NPASS Compound

Natural Product: NPC293799

Natural Product ID	NPC293799
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	Gs-39783
IUPAC Name	4-N,6-N-dicyclopentyl-2-methylsulfanyl-5-nitropyrimidine-4,6-diamine
Synonyms	GS-39783
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL392394
PubChem CID	6604928
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000004] Organosulfur compounds [CHEMONTID:0001202] Thioethers [CHEMONTID:0004631] Aryl thioethers

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 46 48 0 0 0 0 0 0 0 0999 V2000 -0.4677 4.5664 1.4006 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7117 3.2979 1.0945 S 0 0 0 0 0 0 0 0 0 0 0 0 -0.8720 1.8186 0.5470 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.6572 0.7628 0.2719 N 0 0 0 0 0 0 0 0 0 0 0 0 -1.1551 -0.4070 -0.1472 C 0 0 0 0 0 0 0 0 0 0 0 0 0.2154 -0.4617 -0.2793 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0444 0.6166 -0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2984 0.6506 -0.1135 N 0 0 0 0 0 0 0 0 0 0 0 0 3.3312 -0.1969 -0.4986 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1003 -0.6718 0.7232 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4765 -1.0493 0.2187 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6514 -0.3129 -1.0821 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4426 0.5693 -1.2611 C 0 0 0 0 0 0 0 0 0 0 0 0 0.4383 1.7775 0.4241 N 0 0 0 0 0 0 0 0 0 0 0 0 0.7604 -1.7043 -0.7059 N 0 0 0 0 0 0 0 0 0 0 0 0 1.3655 -2.5739 0.1653 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6941 -2.0634 -1.9201 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.9494 -1.5300 -0.4425 N 0 0 0 0 0 0 0 0 0 0 0 0 -3.3833 -1.5613 -0.3354 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.8795 -1.2514 1.0604 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.3915 -1.2197 0.7876 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.5211 -0.6389 -0.6103 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0916 -0.5098 -1.1493 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.2336 5.0466 0.4160 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4617 4.1747 1.8205 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.8947 5.3762 2.0346 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0630 -1.0019 -1.1805 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1682 0.1900 1.4050 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6747 -1.5802 1.1848 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5772 -2.1367 0.0316 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2776 -0.7558 0.9162 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7325 -1.0127 -1.9553 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5532 0.3417 -1.0767 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1514 0.6616 -2.3296 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 1.5681 -0.8022 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0473 2.6146 0.6438 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.4706 -2.4074 -0.7634 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.7561 -2.5573 -0.5844 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.6162 -0.2071 1.3337 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.6074 -1.9896 1.8118 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.6958 -2.3030 0.7104 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.9429 -0.6683 1.5452 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.0268 0.3361 -0.6199 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.0318 -1.3404 -1.3105 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.0681 -0.7279 -2.2371 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.6991 0.4712 -0.8888 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 2 0 4 5 1 0 5 6 2 0 6 7 1 0 7 8 2 3 8 9 1 0 9 10 1 0 10 11 1 0 11 12 1 0 12 13 1 0 7 14 1 0 6 15 1 0 15 16 1 0 15 17 2 0 5 18 1 0 18 19 1 0 19 20 1 0 20 21 1 0 21 22 1 0 22 23 1 0 14 3 1 0 23 19 1 0 13 9 1 0 1 24 1 0 1 25 1 0 1 26 1 0 9 27 1 0 10 28 1 0 10 29 1 0 11 30 1 0 11 31 1 0 12 32 1 0 12 33 1 0 13 34 1 0 13 35 1 0 14 36 1 0 18 37 1 0 19 38 1 0 20 39 1 0 20 40 1 0 21 41 1 0 21 42 1 0 22 43 1 0 22 44 1 0 23 45 1 0 23 46 1 0 M CHG 2 15 1 16 -1 M END

Standard InCHIKey	GSGVDKOCBKBMGG-UHFFFAOYSA-N
Standard InCHI	InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)
SMILES	CSc1nc(c(c(=NC2CCCC2)[nH]1)N(=O)=O)NC1CCCC1

Calculated Properties

Physi-Chem Properties

Molecular Weight:	337.16	Volume:	322.854 ? Van der Waals volume.
Dense:	1.044	LogP:	3.802 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	3.285 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-4.723 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	5.0	Rigid Bonds:	18.0
TPSA:	96.21 ? Topological Polar Surface Area.	H-Bond Acceptor:	7.0
H-Bond Donor:	2.0	Rings:	3.0
Heavy Atoms:	8.0

MedChem Properties

QED Drug-Likeness Score:	0.372	GASA:	0.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	3.24	Fsp³:	0.733
MCE-18:	44.308 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Rejected
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.69	Fluc inhibitor:	0.007 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.317 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.889 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.144	Promiscuous compounds:	0.002

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-4.683	MDCK Permeability:	-4.768
Pgp-inhibitor:	0.136	Pgp-substrate:	0.0
PAMPA:	0.012 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.0
20% Bioavailability (F20%):	0.0	30% Bioavailability (F30%):	0.001
50% Bioavailability (F50%):	0.02

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.129	MRP1:	0.999
Plasma Protein Binding (PPB):	99.106%	Volume Distribution (VD):	-0.143
Fu:	0.741% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.487
OATP1B3 inhibitor:	0.987	BCRP inhibitor:	0.02
BSEP inhibitor:	0.998

ADMET: Metabolism

CYP1A2-inhibitor:	0.983	CYP1A2-substrate:	1.0
CYP2C19-inhibitor:	0.027	CYP2C19-substrate:	1.0
CYP2C9-inhibitor:	0.3	CYP2C9-substrate:	0.0
CYP2D6-inhibitor:	0.797	CYP2D6-substrate:	0.016
CYP3A4-inhibitor:	0.004	CYP3A4-substrate:	1.0
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	1.0
HLM stability:	0.737 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

6.924

Half-life (T1/2):

0.885

ADMET: Toxicity

hERG Blockers:	0.213	hERG Blockers (10um):	0.517
Human Hepatotoxicity (H-HT):	0.648	Drug-induced Liver Injury (DILI):	0.998
AMES Toxicity:	0.839	Rat Oral Acute Toxicity:	0.325
Maximum Recommended Daily Dose:	0.518	Skin Sensitization:	0.999
Carcinogencity:	0.738	Eye Corrosion:	0.0
Eye Irritation:	0.834	Respiratory Toxicity:	0.986
Drug-induced Neurotoxicity:	0.013	Ototoxicity:	0.212
Hematotoxicity:	0.414	Drug-induced Nephrotoxicity:	0.391
Genotoxicity:	0.999	RPMI-8226 Immunitoxicity:	0.042
A549 Cytotoxicity:	0.028	Hek293 Cytotoxicity:	0.941
BCF:	1.55 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	4.051 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	5.297 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	4.928 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	root	n.a.	PMID[18975262]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21465337]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24333010]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21507	Ephedra intermedia	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21507	Ephedra intermedia	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21507	Ephedra intermedia	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO21507	Ephedra intermedia	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO18176	Ephedra sinica	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28125	Ephedra equisetina	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21507	Ephedra intermedia	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Efficacy	2
EC50	2
Emax	1
Potency	7
AC50	3
Activity	3
%max	1
Inhibition	10
%Max (Mean)	13
%Inhib (Mean)	13
IC50	1
Growth Rate	18
Control DMSO Healthy Nuclei (%)	52
Control DMSO Membrane Permeable-Phenotype Cells (%	51
Population Fragmented Nuclei (%)	51
Population Tubulin-Different-Phenotype (%)	49
Total Cell Count	50
Population Mitotic Cells (%)	50
Control DMSO Mitotic Cells (%)	49
Population Mitochondria Different-Phenotype (%)	50
Control DMSO Tubulin Phenotype Different Cells (%)	49
Control DMSO Total Cells	49
Control DMSO Fragmented Nuclei %	49
Control DMSO Pyknosed Nuclei (%)	48
Control DMSO Mitochondria Different-Phenotype Cell	48
Population Healthy Nuclei (%)	48
Population Hoechst High Intensity Objects (%)	48
Population Membrane Permeable-Phenotype (%)	48
Population Pyknosed Nuclei (%)	48
Population Apoptotic (%)	48
Population Normal (%)	48
TIME	6

Activity Type	# Activity
Individual protein	32
Cell line	952
Single protein	10
Organism	11
Protein complex	5
Protein-protein interaction	1
Others	2

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT213	Individual protein	Cytochrome P450 2C19	Homo sapiens	Potency	=	5011.9	nM	PubChem BioAssay data set
NPT150	Individual protein	Anthrax lethal factor	Bacillus anthracis	Potency	=	10000.0	nM	PubChem BioAssay data set
NPT212	Individual protein	Cytochrome P450 2C9	Homo sapiens	Potency	=	1995.3	nM	PubChem BioAssay data set
NPT212	Individual protein	Cytochrome P450 2C9	Homo sapiens	AC50	=	1995.26	nM	PubChem BioAssay data set
NPT213	Individual protein	Cytochrome P450 2C19	Homo sapiens	AC50	=	5011.87	nM	PubChem BioAssay data set
NPT208	Individual protein	Cytochrome P450 1A2	Homo sapiens	AC50	=	3981.07	nM	PubChem BioAssay data set
NPT1407	Individual protein	GABA-B receptor 1	Homo sapiens	%max	=	90.4	%	PMID[28408223]
NPT1407	Individual protein	GABA-B receptor 1	Homo sapiens	EC50	=	79.43	nM	PMID[28408223]
NPT1407	Individual protein	GABA-B receptor 1	Homo sapiens	Activity	=	0.0	%	PMID[28408223]
NPT1627	Individual protein	G-protein coupled receptor 35	Homo sapiens	%Inhib (Mean)	=	-30.56	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Max (Mean)	=	1.3	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Inhib (Mean)	=	-38.08	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Inhib (Mean)	=	-23.08	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Max (Mean)	=	0.41	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Max (Mean)	=	0.521	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	-6.9	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1627	Individual protein	G-protein coupled receptor 35	Homo sapiens	%Max (Mean)	=	16.6	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	-35.42	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Max (Mean)	=	-1.71	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT50	Individual protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	=	891.3	nM	PubChem BioAssay data set
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Max (Mean)	=	-3.04	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Inhib (Mean)	=	-13.48	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Inhib (Mean)	=	27.58	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Max (Mean)	=	-0.6894	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT444	Individual protein	Ubiquitin carboxyl-terminal hydrolase 1	Homo sapiens	Potency	n.a.	15848.9	nM	PubChem BioAssay data set
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-1.12	%	DOI[10.6019/CHEMBL4495564]
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	21.48	%	DOI[10.6019/CHEMBL4495564]
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-47.7	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Inhib (Mean)	=	-20.47	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Max (Mean)	=	-2.204	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-5.72	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Inhib (Mean)	=	-32.01	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Max (Mean)	=	-2.359	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Max (Mean)	=	-0.8	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Inhib (Mean)	=	-13.5	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Max (Mean)	=	18.91	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Inhib (Mean)	=	-25.96	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Inhib (Mean)	=	-59.2	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Max (Mean)	=	2.079	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Inhib (Mean)	=	0.07985	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Max (Mean)	=	5.213	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT997	Protein complex	GABA-B receptor	Homo sapiens	Efficacy	=	132.0	%	PMID[17884493]
NPT997	Protein complex	GABA-B receptor	Homo sapiens	Efficacy	=	153.0	%	PMID[17884493]
NPT997	Protein complex	GABA-B receptor	Homo sapiens	EC50	=	741.31	nM	PMID[17884493]
NPT997	Protein complex	GABA-B receptor	Homo sapiens	Emax	=	146.0	%	PMID[17884493]
NPT197	Protein-protein interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	39810.7	nM	PubChem BioAssay data set
NPT997	Protein complex	GABA-B receptor	Homo sapiens	Activity	=	192.0	%	PMID[25856547]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT886	Cell line	NIH3T3	Mus musculus	IC50	=	60000.0	nM	PMID[23544432]
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	209.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	44507.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	11.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	54.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	647.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	97.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	308.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	474.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	45150.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	77.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	79.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.92	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	51.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	35035.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	85.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	360.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	63.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	36.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	185.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	34.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	55.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	51.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	29842.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	76.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	96.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	76.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	80.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	45.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	553.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	88.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	22878.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	84.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	75.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	98.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	74.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	92.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	29.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	92.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	96.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.78	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	11.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	11.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	91.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	71.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	492.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	856.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	97.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.75	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	26450.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	75.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	80.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	89.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.5	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.97	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	87.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	100.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	91.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	56.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	45535.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	57.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	77.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	60692.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	72.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	322.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	67.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	231.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	11.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	71.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	775.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	95.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	301.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	37.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	68271.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	100.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	8571.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	14221.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.05	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	85.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	29.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	505.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	164.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	20657.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	45.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	346.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	101135.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	72.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	72.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	31171.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	235.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	47.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	93.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	11.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	406.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	78.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	462.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	382.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	74.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	11828.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	37.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	83.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	94.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	71.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	87.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	145.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	96.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	-1.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	51.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	83.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	70.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	47.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	449.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.83	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	154.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	63.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	201.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	83.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	38.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	265.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	70.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	76.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	34.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.85	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	99.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	84.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.92	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	20807.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	119.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	86.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	95.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	255.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	341.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	269.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	25.87	%	DOI[10.21203/rs.3.rs-23951/v1]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-0.1	%	DOI[10.6019/CHEMBL4495565]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	0.02	%	DOI[10.6019/CHEMBL4495565]
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	0.19	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	137.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	67.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	47.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	56.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	-0.14	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	63.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	15057.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	48.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	42.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	134.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	153.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	36.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	129.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	29.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	53.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	67.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	51.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	132.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	73.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	94.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	87.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	17835.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	57.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	16285.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	93.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	55.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	16485.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	133.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	54.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	58.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	135.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	184.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	39.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	70.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	39.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	0.18	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	31.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	162.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	121.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	16657.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	96.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	99.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	54.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	57.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	97.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	95.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	164.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	92.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	44.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	14985.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	172.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	34.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	67.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	70.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	193.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	45.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	15078.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	15171.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	0.9	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	165.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	185.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	0.69	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	168.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2	Others	Unspecified	n.a.	Potency	=	11220.2	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Activity	=	59.0	%	PMID[23544432]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.03833	hr	PMID[23544432]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.0	hr	PMID[23544432]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.955	hr	PMID[23544432]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	1.0	hr	PMID[23544432]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC293799 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	45420
0.1-0.2	4435
0.2-0.3	3
0.3-0.4	0
0.4-0.5	0
0.5-0.6	0
0.6-0.7	0
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
		NPC

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC293799 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	7344
0.1-0.2	1799
0.2-0.3	7
0.3-0.4	0
0.4-0.5	0
0.5-0.6	0
0.6-0.7	0
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
		NPD

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data