n.a. PMID[7714535]
NPO19935 Evodia rutaecarpa Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[8201313]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. PMID[8277318]
NPO33118 Rhamnus Genus Rhamnaceae Eukaryota n.a. n.a. n.a. PMID[8350094]
NPO19935 Evodia rutaecarpa Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[8699182]
NPO29836 Cassia obtusifolia Species Fabaceae Eukaryota n.a. seed n.a. PMID[9810700]
NPO40013 Alvaradoa jamaicensis Species Picramniaceae Eukaryota n.a. n.a. n.a. PMID[9917291]
NPO23256 Mentha arvensis Species Lamiaceae Eukaryota Plant n.a. n.a. Database[FooDB]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota n.a. n.a. Database[FooDB]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. Database[FooDB]
NPO13418 Rumex acetosa Species Polygonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO13418 Rumex acetosa Species Polygonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO13418 Rumex acetosa Species Polygonaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO23256 Mentha arvensis Species Lamiaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO26917 Quercus rubra Species Fagaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5681 Acorus gramineus Species Acoraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30811 Cassia angustifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30021 Rheum emodi Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14014 Eriocheir sinensis Species Varunidae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20881 Rheum officinale Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20490 Erythrophleum ivorense Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19073 Uncaria lancifolia Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO12755 Siphonostegia chinensis Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO574 Rumex nepalensis Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14951 Zanthoxylum acanthopodium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO16040 Pristimera indica Species Celastraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24699 Phlogacanthus curviflorus Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28688 Aster tataricus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO12477 Dodonaea viscosa Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO31520 Polygonum multiflorum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24601 Rumex dentatus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO31136 Cassia tora Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18659 Prunus japonica Species Rosaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO865 Dendrobium loddigesii Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30179 Cassia occidentalis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7632 Rheum tanguticum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7142 Corydalis suaveolens Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28024 Rheum palmatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29836 Cassia obtusifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO4278 Wikstroemia monticola Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20144 Lespedeza tomentosa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20900 Dendrobium chrysotoxum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29776 Cassia acutifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13418 Rumex acetosa Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30972 Morinda officinalis Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14304 Physalis alkekengi Species Solanaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13107 Rumex patientia Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota Seeds n.a. Database[Phenol-Explorer]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15297 Aconitum seravschanicum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11889 Dendrobium chrysanthum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13754 Tanacetum coccineum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5681 Acorus gramineus Species Acoraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7672 Senna tora Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12477 Dodonaea viscosa Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO865 Dendrobium loddigesii Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24699 Phlogacanthus curviflorus Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28024 Rheum palmatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18659 Prunus japonica Species Rosaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24601 Rumex dentatus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26899 Cheilanthes argentea Species Pteridaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20144 Lespedeza tomentosa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28688 Aster tataricus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20881 Rheum officinale Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25801 Harungana madagascariensis Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO29193 Nekemias grossedentata Species Vitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13418 Rumex acetosa Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17018 Salvia greggii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14951 Zanthoxylum acanthopodium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9721 Radix moghaniae philippinensis Species Lymnaeidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2228 Photinia serratifolia Species Rosaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19050 Garcinia polyantha Species Clusiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20900 Dendrobium chrysotoxum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12755 Siphonostegia chinensis Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12759 Rheum australe Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO27363 Gynochthodes officinalis Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13857 Mentha canadensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14014 Eriocheir sinensis Species Varunidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8921 Senna obtusifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19935 Evodia rutaecarpa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO574 Rumex nepalensis Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11777 Pluchea sericea Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12834 Radix polygoni multiflori preparata Species Lymnaeidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26401 Andrographis neesiana Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13107 Rumex patientia Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3022 Toxicopueraria peduncularis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO29417 Fallopia multiflora Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7632 Rheum tanguticum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14304 Physalis alkekengi Species Solanaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11222 Rubus alceifolius Species Rosaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO16040 Pristimera indica Species Celastraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25628 Abrus pulchellus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28260 Senna alexandrina Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3980 Frangula purshiana Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO4278 Wikstroemia monticola Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25430 Xanthoceras sorbifolium Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO27140 Amanita phalloides Species Amanitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12327 Senna occidentalis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26917 Quercus rubra Species Fagaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7142 Corydalis suaveolens Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28626 Isodon rubescens Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21691 Dillenia indica Species Dilleniaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20490 Erythrophleum ivorense Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19073 Uncaria lancifolia Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO865 Dendrobium loddigesii Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO14014 Eriocheir sinensis Species Varunidae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO30972 Morinda officinalis Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO29776 Cassia acutifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO20490 Erythrophleum ivorense Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO30179 Cassia occidentalis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28688 Aster tataricus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO29836 Cassia obtusifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO574 Rumex nepalensis Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO31136 Cassia tora Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO24601 Rumex dentatus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO29449 Boehmeria nivea Species Urticaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17553 Pleione bulbocodioides Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO12755 Siphonostegia chinensis Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO12477 Dodonaea viscosa Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO30811 Cassia angustifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO12875 Pleione yunnanensis Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO13107 Rumex patientia Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO31520 Polygonum multiflorum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO20881 Rheum officinale Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28024 Rheum palmatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO18659 Prunus japonica Species Rosaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO7632 Rheum tanguticum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28626 Isodon rubescens Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO11889 Dendrobium chrysanthum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO16845 Euodia bodinieri Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO19935 Evodia rutaecarpa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO20881 Rheum officinale Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO27363 Gynochthodes officinalis Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO13857 Mentha canadensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO12755 Siphonostegia chinensis Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO16419 Rumex chalepensis Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO2188 Dendrobium candidum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO20900 Dendrobium chrysotoxum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO7632 Rheum tanguticum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO88 Rheum undulatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO18659 Prunus japonica Species Rosaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO29449 Boehmeria nivea Species Urticaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO28688 Aster tataricus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO23256 Mentha arvensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO12875 Pleione yunnanensis Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO8921 Senna obtusifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO23332 Dendrobium fimbriatum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO25238 Rheum coreanum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO5681 Acorus gramineus Species Acoraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO7672 Senna tora Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO865 Dendrobium loddigesii Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO28024 Rheum palmatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO8314 Euodia ruticarpa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO4877 Euodia officinalis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO28260 Senna alexandrina Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO29417 Fallopia multiflora Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO14304 Physalis alkekengi Species Solanaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO17553 Pleione bulbocodioides Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO574 Rumex nepalensis Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12817 Leopoldia comosa Species Hyacinthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13857 Mentha canadensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21564 Senecio behnii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11222 Rubus alceifolius Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11777 Pluchea sericea Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29193 Nekemias grossedentata Species Vitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27140 Amanita phalloides Species Amanitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8819 Nepeta parnassica Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25664 Halorhodospira halochloris Species Ectothiorhodospiraceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO11749 Eria mollis Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14412 Aphyllocladus denticulatus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7142 Corydalis suaveolens Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25238 Rheum coreanum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1671.1 Xanthium strumarium var. canadense Varieties Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4111 Schistostephium artemisiifolium Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO986 Rattus rattus Species Muridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13673 Ipomoea muelleri Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1501 Senecio subdentatus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6079 Adalia bipunctata Species Coccinellidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26886 Carex brevicollis Species Cyperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19692 Quercus variabilis Species Fagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18659 Prunus japonica Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20844 Sphaerella rosigena n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO12079 Dysoxylum cumingianum Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23256 Mentha arvensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3980 Frangula purshiana Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3019 Rhodophyllus icterinus Species Entolomataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2228 Photinia serratifolia Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26326 Ocotea macrophylla Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10216 Leptocereus quadricostatus Species Cactaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19913 Rhynchophorus ferrugineus Species Curculionidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22675 Helichrysum chionosphaerum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24407 Bipolaris heveae Species Pleosporaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9105 Polygonum hypoleucum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11042 Lecanora sordida Species Lecanoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17856 Anaphalis lactea Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9082 Phialophora asteris Species n.a. Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29449 Boehmeria nivea Species Urticaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25628 Abrus pulchellus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18867 Stephanitis takeyai Species Tingidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28688 Aster tataricus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19229 Aniba parviflora Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13403 Gadus morhua callarias Species Gadidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27454 Turbo cornutus Species Turbinidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4158 Hymenoxys lemmonii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6425 Betula davurica Species Betulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3022 Toxicopueraria peduncularis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15422 Carduus tenuiflorus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12755 Siphonostegia chinensis Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5070 Mycocepurus goeldii Species Formicidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26680 Amsinckia intermedia Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4278 Wikstroemia monticola Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2603 Lactuca plumieri Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17822 Fridericia triplinervia Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27790 Delia arenicola Species Anthomyiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4345 Caulocystis cephalornithos Species Sargassaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15430 Abutilon grandiflorum Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27873 Ravenia spectabilis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13754 Tanacetum coccineum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11889 Dendrobium chrysanthum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15347 Carlina diae Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22526 Justicia secunda Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14104 Dendriopoterium menendezii Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19050 Garcinia polyantha Species Clusiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26465 Coreopsis tinctoria Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20947 Tagetes filifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3524 Endothia longirostris Species Cryphonectriaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9448 Dictyopteris australis Species Dictyotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3954 Lanaria lanata Species Lanariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6675 Aplophyllum myrtifolium n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO16988 Pseudodistoma novaezelandiae Species Pseudodistomidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2198 Rivularia firma Species Rivulariaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO88 Rheum undulatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17440 Thryptomene kochii Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26401 Andrographis neesiana Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28174 Poterium sanguisorba Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26917 Quercus rubra Species Fagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12327 Senna occidentalis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14217 Adansonia grandidieri Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27564 Stevia berlandieri Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13237 Teucrium yemense Species n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO9987 Tricholomopsis rutilans Species Tricholomataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26899 Cheilanthes argentea Species Pteridaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2188 Dendrobium candidum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2417 Xylaria longiana Species Xylariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14800 Oophaga granulifera Species Dendrobatidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20490 Erythrophleum ivorense Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19512 Gleichenia quadripartita Species Gleicheniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO559 Mimusops globosa Species Sapotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4997 Xerochrysum viscosum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28024 Rheum palmatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27363 Gynochthodes officinalis Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14953 Thapsia transtagana Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO865 Dendrobium loddigesii Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10359 Chaiturus marrubiastrum Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2779 Syzygium australe Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23412 Uvaria afzelii Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10688 Flacourtia jangomas Species Salicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20144 Lespedeza tomentosa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20753 Grangea maderaspatana Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3110 Selaginella labordei Species Selaginellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2091 Abies pectinata Species Pinaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13523 Neobalanocarpus heimii Species Dipterocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25875 Parkia biglandulosa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4132 Cranfillia fluviatilis Species Blechnaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14248 Mandragora autumnalis Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18830 Valeriana cardamines Species Caprifoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16572 Rhododendron dahuricum Species Ericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13418 Rumex acetosa Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3068 Euphorbia franchetii Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10780 Bletilla striata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7644 Dysoxylum muelleri Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26972 Baccharis potosina Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12108 Aizopsis selskiana Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10239 Magnolia figo Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13107 Rumex patientia Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20881 Rheum officinale Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16419 Rumex chalepensis Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17568 Balanophora laxiflora Species Balanophoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28478 Magnolia ovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14855 Vismia laurentii Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23370 Sticta mougeotiana Species Lobariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13246 Pinalia stricta Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO624 Isaria fumosorosea Species Cordycipitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16040 Pristimera indica Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26202 Loranthus pentandrus Species Loranthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4511 Canarium bengalense Species Burseraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12759 Rheum australe Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25801 Harungana madagascariensis Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12875 Pleione yunnanensis Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19935 Evodia rutaecarpa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18144 Metrodorea nigra Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18287 Penicillium bilaiae Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12477 Dodonaea viscosa Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23639 Cynanchum viminale Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7834 Tricholoma portentosum Species Tricholomataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20560 Polyporus betulinus Species Polyporaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8386 Enceliopsis argophylla Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29099 Sinocrassula indica Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16746 Lendenfeldia frondosa Species Thorectidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20353 Degenia velebitica Species Brassicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8179 Laccaria amethystea Species Tricholomataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19818 Jacquemontia paniculata Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19395 Nepeta granatensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24601 Rumex dentatus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19753 Liabum bourgeaui Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14711.1 Arabidopsis lyrata subsp. lyrata Subspecies Brassicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18008 Viburnum rhytidophyllum Species Adoxaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20900 Dendrobium chrysotoxum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19232 Anchusa azurea Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21244 Delphinium nuttallianum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7632 Rheum tanguticum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19037 Senecio praecox Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24573 Teloschistes flavicans Species Teloschistaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13421 Sphaerella laricina n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO25954 Smilax corbularia Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28260 Senna alexandrina Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17018 Salvia greggii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27239 Maclura tinctoria Species Moraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24699 Phlogacanthus curviflorus Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21112 Chaetomium carinthiacum Species Chaetomiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8780 Melicope triphylla Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20422 Albizia myriophylla Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8921 Senna obtusifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14520 Bassia muricata Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15297 Aconitum seravschanicum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13454 Amphorogyne spicata Species Amphorogynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15746 Athelia rolfsii Species Atheliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27164 Aspergillus alliaceus Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23332 Dendrobium fimbriatum Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7455 Phlomis rigida Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26393.1 Petunia integrifolia subsp. inflata Subspecies Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7198 Scilla socialis Species Hyacinthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10120 Nuxia floribunda Species Stilbaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20625 Delphinium virgatum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5575 Parmelia alpicola Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO397 Thymelaea hirsuta Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13716 Aconitum tasiromontanum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO835 Diatraea saccharalis Species Crambidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11580 Onobrychis arenaria Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16590 Cytophaga hutchinsoni Species Cytophagaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO26777 Pneumatopteris pennigera Species Thelypteridaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16449 Hincksinoflustra denticulata n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO21691 Dillenia indica Species Dilleniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25352 Pluchea odora Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19073 Uncaria lancifolia Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19996 Caulerpa peltata Species Caulerpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26703 Coryphantha ottonis Species Cactaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14014 Eriocheir sinensis Species Varunidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14951 Zanthoxylum acanthopodium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1756 Cremastra appendiculata Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3894 Dendrobium nobile Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26929 Stachybotrys microspora Species Stachybotryaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28626 Isodon rubescens Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18497 Euphorbia aellenii Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2631 Aster sedifolius Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9752 Miliusa velutina Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15472 Oryctes monoceros Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20223 Rosa pomifera Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24629 Achromobacter denitrificans Species Alcaligenaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO21376 Lupinus corymbosus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26111 Lobelia camporum Species Campanulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18252 Cajanus cajan Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14932.1 Dalbergia lanceolaria subsp. paniculata Subspecies Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8605 Xalocoa ocellata Species Graphidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27737 Penicillium shearii Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8666 Acorus tatarinowii Species Acoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16142 Verbascum thapsiforme Species Scrophulariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25430 Xanthoceras sorbifolium Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3214 Lavandula vera Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26171 Solanum linnaeanum Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7819.1 Epichloe festucae var. lolii Varieties Clavicipitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17807 Dysosma versipellis Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26983 Oncoba welwitschii Species Salicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14304 Physalis alkekengi Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8156.1 Taraxacum platycarpum subsp. hondoense Subspecies Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26866 Copaifera reticulata Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24989 Solanum cleistogamum Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19671 Dipsacus azureus Species Caprifoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17553 Pleione bulbocodioides Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12252 Psychotria stachyoides Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7672 Senna tora Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11391 Polygonum cuspidatum Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT4312 Individual Protein Human rhinovirus A protease Human rhinovirus sp. IC50 > 150000.0 nM PMID[496644]
NPT279 Individual Protein Leukocyte elastase Homo sapiens Inhibition = 100.0 % PMID[496645]
NPT279 Individual Protein Leukocyte elastase Homo sapiens IC50 = 6200.0 nM PMID[496645]
NPT278 Individual Protein Cathepsin G Homo sapiens Inhibition = 39.0 % PMID[496645]
NPT762 Cell Line A-431 Homo sapiens Inhibition = 80.5 % PMID[496648]
NPT306 Cell Line PC-3 Homo sapiens Inhibition = 73.2 % PMID[496648]
NPT13 Individual Protein Tyrosine-protein kinase LCK Homo sapiens IC50 > 800.0 ug.mL-1 PMID[496652]
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 19000.0 nM PMID[496653]
NPT65 Cell Line HepG2 Homo sapiens IC50 = 77300.0 nM PMID[496653]
NPT91 Cell Line KB Homo sapiens ED50 = 1.55 ug ml-1 PMID[496655]
NPT80 Cell Line Raji Homo sapiens Activity = 60.0 % PMID[496659]
NPT2757 Individual Protein Purinergic receptor P2Y12 Homo sapiens Inhibition = 7.0 % PMID[496662]
NPT2757 Individual Protein Purinergic receptor P2Y12 Homo sapiens Ki > 10000.0 nM PMID[496662]
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 35481.3 nM PMID[496663]
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 3548.1 nM PMID[496663]
NPT151 Individual Protein 15-hydroxyprostaglandin dehydrogenase [NAD+] Homo sapiens Potency = 14125.4 nM PMID[496663]
NPT501 Individual Protein Alpha-galactosidase A Homo sapiens Potency = 35481.3 nM PMID[496663]
NPT3022 Individual Protein Thioredoxin reductase 2, mitochondrial Rattus norvegicus IC50 = 132000.0 nM PMID[496664]
NPT198 Individual Protein Vitamin D receptor Homo sapiens Potency n.a. 22387.2 nM PMID[496663]
NPT199 Individual Protein DNA polymerase kappa Homo sapiens Potency n.a. 39810.7 nM PMID[496663]
NPT444 Individual Protein Ubiquitin carboxyl-terminal hydrolase 1 Homo sapiens Potency n.a. 44668.4 nM PMID[496663]
NPT368 Cell Line SN12C Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT370 Cell Line NCI-H23 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT369 Cell Line ACHN Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT371 Cell Line UO-31 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT116 Cell Line HL-60 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT374 Cell Line SF-539 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT375 Cell Line Malme-3M Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT373 Cell Line SK-MEL-5 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT111 Cell Line K562 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT376 Cell Line A498 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT377 Cell Line OVCAR-3 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT379 Cell Line HOP-62 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT112 Cell Line MOLT-4 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT380 Cell Line U-251 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT381 Cell Line OVCAR-8 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT382 Cell Line OVCAR-5 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT383 Cell Line SNB-19 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT385 Cell Line SR Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT573 Cell Line M19-MEL Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT323 Cell Line SW-620 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT386 Cell Line KM12 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT455 Cell Line NCI-H522 Homo sapiens GI50 n.a. 78523.56 nM PMID[496665]
NPT387 Cell Line M14 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT388 Cell Line NCI-H322M Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT389 Cell Line RPMI-8226 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT456 Cell Line OVCAR-4 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT390 Cell Line LOX IMVI Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT147 Cell Line SK-MEL-2 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT575 Cell Line KM-20L2 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT81 Cell Line A549 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT392 Cell Line SNB-75 Homo sapiens GI50 n.a. 93756.2 nM PMID[496665]
NPT391 Cell Line HCC 2998 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT393 Cell Line HCT-116 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT395 Cell Line SF-268 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT394 Cell Line EKVX Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT576 Cell Line DMS-114 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT731 Cell Line LXFL 529 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT146 Cell Line SK-OV-3 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT398 Cell Line UACC-62 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT397 Cell Line NCI-H460 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT308 Cell Line CAKI-1 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT399 Cell Line SF-295 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT458 Cell Line IGROV-1 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT577 Cell Line RXF 631 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT403 Cell Line UACC-257 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT578 Cell Line SNB-78 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT579 Cell Line DLD-1 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT404 Cell Line CCRF-CEM Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT405 Cell Line NCI-H226 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT139 Cell Line HT-29 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT170 Cell Line SK-MEL-28 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT407 Cell Line COLO 205 Homo sapiens GI50 n.a. 100000.0 nM PMID[496665]
NPT732 Cell Line HOP-18 Homo sapiens GI50 n.a. 51880.0 nM PMID[496665]
NPT83 Cell Line MCF7 Homo sapiens IC50 > 100.0 ug.mL-1 PMID[496675]
NPT139 Cell Line HT-29 Homo sapiens IC50 > 100.0 ug.mL-1 PMID[496675]
NPT81 Cell Line A549 Homo sapiens IC50 > 100.0 ug.mL-1 PMID[496675]
NPT737 Cell Line HUVEC Homo sapiens IC50 > 100.0 ug.mL-1 PMID[496675]
NPT496 Individual Protein Alpha-L-fucosidase 1 Bos taurus IC50 = 32000.0 nM PMID[496680]
NPT1668 Cell Line NCI-H157 Homo sapiens IC50 = 3000.0 nM PMID[496681]
NPT81 Cell Line A549 Homo sapiens IC50 = 1500.0 nM PMID[496681]
NPT81 Cell Line A549 Homo sapiens Activity < 50.0 % PMID[496681]
NPT1668 Cell Line NCI-H157 Homo sapiens Activity < 50.0 % PMID[496681]
NPT35 Others n.a. LogP = 3.65 n.a. PMID[496643]
NPT544 Protein Family Estrogen receptor Homo sapiens Control = 104.2 % PMID[496647]
NPT544 Protein Family Estrogen receptor Homo sapiens Control = 94.0 % PMID[496647]
NPT544 Protein Family Estrogen receptor Homo sapiens Control = 99.2 % PMID[496647]
NPT637 Organism Fusarium oxysporum Fusarium oxysporum Inhibition = 0.0 % PMID[496648]
NPT1276 Organism Gibberella zeae Gibberella zeae Inhibition = 10.12 % PMID[496648]
NPT825 Organism Phytophthora infestans Phytophthora infestans Inhibition = 19.05 % PMID[496648]
NPT878 Organism Streptococcus mutans Streptococcus mutans MIC > 250.0 ug.mL-1 PMID[496649]
NPT878 Organism Streptococcus mutans Streptococcus mutans Inhibition = 119.9 % PMID[496649]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 0.25 mg/ml PMID[496650]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity > 0.25 mg/ml PMID[496650]
NPT2 Others Unspecified IC50 > 800.0 ug.mL-1 PMID[496654]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 1.44 ug ml-1 PMID[496655]
NPT2 Others Unspecified Activity < 50.0 % PMID[496656]
NPT20967 CELL-LINE Platelet n.a. Activity = 78.9 % PMID[496657]
NPT20967 CELL-LINE Platelet n.a. Activity = 89.6 % PMID[496657]
NPT20967 CELL-LINE Platelet n.a. Activity = 86.8 % PMID[496657]
NPT20967 CELL-LINE Platelet n.a. Activity = 80.7 % PMID[496657]
NPT1 Others Radical scavenging activity IC50 > 100.0 ug.mL-1 PMID[496658]
NPT2 Others Unspecified Activity = 1.5 % PMID[496659]
NPT2 Others Unspecified Activity = 24.7 % PMID[496659]
NPT2 Others Unspecified Activity = 51.1 % PMID[496659]
NPT2 Others Unspecified Activity = 94.2 % PMID[496659]
NPT2 Others Unspecified logIC50 = 2.5 n.a. PMID[496659]
NPT2 Others Unspecified IC50 = 192300.0 nM PMID[496661]
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 28183.8 nM PMID[496663]
NPT792 Individual Protein Arachidonate 15-lipoxygenase Homo sapiens Potency = 12589.3 nM PMID[496663]
NPT7 Individual Protein Thioredoxin reductase 1, cytoplasmic Rattus norvegicus IC50 = 185000.0 nM PMID[496664]
NPT992 Organism Entamoeba histolytica Entamoeba histolytica IC50 = 12.7 ug.mL-1 PMID[496667]
NPT1369 Organism Henosepilachna vigintioctopunctata Henosepilachna vigintioctopunctata Activity = 0.15 cm2 PMID[496668]
NPT1369 Organism Henosepilachna vigintioctopunctata Henosepilachna vigintioctopunctata Activity = 0.32 cm2 PMID[496668]
NPT1369 Organism Henosepilachna vigintioctopunctata Henosepilachna vigintioctopunctata Activity = 0.52 cm2 PMID[496668]
NPT1369 Organism Henosepilachna vigintioctopunctata Henosepilachna vigintioctopunctata Activity = 34.0 % PMID[496668]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 11.3 cm2 PMID[496668]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 21.6 cm2 PMID[496668]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 33.4 cm2 PMID[496668]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 30.0 % PMID[496668]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 5.61 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 4.77 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = -2.34 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = -2.77 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = -2.87 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = -2.94 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = -2.96 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 2.09 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 2.44 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 2.41 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 3.04 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 4.26 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 4.3 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 4.74 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 9.34 n.a. PMID[496669]
NPT1865 Organism Hordeum vulgare Hordeum vulgare FC = 19.91 n.a. PMID[496669]
NPT3519 Organism Blumeria graminis f. sp. hordei Blumeria graminis f. sp. hordei PDI = 4.4 % PMID[496669]
NPT3519 Organism Blumeria graminis f. sp. hordei Blumeria graminis f. sp. hordei Activity = 4.5 % PMID[496669]
NPT3519 Organism Blumeria graminis f. sp. hordei Blumeria graminis f. sp. hordei Activity = 56.6 % PMID[496669]
NPT73 Individual Protein Solute carrier organic anion transporter family member 1B1 Homo sapiens Inhibition = 111.93 % PMID[496671]
NPT72 Individual Protein Solute carrier organic anion transporter family member 1B3 Homo sapiens Inhibition = 112.82 % PMID[496671]
NPT963 Organism Hepatitis B virus Hepatitis B virus IC50 = 300.0 ug.mL-1 PMID[496672]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Potency n.a. 8193.0 nM PMID[496673]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Potency n.a. 366.0 nM PMID[496673]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Potency n.a. 1834.2 nM PMID[496673]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Potency n.a. 3261.7 nM PMID[496673]
NPT862 Individual Protein Epoxide hydratase Homo sapiens Inhibition = 27.1 % PMID[496674]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = -5.66 % PMID[496676]
NPT2 Others Unspecified IC50 = 22.57 ug.mL-1 PMID[496677]
NPT20556 SINGLE PROTEIN Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2 Inhibition = 27.91 % PMID[496678]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = 0.04 % PMID[496679]
NPT2 Others Unspecified IC50 = 5320.0 nM PMID[496680]
NPT2 Others Unspecified IC50 = 26430.0 nM PMID[496680]
NPT24816 SINGLE PROTEIN Alpha-mannosidase Canavalia ensiformis Inhibition < 50.0 % PMID[496680]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC312929 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC126767
1.0 High Similarity NPC118027
1.0 High Similarity NPC245584
1.0 High Similarity NPC289042
1.0 High Similarity NPC56433
1.0 High Similarity NPC190648
0.979 High Similarity NPC147735
0.979 High Similarity NPC255641
0.979 High Similarity NPC470568
0.979 High Similarity NPC290954
0.979 High Similarity NPC294646
0.9786 High Similarity NPC19896
0.9722 High Similarity NPC470569
0.9655 High Similarity NPC154683
0.9655 High Similarity NPC40356
0.9589 High Similarity NPC107109
0.9589 High Similarity NPC208806
0.958 High Similarity NPC34802
0.9574 High Similarity NPC167663
0.9524 High Similarity NPC226656
0.9524 High Similarity NPC66508
0.9507 High Similarity NPC21599
0.9507 High Similarity NPC48762
0.9507 High Similarity NPC193703
0.9504 High Similarity NPC94076
0.9504 High Similarity NPC182255
0.9459 High Similarity NPC14561
0.9459 High Similarity NPC77807
0.9459 High Similarity NPC5379
0.9456 High Similarity NPC214632
0.9448 High Similarity NPC329933
0.9441 High Similarity NPC34482
0.9441 High Similarity NPC49282
0.9437 High Similarity NPC84266
0.9396 High Similarity NPC199463
0.9396 High Similarity NPC37543
0.9396 High Similarity NPC178976
0.9379 High Similarity NPC256672
0.9379 High Similarity NPC2569
0.9379 High Similarity NPC7025
0.9379 High Similarity NPC27221
0.9379 High Similarity NPC472056
0.9379 High Similarity NPC172329
0.9375 High Similarity NPC470570
0.9366 High Similarity NPC49108
0.9333 High Similarity NPC324736
0.932 High Similarity NPC474417
0.932 High Similarity NPC478148
0.932 High Similarity NPC149526
0.9315 High Similarity NPC158338
0.9315 High Similarity NPC100985
0.9315 High Similarity NPC97028
0.9315 High Similarity NPC65589
0.9315 High Similarity NPC288036
0.9315 High Similarity NPC80370
0.9315 High Similarity NPC97029
0.931 High Similarity NPC22005
0.931 High Similarity NPC7943
0.931 High Similarity NPC123202
0.9306 High Similarity NPC28632
0.9291 High Similarity NPC1268
0.9286 High Similarity NPC471905
0.9272 High Similarity NPC84571
0.9272 High Similarity NPC472052
0.9272 High Similarity NPC470342
0.9272 High Similarity NPC472060
0.9267 High Similarity NPC263483
0.9252 High Similarity NPC202595
0.9241 High Similarity NPC163846
0.9241 High Similarity NPC225173
0.9236 High Similarity NPC475201
0.9225 High Similarity NPC472366
0.9214 High Similarity NPC254847
0.9211 High Similarity NPC311740
0.9195 High Similarity NPC329844
0.9195 High Similarity NPC93552
0.9189 High Similarity NPC230848
0.9189 High Similarity NPC258249
0.9189 High Similarity NPC232645
0.9189 High Similarity NPC72958
0.9184 High Similarity NPC65775
0.9184 High Similarity NPC10027
0.9178 High Similarity NPC125801
0.9172 High Similarity NPC478019
0.9167 High Similarity NPC310340
0.9161 High Similarity NPC253822
0.9161 High Similarity NPC305845
0.9161 High Similarity NPC101366
0.9161 High Similarity NPC204045
0.9155 High Similarity NPC138099
0.9155 High Similarity NPC242994
0.9149 High Similarity NPC53414
0.9149 High Similarity NPC53206
0.9139 High Similarity NPC201127
0.9139 High Similarity NPC474637
0.9128 High Similarity NPC312338
0.9128 High Similarity NPC149889
0.9128 High Similarity NPC87708
0.9128 High Similarity NPC175978
0.9122 High Similarity NPC474660
0.9122 High Similarity NPC325983
0.911 High Similarity NPC300540
0.9097 High Similarity NPC268204
0.9097 High Similarity NPC40118
0.9097 High Similarity NPC55832
0.9097 High Similarity NPC26051
0.9097 High Similarity NPC232021
0.9097 High Similarity NPC52789
0.9097 High Similarity NPC135524
0.9097 High Similarity NPC126534
0.9091 High Similarity NPC109232
0.9091 High Similarity NPC477956
0.9091 High Similarity NPC295384
0.9091 High Similarity NPC165172
0.9091 High Similarity NPC181560
0.9091 High Similarity NPC169452
0.9085 High Similarity NPC472419
0.9078 High Similarity NPC141934
0.9073 High Similarity NPC180924
0.9073 High Similarity NPC146211
0.9067 High Similarity NPC210942
0.9067 High Similarity NPC169990
0.906 High Similarity NPC302783
0.906 High Similarity NPC132990
0.906 High Similarity NPC473201
0.906 High Similarity NPC46882
0.9054 High Similarity NPC233267
0.9054 High Similarity NPC291049
0.9041 High Similarity NPC476055
0.9034 High Similarity NPC297600
0.9028 High Similarity NPC259166
0.9028 High Similarity NPC246638
0.9028 High Similarity NPC48624
0.9028 High Similarity NPC172250
0.9028 High Similarity NPC124365
0.9028 High Similarity NPC144118
0.9028 High Similarity NPC215311
0.9028 High Similarity NPC204985
0.9028 High Similarity NPC213659
0.9028 High Similarity NPC265178
0.9028 High Similarity NPC80962
0.9028 High Similarity NPC219917
0.9028 High Similarity NPC326109
0.9028 High Similarity NPC11056
0.9028 High Similarity NPC275734
0.9021 High Similarity NPC55162
0.9021 High Similarity NPC472368
0.9021 High Similarity NPC90665
0.9021 High Similarity NPC279668
0.9021 High Similarity NPC21350
0.9021 High Similarity NPC278323
0.9021 High Similarity NPC143438
0.9021 High Similarity NPC190457
0.9021 High Similarity NPC309154
0.9021 High Similarity NPC251681
0.9021 High Similarity NPC12175
0.9021 High Similarity NPC243528
0.902 High Similarity NPC470810
0.9014 High Similarity NPC98115
0.9014 High Similarity NPC477244
0.9014 High Similarity NPC168105
0.9014 High Similarity NPC477242
0.9014 High Similarity NPC41461
0.9014 High Similarity NPC477243
0.9014 High Similarity NPC25287
0.9014 High Similarity NPC66349
0.9014 High Similarity NPC249606
0.9014 High Similarity NPC274109
0.9014 High Similarity NPC1486
0.9014 High Similarity NPC476333
0.9014 High Similarity NPC193792
0.9014 High Similarity NPC186838
0.9014 High Similarity NPC473391
0.9014 High Similarity NPC12165
0.9014 High Similarity NPC472364
0.9014 High Similarity NPC472367
0.9014 High Similarity NPC150399
0.9013 High Similarity NPC246647
0.9013 High Similarity NPC96342
0.9013 High Similarity NPC164110
0.9013 High Similarity NPC212967
0.9 High Similarity NPC470338
0.9 High Similarity NPC470337
0.9 High Similarity NPC470340
0.9 High Similarity NPC51824
0.9 High Similarity NPC180944
0.9 High Similarity NPC267205
0.9 High Similarity NPC113608
0.9 High Similarity NPC268992
0.8993 High Similarity NPC470107
0.8993 High Similarity NPC295036
0.8993 High Similarity NPC473466
0.8993 High Similarity NPC280295
0.8993 High Similarity NPC227122
0.8993 High Similarity NPC205766
0.8993 High Similarity NPC119929
0.8986 High Similarity NPC472841
0.8986 High Similarity NPC105415
0.898 High Similarity NPC196114
0.898 High Similarity NPC25844

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC312929 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9214 High Similarity NPD1509 Clinical (unspecified phase)
0.8936 High Similarity NPD1607 Approved
0.8903 High Similarity NPD6232 Discontinued
0.8854 High Similarity NPD7473 Discontinued
0.8811 High Similarity NPD1510 Phase 2
0.8794 High Similarity NPD1240 Approved
0.8718 High Similarity NPD6959 Discontinued
0.8693 High Similarity NPD7819 Suspended
0.8658 High Similarity NPD4378 Clinical (unspecified phase)
0.8658 High Similarity NPD2532 Approved
0.8658 High Similarity NPD2533 Approved
0.8658 High Similarity NPD2534 Approved
0.863 High Similarity NPD970 Clinical (unspecified phase)
0.8553 High Similarity NPD3226 Approved
0.8533 High Similarity NPD7410 Clinical (unspecified phase)
0.8503 High Similarity NPD1549 Phase 2
0.8467 Intermediate Similarity NPD7390 Discontinued
0.8452 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.8435 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.8435 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.8397 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.8377 Intermediate Similarity NPD4380 Phase 2
0.8323 Intermediate Similarity NPD7411 Suspended
0.8298 Intermediate Similarity NPD1470 Approved
0.8291 Intermediate Similarity NPD3749 Approved
0.8269 Intermediate Similarity NPD1934 Approved
0.8267 Intermediate Similarity NPD3750 Approved
0.8243 Intermediate Similarity NPD2796 Approved
0.8243 Intermediate Similarity NPD2935 Discontinued
0.8224 Intermediate Similarity NPD1511 Approved
0.8217 Intermediate Similarity NPD2801 Approved
0.82 Intermediate Similarity NPD2800 Approved
0.8188 Intermediate Similarity NPD2346 Discontinued
0.8176 Intermediate Similarity NPD7075 Discontinued
0.8117 Intermediate Similarity NPD1512 Approved
0.8113 Intermediate Similarity NPD7768 Phase 2
0.8113 Intermediate Similarity NPD3882 Suspended
0.8101 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.8098 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.8061 Intermediate Similarity NPD5844 Phase 1
0.8041 Intermediate Similarity NPD6651 Approved
0.8027 Intermediate Similarity NPD943 Approved
0.8026 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.8025 Intermediate Similarity NPD6599 Discontinued
0.8014 Intermediate Similarity NPD1201 Approved
0.8 Intermediate Similarity NPD6099 Approved
0.8 Intermediate Similarity NPD5408 Approved
0.8 Intermediate Similarity NPD5405 Approved
0.8 Intermediate Similarity NPD5404 Approved
0.8 Intermediate Similarity NPD1551 Phase 2
0.8 Intermediate Similarity NPD6100 Approved
0.8 Intermediate Similarity NPD5406 Approved
0.7975 Intermediate Similarity NPD5710 Approved
0.7975 Intermediate Similarity NPD5711 Approved
0.7963 Intermediate Similarity NPD5494 Approved
0.7961 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7947 Intermediate Similarity NPD2344 Approved
0.7933 Intermediate Similarity NPD3748 Approved
0.7925 Intermediate Similarity NPD6801 Discontinued
0.7919 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7888 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.7879 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7879 Intermediate Similarity NPD6166 Phase 2
0.7879 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.7871 Intermediate Similarity NPD6799 Approved
0.7843 Intermediate Similarity NPD1243 Approved
0.784 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.7815 Intermediate Similarity NPD2799 Discontinued
0.7811 Intermediate Similarity NPD6559 Discontinued
0.7792 Intermediate Similarity NPD7003 Approved
0.7792 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7784 Intermediate Similarity NPD3818 Discontinued
0.7764 Intermediate Similarity NPD1465 Phase 2
0.7751 Intermediate Similarity NPD5953 Discontinued
0.7742 Intermediate Similarity NPD2309 Approved
0.7722 Intermediate Similarity NPD920 Approved
0.7716 Intermediate Similarity NPD3817 Phase 2
0.7703 Intermediate Similarity NPD4625 Phase 3
0.7697 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7651 Intermediate Similarity NPD2313 Discontinued
0.7651 Intermediate Similarity NPD3764 Approved
0.7633 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.7625 Intermediate Similarity NPD7458 Discontinued
0.7625 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7619 Intermediate Similarity NPD2798 Approved
0.7611 Intermediate Similarity NPD6776 Approved
0.7611 Intermediate Similarity NPD6781 Approved
0.7611 Intermediate Similarity NPD6779 Approved
0.7611 Intermediate Similarity NPD6780 Approved
0.7611 Intermediate Similarity NPD6778 Approved
0.7611 Intermediate Similarity NPD6777 Approved
0.7611 Intermediate Similarity NPD6782 Approved
0.761 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7605 Intermediate Similarity NPD3926 Phase 2
0.7603 Intermediate Similarity NPD1283 Approved
0.76 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7597 Intermediate Similarity NPD1471 Phase 3
0.7595 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.7595 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7593 Intermediate Similarity NPD37 Approved
0.7588 Intermediate Similarity NPD7074 Phase 3
0.7586 Intermediate Similarity NPD3972 Approved
0.758 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7568 Intermediate Similarity NPD8151 Discontinued
0.7564 Intermediate Similarity NPD4628 Phase 3
0.7558 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7552 Intermediate Similarity NPD1651 Approved
0.7533 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7533 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.7529 Intermediate Similarity NPD7054 Approved
0.7529 Intermediate Similarity NPD7286 Phase 2
0.7514 Intermediate Similarity NPD8313 Approved
0.7514 Intermediate Similarity NPD8312 Approved
0.75 Intermediate Similarity NPD5402 Approved
0.75 Intermediate Similarity NPD230 Phase 1
0.7486 Intermediate Similarity NPD7697 Approved
0.7486 Intermediate Similarity NPD7698 Approved
0.7486 Intermediate Similarity NPD7696 Phase 3
0.7486 Intermediate Similarity NPD7435 Discontinued
0.7485 Intermediate Similarity NPD1247 Approved
0.7485 Intermediate Similarity NPD7472 Approved
0.7483 Intermediate Similarity NPD1876 Approved
0.7471 Intermediate Similarity NPD3751 Discontinued
0.747 Intermediate Similarity NPD919 Approved
0.747 Intermediate Similarity NPD6234 Discontinued
0.7465 Intermediate Similarity NPD405 Clinical (unspecified phase)
0.7455 Intermediate Similarity NPD4967 Phase 2
0.7455 Intermediate Similarity NPD4966 Approved
0.7455 Intermediate Similarity NPD4965 Approved
0.7446 Intermediate Similarity NPD7870 Phase 2
0.7446 Intermediate Similarity NPD7871 Phase 2
0.7442 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.7442 Intermediate Similarity NPD6797 Phase 2
0.744 Intermediate Similarity NPD7229 Phase 3
0.7432 Intermediate Similarity NPD1203 Approved
0.7418 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.74 Intermediate Similarity NPD4908 Phase 1
0.7399 Intermediate Similarity NPD7251 Discontinued
0.7397 Intermediate Similarity NPD1281 Approved
0.7391 Intermediate Similarity NPD5403 Approved
0.7389 Intermediate Similarity NPD2654 Approved
0.7386 Intermediate Similarity NPD8150 Discontinued
0.7379 Intermediate Similarity NPD4626 Approved
0.7375 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7375 Intermediate Similarity NPD5401 Approved
0.7368 Intermediate Similarity NPD7177 Discontinued
0.7356 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.7356 Intermediate Similarity NPD7808 Phase 3
0.7355 Intermediate Similarity NPD4308 Phase 3
0.7333 Intermediate Similarity NPD6534 Approved
0.7333 Intermediate Similarity NPD6535 Approved
0.7326 Intermediate Similarity NPD7701 Phase 2
0.7315 Intermediate Similarity NPD1164 Approved
0.7303 Intermediate Similarity NPD411 Approved
0.7303 Intermediate Similarity NPD4287 Approved
0.7297 Intermediate Similarity NPD4749 Approved
0.7289 Intermediate Similarity NPD4288 Approved
0.7279 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.7279 Intermediate Similarity NPD1610 Phase 2
0.7267 Intermediate Similarity NPD6917 Clinical (unspecified phase)
0.7249 Intermediate Similarity NPD7875 Clinical (unspecified phase)
0.7249 Intermediate Similarity NPD7874 Approved
0.7243 Intermediate Similarity NPD6823 Phase 2
0.723 Intermediate Similarity NPD9717 Approved
0.723 Intermediate Similarity NPD1608 Approved
0.7222 Intermediate Similarity NPD6273 Approved
0.7222 Intermediate Similarity NPD9493 Approved
0.7213 Intermediate Similarity NPD7699 Phase 2
0.7213 Intermediate Similarity NPD7700 Phase 2
0.7211 Intermediate Similarity NPD7801 Approved
0.7205 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.719 Intermediate Similarity NPD6410 Clinical (unspecified phase)
0.719 Intermediate Similarity NPD3268 Approved
0.7186 Intermediate Similarity NPD2296 Approved
0.7181 Intermediate Similarity NPD3600 Clinical (unspecified phase)
0.7176 Intermediate Similarity NPD7199 Phase 2
0.7171 Intermediate Similarity NPD6832 Phase 2
0.7168 Intermediate Similarity NPD7228 Approved
0.7168 Intermediate Similarity NPD7893 Clinical (unspecified phase)
0.7161 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7161 Intermediate Similarity NPD447 Suspended
0.7152 Intermediate Similarity NPD2343 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD4360 Phase 2
0.7143 Intermediate Similarity NPD4363 Phase 3
0.7135 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7135 Intermediate Similarity NPD3787 Discontinued
0.7126 Intermediate Similarity NPD5760 Phase 2
0.7126 Intermediate Similarity NPD5761 Phase 2
0.7123 Intermediate Similarity NPD1548 Phase 1
0.7123 Intermediate Similarity NPD9545 Approved
0.7105 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.7105 Intermediate Similarity NPD9494 Approved
0.7104 Intermediate Similarity NPD4361 Phase 2
0.7104 Intermediate Similarity NPD4362 Clinical (unspecified phase)
0.7102 Intermediate Similarity NPD3658 Clinical (unspecified phase)
0.7097 Intermediate Similarity NPD4307 Phase 2
0.7097 Intermediate Similarity NPD2979 Phase 3
0.7095 Intermediate Similarity NPD8434 Phase 2
0.7093 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7088 Intermediate Similarity NPD6214 Clinical (unspecified phase)

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data